Long chain omega-3 fatty acids and cardiovascular disease: A systematic review

British Journal of Nutrition

Volumn 107, Issue SUPPL. 2, 2012, Pages

  Delgado Lista, Javier ^a,b   Perez Martinez, Pablo ^a,b   Lopez Miranda, Jose ^a,b   Perez Jimenez, Francisco ^a,b  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

Author keywords

Cardiovascular disease; N3; Omega 3

Indexed keywords

ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID PLUS DIPYRIDAMOLE; ALDOSTERONE ANTAGONIST; AMIODARONE; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTICOAGULANT AGENT; ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CLOPIDOGREL; DIGITALIS; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; FUROSEMIDE; GAMMA LINOLENIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; NITRATE; OMEGA 3 FATTY ACID; ORAL ANTIDIABETIC AGENT; PLACEBO; SOTALOL; WARFARIN;

ACUTE HEART INFARCTION; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CORONARY ARTERY DISEASE; DEFIBRILLATOR; DIET SUPPLEMENTATION; DIET THERAPY; DIETARY INTAKE; DRUG CAPSULE; DRUG SAFETY; FAT INTAKE; FATALITY; GASTROINTESTINAL SYMPTOM; GRAFT OCCLUSION; HEART DEATH; HEART FAILURE; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HIGH RISK POPULATION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; LEG DISEASE; MORTALITY; NAUSEA; NONHUMAN; NUTRITIONAL COUNSELING; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESTENOSIS; REVIEW; RISK REDUCTION; SUDDEN DEATH; SYSTEMATIC REVIEW;

CARDIOVASCULAR AGENTS; CARDIOVASCULAR DISEASES; CORONARY DISEASE; DIET; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; HUMANS;

EID: 84861175237     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114512001596     Document Type: Review

References (73)

