Ginseng (Panax quinquefolius) reduces cell growth, lipid acquisition and increases adiponectin expression in 3T3-L1 cells

Evidence-based Complementary and Alternative Medicine

Volumn 2011, Issue , 2011, Pages

  Popovich, David G ^a   Yeo, Chia Rou ^a   Lee, Sea Ming ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; GINSENG EXTRACT; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RG 1; LIPID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN 3T3; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; GINSENG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LC 50; LIQUID CHROMATOGRAPHY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; UPREGULATION; WESTERN BLOTTING;

EID: 79953272785     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1093/ecam/neq051     Document Type: Article

References (31)

1. Wink M., Evolutionary advantage and molecular modes of action of multi-component mixtures used in phytomedicine Current Drug Metabolism 2008 9 10 996 1009
2. Lee M.-S., Kim C.-T., Kim I.-H., Kim Y., Inhibitory effects of green tea catechin on the lipid accumulation in 3T3-l1 adipocytes Phytotherapy Research 2009 23 8 1088 1091
3. Hsu C.-L., Yen G.-C., Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells Journal of Agricultural and Food Chemistry 2007 55 5 1730 1736 (Pubitemid 46479577)
4. Roffey B., Atwal A., Kubow S., Cinnamon water extracts increase glucose uptake but inhibit adiponectin secretion in 3T3-L1 adipose cells Molecular Nutrition and Food Research 2006 50 8 739 745 (Pubitemid 44342471)
5. Gil-Campos M., Caete R., Gil A., Adiponectin, the missing link in insulin resistance and obesity Clinical Nutrition 2004 23 5 963 974 (Pubitemid 39243008)
6. Gregoire F. M., Adipocyte differentiation: from fibroblast to endocrine cell Experimental Biology and Medicine 2001 226 11 997 1002
7. Vuksan V., Sievenpiper J. L., Koo V. Y. Y., Francis T., Beljan-Zdravkovic U., Xu Z., Vidgen E., American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus Archives of Internal Medicine 2000 160 7 1009 1013 (Pubitemid 30191931)
8. Xie J.-T., Mehendale S. R., Li X., Quigg R., Wang X., Wang C.-Z., Ji A. W., Aung H. H., Rue P. A., Bell G. I., Yuan C.-S., Anti-diabetic effect of ginsenoside Re in ob/ob mice Biochimica et Biophysica Acta 2005 1740 3 319 325 (Pubitemid 40804743)
9. Popovich D. G., Kitts D. D., Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line Archives of Biochemistry and Biophysics 2002 406 1 8 (Pubitemid 35191710)
10. Hwang J.-T., Kim S.-H., Lee M.-S., Kim S. H., Yang H.-J., Kim M.-J., Kim H.-S., Ha J., Kim M. S., Kwon D. Y., Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte Biochemical and Biophysical Research Communications 2007 364 4 1002 1008 (Pubitemid 350103699)
11. Hwang J.-T., Lee M.-S., Kim H.-J., Sung M.-J., Kim H. Y., Kim M. S., Kwon D. Y., Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR- signal pathways Phytotherapy Research 2009 23 2 262 266
12. Han K. L., Jung M. H., Sohn J. H., Hwang J. K., Ginsenoside 20S-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor gamma (PPARgamma) in 3T3-L1 adipocytes Biological Pharmaceutical Bulletin 2006 29 110 113 (Pubitemid 43036705)
13. Shang W., Yang Y., Jiang B., Jin H., Zhou L., Liu S., Chen M., Ginsenoside Rb1 promotes adipogenesis in 3T3-L1 cells by enhancing PPAR 2 and C/EBP gene expression Life Sciences 2007 80 7 618 625 (Pubitemid 46074052)
14. Popovich D. G., Yeo S. Y., Zhang W., Ginseng (Panax quinquefolius) and Licorice (Glycyrrhiza uralensis) root extract combinations increase hepatocarcinoma cell (Hep-G2) viability. Evidence-Based Complementary and Alternative Medicine. In press
15. Zhang W., Popovich D. G., Effect of soyasapogenol A and soyasapogenol B concentrated extracts on Hep-G2 cell proliferation and apoptosis Journal of Agricultural and Food Chemistry 2008 56 8 2603 2608 (Pubitemid 351685198)
