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Volumn 13, Issue 5, 2012, Pages 5420-5440

Antibody phage display libraries: Contributions to oncology

Author keywords

Clinical antibodies; Phage display; Tumor markers

Indexed keywords

AUTOANTIBODY; BEVACIZUMAB; BORTEZOMIB; CANCER ANTIBODY; CETUXIMAB; CISPLATIN; CIXUTUMUMAB; ERLOTINIB; FLUOROURACIL; FRESOLIMUMAB; GEMCITABINE; LEXATUMUMAB; MAPATUMUMAB; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1D09C3; MOXETUMOMAB PASUDOTOX; NECITUMUMAB; OXALIPLATIN; PANITUMUMAB; PEMETREXED; RAMUCIRUMAB; SORAFENIB; TUMOR MARKER; UNCLASSIFIED DRUG; ANTIBODY; PEPTIDE LIBRARY; TUMOR ANTIGEN;

EID: 84861541264     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13055420     Document Type: Review
Times cited : (33)

References (111)
  • 1
    • 0036317353 scopus 로고    scopus 로고
    • Therapeutic applications of monoclonal antibodies
    • Berger, M.; Shankar, V.; Vafai, A. Therapeutic applications of monoclonal antibodies. Am. J. Med. Sci. 2002, 324, 14-30.
    • (2002) Am. J. Med. Sci , vol.324 , pp. 14-30
    • Berger, M.1    Shankar, V.2    Vafai, A.3
  • 2
    • 1542618315 scopus 로고    scopus 로고
    • New treatment approaches to indolent non-Hodgkin's lymphoma
    • Seymour, J.F. New treatment approaches to indolent non-Hodgkin's lymphoma. Semin. Oncol. 2004, 31, 27-32.
    • (2004) Semin. Oncol , vol.31 , pp. 27-32
    • Seymour, J.F.1
  • 4
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler, G.; Milstein, C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975, 256, 495-497.
    • (1975) Nature , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 5
    • 0039333356 scopus 로고    scopus 로고
    • Expression of anti-Z-DNA single chain antibody variable fragment on the filamentous phage surface
    • Maranhao, A.Q.; Brigido, M.M. Expression of anti-Z-DNA single chain antibody variable fragment on the filamentous phage surface. Braz. J. Med. Biol. Res. 2000, 33, 569-579.
    • (2000) Braz. J. Med. Biol. Res , vol.33 , pp. 569-579
    • Maranhao, A.Q.1    Brigido, M.M.2
  • 6
    • 0024521904 scopus 로고
    • Genetically engineered antibody molecules
    • Morrison, S.L.; Oi, V.T. Genetically engineered antibody molecules. Adv. Immunol. 1989, 44, 65-92.
    • (1989) Adv. Immunol , vol.44 , pp. 65-92
    • Morrison, S.L.1    Oi, V.T.2
  • 7
    • 27144432842 scopus 로고    scopus 로고
    • Engineered antibody fragments and the rise of single domains
    • Holliger, P.; Hudson, P.J. Engineered antibody fragments and the rise of single domains. Nat. Biotechnol. 2005, 23, 1126-1136.
    • (2005) Nat. Biotechnol , vol.23 , pp. 1126-1136
    • Holliger, P.1    Hudson, P.J.2
  • 10
    • 0025226085 scopus 로고
    • Phage antibodies: Filamentous phage displaying antibody variable domains
    • McCafferty, J.; Griffiths, A.D.; Winter, G.; Chiswell, D.J. Phage antibodies: Filamentous phage displaying antibody variable domains. Nature 1990, 348, 552-554.
    • (1990) Nature , vol.348 , pp. 552-554
    • McCafferty, J.1    Griffiths, A.D.2    Winter, G.3    Chiswell, D.J.4
  • 12
    • 77951473694 scopus 로고    scopus 로고
    • gov Home Page. Available online, accessed on 3 May 2012
    • ClinicalTrials. gov Home Page. Available online: http://clinicaltrials.gov (accessed on 3 May 2012).
    • ClinicalTrials
  • 13
    • 0021818675 scopus 로고
    • Filamentous fusion phage: Novel expression vectors that display cloned antigens on the virion surface
    • Smith, G.P. Filamentous fusion phage: Novel expression vectors that display cloned antigens on the virion surface. Science 1985, 228, 1315-1317.
    • (1985) Science , vol.228 , pp. 1315-1317
    • Smith, G.P.1
  • 14
    • 0028178511 scopus 로고
    • Catalytic antibodies: Perusing combinatorial libraries
    • Posner, B.; Smiley, J.; Lee, I.; Benkovic, S. Catalytic antibodies: Perusing combinatorial libraries. Trends Biochem. Sci. 1994, 19, 145-150.
    • (1994) Trends Biochem. Sci , vol.19 , pp. 145-150
    • Posner, B.1    Smiley, J.2    Lee, I.3    Benkovic, S.4
  • 15
    • 0025838021 scopus 로고
    • Assembly of combinatorial antibody libraries on phage surfaces: The gene III site
    • Barbas, C.F., 3rd.; Kang, A.S.; Lerner, R.A.; Benkovic, S.J. Assembly of combinatorial antibody libraries on phage surfaces: The gene III site. Proc. Natl. Acad. Sci. USA 1991, 88, 7978-7982.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7978-7982
    • Barbas, C.F.1    Kang, A.S.2    Lerner, R.A.3    Benkovic, S.J.4
  • 16
    • 0025835310 scopus 로고
    • Making antibody fragments using phage display libraries
    • Clackson, T.; Hoogenboom, H.R.; Griffiths, A.D.; Winter, G. Making antibody fragments using phage display libraries. Nature 1991, 352, 624-628.
