Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 11, 2012, Pages 3551-3564

  Baruah, Pranjal K ^a   Dinsmore, Jason ^a   King, Amber M ^a   Salomé, Christophe ^a   De Ryck, Marc ^b   Kaminski, Rafal ^b   Provins, Laurent ^b   Kohn, Harold ^a,c  

^a UNC Hamner Institute for Drug Safety Sciences   (United States)

^b UCB PHARMA   (Belgium)

^c The University of North Carolina at Chapel Hill   (United States)

Author keywords

Anticonvulsant activity; Aromatic; Heteroaromatic; Neuropathic pain; Pain attenuating activities; Primary amino acid derivatives

Indexed keywords

AMINO ACID DERIVATIVE; ANALGESIC AGENT; ANTICONVULSIVE AGENT; N BENZYL 2 AMINO 2 (5 METHYLFURAN 2 YL)ACETAMIDE; N BENZYL 2 AMINO 2 (BENZO[B]THIOPHEN 2 YL)ACETAMIDE; N BENZYL 2 AMINO 2 (BENZOFURAN 2 YL)ACETAMIDE; N BENZYL 2 AMINO 2 (FURAN 2 YL)ACETAMIDE; N BENZYL 2 AMINO 2 (FURAN 2 YL)ACETAMIDE 2 AMMONIUM CHLORIDE; N BENZYL 2 AMINO 2 (ISOQUINOLIN 1 YL)ACETAMIDE; N BENZYL 2 AMINO 2 (NAPHTHALEN 1 YL)ACETAMIDE; N BENZYL 2 AMINO 2 (PYRAZIN 2 YL)ACETAMIDE; N BENZYL 2 AMINO 2 (PYRIDIN 2 YL)ACETAMIDE; N BENZYL 2 AMINO 2 (PYRIDIN 3 YL)ACETAMIDE OXALATE; N BENZYL 2 AMINO 2 (PYRIDIN 4 YL)ACETAMIDE OXALATE; N BENZYL 2 AMINO 2 (QUINOLIN 2 YL)ACETAMIDE; N BENZYL 2 AMINO 2 (QUINOLIN 2 YL)ACETAMIDE MALEATE SALT; N BENZYL 2 AMINO 2 (QUINOXALIN 2 YL)ACETAMIDE; N BENZYL 2 AMINO 2 (QUINOXALIN 2 YL)ACETAMIDE OXALATE SALT; N BENZYL 2 AMINO 2 (THIAZOL 2 YL)ACETAMIDE; N BENZYL 2 AMINO 2 (THIOPHEN 2 YL)ACETAMIDE; N BENZYL 2 AMINO 2 AROMATIC ACETAMIDE DERIVATIVE; N BENZYL 2 AMINO 2 HETEROAROMATIC ACETAMIDE DERIVATIVE; N BENZYL 2 AMINO 2 PHENYLACETAMIDE; PHENOBARBITAL; PHENYTOIN; UNCLASSIFIED DRUG; VALPROIC ACID;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CONVULSION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MOUSE; NEUROPATHIC PAIN; NONHUMAN; PROTEIN STRUCTURE; SEIZURE; SINGLE DRUG DOSE; TREMOR;

ACETAMIDES; AMINO ACIDS; ANIMALS; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; MALE; MICE; MICE, INBRED STRAINS; MOLECULAR STRUCTURE; NEURALGIA; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 84861187455     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.04.002     Document Type: Article

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