N -(2-Oxo-3-oxetanyl)carbamic acid esters as N-acylethanolamine acid amidase inhibitors: Synthesis and structure-activity and structure-property relationships

Journal of Medicinal Chemistry

Volumn 55, Issue 10, 2012, Pages 4824-4836

  Duranti, Andrea ^a   Tontini, Andrea ^a   Antonietti, Francesca ^a   Vacondio, Federica ^b   Fioni, Alessandro ^b   Silva, Claudia ^b   Lodola, Alessio ^b   Rivara, Silvia ^b   Solorzano, Carlos ^c   Piomelli, Daniele ^c,d   Tarzia, Giorgio ^a   Mor, Marco ^b  

^a UNIVERSITY OF URBINO   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; BOVINE SERUM ALBUMIN; CARBAMIC ACID ESTER; FATTY ACID AMIDASE INHIBITOR; LACTONE DERIVATIVE; N (2 OXO 3 OXETANYL)CARBAMIC ACID ESTER; N ACYLETHANOLAMINE ACID AMIDASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; DENSITY FUNCTIONAL THEORY; DRUG DESIGN; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; IC 50; IN VITRO STUDY; MOLECULAR MECHANICS; NONHUMAN; QUANTUM MECHANICS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE PROPERTY RELATIONSHIP;

AMIDOHYDROLASES; ANIMALS; CARBAMATES; CATTLE; ESTERS; HUMANS; KINETICS; LACTONES; MALE; QUANTUM THEORY; RATS; RATS, WISTAR; SERUM ALBUMIN, BOVINE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861501412     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300349j     Document Type: Article

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