    • (1991) Nature , vol.352 , pp. 624-628
    • Clackson, T.1    Hoogenboom, H.R.2    Griffiths, A.D.3    Winter, G.4
  • 17
    • 84872597555 scopus 로고    scopus 로고
    • Available online:, accessed on 3 April 2012
    • Tomlinson Library Home Page. Available online: http://www.coloradomesa.edu/cmulibrary/index.html (accessed on 3 April 2012).
    • Tomlinson Library Home Page
  • 18
    • 84855897053 scopus 로고    scopus 로고
    • Use of phage display for the identification of molecular sensors specific for activated Rho
    • Chinestra, P.; Lajoie-Mazenc, I.; Faye, J.C.; Favre, G. Use of phage display for the identification of molecular sensors specific for activated Rho. Meth. Mol. Biol. 2012, 827, 283-303.
    • (2012) Meth. Mol. Biol , vol.827 , pp. 283-303
    • Chinestra, P.1    Lajoie-Mazenc, I.2    Faye, J.C.3    Favre, G.4
  • 20
    • 0030200088 scopus 로고    scopus 로고
    • Selection and evolution of high-affinity human anti-viral antibodies
    • Barbas, C.F., 3rd.; Burton, D.R. Selection and evolution of high-affinity human anti-viral antibodies. Trends Biotechnol. 1996, 14, 230-234.
    • (1996) Trends Biotechnol , vol.14 , pp. 230-234
    • Barbas, C.F.1    Burton, D.R.2
  • 21
    • 19344376838 scopus 로고    scopus 로고
    • Construction of a human Fab phage display library from antibody repertoires of osteosarcoma patients
    • Dantas-Barbosa, C.; Brigido, M.M.; Maranhao, A.Q. Construction of a human Fab phage display library from antibody repertoires of osteosarcoma patients. Genet. Mol. Res. 2005, 4, 126-140.
    • (2005) Genet. Mol. Res , vol.4 , pp. 126-140
    • Dantas-Barbosa, C.1    Brigido, M.M.2    Maranhao, A.Q.3
  • 22
    • 0027218095 scopus 로고
    • High affinity, thyroid-specific human autoantibodies displayed on the surface of filamentous phage use V genes similar to other autoantibodies
    • Portolano, S.; McLachlan, S.M.; Rapoport, B. High affinity, thyroid-specific human autoantibodies displayed on the surface of filamentous phage use V genes similar to other autoantibodies. J. Immunol. 1993, 151, 2839-2851.
    • (1993) J. Immunol , vol.151 , pp. 2839-2851
    • Portolano, S.1    McLachlan, S.M.2    Rapoport, B.3
  • 24
    • 0028792459 scopus 로고
    • A mathematical model for biopanning (affinity selection) using peptide libraries on filamentous phage
    • Mandecki, W.; Chen, Y.C.; Grihalde, N. A mathematical model for biopanning (affinity selection) using peptide libraries on filamentous phage. J. Theor. Biol. 1995, 176, 523-530.
    • (1995) J. Theor. Biol , vol.176 , pp. 523-530
    • Mandecki, W.1    Chen, Y.C.2    Grihalde, N.3
  • 27
    • 0029932458 scopus 로고    scopus 로고
    • Organ targeting in vivo using phage display peptide libraries
    • Pasqualini, R.; Ruoslahti, E. Organ targeting in vivo using phage display peptide libraries. Nature 1996, 380, 364-366.
    • (1996) Nature , vol.380 , pp. 364-366
    • Pasqualini, R.1    Ruoslahti, E.2
  • 28
    • 77951780251 scopus 로고    scopus 로고
    • Automation in the high-throughput selection of random combinatorial libraries-Different approaches for select applications
    • Glokler, J.; Schutze, T.; Konthur, Z. Automation in the high-throughput selection of random combinatorial libraries-Different approaches for select applications. Molecules 2010, 15, 2478-2490.
    • (2010) Molecules , vol.15 , pp. 2478-2490
    • Glokler, J.1    Schutze, T.2    Konthur, Z.3
  • 29
    • 0037156253 scopus 로고    scopus 로고
    • Polyclonal anti-colorectal cancer Fab phage display library selected in one round using density gradient centrifugation to separate antigen-bound and free phage
    • Williams, B.R.; Sharon, J. Polyclonal anti-colorectal cancer Fab phage display library selected in one round using density gradient centrifugation to separate antigen-bound and free phage. Immunol. Lett. 2002, 81, 141-148.
    • (2002) Immunol. Lett , vol.81 , pp. 141-148
    • Williams, B.R.1    Sharon, J.2
  • 31
    • 64649105841 scopus 로고    scopus 로고
    • Controlling the selection stringency of phage display using a microfluidic device
    • Liu, Y.; Adams, J.D.; Turner, K.; Cochran, F.V.; Gambhir, S.S.; Soh, H.T. Controlling the selection stringency of phage display using a microfluidic device. Lab Chip 2009, 9, 1033-1036.
    • (2009) Lab Chip , vol.9 , pp. 1033-1036
    • Liu, Y.1    Adams, J.D.2    Turner, K.3    Cochran, F.V.4    Gambhir, S.S.5    Soh, H.T.6
  • 32
    • 0031574037 scopus 로고    scopus 로고
    • Antibody-ribosome-mRNA (ARM) complexes as efficient selection particles for in vitro display and evolution of antibody combining sites
    • He, M.; Taussig, M.J. Antibody-ribosome-mRNA (ARM) complexes as efficient selection particles for in vitro display and evolution of antibody combining sites. Nucleic Acids Res. 1997, 25, 5132-5134.
    • (1997) Nucleic Acids Res , vol.25 , pp. 5132-5134
    • He, M.1    Taussig, M.J.2
  • 33
    • 24344500862 scopus 로고    scopus 로고
    • The use of scFv-displaying yeast in mammalian cell surface selections
    • Wang, X.X.; Shusta, E.V. The use of scFv-displaying yeast in mammalian cell surface selections. J. Immunol. Meth. 2005, 304, 30-42.
