Selective plasma hydrolysis of glucocorticoid γ-lactones and cyclic carbonates by the enzyme paraoxonase: An ideal plasma inactivation mechanism [1]

Journal of Medicinal Chemistry

Volumn 43, Issue 1, 2000, Pages 19-21

  Biggadike, Keith ^a   Angell, Richard M ^a   Burgess, Colin M ^a   Farrell, Rosanne M ^a   Hancock, Ashley P ^a   Harker, Andy J ^a   Irving, Wendy R ^a   Ioannou, Chris ^a   Procopiou, Panayiotis A ^a   Shaw, Rupert E ^a   Solanke, Yemisi E ^a   Singh, Onkar M P ^a   Snowden, Michael A ^a   Stubbs, Rob J ^a   Walton, Sarah ^a   Weston, Helen E ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLDIALKYLPHOSPHATASE; BECLOMETASONE DIPROPIONATE;

DRUG CONFORMATION; DRUG EFFECT; DRUG FORMULATION; DRUG HYDROLYSIS; DRUG PROTEIN BINDING; ENZYME INACTIVATION; HUMAN; LETTER; STRUCTURE ACTIVITY RELATION;

ARYLDIALKYLPHOSPHATASE; CARBONATES; ESTERASES; GLUCOCORTICOIDS; HUMANS; HYDROLYSIS; LACTONES; LUNG; PRODRUGS; STEREOISOMERISM; SUBCELLULAR FRACTIONS;

EID: 0034642502     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990436t     Document Type: Letter

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