Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses

Journal of Biological Chemistry

Volumn 285, Issue 47, 2010, Pages 36352-36360

  Johnston, Jonathan B ^a   Ouellet, Hugues ^a   Ortiz De Montellano, Paul R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITIES; CATALYTIC EFFICIENCIES; CHOLESTEROL METABOLISM; CYTOCHROME P450; DRUG TARGETS; FUNCTIONAL REDUNDANCY; GENETIC ANALYSIS; GENETIC COMPLEMENTATION; GROWTH DEFECTS; IN-VITRO ANALYSIS; M. TUBERCULOSIS; MONOOXYGENASE ACTIVITIES; MONOOXYGENASES; MYCOBACTERIUM TUBERCULOSIS; SEQUENTIAL OXIDATION; SIDE CHAINS; VIRULENT STRAINS; WESTERN-BLOT ANALYSIS;

ALCOHOLS; ALDEHYDES; BINDING ENERGY; CARBOXYLIC ACIDS; CATALYSTS; ENZYMES; METABOLISM; QUALITY ASSURANCE; REDUNDANCY; STEREOCHEMISTRY;

CHOLESTEROL;

CHOLEST 4 EN 3 ONE; CYTOCHROME P450 124A1; CYTOCHROME P450 125A1; CYTOCHROME P450 142A1; STEROID MONOOXYGENASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL GROWTH; CHOLESTEROL METABOLISM; CONTROLLED STUDY; GENE EXPRESSION; GENETIC COMPLEMENTATION; HYDROXYLATION; LIPID OXIDATION; LIPOLYSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; STRAIN DIFFERENCE; WESTERN BLOTTING;

BLOTTING, WESTERN; CHOLESTENONES; CHOLESTEROL; CYTOCHROME P-450 ENZYME SYSTEM; GENETIC COMPLEMENTATION TEST; HYDROXYLATION; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 78449258062     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.161117     Document Type: Article

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