1. Kris-Etherton PM, Harris WS & Appel LJ (2002) Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106, 2747-2757. (Pubitemid 35364932)
2. Lichtenstein AH, Appel LJ, Brands M, et al. (2006) Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 114, 82-96. (Pubitemid 44305278)
3. Lavie CJ, Milani RV, Mehra MR, et al. (2009) Omega-3 polyunsaturated fatty acids and cardiovascular diseases. J Am Coll Cardiol 54, 585-594.
4. Mente A, de Koning L, Shannon HS, et al. (2009) A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch Intern Med 169, 659-669.
5. Riediger ND, Othman RA, Suh M, et al. (2009) A systemic review of the roles of n-3 fatty acids in health and disease. J Am Diet Assoc 109, 668-679.
6. Filion KB, El Khoury F, Bielinski M, et al. (2010) Omega-3 fatty acids in high-risk cardiovascular patients: a metaanalysis of randomized controlled trials. BMC Cardiovasc Disord 10, 24.
7. Jadad AR, Moore RA, Carroll D, et al. (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17, 1-12. (Pubitemid 26120810)
8. Dehmer GJ, Popma JJ, van den Berg EK, et al. (1988) Reduction in the rate of early restenosis after coronary angioplasty by a diet supplemented with n-3 fatty acids. N Engl J Med 319, 733-740.
9. Nye ER, Ablett MB, Robertson MC, et al. (1990) Effect of eicosapentaenoic acid on restenosis rate, clinical course and blood lipids in patients after percutaneous transluminal coronary angioplasty. Aust N Z J Med 20, 549-552.
10. Bairati I, Roy L & Meyer F (1992) Double-blind, randomized, controlled trial of fish oil supplements in prevention of recurrence of stenosis after coronary angioplasty. Circulation 85, 950-956.
11. Leaf A, Jorgensen MB, Jacobs AK, et al. (1994) Do fish oils prevent restenosis after coronary angioplasty? Circulation 90, 2248-2257. (Pubitemid 24354309)
12. Sacks FM, Stone PH, Gibson CM, et al. (1995) Controlled trial of fish oil for regression of human coronary atherosclerosis. HARP Research Group. J Am Coll Cardiol 25, 1492-1498.
13. Eritsland J, Arnesen H, Gronseth K, et al. (1996) Effect of dietary supplementation with n-3 fatty acids on coronary artery bypass graft patency. Am J Cardiol 77, 31-36. (Pubitemid 26018387)
14. Leng GC, Lee AJ, Fowkes FG, et al. (1998) Randomized controlled trial of gamma-linolenic acid and eicosapentaenoic acid in peripheral arterial disease. Clin Nutr 17, 265-271. (Pubitemid 29121708)
15. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. (1999) Lancet 354, 447-455.
16. Johansen O, Brekke M, Seljeflot I, et al. (1999) N-3 fatty acids do not prevent restenosis after coronary angioplasty: results from the CART study. Coronary Angioplasty Restenosis Trial. J Am Coll Cardiol 33, 1619-1626.
17. von Schacky C, Angerer P, Kothny W, et al. (1999) The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 130, 554-562. (Pubitemid 29169382)
18. Nilsen DW, Albrektsen G, Landmark K, et al. (2001) Effects of a high-dose concentrate of n-3 fatty acids or corn oil introduced early after an acute myocardial infarction on serum triacylglycerol and HDL cholesterol. Am J Clin Nutr 74, 50-56. (Pubitemid 32577089)
19. Burr ML, Ashfield-Watt PA, Dunstan FD, et al. (2003) Lack of benefit of dietary advice to men with angina: results of a controlled trial. Eur J Clin Nutr 57, 193-200. (Pubitemid 36240469)
20. Leaf A, Albert CM, Josephson M, et al. (2005) Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake. Circulation 112, 2762-2768. (Pubitemid 41641669)
21. Raitt MH, Connor WE, Morris C, et al. (2005) Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators: a randomized controlled trial. JAMA 293, 2884-2891. (Pubitemid 41029142)
22. Brouwer IA, Zock PL, Camm AJ, et al. (2006) Effect of fish oil on ventricular tachyarrhythmia and death in patients with implantable cardioverter defibrillators: the Study on Omega-3 Fatty Acids and Ventricular Arrhythmia (SOFA) randomized trial. JAMA 295, 2613-2619. (Pubitemid 43882336)
23. Yokoyama M, Origasa H, Matsuzaki M, et al. (2007) Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 369, 1090-1098. (Pubitemid 46483662)
24. Gissi HFI, Tavazzi L, Maggioni AP, et al. (2008) Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet 372, 1223-1230.
25. Einvik G, Klemsdal TO, Sandvik L, et al. (2010) A randomized clinical trial on n-3 polyunsaturated fatty acids supplementation and all-cause mortality in elderly men at high cardiovascular risk. Eur J Cardiovasc Prev Rehabil 17, 588-592.
26. Galan P, Kesse-Guyot E, Czernichow S, et al. (2010) Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial. BMJ 341, c6273.
27. Rauch B, Schiele R, Schneider S, et al. (2010) OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guidelineadjusted therapy after myocardial infarction. Circulation 122, 2152-2159.
28. Nodari S, Triggiani M, Campia U, et al. (2011) Effects of n-3 polyunsaturated fatty acids on left ventricular function and functional capacity in patients with dilated cardiomyopathy. J Am Coll Cardiol 57, 870-879.
