Synthesis, Anti-HIV Activity Studies, and insilico Rationalization of Cyclobutane-Fused Nucleosides

ChemMedChem

Volumn 7, Issue 6, 2012, Pages 1044-1056

  Figueras, Antoni ^a   Miralles Llumà, Rosa ^a   Flores, Ramon ^a   Rustullet, Albert ^a   Busqué, Félix ^a   Figueredo, Marta ^a   Font, Josep ^a   Alibés, Ramon ^a   Maréchal, Jean Didier ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Antiviral agents; Carbocycles; HIV 1; Molecular modeling; Nucleosides

Indexed keywords

1 (1' CHLORO 4' HYDROXYMETHYL 3' OXABICYCLO[3.2.0]HEPT 2 YL)THYMINE; 1 (1' FLUORO 4' HYDROXYMETHYL 3' OXABICYCLO[3.2.0]HEPT 2 YL)THYMINE; 1 (4 HYDROXYMETHYL 3 OXABICYCLO[3.2.0]HEPT 6 EN 2 YL)THYMINE; 1 (4 TERT BUTYLDIMETHYLSILYLOXYMETHYL 3 OXABICYCLO[3.2.0]HEPT 6 EN 2 YL)THYMINE; 1 (4' HYDROXYMETHYL 6' HYDROXY 3' OXABICYCLO[3.2.0]HEPT 2 YL)THYMINE; 1 (4' HYDROXYMETHYL 6' METHYLENE 3' OXABICYCLO[3.2.0]HEPT 2 YL)THYMINE; 1 (4' HYDROXYMETHYL 6' OXO 3' OXABICYCLO[3.2.0]HEPT 2 YL)THYMINE; 1 (4' TERT BUTYLDIMETHYLSILYLOXYMETHYL 1' CHLORO 3' OXABICYCLO[3.2.0]HEPT 2 YL)THYMINE; 1 (4' TERT BUTYLDIMETHYLSILYLOXYMETHYL 1' FLUORO 3' OXABICYCLO[3.2.0]HEPT 2 YL)THYMINE; 1 (4' TERT BUTYLDIMETHYLSILYLOXYMETHYL 6' METHYLENE 3' OXABICYCLO[3.2.0]HEPT 2 YL)THYMINE; 1 (4' TERT BUTYLDIMETHYLSILYLOXYMETHYL 6' OXO 3' OXABICYCLO[3.2.0]HEPT 2 YL)THYMINE; 1 (4' TERT BUTYLDIMETHYLSILYLOXYMETHYL 6',6' DIETHOXY 3' OXABICYCLO[3.2.0]HEPT 2 YL)THYMINE; 1 (HYDROXYMETHYL 3 OXABICYCLO[3.2.0]HEPT 6 EN 2 YL)THYMINE; 2 ACETYLOXY 4 TERT BUTYLDIMETHYLSILYLOXYMETHYL 6,6 DIETHOXY 3 OXABICYCLO[3.2.0]HEPTANE; 4 TERT BUTYLDIMETHYLSILYLOXYMETHYL 6,6 DIETHOXY 3 OXABICYCLO[3.2.0]HEPTAN 2 ONE; 4 TERT BUTYLDIMETHYLSILYLOXYMETHYL 7,7 DIETHOXY 3 OXABICYCLO[3.2.0]HEPTAN 2 ONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CYCLOBUTANE DERIVATIVE; NUCLEOSIDE ANALOG; RNA DIRECTED DNA POLYMERASE; STAVUDINE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CATALYSIS; CYCLOADDITION; DRUG CONFORMATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOLECULAR DOCKING; MOLECULAR MODEL; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL;

BINDING SITES; COMPUTER SIMULATION; CYCLOBUTANES; ENZYME INHIBITORS; HIV; HIV REVERSE TRANSCRIPTASE; HUMANS; NUCLEOSIDES; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE INHIBITORS; STEREOISOMERISM;

EID: 84861556548     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200059     Document Type: Article

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