ERBB2 overexpression triggers transient high mechanoactivity of breast tumor cells

Cytoskeleton

Volumn 69, Issue 5, 2012, Pages 267-277

  Martin, Mireille ^a   Müller, Karla ^b   Cadenas, Cristina ^c   Hermes, Matthias ^c   Zink, Mareike ^b   Hengstler, Jan G ^c   Käs, Josef A ^b  

^a UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c TU DORTMUND UNIVERSITY   (Germany)

Author keywords

Breast cancer; Cancer development; Early micrometastasis; MCF 7 NeuT; Optical stretcher

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2;

ARTICLE; BIOMECHANICS; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL MOTILITY; CELL STRAIN MCF 7; CELL SUSPENSION; CONTROLLED STUDY; CYTOSKELETON; ELASTICITY; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; LASER; MAJOR CLINICAL STUDY; METASTASIS; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TUMOR GENE; TUMOR GROWTH; UPREGULATION;

BLOTTING, WESTERN; BREAST; BREAST NEOPLASMS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COHORT STUDIES; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MECHANOTRANSDUCTION, CELLULAR; NEOPLASM METASTASIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, ERBB-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 84861193638     PISSN: 19493584     EISSN: 19493592     Source Type: Journal    
DOI: 10.1002/cm.21023     Document Type: Article

References (38)