    • (2005) J. Immunol. Meth , vol.304 , pp. 30-42
    • Wang, X.X.1    Shusta, E.V.2
  • 34
    • 0035424963 scopus 로고    scopus 로고
    • In vitro display technologies: Novel developments and applications
    • Amstutz, P.; Forrer, P.; Zahnd, C.; Pluckthun, A. In vitro display technologies: Novel developments and applications. Curr. Opin. Biotechnol. 2001, 12, 400-405.
    • (2001) Curr. Opin. Biotechnol , vol.12 , pp. 400-405
    • Amstutz, P.1    Forrer, P.2    Zahnd, C.3    Pluckthun, A.4
  • 35
    • 36148986778 scopus 로고    scopus 로고
    • Vectors selected from adeno-associated viral display peptide libraries for leukemia cell-targeted cytotoxic gene therapy
    • Michelfelder, S.; Lee, M.K.; deLima-Hahn, E.; Wilmes, T.; Kaul, F.; Muller, O.; Kleinschmidt, J.A.; Trepel, M. Vectors selected from adeno-associated viral display peptide libraries for leukemia cell-targeted cytotoxic gene therapy. Exp. Hematol. 2007, 35, 1766-1776.
    • (2007) Exp. Hematol , vol.35 , pp. 1766-1776
    • Michelfelder, S.1    Lee, M.K.2    Delima-Hahn, E.3    Wilmes, T.4    Kaul, F.5    Muller, O.6    Kleinschmidt, J.A.7    Trepel, M.8
  • 36
    • 77953664125 scopus 로고    scopus 로고
    • Baculovirus for eukaryotic protein display
    • Grabherr, R.; Ernst, W. Baculovirus for eukaryotic protein display. Curr. Gene Ther. 2010, 10, 195-200.
    • (2010) Curr. Gene Ther , vol.10 , pp. 195-200
    • Grabherr, R.1    Ernst, W.2
  • 38
    • 34548522063 scopus 로고    scopus 로고
    • Alternative non-antibody scaffolds for molecular recognition
    • Skerra, A. Alternative non-antibody scaffolds for molecular recognition. Curr. Opin. Biotechnol. 2007, 18, 295-304.
    • (2007) Curr. Opin. Biotechnol , vol.18 , pp. 295-304
    • Skerra, A.1
  • 39
    • 79953119750 scopus 로고    scopus 로고
    • Miniproteins as phage display-scaffolds for clinical applications
    • Zoller, F.; Haberkorn, U.; Mier, W. Miniproteins as phage display-scaffolds for clinical applications. Molecules 2011, 16, 2467-2485.
    • (2011) Molecules , vol.16 , pp. 2467-2485
    • Zoller, F.1    Haberkorn, U.2    Mier, W.3
  • 40
    • 0020614961 scopus 로고
    • Independent immunodominant and immunorecessive tumor-specific antigens on a malignant tumor: Antigenic dissection with cytolytic T cell clones
    • Wortzel, R.D.; Urban, J.L.; Philipps, C.; Fitch, F.W.; Schreiber, H. Independent immunodominant and immunorecessive tumor-specific antigens on a malignant tumor: Antigenic dissection with cytolytic T cell clones. J. Immunol. 1983, 130, 2461-2466.
    • (1983) J. Immunol , vol.130 , pp. 2461-2466
    • Wortzel, R.D.1    Urban, J.L.2    Philipps, C.3    Fitch, F.W.4    Schreiber, H.5
  • 41
    • 0029021085 scopus 로고
    • Anti-melanoma antibodies from melanoma patients immunized with genetically modified autologous tumor cells: Selection of specific antibodies from single-chain Fv fusion phage libraries
    • Cai, X.; Garen, A. Anti-melanoma antibodies from melanoma patients immunized with genetically modified autologous tumor cells: Selection of specific antibodies from single-chain Fv fusion phage libraries. Proc. Natl. Acad. Sci. USA 1995, 92, 6537-6541.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 6537-6541
    • Cai, X.1    Garen, A.2
  • 42
    • 0030892514 scopus 로고    scopus 로고
    • A model system for detection and isolation of a tumor cell surface antigen using antibody phage display
    • Pereira, S.; Maruyama, H.; Siegel, D.; van Belle, P.; Elder, D.; Curtis, P.; Herlyn, D. A model system for detection and isolation of a tumor cell surface antigen using antibody phage display. J. Immunol. Meth. 1997, 203, 11-24.
    • (1997) J. Immunol. Meth , vol.203 , pp. 11-24
    • Pereira, S.1    Maruyama, H.2    Siegel, D.3    van Belle, P.4    Elder, D.5    Curtis, P.6    Herlyn, D.7
  • 43
    • 73449125097 scopus 로고    scopus 로고
    • Isolation of osteosarcoma-associated human antibodies from a combinatorial Fab phage display library
    • doi:10.1155/2009/157531
    • Dantas-Barbosa, C.; Faria, F.P.; Brigido, M.M.; Maranhao, A.Q. Isolation of osteosarcoma-associated human antibodies from a combinatorial Fab phage display library. J. Biomed. Biotechnol. 2009, 2009, doi:10.1155/2009/157531.
    • (2009) J. Biomed. Biotechnol , Issue.2009
    • Dantas-Barbosa, C.1    Faria, F.P.2    Brigido, M.M.3    Maranhao, A.Q.4
  • 44
    • 0032031738 scopus 로고    scopus 로고
    • Panning phage antibody libraries on cells: Isolation of human Fab fragments against ovarian carcinoma using guided selection
    • Figini, M.; Obici, L.; Mezzanzanica, D.; Griffiths, A.; Colnaghi, M.I.; Winter, G.; Canevari, S. Panning phage antibody libraries on cells: Isolation of human Fab fragments against ovarian carcinoma using guided selection. Cancer Res. 1998, 58, 991-996.
