Gender-Specific Gene Expression in Post-Mortem Human Brain: Localization to Sex Chromosomes

Neuropsychopharmacology

Volumn 29, Issue 2, 2004, Pages 373-384

  Vawter, Marquis P ^a,e,f   Evans, Simon ^b,e   Choudary, Prabhakara ^c,e   Tomita, Hiroaki ^a,e   Meador Woodruff, Jim ^b   Molnar, Margherita ^c,e   Li, Jun ^d,e   Lopez, Juan F ^b,e   Myers, Rick ^d,e   Cox, David ^d   Watson, Stanley J ^b,e   Akil, Huda ^b,e   Jones, Edward G ^c,e   Bunney, William E ^a,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d STANFORD UNIVERSITY   (United States)

^e NONE   (United States)

^f University of California   (United States)

Author keywords

DBY; RPS4Y; SMCY; USP9Y; UTY; VCX; VCY; XIST

Indexed keywords

ARTICLE; BRAIN; CADAVER; CELL POPULATION; CELL TYPE; CEREBELLUM; CINGULATE GYRUS; CLINICAL ARTICLE; DNA MICROARRAY; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; MENTAL DISEASE; NERVE CELL; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PREFRONTAL CORTEX; PRIORITY JOURNAL; SEX CHROMOSOME; SEX DIFFERENCE; X CHROMOSOME; Y CHROMOSOME;

ACTINS; ADULT; AGED; AGED, 80 AND OVER; BRAIN; CHROMOSOMES, HUMAN, Y; CONFIDENCE INTERVALS; DEAD-BOX RNA HELICASES; ENDOPEPTIDASES; FEMALE; GENDER IDENTITY; GENE EXPRESSION; HUMANS; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OVARY; POSTMORTEM CHANGES; PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEINS; RNA, MESSENGER; RNA, UNTRANSLATED; SEX CHROMOSOMES; TESTIS;

EID: 10744226630     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300337     Document Type: Article

References (31)

1. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders 4th edn American Psychiatric Association: Washington, DC.
2. Andreasen NC, Flaum M, Swayze II V, O'Leary DS, Alliger R, Cohen G et al (1993). Intelligence and brain structure in normal individuals. Am J Psychiatry 150: 130-134.
3. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM et al (2000). Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25: 25-29.
4. Brockdorff N, Ashworth A, Kay GF, Cooper P, Smith S, McCabe VM et al (1991). Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome. Nature 351: 329-331.
5. Brown CJ, Hendrich BD, Rupert JL, Lafreniere RG, Xing Y, Lawrence J et al (1992). The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell 71: 527-542.
6. Carruth LL, Reisert I, Arnold AP (2002). Sex chromosome genes directly affect brain sexual differentiation. Nat Neurosci 5: 933-934.
7. Dennis Jr G, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC et al (2003). DAVID: database for annotation, visualization, and integrated discovery. Genome Biol 4: 1-11(Article R60).
8. Eriksson A, Wahlestedt C, Nordqvist K (1999). Isolation of sex-specific cDNAs from fetal mouse brain using mRNA differential display and representational difference analysis. Brain Res Mol Brain Res 74: 91-97.
9. Escalona PR, McDonald WM, Doraiswamy PM, Boyko OB, Husain MM, Figiel GS et al (1991). In vivo stereological assessment of human cerebellar volume: effects of gender and age. AJNR Am J Neuroradiol 12: 927-929.
10. Fisher EM, Beer-Romero P, Brown LG, Ridley A, McNeil JA, Lawrence JB et al (1990). Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome. Cell 63: 1205-1218.
11. Gee CE, Chen CL, Roberts JL, Thompson R, Watson SJ (1983). Identification of proopiomelanocortin neurones in rat hypothalamus by in situ cDNA-mRNA hybridization. Nature 306: 374-376.
12. Giedd JN, Snell JW, Lange N, Rajapakse JC, Casey BJ, Kozuch PL et al (1996). Quantitative magnetic resonance imaging of human brain development: ages 4-18. Cereb Cortex 6: 551-560.
13. Graves JA (1995). The evolution of mammalian sex chromosomes and the origin of sex determining genes. Philos Trans R Soc Lond B Biol Sci 350: 305-311; discussion 311-312.
14. Gur RC, Mozley PD, Resnick SM, Gottlieb GL, Kohn M, Zimmerman R et al (1991). Gender differences in age effect on brain atrophy measured by magnetic resonance imaging. Proc Natl Acad Sci USA 88: 2845-2849.
15. Jones EG, Hendry SH, Liu XB, Hodgins S, Potkin SG, Tourtellotte WW (1992). A method for fixation of previously fresh-frozen human adult and fetal brains that preserves histological quality and immunoreactivity. J Neurosci Methods 44: 133-144.
16. Kanehisa M, Goto S (2000). KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28: 27-30.
17. Lahn BT, Page DC (1997). Functional coherence of the human Y chromosome. Science 278: 675-680.
18. Li C, Wong WH (2001). Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci USA 98: 31-36.
19. Mayer A, Lahr G, Swaab DF, Pilgrim C, Reisert I (1998). The Y-chromosomal genes SRY and ZFY are transcribed in adult human brain. Neurogenetics 1: 281-288.
20. Meador-Woodruff JH, Mansour A, Bunzow JR, Van Tol HH, Watson Jr SJ, Civelli O (1989). Distribution of D2 dopamine receptor mRNA in rat brain. Proc Natl Acad Sci USA 86: 7625-7628.
21. Pakkenberg B, Pelvig D, Marner L, Bundgaard MJ, Gundersen HJ, Nyengaard JR et al (2003). Aging and the human neocortex. Exp Gerontol 38: 95-99.
22. Rabinowicz T, Petetot JM, Gartside PS, Sheyn D, Sheyn T, de CM (2002). Structure of the cerebral cortex in men and women. J Neuropathol Exp Neurol 61: 46-57.
23. Reisert I, Pilgrim C (1991). Sexual differentiation of monoaminergic neurons - genetic or epigenetic? Trends Neurosci 14: 468-473.
24. Sibug R, Kuppers E, Beyer C, Maxson SC, Pilgrim C, Reisert I (1996). Genotype-dependent sex differentiation of dopaminergic neurons in primary cultures of embryonic mouse brain. Brain Res Dev Brain Res 93: 136-142.
25. Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG et al (2003). The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature 423: 825-837.
26. Su A, Cooke M, Ching K, Hakak Y, Walker J, Wiltshire T et al (2002). Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci USA 99: 4465-4470.
27. Sudbrak R, Wieczorek G, Nuber UA, Mann W, Kirchner R, Erdogan F et al (2001). X chromosome-specific cDNA arrays: identification of genes that escape from X-inactivation and other applications. Hum Mol Genet 10: 77-83.
28. Tighilet B, Huntsman MM, Hashikawa T, Murray KD, Isackson PJ, Jones EG (1998). Cell-specific expression of type II calcium/ calmodulin-dependent protein kinase isoforms and glutamate receptors in normal and visually deprived lateral geniculate nucleus of monkeys. J Comp Neurol 390: 278-296.
29. Vogt MH, van den Muijsenberg JW, Goulmy E, Spierings E, Kluck P, Kester MG et al (2002). The DBY gene codes for an HLA-DQ5-restricted human male-specific minor histocompatibility antigen involved in graft-versus-host disease. Blood 99: 3027-3032.
30. Xu J, Burgoyne PS, Arnold AP (2002). Sex differences in sex chromosome gene expression in mouse brain. Hum Mol Genet 11: 1409-1419.
31. Xu J, Kobayashi S, Yamaguchi S, Iijima K, Okada K, Yamashita K (2000). Gender effects on age-related changes in brain structure. AJNR Am J Neuroradiol 21: 112-118.