Understanding the sexome: Measuring and reporting sex differences in gene systems

Endocrinology

Volumn 153, Issue 6, 2012, Pages 2551-2555

  Arnold, Arthur P ^a   Lusis, Aldons J ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; HISTONE; PROTEOME; TRANSCRIPTION FACTOR; TRANSCRIPTOME;

CELL FUNCTION; CHROMOSOME INACTIVATION; DNA METHYLATION; ESTROGEN RESPONSIVE ELEMENT; GENE; GENE CONTROL; GENE PRODUCT; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; GENOTYPE; HUMAN; INCIDENCE; MEASUREMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; REGULATORY MECHANISM; SEX DIFFERENCE; SEXOME; SHORT SURVEY; SRY GENE; X CHROMOSOME; XIST GENE; Y CHROMOSOME;

FEMALE; GENE REGULATORY NETWORKS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MODELS, GENETIC; SEX FACTORS; TRANSCRIPTOME;

EID: 84861309996     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-2134     Document Type: Short Survey

References (43)

1. Beery AK, Zucker I 2011 Sex bias in neuroscience and biomedical research. Neurosci Biobehav Rev 35:565-572
2. Taylor KE, Vallejo-Giraldo C, Schaible NS, Zakeri R, Miller VM 2011 Reporting of sex as a variable in cardiovascular studies using cultured cells. Biol Sex Differ 2:11
3. Mogil JS, Chanda ML 2005 The case for the inclusion of female subjects in basic science studies of pain. Pain 117:1-5 (Pubitemid 41764767)
4. Arnold AP 2010 Promoting the understanding of sex differences to enhance equity and excellence in biomedical science. Biol Sex Differ 1:1
5. Deng X, Hiatt JB, Nguyen DK, Ercan S, Sturgill D, Hillier LW, Schlesinger F, Davis CA, Reinke VJ, Gingeras TR, Shendure J, Waterston RH, Oliver B, Lieb JD, Disteche CM 2011 Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster. Nat Genet 43:1179-1185
6. Charlesworth B 1996 The evolution of chromosomal sex determination and dosage compensation. Curr Biol 6:149-162
7. Ober C, Loisel DA, Gilad Y 2008 Sex-specific genetic architecture of human disease. Nat Rev Genet 9:911-922 (Pubitemid 50329067)
8. Voskuhl R 2011 Sex differences in autoimmune diseases. Biol Sex Differ 2:1
9. Karasik D, Ferrari SL 2008 Contribution of gender-specific genetic factors to osteoporosis risk. Ann Hum Genet 72:696-714
10. Arnold AP 2009 The organizational-activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues. Horm Behav 55:570-578
11. Arnold AP 2012 The end of gonad-centric sex determination in mammals. Trends Genet 28:55-61
12. Phoenix CH, Goy RW, Gerall AA, Young WC 1959 Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 65:369-382
13. De Vries GJ 2004 Minireview: sex differences in adult and developing brains: compensation, compensation, compensation. Endocrinology 145:1063-1068 (Pubitemid 38280983)
14. Dewing P, Shi T, Horvath S, Vilain E 2003 Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation. Brain Res Mol Brain Res 118:82-90 (Pubitemid 37238990)
15. Rinn JL, Rozowsky JS, Laurenzi IJ, Petersen PH, Zou K, Zhong W, Gerstein M, Snyder M 2004 Major molecular differences between mammalian sexes are involved in drug metabolism and renal function. Dev Cell 6:791-800 (Pubitemid 38745414)
16. Vawter MP, Evans S, Choudary P, Tomita H, Meador-Woodruff J, Molnar M, Li J, Lopez JF, Myers R, Cox D, Watson SJ, Akil H, Jones EG, Bunney WE 2004 Gender-specific gene expression in post-mortem human brain: localization to sex chromosomes. Neuropsychopharmacology 29:373-384 (Pubitemid 38175155)
17. Reinius B, Saetre P, Leonard JA, Blekhman R, Merino-Martinez R, Gilad Y, Jazin E 2008 An evolutionarily conserved sexual signature in the primate brain. PLoS Genet 4:e1000100
18. Isensee J, Witt H, Pregla R, Hetzer R, Regitz-Zagrosek V, Noppinger PR2008 Sexually dimorphic gene expression in the heart of mice and men. J Mol Med 86:61-74
19. Sárvári M, Kalló I, Hrabovszky E, Solymosi N, Tóth K, Likó I, Molnár B, Tihanyi K, Liposits Z 2010 Estradiol replacement alters expression of genes related to neurotransmission and immune surveillance in the frontal cortex of middle-aged, ovariectomized rats. Endocrinology 151:3847-3862
20. Stamova B, Tian Y, Jickling G, Bushnell C, Zhan X, Liu D, Ander BP, Verro P, Patel V, Pevec WC, Hedayati N, Dawson DL, Jauch EC, Pancioli A, Broderick JP, Sharp FR 2012 The X-chromosome has a different pattern of gene expression in women compared with men with ischemic stroke. Stroke 43:326-334
21. Tian Y, Stamova B, Jickling GC, Liu D, Ander BP, Bushnell C, Zhan X, Davis RR, Verro P, Pevec WC, Hedayati N, Dawson DL, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR 14 December 2011 Effects of gender on gene expression in the blood of ischemic stroke patients. J Cereb Blood Flow Metab 10.1038/jcbfm.2011.179