    • (1998) Cancer Res , vol.58 , pp. 991-996
    • Figini, M.1    Obici, L.2    Mezzanzanica, D.3    Griffiths, A.4    Colnaghi, M.I.5    Winter, G.6    Canevari, S.7
  • 52
    • 34248224081 scopus 로고    scopus 로고
    • Autoantibody profiles reveal ubiquilin 1 as a humoral immune response target in lung adenocarcinoma
    • Chen, G.; Wang, X.; Yu, J.; Varambally, S.; Yu, J.; Thomas, D.G.; Lin, M.Y.; Vishnu, P.; Wang, Z.; Wang, R.; et al. Autoantibody profiles reveal ubiquilin 1 as a humoral immune response target in lung adenocarcinoma. Cancer Res. 2007, 67, 3461-3467.
    • (2007) Cancer Res , vol.67 , pp. 3461-3467
    • Chen, G.1    Wang, X.2    Yu, J.3    Varambally, S.4    Yu, J.5    Thomas, D.G.6    Lin, M.Y.7    Vishnu, P.8    Wang, Z.9    Wang, R.10
  • 55
    • 79958776633 scopus 로고    scopus 로고
    • Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies
    • doi:10.1371/journal.pone.0021018
    • Yang, J.; Baskar, S.; Kwong, K.Y.; Kennedy, M.G.; Wiestner, A.; Rader, C. Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies. PLoS One 2011, 6, doi:10.1371/journal.pone.0021018.
    • (2011) PLoS One , vol.6
    • Yang, J.1    Baskar, S.2    Kwong, K.Y.3    Kennedy, M.G.4    Wiestner, A.5    Rader, C.6
  • 56
    • 77649225962 scopus 로고    scopus 로고
    • Novel conjugates of single-chain Fv antibody fragments specific for stem cell antigen CD123 mediate potent death of acute myeloid leukaemia cells
    • Stein, C.; Kellner, C.; Kugler, M.; Reiff, N.; Mentz, K.; Schwenkert, M.; Stockmeyer, B.; Mackensen, A.; Fey, G.H. Novel conjugates of single-chain Fv antibody fragments specific for stem cell antigen CD123 mediate potent death of acute myeloid leukaemia cells. Br. J. Haematol. 2010, 148, 879-889.
    • (2010) Br. J. Haematol , vol.148 , pp. 879-889
    • Stein, C.1    Kellner, C.2    Kugler, M.3    Reiff, N.4    Mentz, K.5    Schwenkert, M.6    Stockmeyer, B.7    Mackensen, A.8    Fey, G.H.9
  • 57
    • 79960936402 scopus 로고    scopus 로고
    • Isolation of functional single domain antibody by whole cell immunization: Implications for cancer treatment
    • Baral, T.N.; Murad, Y.; Nguyen, T.D.; Iqbal, U.; Zhang, J. Isolation of functional single domain antibody by whole cell immunization: Implications for cancer treatment. J. Immunol. Meth. 2011, 371, 70-80.
    • (2011) J. Immunol. Meth , vol.371 , pp. 70-80
    • Baral, T.N.1    Murad, Y.2    Nguyen, T.D.3    Iqbal, U.4    Zhang, J.5
  • 59
    • 0030265393 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and its receptors
    • Klagsbrun, M.; D'Amore, P.A. Vascular endothelial growth factor and its receptors. Cytokine Growth Factor Rev. 1996, 7, 259-270.
    • (1996) Cytokine Growth Factor Rev , vol.7 , pp. 259-270
    • Klagsbrun, M.1    D'amore, P.A.2
  • 60
    • 70349736369 scopus 로고    scopus 로고
    • A single-step procedure of recombinant library construction for the selection of efficiently produced llama VH binders directed against cancer markers
    • Kastelic, D.; Frkovic-Grazio, S.; Baty, D.; Truan, G.; Komel, R.; Pompon, D. A single-step procedure of recombinant library construction for the selection of efficiently produced llama VH binders directed against cancer markers. J. Immunol. Meth. 2009, 350, 54-62.
    • (2009) J. Immunol. Meth , vol.350 , pp. 54-62
    • Kastelic, D.1    Frkovic-Grazio, S.2    Baty, D.3    Truan, G.4    Komel, R.5    Pompon, D.6
  • 61
    • 77950880605 scopus 로고    scopus 로고
    • Engineering anti-vascular endothelial growth factor single chain disulfide-stabilized antibody variable fragments (sc-dsFv) with phage-displayed sc-dsFv libraries
    • Huang, Y.J.; Chen, I.C.; Yu, C.M.; Lee, Y.C.; Hsu, H.J.; Ching, A.T.; Chang, H.J.; Yang, A.S. Engineering anti-vascular endothelial growth factor single chain disulfide-stabilized antibody variable fragments (sc-dsFv) with phage-displayed sc-dsFv libraries. J. Biol. Chem. 2010, 285, 7880-7891.
    • (2010) J. Biol. Chem , vol.285 , pp. 7880-7891
    • Huang, Y.J.1    Chen, I.C.2    Yu, C.M.3    Lee, Y.C.4    Hsu, H.J.5    Ching, A.T.6    Chang, H.J.7    Yang, A.S.8
  • 62
    • 79955732814 scopus 로고    scopus 로고
    • Antibody engineering using phage display with a coiled-coil heterodimeric Fv antibody fragment
    • doi:10.1371/journal.pone.0019023
    • Wang, X.; Zhong, P.; Luo, P.P.; Wang, K.C. Antibody engineering using phage display with a coiled-coil heterodimeric Fv antibody fragment. PLoS One 2011, 6, doi:10.1371/journal.pone.0019023.
    • (2011) PLoS One , pp. 6
    • Wang, X.1    Zhong, P.2    Luo, P.P.3    Wang, K.C.4
  • 63
    • 0037137903 scopus 로고    scopus 로고
    • Selection of high affinity human neutralizing antibodies to VEGFR2 from a large antibody phage display library for antiangiogenesis therapy
    • Lu, D.; Jimenez, X.; Zhang, H.; Bohlen, P.; Witte, L.; Zhu, Z. Selection of high affinity human neutralizing antibodies to VEGFR2 from a large antibody phage display library for antiangiogenesis therapy. Int. J. Cancer 2002, 97, 393-399.
