Defining the structural parameters that confer anticonvulsant activity by the site-by-site modification of (R)-N′-benzyl 2-amino-3-methylbutanamide

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6432-6442

  King, Amber M ^a   De Ryck, Marc ^b   Kaminski, Rafal ^b   Valade, Anne ^b   Stables, James P ^c   Kohn, Harold ^a,d  

^a University of North Carolina   (United States)

^b UCB PHARMA   (Belgium)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^d University of North Carolina at Chapel Hill   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBON; HYDROCARBON; N BENZYL 2 HYDROXYBUTANAMIDE; N BENZYL 2 METHYLBUTANAMIDE; N BENZYL BUTANAMIDE; N' BENZYL 2 AMINO 3 METHYLBUTANAMIDE; N' BENZYL N (METHYL)AMINO 2 METHYLBUTANAMIDE HYDROCHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; ATOM; DRUG EFFICACY; DRUG SYNTHESIS; ELECTRON; MALE; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

AMINOBUTYRIC ACIDS; ANIMALS; ANTICONVULSANTS; MALE; MICE; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80053906575     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200760a     Document Type: Article

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