Structural and functional diversity of paraoxonases

Nature Medicine

Volumn 2, Issue 11, 1996, Pages 1186-1187

  La Du, Bert N ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLESTERASE; ISOENZYME; ORGANOPHOSPHATE; ORGANOPHOSPHATE PESTICIDE;

ENZYME KINETICS; ENZYME STRUCTURE; HUMAN; NOTE; PRIORITY JOURNAL;

ARYLDIALKYLPHOSPHATASE; ESTERASES; ORGANOPHOSPHORUS COMPOUNDS; SARIN; SOMAN; VARIATION (GENETICS);

EID: 0029905656     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1196-1186     Document Type: Note

References (11)

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2. La Du, B.N. Human serum paraoxonase/ arylesterase. in Pharmacogenetics of Drug Metabolism (ed. Karlow, W.) 51-91 (Pergamon, New York, 1992).
3. Davies, H.G. et al. The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin. Nature Genet. 14, 334-336 (1996).
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7. Humbert, R. et al. The molecular basis of the human serum paraoxonase activity polymorphism. Nature Genet. 3, 73-76 (1993).
8. Watson, A.D. et al. Protective effect of high density lipoprotein-associated paraoxonase: Inhibition of the biological activity of minimally oxidized low density lipoprotein. J. Clin. Invest. 96, 2882-2891 (1995).
9. Sorenson, R.C., Primo-Parmo, S.L., Camper, S.A. & La Du, B.N. The genetic mapping and gene structure of mouse paraoxonase/arylesterase. Genamics 30, 431-438 (1995).
10. Primo-Parmo, S. L., Sorenson, R.C., Teiber, J. & La Du. The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics 33, 498-507 (1996).
11. Ruiz, J.H. et al. The polymorphism (Gln-Arg192) of the high-density lipoprotein-bound enzyme paraoxonase is an independent cardiovascular risk factor in non-insulin-dependent diabetic patients. Lancet 346, 869-872 (1995).