Analysis of tissue and salivary nicotinamide N-methyltransferase in oral squamous cell carcinoma: Basis for the development of a noninvasive diagnostic test for early-stage disease

Biological Chemistry

Volumn 393, Issue 6, 2012, Pages 505-511

  Sartini, Davide ^a   Pozzi, Valentina ^a   Renzi, Elisabetta ^a   Morganti, Stefano ^a   Rocchetti, Romina ^a   Rubini, Corrado ^a   Santarelli, Andrea ^a   Muzio, Lorenzo Lo ^b,c   Emanuelli, Monica ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b REFERRAL CANCER CENTER OF BASILICATA   (Italy)

^c UNIVERSITY OF FOGGIA   (Italy)

Author keywords

enzyme activity; oral cancer; salivary tumor marker

Indexed keywords

NICOTINAMIDE METHYLTRANSFERASE; SALIVA PROTEIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER MORTALITY; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIAGNOSTIC TEST; DISEASE ASSOCIATION; EARLY CANCER; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; MALE; MOUTH MUCOSA; MOUTH SQUAMOUS CELL CARCINOMA; NON INVASIVE PROCEDURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALIVA LEVEL; WESTERN BLOTTING;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; EARLY DETECTION OF CANCER; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; NICOTINAMIDE N-METHYLTRANSFERASE; SALIVA;

EID: 84861386073     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/hsz-2012-0112     Document Type: Article

References (31)

