-
1
-
-
44849101184
-
The humoral immune system has a key prognostic impact in node-negative breast cancer
-
Schmidt M, Böhm D, von T, et al. The humoral immune system has a key prognostic impact in node-negative breast cancer. Cancer Res 2008;68:5405-13.
-
(2008)
Cancer Res
, vol.68
, pp. 5405-5413
-
-
Schmidt, M.1
Böhm, D.2
von, T.3
-
2
-
-
33646742442
-
Dephosphorylation of p-ERK1/2 in relation to tumor remission after ERBB2 and Raf1 blocking therapy in a conditional mouse tumor model
-
Hausherr CK, Schiffer IB, Gebhard S, et al. Dephosphorylation of p-ERK1/2 in relation to tumor remission after ERBB2 and Raf1 blocking therapy in a conditional mouse tumor model. Mol Carcinog 2006;45: 302-8.
-
(2006)
Mol Carcinog
, vol.45
, pp. 302-308
-
-
Hausherr, C.K.1
Schiffer, I.B.2
Gebhard, S.3
-
3
-
-
33749034462
-
ErbB-3 predicts survival in ovarian cancer
-
Tanner B, Hasenclever D, Stern K, et al. ErbB-3 predicts survival in ovarian cancer. J Clin Oncol 2006;24:4317-23.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4317-4323
-
-
Tanner, B.1
Hasenclever, D.2
Stern, K.3
-
4
-
-
0035874049
-
C-erbB2 expression in small cell lung cancer is associated with poor prognosis
-
Micke P, Hengstler JG, Ros R, et al. C-erbB2 expression in small cell lung cancer is associated with poor prognosis. Int J Cancer 2001;92: 474-9.
-
(2001)
Int J Cancer
, vol.92
, pp. 474-479
-
-
Micke, P.1
Hengstler, J.G.2
Ros, R.3
-
5
-
-
0033168055
-
Contribution of c-erbB2 and topoisomerase IIα to chemoresistance in ovarian cancer
-
Hengstler JG, Lange J, Kett A, et al. Contribution of c-erbB2 and topoisomerase IIα to chemoresistance in ovarian cancer. Cancer Res 1999;59:3206-14.
-
(1999)
Cancer Res
, vol.59
, pp. 3206-3214
-
-
Hengstler, J.G.1
Lange, J.2
Kett, A.3
-
6
-
-
14144254083
-
Correlation of HER2 gene amplification with expression of the apoptosis-suppressing genes bcl-2 and bcl-x-L in ductal carcinoma in situ of the breast
-
Siziopikou KP, Khan S. Correlation of HER2 gene amplification with expression of the apoptosis-suppressing genes bcl-2 and bcl-x-L in ductal carcinoma in situ of the breast. Appl Immunohistochem Mol Morphol 2005;13:14-8.
-
(2005)
Appl Immunohistochem Mol Morphol
, vol.13
, pp. 14-18
-
-
Siziopikou, K.P.1
Khan, S.2
-
7
-
-
9344244740
-
Trastuzumab down-regulates Bcl-2 expression and potentiates apoptosis induction by Bcl-2/Bcl-XL bispecific antisense oligonucleotides in ERBB2 gene-amplified breast cancer cells
-
Milella M, Trisciuoglio D, Bruno T, et al. Trastuzumab down-regulates Bcl-2 expression and potentiates apoptosis induction by Bcl-2/Bcl-XL bispecific antisense oligonucleotides in ERBB2 gene-amplified breast cancer cells. Clin Cancer Res 2004;10:7747-56.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7747-7756
-
-
Milella, M.1
Trisciuoglio, D.2
Bruno, T.3
-
8
-
-
0032575752
-
Mitochondria and apoptosis
-
Green DR, Reed JC. Mitochondria and apoptosis. Science 1998;281: 1309-12.
-
(1998)
Science
, vol.281
, pp. 1309-1312
-
-
Green, D.R.1
Reed, J.C.2
-
9
-
-
0036716281
-
The Bcl2 family: Regulators of the cellular life-or-death switch
-
Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2002;2:647-56.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 647-656
-
-
Cory, S.1
Adams, J.M.2
-
10
-
-
0027970798
-
Immunocytochemical localization of BCL-2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy
-
Gee JM, Robertson JF, Ellis IO, et al. Immunocytochemical localization of BCL-2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy. Int J Cancer 1994;59:619-28.