    • (2002) Int. J. Cancer , vol.97 , pp. 393-399
    • Lu, D.1    Jimenez, X.2    Zhang, H.3    Bohlen, P.4    Witte, L.5    Zhu, Z.6
  • 64
    • 18644368033 scopus 로고    scopus 로고
    • A novel peptide isolated from a phage display library inhibits tumor growth and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain receptor
    • Hetian, L.; Ping, A.; Shumei, S.; Xiaoying, L.; Luowen, H.; Jian, W.; Lin, M.; Meisheng, L.; Junshan, Y.; Chengchao, S. A novel peptide isolated from a phage display library inhibits tumor growth and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain receptor. J. Biol. Chem. 2002, 277, 43137-43142.
    • (2002) J. Biol. Chem , vol.277 , pp. 43137-43142
    • Hetian, L.1    Ping, A.2    Shumei, S.3    Xiaoying, L.4    Luowen, H.5    Jian, W.6    Lin, M.7    Meisheng, L.8    Junshan, Y.9    Chengchao, S.10
  • 65
    • 40749154403 scopus 로고    scopus 로고
    • Identification of a neutralizing scFv binding to human vascular endothelial growth factor 165 (VEGF165) using a phage display antibody library
    • Lin, Z.; Cao, P.; Lei, H. Identification of a neutralizing scFv binding to human vascular endothelial growth factor 165 (VEGF165) using a phage display antibody library. Appl. Biochem. Biotechnol. 2008, 144, 15-26.
    • (2008) Appl. Biochem. Biotechnol , vol.144 , pp. 15-26
    • Lin, Z.1    Cao, P.2    Lei, H.3
  • 66
    • 78651499207 scopus 로고    scopus 로고
    • Isolation of a novel neutralizing antibody fragment against human vascular endothelial growth factor from a phage-displayed human antibody repertoire using an epitope disturbing strategy
    • Lamdan, H.; Ayala, M.; Rojas, G.; Munoz, Y.; Morera, Y.; Guirola, O.; Chinea, G.; Gavilondo, J.V. Isolation of a novel neutralizing antibody fragment against human vascular endothelial growth factor from a phage-displayed human antibody repertoire using an epitope disturbing strategy. J. Biotechnol. 2011, 151, 166-174.
    • (2011) J. Biotechnol , vol.151 , pp. 166-174
    • Lamdan, H.1    Ayala, M.2    Rojas, G.3    Munoz, Y.4    Morera, Y.5    Guirola, O.6    Chinea, G.7    Gavilondo, J.V.8
  • 67
    • 77957768682 scopus 로고    scopus 로고
    • Phage-derived fully human monoclonal antibody fragments to human vascular endothelial growth factor-C block its interaction with VEGF receptor-2 and 3
    • doi:10.1371/journal.pone.0011941
    • Rinderknecht, M.; Villa, A.; Ballmer-Hofer, K.; Neri, D.; Detmar, M. Phage-derived fully human monoclonal antibody fragments to human vascular endothelial growth factor-C block its interaction with VEGF receptor-2 and 3. PLoS One 2010, 5, doi:10.1371/journal.pone.0011941.
    • (2010) PLoS One , pp. 5
    • Rinderknecht, M.1    Villa, A.2    Ballmer-Hofer, K.3    Neri, D.4    Detmar, M.5
  • 68
    • 67649683033 scopus 로고    scopus 로고
    • Antiangiogenic targeting liposomes increase therapeutic efficacy for solid tumors
    • Chang, D.K.; Chiu, C.Y.; Kuo, S.Y.; Lin, W.C.; Lo, A.; Wang, Y.P.; Li, P.C.; Wu, H.C. Antiangiogenic targeting liposomes increase therapeutic efficacy for solid tumors. J. Biol. Chem. 2009, 284, 12905-12916.
    • (2009) J. Biol. Chem , vol.284 , pp. 12905-12916
    • Chang, D.K.1    Chiu, C.Y.2    Kuo, S.Y.3    Lin, W.C.4    Lo, A.5    Wang, Y.P.6    Li, P.C.7    Wu, H.C.8
  • 69
    • 0023082137 scopus 로고
    • Receptors for epidermal growth factor and other polypeptide mitogens
    • Carpenter, G. Receptors for epidermal growth factor and other polypeptide mitogens. Annu. Rev. Biochem. 1987, 56, 881-914.
    • (1987) Annu. Rev. Biochem , vol.56 , pp. 881-914
    • Carpenter, G.1
  • 70
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon, D.J.; Clark, G.M.; Wong, S.G.; Levin, W.J.; Ullrich, A.; McGuire, W.L. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987, 235, 177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 71
    • 0035871618 scopus 로고    scopus 로고
    • Identification of epitope regions recognized by tumor inhibitory and stimulatory anti-ErbB-2 monoclonal antibodies: Implications for vaccine design
    • Yip, Y.L.; Smith, G.; Koch, J.; Dubel, S.; Ward, R.L. Identification of epitope regions recognized by tumor inhibitory and stimulatory anti-ErbB-2 monoclonal antibodies: Implications for vaccine design. J. Immunol. 2001, 166, 5271-5278.
    • (2001) J. Immunol , vol.166 , pp. 5271-5278
    • Yip, Y.L.1    Smith, G.2    Koch, J.3    Dubel, S.4    Ward, R.L.5
  • 74
    • 2942544476 scopus 로고    scopus 로고
    • Isolation and characterisation of a human anti-idiotypic scFv used as a surrogate tumour antigen to elicit an anti-HER-2/neu humoral response in mice
    • Coelho, M.; Gauthier, P.; Pugniere, M.; Roquet, F.; Pelegrin, A.; Navarro-Teulon, I. Isolation and characterisation of a human anti-idiotypic scFv used as a surrogate tumour antigen to elicit an anti-HER-2/neu humoral response in mice. Br. J. Cancer 2004, 90, 2032-2041.