22. Maillot G, Lacroix-Triki M, Pierredon S, Gratadou L, Schmidt S, Bénès V, Roché H, Dalenc F, Auboeuf D, Millevoi S, Vagner S 2009 Widespread estrogen-dependent repression of micrornas involved in breast tumor cell growth. Cancer Res 69:8332-8340
23. Yang X, Schadt EE, Wang S, Wang H, Arnold AP, Ingram-Drake L, Drake TA, Lusis AJ 2006 Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res 16:995-1004 (Pubitemid 44162259)
24. Hager R, Cheverud JM, Leamy LJ, Wolf JB 2008 Sex dependent imprinting effects on complex traits in mice. BMC Evol Biol 8:303
25. Gregg C, Zhang J, Butler JE, Haig D, Dulac C 2010 Sex-specific parent-of-origin allelic expression in the mouse brain. Science 329:682-685
26. Kim CX, Bailey KR, Klee GG, Ellington AA, Liu G, Mosley Jr TH, Rehman H, Kullo IJ 2010 Sex and ethnic differences in 47 candidate proteomic markers of cardiovascular disease: the Mayo Clinic proteomic markers of arteriosclerosis study. PLoS One 5:e9065
27. Ananthi S, Santhosh RS, Nila MV, Prajna NV, Lalitha P, Dharmalingam K 2011 Comparative proteomics of human male and female tears by two-dimensional electrophoresis. Exp Eye Res 92:454-463
28. Metskas LA, Kulp M, Scordilis SP 2010 Gender dimorphism in the exercise-naive murine skeletal muscle proteome. Cell Mol Biol Lett 15:507-516
29. Fleissig Y, Reichenberg E, Redlich M, Zaks B, Deutsch O, Aframian DJ, Palmon A 2010 Comparative proteomic analysis of human oral fluids according to gender and age. Oral Dis 16:831-838
30. Diedrich M, Tadic J, Mao L, Wacker MA, Nebrich G, Hetzer R, Regitz-Zagrosek V, Klose J 2007 Heart protein expression related to age and sex in mice and humans. Int J Mol Med 20:865-874
31. Mittelstrass K, Ried JS, Yu Z, Krumsiek J, Gieger C, Prehn C, Roemisch- Margl W, Polonikov A, Peters A, Theis FJ, Meitinger T, Kronenberg F, Weidinger S, Wichmann HE, Suhre K, Wang-Sattler R, Adamski J, Illig T 2011 Discovery of sexual dimorphisms in metabolic and genetic biomarkers. PLoS Genet 7:e1002215
32. Berchtold NC, Cribbs DH, Coleman PD, Rogers J, Head E, Kim R, Beach T, Miller C, Troncoso J, Trojanowski JQ, Zielke HR, Cotman CW 2008 Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci USA 105: 15605-15610
33. McCarthy MM, Auger AP, Bale TL, De Vries GJ, Dunn GA, Forger NG, Murray EK, Nugent BM, Schwarz JM, Wilson ME 2009 The epigenetics of sex differences in the brain. J Neurosci 29:12815-12823
34. Fawcett GL, Roseman CC, Jarvis JP, Wang B, Wolf JB, Cheverud JM 2008 Genetic architecture of adiposity and organ weight using combined generation QTL analysis. Obesity 16:1861-1868
35. Kenney-Hunt JP, Wang B, Norgard EA, Fawcett G, Falk D, Pletscher LS, Jarvis JP, Roseman C, Wolf J, Cheverud JM 2008 Pleiotropic patterns of quantitative trait loci for 70 murine skeletal traits. Genetics 178:2275-2288
36. Farber CR, Medrano JF 2007 Fine mapping reveals sex bias in quantitative trait loci affecting growth, skeletal size and obesity-related traits on mouse chromosomes 2 and 11. Genetics 175:349-360 (Pubitemid 46168578)
37. Stylianou IM, Korstanje R, Li R, Sheehan S, Paigen B, Churchill GA 2006 Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome 17:22-36 (Pubitemid 43099502)
38. Avery CL, Freedman BI, Kraja AT, Borecki IB, Miller MB, Pankow JS, Arnett D, Lewis CE, Myers RH, Hunt SC, North KE 2006 Genotype- by-sex interaction in the aetiology of type 2 diabetes mellitus: support for sex-specific quantitative trait loci in hypertension genetic epidemiology network participants. Diabetologia 49:2329-2336 (Pubitemid 44359093)
39. Taylor BA, Tarantino LM, Phillips SJ 1999 Gender-influenced obesity QTLs identified in a cross involving the KK type II diabetesprone mouse strain. Mamm Genome 10:963-968 (Pubitemid 29470936)
40. Wang S, Yehya N, Schadt EE, Wang H, Drake TA, Lusis AJ 2006 Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet 2:e15
41. van Nas A, Guhathakurta D, Wang SS, Yehya N, Horvath S, Zhang B, Ingram-Drake L, Chaudhuri G, Schadt EE, Drake TA, Arnold AP, Lusis AJ 2009 Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology 150:1235-1249
42. Cicatiello L, Mutarelli M, Grober OM, Paris O, Ferraro L, Ravo M, Tarallo R, Luo S, Schroth GP, Seifert M, Zinser C, Chiusano ML, Traini A, De Bortoli M, Weisz A 2010 Estrogen receptor α controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs. Am J Pathol 176:2113-2130
43. Itoh Y, Melamed E, Yang X, Kampf K, Wang S, Yehya N, Van Nas A, Replogle K, Band MR, Clayton DF, Schadt EE, Lusis AJ, Arnold AP 2007 Dosage compensation is less effective in birds than in mammals. J Biol 6:2