Sexually dimorphic gene expression in the heart of mice and men

Journal of Molecular Medicine

Volumn 86, Issue 1, 2008, Pages 61-74

  Isensee, Jörg ^a,c   Witt, Henning ^a,c   Pregla, Reinhard ^b   Hetzer, Roland ^b   Regitz Zagrosek, Vera ^a,b   Ruiz Noppinger, Patricia ^a,c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^c MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

Author keywords

Age; Gender; Gene expression; Heart; Microarray analysis; Sex

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE III; CYTOCHROME P450 2B; UNSPECIFIC MONOOXYGENASE;

ANIMAL TISSUE; ARTICLE; CAR5B GENE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DDX3Y GENE; EIF2S3X GENE; EIF2S3Y GENE; FEMALE; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE LOCATION; GENETIC TRANSCRIPTION; GPM6B GENE; HEART; HEART LEFT VENTRICLE; HUMAN; HUMAN TISSUE; JARID1D GENE; MALE; MICROARRAY ANALYSIS; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; SEX CHROMOSOME; SEX DIFFERENCE; TIMP1 GENE; XIST GENE; Y CHROMOSOME;

AGE FACTORS; ANIMALS; CHROMOSOMES, HUMAN, X; CHROMOSOMES, HUMAN, Y; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENES, X-LINKED; GENES, Y-LINKED; HUMANS; MALE; MICE; MYOCARDIUM; SEX CHARACTERISTICS; SEX CHROMOSOMES; SEX FACTORS;

EID: 38149016903     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-007-0240-z     Document Type: Article

References (51)