    • (2004) Br. J. Cancer , vol.90 , pp. 2032-2041
    • Coelho, M.1    Gauthier, P.2    Pugniere, M.3    Roquet, F.4    Pelegrin, A.5    Navarro-Teulon, I.6
  • 75
    • 38449103874 scopus 로고    scopus 로고
    • Evaluation of anti-VEGFR-3 specific scFv antibodies as potential therapeutic and diagnostic tools for tumor lymph-angiogenesis
    • Zehnder-Fjallman, A.H.; Marty, C.; Halin, C.; Hohn, A.; Schibli, R.; Ballmer-Hofer, K.; Schwendener, R.A. Evaluation of anti-VEGFR-3 specific scFv antibodies as potential therapeutic and diagnostic tools for tumor lymph-angiogenesis. Oncol. Rep. 2007, 18, 933-941.
    • (2007) Oncol. Rep , vol.18 , pp. 933-941
    • Zehnder-Fjallman, A.H.1    Marty, C.2    Halin, C.3    Hohn, A.4    Schibli, R.5    Ballmer-Hofer, K.6    Schwendener, R.A.7
  • 76
    • 0037107551 scopus 로고    scopus 로고
    • Fibronectin at a glance
    • Pankov, R.; Yamada, K.M. Fibronectin at a glance. J. Cell Sci. 2002, 115, 3861-3863.
    • (2002) J. Cell Sci , vol.115 , pp. 3861-3863
    • Pankov, R.1    Yamada, K.M.2
  • 78
    • 34447306888 scopus 로고    scopus 로고
    • Small-animal PET of tumor angiogenesis using a (76)Br-labeled human recombinant antibody fragment to the ED-B domain of fibronectin
    • Rossin, R.; Berndorff, D.; Friebe, M.; Dinkelborg, L.M.; Welch, M.J. Small-animal PET of tumor angiogenesis using a (76)Br-labeled human recombinant antibody fragment to the ED-B domain of fibronectin. J. Nucl. Med. 2007, 48, 1172-1179.
    • (2007) J. Nucl. Med , vol.48 , pp. 1172-1179
    • Rossin, R.1    Berndorff, D.2    Friebe, M.3    Dinkelborg, L.M.4    Welch, M.J.5
  • 81
    • 79951771952 scopus 로고    scopus 로고
    • Single chain anti-c-Met antibody conjugated nanoparticles for in vivo tumor-targeted imaging and drug delivery
    • Lu, R.M.; Chang, Y.L.; Chen, M.S.; Wu, H.C. Single chain anti-c-Met antibody conjugated nanoparticles for in vivo tumor-targeted imaging and drug delivery. Biomaterials 2011, 32, 3265-3274.
    • (2011) Biomaterials , vol.32 , pp. 3265-3274
    • Lu, R.M.1    Chang, Y.L.2    Chen, M.S.3    Wu, H.C.4
  • 82
    • 84855705029 scopus 로고    scopus 로고
    • Synthesis and evaluation of 99mTc-labelled monoclonal antibody 1D09C3 for molecular imaging of major histocompatibility complex class II protein expression
    • Malviya, G.; de Vries, E.F.; Dierckx, R.A.; Signore, A. Synthesis and evaluation of 99mTc-labelled monoclonal antibody 1D09C3 for molecular imaging of major histocompatibility complex class II protein expression. Mol. Imag. Biol. 2011, 13, 930-939.
    • (2011) Mol. Imag. Biol , vol.13 , pp. 930-939
    • Malviya, G.1    de Vries, E.F.2    Dierckx, R.A.3    Signore, A.4
  • 83
    • 32944465385 scopus 로고    scopus 로고
    • The anti-human leukocyte antigen-DR monoclonalantibody 1D09C3 activates the mitochondrial cell death pathway and exerts a potent antitumor activity in lymphoma-bearing nonobese diabetic/severe combined immunodeficient mice
    • Carlo-Stella, C.; Di Nicola, M.; Turco, M.C.; Cleris, L.; Lavazza, C.; Longoni, P.; Milanesi, M.; Magni, M.; Ammirante, M.; Leone, A.; et al. The anti-human leukocyte antigen-DR monoclonalantibody 1D09C3 activates the mitochondrial cell death pathway and exerts a potent antitumor activity in lymphoma-bearing nonobese diabetic/severe combined immunodeficient mice. Cancer Res. 2006, 66, 1799-1808.
    • (2006) Cancer Res , vol.66 , pp. 1799-1808
    • Carlo-Stella, C.1    di Nicola, M.2    Turco, M.C.3    Cleris, L.4    Lavazza, C.5    Longoni, P.6    Milanesi, M.7    Magni, M.8    Ammirante, M.9    Leone, A.10
  • 86
    • 9144234724 scopus 로고    scopus 로고
    • A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo
    • Burtrum, D.; Zhu, Z.; Lu, D.; Anderson, D.M.; Prewett, M.; Pereira, D.S.; Bassi, R.; Abdullah, R.; Hooper, A.T.; Koo, H.; et al. A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res. 2003, 63, 8912-8921.
    • (2003) Cancer Res , vol.63 , pp. 8912-8921
    • Burtrum, D.1    Zhu, Z.2    Lu, D.3    Anderson, D.M.4    Prewett, M.5    Pereira, D.S.6    Bassi, R.7    Abdullah, R.8    Hooper, A.T.9    Koo, H.10
  • 88
    • 84858334156 scopus 로고    scopus 로고
    • A phase I/II study of erlotinib in combination with the anti-insulin-like growth factor-1 receptor monoclonal antibody IMC-A12 (cixutumumab) in patients with advanced non-small cell lung cancer
    • Weickhardt, A.; Doebele, R.; Oton, A.; Lettieri, J.; Maxson, D.; Reynolds, M.; Brown, A.; Jackson, M.K.; Dy, G.; Adjei, A.; et al. A phase I/II study of erlotinib in combination with the anti-insulin-like growth factor-1 receptor monoclonal antibody IMC-A12 (cixutumumab) in patients with advanced non-small cell lung cancer. J. Thorac. Oncol. 2012, 7, 419-426.