1. Aksoy, S., Szumlanski, C.L., and Weinshilboum, R.M. (1994). Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. J. Biol. Chem. 269 , 14835-14840.
2. Audrito, V., Vaisitti, T., Rossi, D., Gottardi, D., D'Arena, G., Laurenti, L., Gaidano, G., Malavasi, F., and Deaglio, S. (2011). Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network. Cancer Res. 71 , 4473-4483.
3. Balducci, E., Orsomando, G., Polzonetti, V., Vita, A., Emanuelli, M., Raffaelli, N., Ruggieri, S., Magni, G., and Natalini, P. (1995). NMN adenylyltransferase from bull testis: purification and properties. Biochem. J. 310 , 395-400.
4. Bartuś, M., Lomnicka, M., Kostogrys, R.B., Kaźmierczak, P., Watala, C., Slomińska, E.M., Smoleński, R.T., Pisulewski, P.M., Adamus, J., Gebicki, J., et al. (2008). 1-Methylnicotinamide (MNA) prevents endothelial dysfunction in hypertriglyceridemic and diabetic rats. Pharmacol. Rep. 60 , 127-138.
5. Bradford, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 , 248-254.
6. Brzozowski, T., Konturek, P.C., Chlopicki, S., Sliwowski, Z., Pawlik, M., Ptak-Belowska, A., Kwiecien, S., Drozdowicz, D., Pajdo, R., Slonimska, E., et al. (2008). Therapeutic potential of 1-methylnicotinamide against acute gastric lesions induced by stress: role of endogenous prostacyclin and sensory nerves. J. Pharmacol. Exp. Ther. 326 , 105-116.
7. Chlopicki, S., Swies, J., Mogielnicki, A., Buczko, W., Bartus, M., Lomnicka, M., Adamus, J., and Gebicki, J. (2007). 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway. Br. J. Pharmacol. 152 , 230-239.
8. D'Andrea, F.P., Safwat, A., Kassem, M., Gautier, L., Overgaard, J., and Horsman, M.R. (2011). Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance. Radiother. Oncol. 99 , 373-378.
9. Debigaré, R., Maltais, F., Côté, C.H., Michaud, A., Caron, M.A., Mofarrahi, M., Leblanc, P., and Hussain, S.N. (2008). Profiling of mRNA expression in quadriceps of patients with COPD and muscle wasting. COPD 5 , 75-84.
10. Emanuelli, M., Santarelli, A., Sartini, D., Ciavarella, D., Rossi, V., Pozzi, V., Rubini, C., and Lo Muzio, L. (2010). Nicotinamide N-methyltransferase upregulation correlates with tumour differentiation in oral squamous cell carcinoma. Histol. Histopathol. 25 , 15-20.
11. Furuta, H., Kondo, Y., Nakahata, S., Hamasaki, M., Sakoda, S., and Morishita, K. (2010). NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma. Biochem. Biophys. Res. Commun. 391 , 1785-1791.
12. Jang, J.S., Cho, H.Y., Lee, Y.J., Ha, W.S., and Kim, H.W. (2004). The differential proteome profile of stomach cancer: identification of the biomarker candidates. Oncol. Res. 14 , 491-499.
13. Kassem, H.Sh., Sangar, V., Cowan, R., Clarke, N., and Margison, G.P. (2002). A potential role of heat shock proteins and nicotinamide N-methyl transferase in predicting response to radiation in bladder cancer. Int. J. Cancer. 101 , 454-460.
14. Kim, D.S., Choi, Y.P., Kang, S., Gao, M.Q., Kim, B., Park, H.R., Choi, Y.D., Lim, J.B., Na, H.J., Kim, H.K., et al. (2010). Panel of candidate biomarkers for renal cell carcinoma. J. Proteome. Res. 9 , 3710-3719.
15. Markert, J.M., Fuller, C.M., Gillespie, G.Y., Bubien, J.K., McLean, L.A., Hong, R.L., Lee, K., Gullans, S.R., Mapstone, T.B., and Benos, D.J. (2001). Differential gene expression profiling in human brain tumors. Physiol. Genomics. 5 , 21-33.
16. Mateuszuk, L ., Khomich, T.I., Slomińska, E., Gajda, M., Wójcik, L., Lomnicka, M., Gwóźdź, P., and Chlopicki, S. (2009). Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis. Pharmacol. Rep. 61 , 76-85.
17. Parsons, R.B., Aravindan, S., Kadampeswaran, A., Evans, E.A., Sandhu, K.K., Levy, E.R., Thomas, M.G., Austen, B.M., and Ramsden, D.B. (2011). The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors. Biochem. J. 436 , 145-155.
18. Peng, Y., Sartini, D., Pozzi, V., Wilk, D., Emanuelli, M., and Yee, V.C. (2011). Structural basis of substrate recognition in human nicotinamide N-methyltransferase. Biochemistry 50 , 7800-7808.
19. Pozzi, V., Mazzotta, M., Lo Muzio, L., Sartini, D., Santarelli, A., Renzi, E., Rocchetti, R., Tomasetti, M., Ciavarella, D., and Emanuelli, M. (2011). Inhibiting proliferation in KB cancer cells by RNA interference-mediated knockdown of nicotinamide N-methyltransferase expression. Int. J. Immunopathol. Pharmacol. 24 , 69-77.
20. Roessler, M., Rollinger, W., Palme, S., Hagmann, M.L, Berndt, P., Engel, A.M., Schneidinger, B., Pfeffer, M., Andres, H., Karl, J., et al. (2005). Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer. Clin. Cancer Res. 11 , 6550-6557.
21. Rogers, C.D., Fukushima, N., Sato, N., Shi, C., Prasad, N., Hustinx, S.R., Matsubayashi, H., Canto, M., Eshleman, J.R., Hruban, R.H., et al. (2006). Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs. Cancer Biol. Ther. 5 , 1383-1389.
22. Sartini, D., Muzzonigro, G., Milanese, G., Pierella, F., Rossi, V., and Emanuelli, M. (2006). Identification of nicotinamide N-methyltransferase as a novel tumor marker for renal clear cell carcinoma. J. Urol. 176 , 2248-2254.
23. Sartini, D., Santarelli, A., Rossi, V., Goteri, G., Rubini, C., Ciavarella, D., Lo Muzio, L., and Emanuelli, M. (2007). Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma. Mol. Med. 13 , 415-421.
24. Sternak, M., Khomich, T.I., Jakubowski, A., Szafarz, M., Szczepański, W., Bialas, M., Stojak, M., Szymura-Oleksiak, J., and Chlopicki, S. (2010). Nicotinamide N-methyltransferase (NNMT) and 1-methylnicotinamide (MNA) in experimental hepatitis induced by concanavalin A in the mouse. Pharmacol Rep. 62 , 483-493.
25. Tang, S.W., Yang, T.C., Lin, W.C., Chang, W.H., Wang, C.C., Lai, M.K., and Lin, J.Y. (2011). Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase- 2 expression in clear cell renal cell carcinoma cells. Carcinogenesis 32 , 138-145.
26. Tomida, M., Mikami, I., Takeuchi, S., Nishimura, H., and Akiyama, H. (2009). Serum levels of nicotinamide N-methyltransferase in patients with lung cancer. J. Cancer Res. Clin. Oncol. 135 , 1223-1229.
27. Williams, A.C. and Ramsden, D.B. (2005). Autotoxicity, methylation and a road to the prevention of Parkinson's disease. J. Clin. Neurosci. 12 , 6-11.
28. Wu, Y., Siadaty, M.S., Berens, M.E., Hampton, G.M., and Theodorescu, D. (2008). Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration. Oncogene 27 , 6679-6689.
29. Wu, J.Y., Yi, C., Chung, H.R., Wang, D.J., Chang, W.C., Lee, S.Y., Lin, C.T., Yang, Y.C., and Yang, W.C. (2010). Potential biomarkers in saliva for oral squamous cell carcinoma. Oral. Oncol. 46 , 226-231.
30. Xu, J., Moatamed, F., Caldwell, J.S., Walker, J.R., Kraiem, Z., Taki, K., Brent, G.A., and Hershman, J.M. (2003). Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells. J. Clin. Endocrinol. Metab. 88 , 4990-4996.
31. Zhang, J. (2003). Are poly(ADP-ribosyl)ation by PARP-1 and deacetylation by Sir2 linked ? Bioessays 25 , 808-814.