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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 23, 2011, Pages 7001-7005

Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity

(12) Mihalic, Jeffrey T a Chen, Xiaoqi a Fan, Pingchen a Chen, Xi a Fu, Ying a Liang, Lingming a Reed, Michael a Tang, Liang a Chen, Jin Long a Jaen, Juan a Li, Leping a Dai, Kang a

a AMGEN INC (United States)

Author keywords

MCHR1; Melanin concentrating hormone

Indexed keywords

INDOLE; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; DOG; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FOOD INTAKE; HUMAN; NONHUMAN; OBESITY; RAT; RHESUS MONKEY;

ANIMALS; ANTI-OBESITY AGENTS; DOGS; DRUG DISCOVERY; EATING; HEK293 CELLS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MACACA MULATTA; MOLECULAR STRUCTURE; RATS; RECEPTORS, PITUITARY HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

MACACA FASCICULARIS; RATTUS;

EID: 80255122795 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.09.110 Document Type: Article

Times cited : (20)

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