    • (2012) J. Thorac. Oncol , vol.7 , pp. 419-426
    • Weickhardt, A.1    Doebele, R.2    Oton, A.3    Lettieri, J.4    Maxson, D.5    Reynolds, M.6    Brown, A.7    Jackson, M.K.8    Dy, G.9    Adjei, A.10
  • 89
    • 77957962308 scopus 로고    scopus 로고
    • Randomized, phase II study of the insulin-like growth factor-1 receptor inhibitor IMC-A12, with or without cetuximab, in patients with cetuximab- or panitumumab-refractory metastatic colorectal cancer
    • Reidy, D.L.; Vakiani, E.; Fakih, M.G.; Saif, M.W.; Hecht, J.R.; Goodman-Davis, N.; Hollywood, E.; Shia, J.; Schwartz, J.; Chandrawansa, K.; et al. Randomized, phase II study of the insulin-like growth factor-1 receptor inhibitor IMC-A12, with or without cetuximab, in patients with cetuximab- or panitumumab-refractory metastatic colorectal cancer. J. Clin. Oncol. 2010, 28, 4240-4246.
    • (2010) J. Clin. Oncol , vol.28 , pp. 4240-4246
    • Reidy, D.L.1    Vakiani, E.2    Fakih, M.G.3    Saif, M.W.4    Hecht, J.R.5    Goodman-Davis, N.6    Hollywood, E.7    Shia, J.8    Schwartz, J.9    Chandrawansa, K.10
  • 90
    • 84862907964 scopus 로고    scopus 로고
    • Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and ewing sarcoma: A report from the children's oncology group
    • Malempati, S.; Weigel, B.; Ingle, A.M.; Ahern, C.H.; Carroll, J.M.; Roberts, C.T.; Reid, J.M.; Schmechel, S.; Voss, S.D.; Cho, S.Y.; et al. Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and ewing sarcoma: A report from the children's oncology group. J. Clin. Oncol. 2012, 30, 256-262.
    • (2012) J. Clin. Oncol , vol.30 , pp. 256-262
    • Malempati, S.1    Weigel, B.2    Ingle, A.M.3    Ahern, C.H.4    Carroll, J.M.5    Roberts, C.T.6    Reid, J.M.7    Schmechel, S.8    Voss, S.D.9    Cho, S.Y.10
  • 92
    • 79952752582 scopus 로고    scopus 로고
    • Necitumumab, a fully human IgG1 mAb directed against the EGFR for the potential treatment of cancer
    • Dienstmann, R.; Tabernero, J. Necitumumab, a fully human IgG1 mAb directed against the EGFR for the potential treatment of cancer. Cur. Opin. Investig. Drugs 2010, 11, 1434-1441.
    • (2010) Cur. Opin. Investig. Drugs , vol.11 , pp. 1434-1441
    • Dienstmann, R.1    Tabernero, J.2
  • 93
    • 77949726425 scopus 로고    scopus 로고
    • A phase I pharmacologic study of necitumumab (IMC-11F8), a fully human IgG1 monoclonal antibody directed against EGFR in patients with advanced solid malignancies
    • Kuenen, B.; Witteveen, P.O.; Ruijter, R.; Giaccone, G.; Dontabhaktuni, A.; Fox, F.; Katz, T.; Youssoufian, H.; Zhu, J.; Rowinsky, E.K.; et al. A phase I pharmacologic study of necitumumab (IMC-11F8), a fully human IgG1 monoclonal antibody directed against EGFR in patients with advanced solid malignancies. Clin. Cancer Res. 2010, 16, 1915-1923.
    • (2010) Clin. Cancer Res , vol.16 , pp. 1915-1923
    • Kuenen, B.1    Witteveen, P.O.2    Ruijter, R.3    Giaccone, G.4    Dontabhaktuni, A.5    Fox, F.6    Katz, T.7    Youssoufian, H.8    Zhu, J.9    Rowinsky, E.K.10
  • 94
    • 80051528496 scopus 로고    scopus 로고
    • Necitumumab in the treatment of advanced non-small cell lung cancer: Translation from preclinical to clinical development
    • Dienstmann, R.; Felip, E. Necitumumab in the treatment of advanced non-small cell lung cancer: Translation from preclinical to clinical development. Expert Opin. Biol. Ther. 2011, 11, 1223-1231.
    • (2011) Expert Opin. Biol. Ther , vol.11 , pp. 1223-1231
    • Dienstmann, R.1    Felip, E.2
  • 95
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara, N.; Hillan, K.J.; Gerber, H.P.; Novotny, W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat. Rev. Drug Discov. 2004, 3, 391-400.
    • (2004) Nat. Rev. Drug Discov , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 96
    • 70349277438 scopus 로고    scopus 로고
    • Monoclonal antibodies targeting vascular endothelial growth factor: Current status and future challenges in cancer therapy
    • Hsu, J.Y.; Wakelee, H.A. Monoclonal antibodies targeting vascular endothelial growth factor: Current status and future challenges in cancer therapy. BioDrugs 2009, 23, 289-304.
    • (2009) BioDrugs , vol.23 , pp. 289-304
    • Hsu, J.Y.1    Wakelee, H.A.2
  • 97
    • 77649213706 scopus 로고    scopus 로고
    • Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2
    • Spratlin, J.L.; Cohen, R.B.; Eadens, M.; Gore, L.; Camidge, D.R.; Diab, S.; Leong, S.; O'Bryant, C.; Chow, L.Q.; Serkova, N.J.; et al. Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. J. Clin. Oncol. 2010, 28, 780-787.
