6-Bicycloaryl substituted (S)- and (R)-5,6-dihydro-2H-pyran-2-ones: Asymmetric synthesis, and anti-proliferative properties

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 1, 2009, Pages 311-318

  Kasaplar, Pinar ^a   Yilmazer, Özgür ^a   Çaǧir, Ali ^a  

^a IZMIR INSTITUTE OF TECHNOLOGY   (Turkey)

Author keywords

(R) Goniothalamin; Cancer cell lines; Conformationally constrained analogues; Cytotoxic activity

Indexed keywords

2 PYRONE DERIVATIVE; 5,6 DIHYDRO 2H PYRAN 2 ONE DERIVATIVE; 5,6 DIHYDRO 6 (NAPHTHALEN 2 YL)PYRAN 2 ONE; 6 (NAPHTHALEN 2 YL) 5,6 DIHYDRO 2H PYRAN 2 ONE; BICYCLO COMPOUND; GONIOTHALAMIN; LACTONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC SYNTHESIS; CANCER CELL CULTURE; CELL STRAIN MCF 7; CONTROLLED STUDY; CULTURE MEDIUM; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; HUMAN; HUMAN CELL; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; KETONES; PYRANS; PYRONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 57649200458     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.069     Document Type: Article

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