Synthesis and biological evaluation of 2',3'-didehydro-2',3'-dideoxy-5- fluorocytidine (D4FC) analogues: Discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase

Journal of Medicinal Chemistry

Volumn 42, Issue 5, 1999, Pages 859-867

  Shi, Junxing ^a,b   McAtee, J Jeffrey ^c   Wirtz, Susan Schlueter ^a,b   Tharnish, Phillip ^a,b   Juodawlkis, Amy ^a,b   Liotta, Dennis C ^c   Schinazi, Raymond F ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Georgia Vet Aff Res Ctr AIDS H   (United States)

^c EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',3' DIDEOXYCYTIDINE DERIVATIVE; ALPHA DEXTRO 2',3' DIDEHYDRO 2',3' DIDEOXY 5 FLUOROURIDINE; ANTINEOPLASTIC AGENT; BETA ALPHA 2',3' DIDEHYDRO 2',3' DIDEOXY 5 FLUOROURIDINE; BETA DEXTRO 2',3' DIDEHYDRO 2',3' DIDEOXY 5 FLUORO 5' O VALERYLCYTIDINE; BETA DEXTRO 2',3' DIDEHYDRO 2',3' DIDEOXY 5 FLUOROURIDINE; BETA DEXTRO 5' O ACETYL 2',3' DIDEHYDRO 2',3' DIDEOXY 5 FLUOROCYTIDINE; BETA DEXTRO 5' O BUTYRYL 2',3' DIDEHYDRO 2',3' DIDEOXY 5 FLUOROCYTIDINE; BETA DEXTRO N ACETYL 2',3' DIDEHYDRO 2',3' DIDEOXY 5 FLUOROCYTIDINE; CYCLOHEXIMIDE; ELVUCITABINE; FLUOROURACIL DERIVATIVE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CANCER; CYTOTOXICITY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-HIV AGENTS; ANTINEOPLASTIC AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; PHOSPHORIC ACID ESTERS; RATS; REVERSE TRANSCRIPTASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; ZALCITABINE;

EID: 0033545678     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980510s     Document Type: Article

References (22)

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