-
(1994)
Int J Cancer
, vol.59
, pp. 619-628
-
-
Gee, J.M.1
Robertson, J.F.2
Ellis, I.O.3
-
11
-
-
0028115802
-
Bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer
-
Leek RD, Kaklamanis L, Pezzella F, Gatter KC, Harris AL. Bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer. Br J Cancer 1994;69:135-9.
-
(1994)
Br J Cancer
, vol.69
, pp. 135-139
-
-
Leek, R.D.1
Kaklamanis, L.2
Pezzella, F.3
Gatter, K.C.4
Harris, A.L.5
-
12
-
-
32944460800
-
Herceptin sensitizes ErbB2-overexpressing cells to apoptosis by reducing antiapoptotic Mcl-1 expression
-
Henson ES, Hu X, Gibson SB. Herceptin sensitizes ErbB2-overexpressing cells to apoptosis by reducing antiapoptotic Mcl-1 expression. Clin Cancer Res 2006;12:845-53.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 845-853
-
-
Henson, E.S.1
Hu, X.2
Gibson, S.B.3
-
13
-
-
13444309091
-
Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells
-
Trost TM, Lausch EU, Fees SA, et al. Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells. Cancer Res 2005;65:840-9.
-
(2005)
Cancer Res
, vol.65
, pp. 840-849
-
-
Trost, T.M.1
Lausch, E.U.2
Fees, S.A.3
-
14
-
-
10744230388
-
Switching off ERBB2/ neu in a tetracycline controlled mouse tumor model leads to apoptosis and tumor-size dependent remission
-
Schiffer IB, Gebhard S, Heimerdinger CK, et al. Switching off ERBB2/ neu in a tetracycline controlled mouse tumor model leads to apoptosis and tumor-size dependent remission. Cancer Res 2003;63:7221-31.
-
(2003)
Cancer Res
, vol.63
, pp. 7221-7231
-
-
Schiffer, I.B.1
Gebhard, S.2
Heimerdinger, C.K.3
-
15
-
-
0029022369
-
Transcriptional activation by tetracyclines in mammalian cells
-
Gossen M, Freundlieb S, Bender G, Müller G, Hillen W, Bujard H. Transcriptional activation by tetracyclines in mammalian cells. Science 1995;268:1766-9.
-
(1995)
Science
, vol.268
, pp. 1766-1769
-
-
Gossen, M.1
Freundlieb, S.2
Bender, G.3
Müller, G.4
Hillen, W.5
Bujard, H.6
-
16
-
-
0026720075
-
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
-
Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A 1992;89:5547-51.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 5547-5551
-
-
Gossen, M.1
Bujard, H.2
-
17
-
-
0029759113
-
Reversible tumorigenesis in mice by conditional expression of the HER2/ c-erbB2 receptor tyrosine kinase
-
Baasner S, Melchner H, Klenner T, Hilgard P, Beckers T. Reversible tumorigenesis in mice by conditional expression of the HER2/ c-erbB2 receptor tyrosine kinase. Oncogene 1996;13:901-11.
-
(1996)
Oncogene
, vol.13
, pp. 901-911
-
-
Baasner, S.1
Melchner, H.2
Klenner, T.3
Hilgard, P.4
Beckers, T.5
-
18
-
-
0035894866
-
Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord
-
Yamamoto S, Nagao M, Sugimori M, et al. Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord. J Neurosci 2001;21:9814-23.
-
(2001)
J Neurosci
, vol.21
, pp. 9814-9823
-
-
Yamamoto, S.1
Nagao, M.2
Sugimori, M.3
-
19
-
-
17144427727
-
Inhibitors of apoptosis confer resistance to tumour suppression by adoptively transplanted cytotoxic T-lymphocytes in vitro and in vivo
-
Huber C, Bobek N, Kuball J, et al. Inhibitors of apoptosis confer resistance to tumour suppression by adoptively transplanted cytotoxic T-lymphocytes in vitro and in vivo. Cell Death Differ 2005;12:317-25.
-
(2005)
Cell Death Differ
, vol.12
, pp. 317-325
-
-
Huber, C.1
Bobek, N.2
Kuball, J.3
-
20
-
-
35648973642
-
Targeting BCL-2 family proteins to overcome drug resistance in non-small cell lung cancer
-
Wesarg E, Hoffarth S, Wiewrodt R, et al. Targeting BCL-2 family proteins to overcome drug resistance in non-small cell lung cancer. Int J Cancer 2007;121:2387-94.