    • (2010) J. Clin. Oncol , vol.28 , pp. 780-787
    • Spratlin, J.L.1    Cohen, R.B.2    Eadens, M.3    Gore, L.4    Camidge, D.R.5    Diab, S.6    Leong, S.7    O'Bryant, C.8    Chow, L.Q.9    Serkova, N.J.10
  • 98
    • 73349135923 scopus 로고    scopus 로고
    • TRIO-012: A multicenter, multinational, randomized, double-blind phase III study of IMC-1121B plus docetaxel versus placebo plus docetaxel in previously untreated patients with HER2-negative, unresectable, locally recurrent or metastatic breast cancer
    • Mackey, J.; Gelmon, K.; Martin, M.; McCarthy, N.; Pinter, T.; Rupin, M.; Youssoufian, H. TRIO-012: A multicenter, multinational, randomized, double-blind phase III study of IMC-1121B plus docetaxel versus placebo plus docetaxel in previously untreated patients with HER2-negative, unresectable, locally recurrent or metastatic breast cancer. Clin. Breast Cancer 2009, 9, 258-261.
    • (2009) Clin. Breast Cancer , vol.9 , pp. 258-261
    • Mackey, J.1    Gelmon, K.2    Martin, M.3    McCarthy, N.4    Pinter, T.5    Rupin, M.6    Youssoufian, H.7
  • 101
    • 84858229586 scopus 로고    scopus 로고
    • Development of a radioiodinated apoptosis-inducing ligand, rhTRAIL, and a radiolabelled agonist TRAIL receptor antibody for clinical imaging studies
    • Duiker, E.; Dijkers, E.; Heerspink, H.L.; de Jong, S.; van der Zee, A.; Jager, P.; Kosterink, J.; de Vries, E.; Hooge, M.L. Development of a radioiodinated apoptosis-inducing ligand, rhTRAIL, and a radiolabelled agonist TRAIL receptor antibody for clinical imaging studies. Br. J. Pharmacol. 2011, 165, 2203-2212.
    • (2011) Br. J. Pharmacol , vol.165 , pp. 2203-2212
    • Duiker, E.1    Dijkers, E.2    Heerspink, H.L.3    de Jong, S.4    van der Zee, A.5    Jager, P.6    Kosterink, J.7    de Vries, E.8    Hooge, M.L.9
  • 103
    • 76349085626 scopus 로고    scopus 로고
    • Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer
    • Trarbach, T.; Moehler, M.; Heinemann, V.; Kohne, C.H.; Przyborek, M.; Schulz, C.; Sneller, V.; Gallant, G.; Kanzler, S. Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer. Br. J. Cancer 2010, 102, 506-512.
    • (2010) Br. J. Cancer , vol.102 , pp. 506-512
    • Trarbach, T.1    Moehler, M.2    Heinemann, V.3    Kohne, C.H.4    Przyborek, M.5    Schulz, C.6    Sneller, V.7    Gallant, G.8    Kanzler, S.9
  • 104
    • 17744396145 scopus 로고    scopus 로고
    • Death to the bad guys: Targeting cancer via Apo2L/TRAIL
    • Bouralexis, S.; Findlay, D.M.; Evdokiou, A. Death to the bad guys: Targeting cancer via Apo2L/TRAIL. Apoptosis 2005, 10, 35-51.
    • (2005) Apoptosis , vol.10 , pp. 35-51
    • Bouralexis, S.1    Findlay, D.M.2    Evdokiou, A.3
  • 106
    • 72449141229 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors
    • Wakelee, H.A.; Patnaik, A.; Sikic, B.I.; Mita, M.; Fox, N.L.; Miceli, R.; Ullrich, S.J.; Fisher, G.A.; Tolcher, A.W. Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors. Ann. Oncol. 2010, 21, 376-381.
    • (2010) Ann. Oncol , vol.21 , pp. 376-381
    • Wakelee, H.A.1    Patnaik, A.2    Sikic, B.I.3    Mita, M.4    Fox, N.L.5    Miceli, R.6    Ullrich, S.J.7    Fisher, G.A.8    Tolcher, A.W.9
  • 108
    • 0036554968 scopus 로고    scopus 로고
    • Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display
    • Salvatore, G.; Beers, R.; Margulies, I.; Kreitman, R.J.; Pastan, I. Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display. Clin. Cancer Res. 2002, 8, 995-1002.
    • (2002) Clin. Cancer Res , vol.8 , pp. 995-1002
    • Salvatore, G.1    Beers, R.2    Margulies, I.3    Kreitman, R.J.4    Pastan, I.5
  • 109
    • 81555214408 scopus 로고    scopus 로고
    • A guide to taming a toxin-Recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer
    • Weldon, J.E.; Pastan, I. A guide to taming a toxin-Recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer. FEBS J. 2011, 278, 4683-4700.
    • (2011) FEBS J , vol.278 , pp. 4683-4700
    • Weldon, J.E.1    Pastan, I.2
  • 110
    • 33645467075 scopus 로고    scopus 로고
    • Characterization of a CC49-based single-chain fragment-β-lactamase fusion protein for antibody-directed enzyme prodrug therapy (ADEPT)
    • Alderson, R.F.; Toki, B.E.; Roberge, M.; Geng, W.; Basler, J.; Chin, R.; Liu, A.; Ueda, R.; Hodges, D.; Escandon, E.; et al. Characterization of a CC49-based single-chain fragment-β-lactamase fusion protein for antibody-directed enzyme prodrug therapy (ADEPT). Bioconjug. Chem. 2006, 17, 410-418.
    • (2006) Bioconjug. Chem , vol.17 , pp. 410-418
    • Alderson, R.F.1    Toki, B.E.2    Roberge, M.3    Geng, W.4    Basler, J.5    Chin, R.6    Liu, A.7    Ueda, R.8    Hodges, D.9    Escandon, E.10


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