16. Zhang W., Yeo M. C., Tang F. Y., Popovich D. G., Bioactive responses of Hep-G2 cells to soyasaponin extracts differs with respect to extraction conditions Food and Chemical Toxicology 2009 47 9 2202 2208
17. Janderov L., McNeil M., Murrell A. N., Mynatt R. L., Smith S. R., Human mesenchymal stem cells as an in vitro model for human adipogenesis Obesity Research 2003 11 1 65 74 (Pubitemid 41137540)
18. Popovich D. G., Kitts D. D., Generation of ginsenosides Rg3 and Rh2 from North American ginseng Phytochemistry 2004 65 3 337 344 (Pubitemid 38147347)
19. Chu C.-Y., Lee H.-J., Chu C.-Y., Yin Y.-F., Tseng T.-H., Protective effects of leaf extract of Zanthoxylum ailanthoides on oxidation of low-density lipoprotein and accumulation of lipid in differentiated THP-1 cells Food and Chemical Toxicology 2009 75 596 601
20. Popovich D. G., Kitts D. D., Mechanistic studies on protopanaxadiol, Rh2, and ginseng (Panax quinquefolius) extract induced cytotoxicity in intestinal Caco-2 cells Journal of Biochemical and Molecular Toxicology 2004 18 3 143 149 (Pubitemid 39069608)
21. Kitts D. D., Popovich D. G., Hu C., Characterizing the mechanism for ginsenoside-induced cytotoxicity in cultured leukemia (THP-1) cells Canadian Journal of Physiology and Pharmacology 2007 85 11 1173 1183 (Pubitemid 351196415)
22. Popov A. M., A comparative study of the hemolytic and cytotoxic activities of triterpenoids isolated from ginseng and sea cucumbers Izvestiya Rossiiskoi Akademii NaukSeriya Biologicheskaya 2002 2 155 164
23. Camp H. S., Ren D., Leff T., Adipogenesis and fat-cell function in obesity and diabetes Trends in Molecular Medicine 2002 8 9 442 447 (Pubitemid 34975991)
24. Abbasi F., Chu J. W., Lamendola C., McLaughlin T., Hayden J., Reaven G. M., Reaven P. D., Discrimination between obesity and insulin resistance in the relationship with adiponectin Diabetes 2004 53 3 585 590 (Pubitemid 38270626)
25. Rudich A., Tlrosh A., Potashnik R., Hemi R., Kanety H., Bashan N., Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes Diabetes 1998 47 10 1562 1569 (Pubitemid 28445343)
26. Hegarty B. D., Turner N., Cooney G. J., Kraegen E. W., Insulin resistance and fuel homeostasis: the role of AMP-activated protein kinase Acta Physiologica 2009 196 1 129 145
27. Zhang Z., Li X., Lv W., Yang Y., Gao H., Yang J., Shen Y., Ning G., Ginsenoside Re reduces insulin resistance through inhibition of c-Jun NH2-terminal kinase and nuclear factor- B Molecular Endocrinology 2008 22 1 186 195
28. Arita Y., Kihara S., Ouchi N., Takahashi M., Maeda K., Miyagawa J.-I., Hotta K., Shimomura I., Nakamura T., Miyaoka K., Kuriyama H., Nishida M., Yamashita S., Okubo K., Matsubara K., Muraguchi M., Ohmoto Y., Funahashi T., Matsuzawa Y., Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity Biochemical and Biophysical Research Communications 1999 257 1 79 83 (Pubitemid 29299050)
29. Tschritter O., Fritsche A., Thamer C., Haap M., Shirkavand F., Rahe S., Staiger H., Maerker E., Hring H., Stumvoll M., Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism Diabetes 2003 52 2 239 243 (Pubitemid 36173174)
30. Weyer C., Funahashi T., Tanaka S., Hotta K., Matsuzawa Y., Pratley R. E., Tataranni P. A., Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia Journal of Clinical Endocrinology and Metabolism 2001 86 5 1930 1935 (Pubitemid 32472900)
31. Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S., Yamashita S., Noda M., Kita S., Ueki K., Eto K., Akanuma Y., Froguel P., Foufelle F., Ferre P., Carling D., Kimura S., Nagai R., Kahn B. B., Kadowaki T., Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase Nature Medicine 2002 8 11 1288 1295 (Pubitemid 35373562)