1. Rinn JL, Rozowsky JS, Laurenzi IJ, Petersen PH, Zou K, Zhong W, Gerstein M, Snyder M (2004) Major molecular differences between mammalian sexes are involved in drug metabolism and renal function. Dev Cell 6:791-800
2. Ahluwalia A, Clodfelter KH, Waxman DJ (2004) Sexual dimorphism of rat liver gene expression: regulatory role of growth hormone revealed by deoxyribonucleic acid microarray analysis. Mol Endocrinol 18:747-760
3. Yang X, Schadt EE, Wang S, Wang H, Arnold AP, Ingram-Drake L, Drake TA, Lusis AJ (2006) Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res 16:995-1004
4. Rinn JL, Snyder M (2005) Sexual dimorphism in mammalian gene expression. Trends Genet 21:298-305
5. Hayward CS, Kelly RP, Collins P (2000) The roles of gender, the menopause and hormone replacement on cardiovascular function. Cardiovasc Res 46:28-49
6. Mendelsohn ME, Karas RH (2005) Molecular and cellular basis of cardiovascular gender differences. Science 308:1583-1587
7. Regitz-Zagrosek V (2006) Therapeutic implications of the gender-specific aspects of cardiovascular disease. Nat Rev Drug Discov 5:425-439
8. McKenna NJ, O'Malley BW (2002) Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 108:465-474
9. Bjornstrom L, Sjoberg M (2005) Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol Endocrinol 19:833-842
10. Edwards DP (2005) Regulation of signal transduction pathways by estrogen and progesterone. Annu Rev Physiol 67:335-376
11. van Eickels M, Grohe C, Cleutjens JP, Janssen BJ, Wellens HJ, Doevendans PA (2001) 17beta-estradiol attenuates the development of pressure-overload hypertrophy. Circulation 104:1419-1423
12. Gabel SA, Walker VR, London RE, Steenbergen C, Korach KS, Murphy E (2005) Estrogen receptor beta mediates gender differences in ischemia/reperfusion injury. J Mol Cell Cardiol 38:289-297
13. Pare G, Krust A, Karas RH, Dupont S, Aronovitz M, Chambon P, Mendelsohn ME (2002) Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury. Circ Res 90:1087-1092
14. Egan KM, Lawson JA, Fries S, Koller B, Rader DJ, Smyth EM, Fitzgerald GA (2004) COX-2-derived prostacyclin confers atheroprotection on female mice. Science 306:1954-1957
15. Xin HB, Senbonmatsu T, Cheng DS, Wang YX, Copello JA, Ji GJ, Collier ML, Deng KY, Jeyakumar LH, Magnuson MA, Inagami T, Kotlikoff MI, Fleischer S (2002) Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature 416:334-338
16. Udy GB, Towers RP, Snell RG, Wilkins RJ, Park SH, Ram PA, Waxman DJ, Davey HW (1997) Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci U S A 94:7239-7244
17. Jarukamjorn K, Sakuma T, Jaruchotikamol A, Ishino Y, Oguro M, Nemoto N (2006) Modified expression of cytochrome P450 mRNAs by growth hormone in mouse liver. Toxicology 219:97-105
18. Xu J, Burgoyne PS, Arnold AP (2002) Sex differences in sex chromosome gene expression in mouse brain. Hum Mol Genet 11:1409-1419
19. Nguyen DK, Disteche CM (2006) Dosage compensation of the active X chromosome in mammals. Nat Genet 38:47-53
20. Carrel L, Willard HF (2005) X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 434:400-404
21. Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC (2003) The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature 423:825-837
22. Nelson JF, Felicio LS, Randall PK, Sims C, Finch CE (1982) A longitudinal study of estrous cyclicity in aging C57BL/6J mice: I. Cycle frequency, length and vaginal cytology. Biol Reprod 27:327-339
23. Tusher VG, Tibshirani R, Chu G (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 98:5116-5121, Epub 2001 Apr 17
24. Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA (2003) DAVID: database for annotation, visualization, and integrated discovery. Genome Biol 4:P3
25. Hosack DA, Dennis G, Jr., Sherman BT, Lane HC, Lempicki RA (2003) Identifying biological themes within lists of genes with EASE. Genome Biol 4:R70, Epub 2003 Sep 11
26. Peirson SN, Butler JN, Foster RG (2003) Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis. Nucleic Acids Res 31:e73
27. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3:RESEARCH0034
28. Rozen S, Skaletsky H (2000) Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 132:365-386
29. Waku S, Iida N, Ishihara T (2000) Significance of brain natriuretic peptide measurement as a diagnostic indicator of cardiac function. Methods Inf Med 39:249-253
30. Xu J, Watkins R, Arnold AP (2006) Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain. Gene Expr Patterns 6:146-155, Epub 2005 Dec 1
31. Ditton HJ, Zimmer J, Kamp C, Rajpert-De Meyts E, Vogt PH (2004) The AZFa gene DBY (DDX3Y) is widely transcribed but the protein is limited to the male germ cells by translation control. Hum Mol Genet 13:2333-2341, Epub 2004 Aug 4
32. Yedavalli VS, Neuveut C, Chi YH, Kleiman L, Jeang KT (2004) Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function. Cell 119:381-392
33. Brown GM, Furlong RA, Sargent CA, Erickson RP, Longepied G, Mitchell M, Jones MH, Hargreave TB, Cooke HJ, Affara NA (1998) Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene. Hum Mol Genet 7:97-107
34. Brown CJ, Ballabio A, Rupert JL, Lafreniere RG, Grompe M, Tonlorenzi R, Willard HF (1991) A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature 349:38-44
35. Penny GD, Kay GF, Sheardown SA, Rastan S, Brockdorff N (1996) Requirement for Xist in X chromosome inactivation. Nature 379:131-137
36. Panning B, Dausman J, Jaenisch R (1997) X chromosome inactivation is mediated by Xist RNA stabilization. Cell 90:907-916
37. Clodfelter KH, Holloway MG, Hodor P, Park SH, Ray WJ, Waxman DJ (2006) Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis. Mol Endocrinol 20:1333-1351
38. Thum T, Borlak J (2000) Gene expression in distinct regions of the heart. Lancet 355:979-983
39. Amador-Noguez D, Yagi K, Venable S, Darlington G (2004) Gene expression profile of long-lived Ames dwarf mice and Little mice. Aging Cell 3:423-441
40. Boylston WH, DeFord JH, Papaconstantinou J (2006) Identification of longevity-associated genes in long-lived Snell and Ames dwarf mice. AGE 28:125-144
41. Dodgson SJ, Tashian RE, Gross G, Carter ND (1991) The carbonic anhydrases: cellular physiology and molecular genetics. Plenum, New York
42. Shiels A, Jeffery S, Phillips IR, Shephard EA, Wilson CA, Carter ND (1983) Sexual differentiation of rat liver carbonic anhydrase III. Biochim Biophys Acta 760:335-342
43. Teng CT (2002) Lactoferrin gene expression and regulation: an overview. Biochem Cell Biol 80:7-16
44. Tan YF, Li FX, Piao YS, Sun XY, Wang YL (2003) Global gene profiling analysis of mouse uterus during the oestrous cycle. Reproduction 126:171-182
45. Wilson TE, Fahrner TJ, Johnston M, Milbrandt J (1991) Identification of the DNA binding site for NGFI-B by genetic selection in yeast. Science 252:1296-1300
46. Bassett MH, White PC, Rainey WE (2004) A role for the NGFI-B family in adrenal zonation and adrenocortical disease. Endocr Res 30:567-574
47. Boheler KR, Volkova M, Morrell C, Garg R, Zhu Y, Margulies K, Seymour AM, Lakatta EG (2003) Sex- and age-dependent human transcriptome variability: implications for chronic heart failure. Proc Natl Acad Sci USA 100:2754-2759
48. Weinberg EO, Mirotsou M, Gannon J, Dzau VJ, Lee RT, Pratt RE (2003) Sex dependence and temporal dependence of the left ventricular genomic response to pressure overload. Physiol Genomics 12:113-127
49. Scott DM, Ehrmann IE, Ellis PS, Bishop CE, Agulnik AI, Simpson E, Mitchell MJ (1995) Identification of a mouse male-specific transplantation antigen, H-Y. Nature 376:695-698
50. Kim TG, Chen J, Sadoshima J, Lee Y (2004) Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. Mol Cell Biol 24:10151-10160
51. Maisel AS, Clopton P, Krishnaswamy P, Nowak RM, McCord J, Hollander JE, Duc P, Omland T, Storrow AB, Abraham WT, Wu AH, Steg G, Westheim A, Knudsen CW, Perez A, Kazanegra R, Bhalla V, Herrmann HC, Aumont MC, McCullough PA (2004) Impact of age, race, and sex on the ability of B-type natriuretic peptide to aid in the emergency diagnosis of heart failure: results from the Breathing Not Properly (BNP) multinational study. Am Heart J 147:1078-1084