-
(2007)
Int J Cancer
, vol.121
, pp. 2387-2394
-
-
Wesarg, E.1
Hoffarth, S.2
Wiewrodt, R.3
-
21
-
-
43249106962
-
Trastuzumab therapy vs tetracycline controlled ERBB2 downregulation: Influence on tumour development in an ERBB2-dependent mouse tumour model
-
Hermes M, Schormann W, Brulport M, et al. Trastuzumab therapy vs tetracycline controlled ERBB2 downregulation: influence on tumour development in an ERBB2-dependent mouse tumour model. Br J Cancer 2008;98:1525-32.
-
(2008)
Br J Cancer
, vol.98
, pp. 1525-1532
-
-
Hermes, M.1
Schormann, W.2
Brulport, M.3
-
22
-
-
13844310310
-
Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
-
Wang Y, Klijn JG, Zhang Y, et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 2005;365:671-9.
-
(2005)
Lancet
, vol.365
, pp. 671-679
-
-
Wang, Y.1
Klijn, J.G.2
Zhang, Y.3
-
23
-
-
34250652449
-
Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series
-
Desmedt C, Piette F, Loi S, et al. Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series. Clin Can Res 2007;3:3207-14.
-
(2007)
Clin Can Res
, vol.3
, pp. 3207-3214
-
-
Desmedt, C.1
Piette, F.2
Loi, S.3
-
24
-
-
34247145491
-
Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade
-
Loi S, Haibe-Kains B, Desmedt C, et al. Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade. J Clin Oncol 2007;25:1239-46.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1239-1246
-
-
Loi, S.1
Haibe-Kains, B.2
Desmedt, C.3
-
25
-
-
33645730359
-
ERBB2-mediated transcriptional up-regulation of the α5β1 integrin fibronectin receptor promotes tumor cell survival under adverse conditions
-
Spangenberg C, Lausch EU, Trost TM, et al. ERBB2-mediated transcriptional up-regulation of the α5β1 integrin fibronectin receptor promotes tumor cell survival under adverse conditions. Cancer Res 2006;66:3715-25.
-
(2006)
Cancer Res
, vol.66
, pp. 3715-3725
-
-
Spangenberg, C.1
Lausch, E.U.2
Trost, T.M.3
-
26
-
-
62149144092
-
Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells
-
Rizzi F, Caccamo AE, Belloni L, Bettuzzi S. Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells. J Cell Physiol 2009;219:314-23.
-
(2009)
J Cell Physiol
, vol.219
, pp. 314-323
-
-
Rizzi, F.1
Caccamo, A.E.2
Belloni, L.3
Bettuzzi, S.4
-
27
-
-
38949153810
-
A phase I study of OGX-011, a 2′-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer
-
Chi KN, Siu LL, Hirte H, et al. A phase I study of OGX-011, a 2′-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer. Clin Cancer Res 2008;14:833-9.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 833-839
-
-
Chi, K.N.1
Siu, L.L.2
Hirte, H.3
-
28
-
-
54049152777
-
Clusterin: A potential target for improving response to antiestrogens
-
Toffanin S, Daidone MG, Miodini P, et al. Clusterin: a potential target for improving response to antiestrogens. Int J Oncol 2008;33:791-8.
-
(2008)
Int J Oncol
, vol.33
, pp. 791-798
-
-
Toffanin, S.1
Daidone, M.G.2
Miodini, P.3
-
29
-
-
33947111881
-
Clusterin over-expression modulates proapoptotic and antiproliferative effects of 1,25(OH)2D3 in prostate cancer cells in vitro
-
Shannan B, Seifert M, Boothman DA, Tilgen W, Reichrath J. Clusterin over-expression modulates proapoptotic and antiproliferative effects of 1,25(OH)2D3 in prostate cancer cells in vitro. J Steroid Biochem Mol Biol 2007;103:721-5.
-
(2007)
J Steroid Biochem Mol Biol
, vol.103
, pp. 721-725
-
-
Shannan, B.1
Seifert, M.2
Boothman, D.A.3
Tilgen, W.4
Reichrath, J.5
-
30
-
-
34547635804
-
Expression of cancer-testis antigen CT7 (MAGE-C1) in breast cancer: An immunohistochemical study with emphasis on prognostic utility
-
Krüger S, Ola V, Feller AC, Fischer D, Friedrich M. Expression of cancer-testis antigen CT7 (MAGE-C1) in breast cancer: an immunohistochemical study with emphasis on prognostic utility. Pathol Oncol Res 2007;13:91-6.
