Mycobacterium tuberculosis cytochrome P450 enzymes: A cohort of novel TB drug targets

Biochemical Society Transactions

Volumn 40, Issue 3, 2012, Pages 573-579

  Hudson, Sean A ^a   McLean, Kirsty J ^b   Munro, Andrew W ^b   Abell, Chris ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Cytochrome P450; Drug discovery; Fragment based drug discovery; High throughput screening (HTS); Mycobacterium tuberculosis; Tuberculosis

Indexed keywords

AMIKACIN; ANTIFUNGAL AGENT; BACTERIAL ENZYME; CAPREOMYCIN; CYTOCHROME P450; CYTOCHROME P450 121; CYTOCHROME P450 124; CYTOCHROME P450 125; CYTOCHROME P450 128; CYTOCHROME P450 142; CYTOCHROME P450 51B1; CYTOCHROME P450 INHIBITOR; FORMAMIDE DERIVATIVE; KANAMYCIN; MYCOBACTERIUM TUBERCULOSIS CYTOCHROME P450; N (4 PYRIDYL)FORMAMIDE DERIVATIVE; PYRROLE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

CATALYSIS; CHEMICAL BOND; CONFERENCE PAPER; CRYSTAL STRUCTURE; DEMETHYLATION; DRUG TARGETING; GENOMICS; HIGH THROUGHPUT SCREENING; HUMAN; MICROBIAL ACTIVITY; MUTAGENESIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REDUCTION; SYNTHESIS; TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; CYTOCHROME P-450 ENZYME SYSTEM; HOST-PATHOGEN INTERACTIONS; HUMANS; MOLECULAR TARGETED THERAPY; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 84861490752     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20120062     Document Type: Conference Paper

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