Synthesis and biological evaluation of new potential inhibitors of N-acylethanolamine hydrolyzing acid amidase

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 3, 2010, Pages 1210-1213

  Saturnino, Carmela ^a   Petrosino, Stefania ^a,b   Ligresti, Alessia ^b   Palladino, Chiara ^a   Martino, Giovanni De ^a   Bisogno, Tiziana ^b   Marzo, Vincenzo Di ^b  

^a UNIVERSITY OF SALERNO   (Italy)

^b CNR   (Italy)

Author keywords

Degradation; Endocannabinoid; Enzyme; Inflammation; N Acylethanolamines; NAAA; Palmitoylethanolamide; Vanilloid

Indexed keywords

AMIDE; CARBAMIC ACID DERIVATIVE; CYCLOHEXYHEXADECANOATE; DECANOIC ACID DERIVATIVE; ENZYME INHIBITOR; ESTER DERIVATIVE; ETHANOLAMINE DERIVATIVE; FATTY ACID AMIDASE; HEXADECYLPROPIONATE; N (3 HYDROXY PROPIONYL)PENTADECANAMIDE; N ACYLETHANOLAMINE HYDROLYZING ACID AMIDASE; N PALMITOYL ETHANOLAMINE; N PENTADECYLBENZAMIDE; N PENTADECYLCYCLOHEXANECARBOXAMIDE; PALMITIC ACID; UNCLASSIFIED DRUG; AMIDASE; ENDOCANNABINOID; NAAA PROTEIN, HUMAN; PALMIDROL; PALMITIC ACID DERIVATIVE;

ARTICLE; CELL STRAIN HEK293; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; ENZYME ACTIVITY; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROLYSIS; IC 50; LIQUID CHROMATOGRAPHY; ANTAGONISTS AND INHIBITORS; CELL LINE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG SCREENING; METABOLISM; PROCEDURES; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMIDOHYDROLASES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENDOCANNABINOIDS; ENZYME INHIBITORS; ETHANOLAMINES; HUMANS; HYDROLYSIS; PALMITIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 74049085872     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.11.134     Document Type: Article

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