-
(2007)
Pathol Oncol Res
, vol.13
, pp. 91-96
-
-
Krüger, S.1
Ola, V.2
Feller, A.C.3
Fischer, D.4
Friedrich, M.5
-
31
-
-
33846069673
-
Clusterin expression and univariate analysis of overall survival in human breast cancer
-
Zhang S, Zhang D, Zhu Y, Guo H, Zhao X, Sun B. Clusterin expression and univariate analysis of overall survival in human breast cancer. Technol Cancer Res Treat 2006;5:573-8.
-
(2006)
Technol Cancer Res Treat
, vol.5
, pp. 573-578
-
-
Zhang, S.1
Zhang, D.2
Zhu, Y.3
Guo, H.4
Zhao, X.5
Sun, B.6
-
33
-
-
0035884701
-
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
-
Sowter HM, Ratcliffe PJ, Watson P, Greenberg AH, Harris AL. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res 2001;61:6669-73.
-
(2001)
Cancer Res
, vol.61
, pp. 6669-6673
-
-
Sowter, H.M.1
Ratcliffe, P.J.2
Watson, P.3
Greenberg, A.H.4
Harris, A.L.5
-
34
-
-
0028775458
-
Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins
-
Boyd JM, Malstrom S, Subramanian T, et al. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. Cell 1994;79:341-51.
-
(1994)
Cell
, vol.79
, pp. 341-351
-
-
Boyd, J.M.1
Malstrom, S.2
Subramanian, T.3
-
35
-
-
33846882638
-
BNIP3 as a progression marker in primary human breast cancer; opposing functions in in situ versus invasive cancer
-
Tan EY, Campo L, Han C, et al. BNIP3 as a progression marker in primary human breast cancer; opposing functions in in situ versus invasive cancer. Clin Cancer Res 2007;13:467-74.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 467-474
-
-
Tan, E.Y.1
Campo, L.2
Han, C.3
-
36
-
-
30444446961
-
The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia
-
Holleman A, den Boer ML, de Menezes RX, et al. The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia. Blood 2006;107:769-76.
-
(2006)
Blood
, vol.107
, pp. 769-776
-
-
Holleman, A.1
den Boer, M.L.2
de Menezes, R.X.3
-
37
-
-
30044442094
-
Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage
-
Perier C, Tieu K, Guegan C, et al. Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage. Proc Natl Acad Sci U S A 2005;102:19126-31.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 19126-19131
-
-
Perier, C.1
Tieu, K.2
Guegan, C.3
-
38
-
-
0035823238
-
-
Puthalakath H, Villunger A, O'Reilly LA, et al. Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science 2001;293: 1829-32.
-
Puthalakath H, Villunger A, O'Reilly LA, et al. Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science 2001;293: 1829-32.
-
-
-
-
39
-
-
0027282044
-
Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
-
Boise LH, Gonzalez-Garcia M, Postema CE, et al. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993;74:597-608.
-
(1993)
Cell
, vol.74
, pp. 597-608
-
-
Boise, L.H.1
Gonzalez-Garcia, M.2
Postema, C.E.3
-
40
-
-
0032566649
-
Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis
-
Marzo I, Brenner C, Zamzami N, et al. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 1998;281:2027-31.
-
(1998)
Science
, vol.281
, pp. 2027-2031
-
-
Marzo, I.1
Brenner, C.2
Zamzami, N.3
-
41
-
-
0042701989
-
BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis
-
Qin W, Hu J, Guo M, et al. BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. Biochem Biophys Res Commun 2003;308:379-85.
-
(2003)
Biochem Biophys Res Commun
, vol.308
, pp. 379-385
-
-
Qin, W.1
Hu, J.2
Guo, M.3
-
42
-
-
42049114828
-
The Bax Inhibitor-1 (BI-1) family in apoptosis and tumorigenesis
-
Reimers K, Choi CY, Bucan V, Vogt PM. The Bax Inhibitor-1 (BI-1) family in apoptosis and tumorigenesis. Curr Mol Med 2008;8:148-56.
-
(2008)
Curr Mol Med
, vol.8
, pp. 148-156
-
-
Reimers, K.1
Choi, C.Y.2
Bucan, V.3
Vogt, P.M.4
-
43
-
-
27744441148
-
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells
-
Götz R, Wiese S, Takayama S, et al. Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat Neurosci 2005;8:1169-78.
-
(2005)
Nat Neurosci
, vol.8
, pp. 1169-1178
-
-
Götz, R.1
Wiese, S.2
Takayama, S.3
-
44
-
-
0028847915
-
Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity
-
Takayama S, Sato T, Krajewski S, et al. Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell 1995;80:279-84.
-
(1995)
Cell
, vol.80
, pp. 279-284
-
-
Takayama, S.1
Sato, T.2
Krajewski, S.3
|