1. Ben-Ze'ev A. 1985. The cytoskeleton in cancer cells. Biochim Biophys Acta 780: 197-212.
2. Brase JC, Schmidt M, Fischbach T, Sültmann H, Bojar H, Koelbl H, Hellwig B, Rahnenführer J, Hengstler JG, Gehrmann MC. 2010. ERBB2 and TOP2A in breast cancer: a comprehensive analysis of gene amplification, RNA levels, and protein expression and their influence on prognosis and prediction. Clin Cancer Res 16: 2391-2401.
3. Brunner NK 2009. Passive and active single-cell biomechanics: a new perspective in cancer diagnosis. Soft Matter 2171-2178.
4. Cadenas C, Franckenstein D, Schmidt M, Gehrmann M, Hermes M, Geppert B, Schormann W, Maccoux LJ, Schug M, Schumann A, et al. 2010. Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer. Breast Cancer Res 12: R44.
5. Cross SE, Jin Y-S, Rao J, Gimzewski JK. 2007. Nanomechanical analysis of cells from cancer patients. Nat Nanotechnol 2: 780-783.
6. Desmedt C, Piette F, Loi S, Wang Y, Lallemand F, Haibe-Kains B, Viale G, Delorenzi M, Zhang Y, d'Assignies MS, et al. 2007. Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series. Clin Cancer Res 13: 3207-3214.
7. Dirac AMG, Bernards R. 2003. Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53. J Biol Chem 278: 11731-11734.
8. Evans EA, Calderwood DA. 2007. Forces and bond dynamics in cell adhesion. Science 316: 1148-1153.
9. Fritsch A, Hockel M, Kiessling T, Nnetu KD, Wetzel F, Zink M, Käs J. 2010. Are biomechanical changes necessary for tumour progression? Nat Phys 6: 730-732.
10. Giampieri S, Manning C, Hooper S, Jones L, Hill CS, Sahai E. 2009. Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell Biol 11: 1287-1296.
11. Gire V, Wynford-Thomas D. 1998. Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies. Mol Cell Biol 18: 1611-1621.
12. Gorgoulis VG, Halazonetis TD. 2010. Oncogene-induced senescence: the bright and dark side of the response. Curr Opin Cell Biol 816-827.
13. Guck J, Ananthakrishnan R, Mahmood H, Moon TJ, Cunningham CC, Käs JA. 2001. The Optical Stretcher: a novel laser tool to micromanipulate cells. Biophys J 81: 767-784.
14. Guck J, Schinkinger S, Lincoln B, Wottawah F, Ebert S, Romeyke M, Lenz D, Erickson HM, Ananthakrishnan R, Mitchell D, et al. 2005. Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence. Biophys J 88: 3689-3698.
15. Helfand BT. 2004. Intermediate filaments are dynamic and motile elements of cellular architecture. J Cell Sci 117(Part 2): 133-142.
16. Hellwig B, Hengstler JG, Schmidt M, Gehrmann MC, Schormann W, Rahnenführer J. 2010. Comparison of scores for bimodality of gene expression distributions and genome-wide evaluation of the prognostic relevance of high-scoring genes. BMC Bioinformatics 11: 276.
17. Hengstler JG, Bockamp EO, Hermes M, Brulport M, Bauer A, Schormann W, Schiffer IB, Hausherr C, Eshkind L, Antunes C, et al. 2006. Oncogene-blocking therapies: new insights from conditional mouse tumor models. Curr Cancer Drug Targets 6: 603-612.
18. Lautenschläger F. 2009. The regulatory role of cell mechanics for migration of differentiating myeloid cells. Proc Natl Acad Sci U S A 106: 15696-15701.
19. Lekka M. 1999. Elasticity of normal and cancerous human bladder cells studied by scanning force microscopy. Eur Biophys J 28: 312-316.
20. Lincoln B, Schinkinger S, Travis K, Wottawah F, Ebert S, Sauer F, Guck J. 2007a. Reconfigurable microfluidic integration of a dual-beam laser trap with biomedical applications. Biomed Microdevices 9: 703-710.
21. Lincoln B, Wottawah F, Schinkinger S, Ebert S, Guck J. 2007b. High-throughput rheological measurements with an optical stretcher. Methods Cell Biol 83: 397-423.
22. Loi S, Haibe-Kains B, Desmedt C, Lallemand F, Tutt AM, Gillet C, Ellis P, Harris A, Bergh J, Foekens JA, et al. 2007. Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade. J Clin Oncol 25: 1239-1246.
23. Martin M, Mueller K, Wottawah F, Schinkinger S, Lincoln B, Romeyke M, Käs JA. 2006. Feeling with light for cancer. Proc SPIE 6080: 126-135.
24. McDuff FKE, Turner SD. 2011. Jailbreak: oncogene-induced senescence and its evasion. Cell Signal 23: 6-13.
25. Mierke CT, Rösel D, Fabry B, Brábek J. 2008. Contractile forces in tumor cell migration. Eur J Cell Biol 87: 669-676.
26. Obarzanek-Fojt M, Favre B, Huber M, Ryser S, Moodycliffe AM, Wipff PJ, Hinz B, Hohl D. 2011. Induction of p38, tumour necrosis factor-α and RANTES by mechanical stretching of keratinocytes expressing mutant keratin 10R156H. Br J Dermatol 164: 125-134.
27. Pawlak G, Helfman DM. 2001. Cytoskeletal changes in cell transformation and tumorigenesis. Curr Opin Genet Dev 11: 41-47.
28. Petry IB, Fieber E, Schmidt M, Gehrmann M, Gebhard S, Hermes M, Schormann W, Selinski S, Freis E, Schwender H, et al. 2010. ERBB2 induces an antiapoptotic expression pattern of Bcl-2 family members in node-negative breast cancer. Clin Cancer Res 16: 451-460.
29. Rao KM, Cohen HJ. 1991. Actin cytoskeletal network in aging and cancer. Mutat Res 256: 139-148.
30. Remmerbach TW, Wottawah F, Dietrich J, Lincoln B, Wittekind C and Guck J. 2009. Oral cancer diagnosis by mechanical phenotyping. Cancer Res 69: 1728-1732.
31. Sage JA, Miller L, Pérez-Mancera PA, Wysocki JM, Jacks T. 2003. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424: 223-228.
32. Schmidt M, Hasenclever D, Schaeffer M, Boehm D, Cotarelo C, Steiner E, Lebrecht A, Siggelkow W, Weikel W, Schiffer-Petry I, et al. 2008. Prognostic effect of epithelial cell adhesion molecule overexpression in untreated node-negative breast cancer. Clin Cancer Res 14: 5849-5855.
33. Schmidt M, Petry IB, Böhm D, Lebrecht A, von Törne C, Gebhard S, Gerhold-Ay A, Cotarelo C, Battista M, Schormann W, et al. 2011. Ep-CAM RNA expression predicts metastasis-free survival in three cohorts of untreated node-negative breast cancer. Breast Cancer Res Treat 125: 637-646.
34. Schulze C, Wetzel F, Kueper T, Malsen A, Muhr G, Jaspers S, Blatt T, Wittern KP, Wenck H, Käs JA. 2010. Stiffening of human skin fibroblasts with age. Biophys J 99: 2434-2442.
35. Spangenberg C, Lausch EU, Trost TM, Prawitt D, May A, Keppler R, Fees SA, Reutzel D, Bell C, Schmitt S, et al. 2006. ERBB2-mediated transcriptional up-regulation of the alpha5beta1 integrin fibronectin receptor promotes tumor cell survival under adverse conditions. Cancer Res 66: 3715-3725.
36. Trost TM, Lausch EU, Fees SA, Schmitt S, Enklaar T, Reutzel D, Brixel LR, Schmidtke P, Maringer M, Schiffere IB, et al. 2005. Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells. Cancer Res 65: 840-849.
37. Wang Y, Klijn J, Zhang Y, Atkins D, Foekens J. 2007. Gene expression profiles and prognostic markers for primary breast cancer. Methods Mol Biol 377: 131-138.
38. Yang XR, Xu Y, Shi GM, Fan J, Zhou J, Ji Y, Sun HC, Qiu SJ, Yu B, Gao Q, et al. 2008. Cytokeratin 10 and cytokeratin 19: predictive markers for poor prognosis in hepatocellular carcinoma patients after curative resection. Clin Cancer Res 14: 3850-3859.