Identification of an IgE reactive peptide in hen egg riboflavin binding protein subjected to simulated gastrointestinal digestion

Journal of Agricultural and Food Chemistry

Volumn 60, Issue 20, 2012, Pages 5215-5220

  Martos, Gustavo ^a   Pineda Vadillo, Carlos ^a   Miralles, Beatriz ^a   Alonso Lebrero, Elena ^b   López Fandiño, Rosina ^a   Molina, Elena ^a   Belloque, Josefina ^a  

^a INSTITUTE OF FOOD SCIENCE RESEARCH CIAL   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

Author keywords

allergen; digestion; egg white; IgE binding; riboflavin binding protein

Indexed keywords

ALLERGEN; ALLERGIC PATIENTS; BINDING CAPACITIES; BINDING PEPTIDE; DISULFIDE BONDS; EGG ALLERGY; EGG WHITE; GASTROINTESTINAL DIGESTION; HEN EGG; IGE BINDING; IMMUNOBLOTS; INTACT PROTEINS; MALDI-TOF/TOF; PROTEIN FRAGMENTS; RIBOFLAVIN BINDING PROTEIN;

BODY FLUIDS; COVALENT BONDS; MASS SPECTROMETRY; SLUDGE DIGESTION;

PEPTIDES;

ALLERGEN; CARRIER PROTEIN; EGG PROTEIN; IMMUNOGLOBULIN E; PEPTIDE; RIBOFLAVIN BINDING PROTEIN; RIBOFLAVIN-BINDING PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BLOOD; CHEMISTRY; CHICKEN; DIGESTION; EGG; EGG ALLERGY; FEMALE; HUMAN; IMMUNOBLOTTING; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS;

ALLERGENS; AMINO ACID SEQUENCE; ANIMALS; CHICKENS; DIGESTION; EGG HYPERSENSITIVITY; EGG PROTEINS; EGGS; FEMALE; HUMANS; IMMUNOBLOTTING; IMMUNOGLOBULIN E; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; PEPTIDES;

EID: 84861450703     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf3001586     Document Type: Article

References (24)

1. Savage, J. H.; Matsui, E. C.; Skripak, J. M.; Wood, R. A. The natural history of egg allergy J. Allergy Clin. Immunol. 2007, 120, 1413-1417
2. Amo, A.; Rodriguez-Perez, R.; Blanco, J.; Villota, J.; Juste, S.; Moneo, I.; Caballero, M. L. Gal d 6 is the second allergen characterized from egg yolk J. Agric. Food Chem. 2010, 58, 7453-7457
3. Guérin-Dubiard, C.; Pasco, M.; Mollé, D.; Désert, C.; Croguennec, T.; Nau, F. Proteomic analysis of hen egg white J. Agric. Food Chem. 2006, 54, 3901-3910
4. Adiga, P. R. Riboflavin carrier protein in reproduction. In Vitamin Receptors; Dakshinamurti, K., Ed.; Cambridge University Press: Cambridge, U.K., 1994; pp 137-176.
5. White, H. B., III; Armstrong, J.; Whitehead, C. C. Riboflavin-binding protein Biochem. J. 1986, 238, 671-675
6. White, H. B., III; Merrill, A. H., Jr. Riboflavin binding proteins Annu. Rev. Nutr. 1988, 8, 279-299
7. Monaco, H. L. Crystal structure of chicken riboflavin protein EMBO J. 1997, 16, 1475-1483
8. Croguennec, T.; Guérin-Dubiard, C.; Nau, F. Riboflavin binding protein (flavoprotein). In Bioactive Egg Compounds; Huopalahti, R.; López Fandiño, R.; Anton, M.; Schade, R., Eds.; Springer-Verlag: Berlin, Germany, 2007; pp 69-74.
9. Lehrer, S. B.; Reese, G. Applications of molecular biology in food allergy. Allergens of animal origin Alergol. Inmunol. Clin. 2001, 16 (S2) 20-25
10. Peltre, G.; Bernard, H.; Grassi, J.; David, B.; Wal, J. M. Cross-reaction between calcium-sensitive bovine caseins and riboflavin binding-protein in allergy to cow's milk-proteins J. Allergy Clin. Immunol. 1994, 93, 210-210
11. Maehashi, K.; Matano, M.; Nonaka, M.; Udaka, S.; Yamamoto, Y. Riboflavin-binding protein is a novel bitter inhibitor Chem. Senses 2008, 33, 57-63
12. Moreno, F. J.; Mackie, A. R.; Mills, E. N. C. Phospholipid interactions protect the milk allergen α-lactalbumin from proteolysis during in vitro digestion J. Agric. Food Chem. 2005, 53, 9810-9816
13. Martos, G.; Contreras, P.; Molina, E.; López-Fandiño, R. Egg white ovalbumin digestion mimicking physiological conditions J. Agric. Food Chem. 2010, 58, 5640-5648
14. Jiménez-Saiz, R.; Martos, G.; Carrillo, W.; López- Fandiño, R.; Molina, E. Susceptibility of lysozyme to in vitro digestion and immunoreactivity of its digests Food Chem. 2011, 127, 1719-1726
15. Jiménez-Saiz, R.; Belloque, J.; Molina, E.; López- Fandiño, R. Human immunoglobulin E binding to heated and glycated ovalbumin and ovomucoid before and after in vitro digestion J. Agric. Food Chem. 2011, 59, 10044-10051
16. Shevchenko, A.; Tomas, H.; Havlis, J.; Olsen, J. V.; Mann, M. In-gel digestion for mass spectrometric characterization of proteins and proteomes Nat. Protoc. 2006, 1, 2856-2860
17. Luque-Garcia, J. L.; Zhou, G.; Sun, T. T.; Neubert, T. A. Use of nitrocellulose membranes for protein characterization by matrix-assisted laser desorption/ionization mass spectrometry Anal. Chem. 2006, 78, 5102-5108
18. Harvey, D. J.; Wing, D. R.; Kuster, B.; Wilson, I. B. H. Composition of N-linked carbohydrates from ovalbumin and co-purified glycoproteins J. Am. Soc. Mass Spectrom. 2000, 11, 564-571
19. Hirose, J.; Kitabatake, N.; Kimura, A.; Narita, H. Recognition of native and/or thermally induced denatured forms of the major food allergen, ovomucoid, by human IgE and mouse monoclonal IgG antibodies Biosci., Biotechnol., Biochem. 2004, 68, 2490-2497
20. Cooke, S. K.; Sampson, H. A. Allergenic properties of ovomucoid in man J. Immunol. 1997, 59, 2026-2032
21. Rupa, P.; Nakamura, S.; Mine, Y. Genetically glycosylated ovomucoid third domain can modulate Immunoglobulin E antibody production and cytoline response in BALB/c mice Clin. Exp. Allergy 2007, 37, 918-928
22. Amoresano, A.; Brancaccio, A.; Andolfo, A.; Perduca, M.; Monaco, H. L.; Marino, G. The carbohydrates of the isoforms of three avian riboflavin-binding proteins Eur. J. Biochem. 1999, 263, 849-858
23. Subramanian, S.; Adiga, P. R. Identification and mapping of linear antigenic determinants of chicken riboflavin carrier protein Biochim. Biophys. Acta: Protein Struct. Mol. Enzymol. 1998, 1429, 74-82
24. Subramanian, S.; Andal, S.; Karande, A. A.; Adiga, P. R. Epitope mapping and evaluation of specificity of T-helper sites in four major antigenic peptides of chicken riboflavin carrier protein in outbred rats Biochem. Biophys. Res. Commun. 2003, 311, 11-16