The cytotoxic styryl lactone goniothalamin is an inhibitor of nucleocytoplasmic transport

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 9, 2010, Pages 2843-2846

  Wach, Jean Yves ^a,b   Güttinger, Stephan ^c   Kutay, Ulrike ^c   Gademann, Karl ^a,b  

^a EPFL   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c ETH ZURICH   (Switzerland)

Author keywords

Chemical biology; Natural products; Organic synthesis; Target identification

Indexed keywords

ANTINEOPLASTIC AGENT; GONIOTHALAMIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CYTOTOXICITY; DIELS ALDER REACTION; DRUG MECHANISM; DRUG SYNTHESIS; ENANTIOSELECTIVITY; HUMAN; NUCLEOCYTOPLASMIC TRANSPORT; SONOGASHIRA REACTION;

ACTIVE TRANSPORT, CELL NUCLEUS; BINDING SITES; CATALYSIS; CELL NUCLEUS; CHROMIUM; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HELA CELLS; HUMANS; LACTONES; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRONES; STEREOISOMERISM; TETRAHYDROISOQUINOLINES;

ALNUS;

EID: 77950864791     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.049     Document Type: Article

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