Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: Evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen

Journal of Biological Chemistry

Volumn 285, Issue 49, 2010, Pages 38270-38282

  Driscoll, Max D ^a   McLean, Kirsty J ^a   Levy, Colin ^a   Mast, Natalia ^b   Pikuleva, Irina A ^b   Lafite, Pierre ^c   Rigby, Stephen E J ^a   Leys, David ^a   Munro, Andrew W ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITÉ D'ORLÉANS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIOCHEMICAL CHARACTERIZATION; CHOLESTEROL METABOLISM; CYTOCHROME P450; DISTAL POCKET; GENE CLUSTERS; HEME IRON; HEMOPROTEINS; HIGH AFFINITY; HIGH SPIN STATE; HOST RESPONSE; HUMAN PATHOGENS; HYDROXYLASE ACTIVITY; M. TUBERCULOSIS; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; OXIDIZING ACTIVITY; REDOX PARTNERS; STEROL OXIDATION; THERAPEUTIC POTENTIALS;

CRYSTAL STRUCTURE; FATTY ACIDS; GENES; METABOLISM; POLYMER BLENDS; PORPHYRINS; SPIN DYNAMICS;

CHOLESTEROL;

4 CHOLESTEROL 3 ONE; 4 PHENYLIMIDAZOLE; CHOLESTEROL; CHOLESTEROL 27 HYDROXYLASE; CLOTRIMAZOLE; CYTOCHROME P450; CYTOCHROME P450 CYP124; CYTOCHROME P450 CYP125; CYTOCHROME P450 CYP142; ECONAZOLE; FATTY ACID; FLUCONAZOLE; ITRACONAZOLE; KETOCONAZOLE; MICONAZOLE; OXYGENASE; UNCLASSIFIED DRUG; VORICONAZOLE;

ARTICLE; BACTERIAL STRAIN; BINDING AFFINITY; BIOCHEMISTRY; CATALYSIS; CHOLESTEROL METABOLISM; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; HUMAN; IMMUNE RESPONSE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

CHOLESTEROL; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; HOST-PATHOGEN INTERACTIONS; HUMANS; HYDROXYLATION; MYCOBACTERIUM TUBERCULOSIS; OXIDATION-REDUCTION; PROTEIN STRUCTURE, TERTIARY;

MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 78649649951     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.164293     Document Type: Article

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