Synthesis of methoxylated goniothalamin, aza-goniothalamin and γ-pyrones and their in vitro evaluation against human cancer cells

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 11, 2012, Pages 3635-3651

  Barcelos, Rosimeire Coura ^a   Pastre, Julio Cezar ^a   Caixeta, Vanessa ^a   Vendramini Costa, Débora Barbosa ^a   De Carvalho, João Ernesto ^a   Pilli, Ronaldo Aloise ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Pyrones; Antiproliferative activity; Aza goniothalamin; Cancer cells; Dihydro pyrones; Goniothalamin

Indexed keywords

1 (2,4 DIMETHOXYHENYL)HEXA 1,5 DIEN 3 OL; 1 (3,4 DIMETHOXYHENYL)HEXA 1,5 DIEN 3 OL; 1 (4 METHOXYHENYL)HEXA 1,5 DIEN 3 OL; 1 [2 (TRIFLUOROMETHYL)PHENYL]HEXA 1,5 DIEN 3 OL; 1 [4 (TRIFLUOROMETHYL)PHENYL]HEXA 1,5 DIEN 3 OL; 2 (3,4 DIMETHOXYSTYRYL) 2H PYRAN 4(3H) ONE; 2 (3,4 DIMETHOXYSTYRYL) 4H PYRAN 4 ONE; 2 (3,4,5 TRIMETHOXYSTYRYL) 2H PYRAN 4(3H) ONE; 2 (4 METHOXYPHENYL) 4H PYRAN 4 ONE; 2 (4 METHOXYSTYRYL) 2H PYRAN 4(3H) ONE; 2 (4 METHOXYSTYRYL) 4H PYRAN 4 ONE; 2 [2 (BENZO[D][1,3]DIOXOL 5 YL)VINYL] 2H PYRAN 4(3H) ONE; 2 [4 (TRIFLUOROMETHYL)STYRYL] 2H PYRAN 4(3H) ONE; 2 STYRYL 2H PYRAN 4(3H) ONE; 2 STYRYL 4H PYRAN 4 ONE; 2 VINYL 2H PYRAN 4(3H)ONE; 3 (2,4 DIMETHOXYPHENYL)ACRYLALDEHYDE; 3 (3,4 DIMETHOXYPHENYL)ACRYLALDEHYDE; 3 (3,4,5 TRIMETHOXYPHENYL)ACRYLALDEHYDE; 3 (3,5 DIMETHOXYPHENYL)ACRYLALDEHYDE; 3 [2 (TRIFLUOROMETHYL)PHENYL]ACRYLALDEHYDE; 3 [4 (TRIFLUOROMETHYL)PHENYL]ACRYLALDEHYDE; 5 BROMO 2 (4 METHOXYPHENYL) 2H PYRAN 4(3H) ONE; 5 IODO 2 (4 METHOXYPHENYL) 2H PYRAN 4(3H) ONE; ANTINEOPLASTIC AGENT; AZA GONIOTHALAMIN; DOXORUBICIN; GONIOTHALAMIN; PYRONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE;

CELL LINE, TUMOR; CELL PROLIFERATION; DOXORUBICIN; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; KERATINOCYTES; MOLECULAR STRUCTURE; PYRONES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861198518     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.03.059     Document Type: Article

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