29. Kromhout D, Giltay EJ, Geleijnse JM, et al. (2010) n-3 fatty acids and cardiovascular events after myocardial infarction. N Engl J Med 363, 2015-2026.
30. von Schacky C & Harris WS (2007) Cardiovascular benefits of omega-3 fatty acids. Cardiovasc Res 73, 310-315. (Pubitemid 44937689)
31. Mozaffarian D (2008) Fish and n-3 fatty acids for the prevention of fatal coronary heart disease and sudden cardiac death. Am J Clin Nutr 87, 1991S-1996S. (Pubitemid 351872680)
32. Marik PE & Varon J (2009) Omega-3 dietary supplements and the risk of cardiovascular events: a systematic review. Clin Cardiol 32, 365-372.
33. Saravanan P, Davidson NC, Schmidt EB, et al. (2010) Cardiovascular effects of marine omega-3 fatty acids. Lancet 376, 540-550.
34. Singh RB, Niaz MA, Sharma JP, et al. (1997) Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival-4. Cardiovasc Drugs Ther 11, 485-491. (Pubitemid 27367714)
35. Horton R (2005) Expression of concern: Indo-Mediterranean Diet Heart Study. Lancet 366, 354-356. (Pubitemid 41073948)
36. White C (2005) Suspected research fraud: difficulties of getting at the truth. BMJ 331, 281-288. (Pubitemid 41097914)
37. Iso H, Kobayashi M, Ishihara J, et al. (2006) Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese: the Japan Public Health Center-Based (JPHC) Study Cohort I. Circulation 113, 195-202.
38. Watanabe N, Watanabe Y, Kumagai M, et al. (2009) Administration of dietary fish oil capsules in healthy middle-aged Japanese men with a high level of fish consumption. Int J Food Sci Nutr 60, Suppl. 5, 136-142.
39. Origasa H, Yokoyama M, Matsuzaki M, et al. (2010) Clinical importance of adherence to treatment with eicosapentaenoic acid by patients with hypercholesterolemia. Circ J 74, 510-517.
40. Mozaffarian D (2007) Fish, n-3 fatty acids, and cardiovascular haemodynamics. J Cardiovasc Med (Hagerstown) 8, Suppl. 1, S23-S26. (Pubitemid 47429077)
41. Perez-Martinez P, Delgado-Lista J, Perez-Jimenez F, et al. (2010) Update on genetics of postprandial lipemia. Atheroscler Suppl 11, 39-43.
42. Teslovich TM, Musunuru K, Smith AV, et al. (2010) Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707-713.
43. Pishva H, Mahboob SA, Mehdipour P, et al. (2010) Fatty acidbinding protein-2 genotype influences lipid and lipoprotein response to eicosapentaenoic acid supplementation in hypertriglyceridemic subjects. Nutrition 26, 1117-1121.
44. Olano-Martin E, Anil E, Caslake MJ, et al. (2010) Contribution of apolipoprotein E genotype and docosahexaenoic acid to the LDL-cholesterol response to fish oil. Atherosclerosis 209, 104-110.
45. Caslake MJ, Miles EA, Kofler BM, et al. (2008) Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study. Am J Clin Nutr 88, 618-629.
46. Mozaffarian D & Rimm EB (2006) Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA 296, 1885-1899. (Pubitemid 44596197)
47. Thies F, Garry JM, Yaqoob P, et al. (2003) Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial. Lancet 361, 477-485. (Pubitemid 36173713)
48. Harris WS, Miller M, Tighe AP, et al. (2008) Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 197, 12-24.
49. Serhan CN, Chiang N & Van Dyke TE (2008) Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 8, 349-361. (Pubitemid 351595216)
50. Morris MC, Sacks F & Rosner B (1993) Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation 88, 523-533. (Pubitemid 23228051)
51. Yamagishi K, Nettleton JA & Folsom AR (2008) Plasma fatty acid composition and incident heart failure in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J 156, 965-974.
52. Mozaffarian D, Psaty BM, Rimm EB, et al. (2004) Fish intake and risk of incident atrial fibrillation. Circulation 110, 368-373. (Pubitemid 38993844)
53. Gillet L, Roger S, Bougnoux P, et al. (2011) Beneficial effects of omega-3 long-chain fatty acids in breast cancer and cardiovascular diseases: voltage-gated sodium channels as a common feature? Biochimie 93, 4-6.
54. Saravanan P, Bridgewater B, West AL, et al. (2010) Omega-3 fatty acid supplementation does not reduce risk of atrial fibrillation after coronary artery bypass surgery: a randomized, double-blind, placebo-controlled clinical trial. Circ Arrhythm Electrophysiol 3, 46-53.
55. Brouwer IA, Raitt MH, Dullemeijer C, et al. (2009) Effect of fish oil on ventricular tachyarrhythmia in three studies in patients with implantable cardioverter defibrillators. Eur Heart J 30, 820-826.
56. Verkerk AO, van Ginneken AC, Berecki G, et al. (2006) Incorporated sarcolemmal fish oil fatty acids shorten pig ventricular action potentials. Cardiovasc Res 70, 509-520. (Pubitemid 44255555)
57. Coronel R, Wilms-Schopman FJ, Den Ruijter HM, et al. (2007) Dietary n-3 fatty acids promote arrhythmias during acute regional myocardial ischemia in isolated pig hearts. Cardiovasc Res 73, 386-394. (Pubitemid 44963519)
58. Wang C, Harris WS, Chung M, et al. (2006) n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primaryand secondary-prevention studies: a systematic review. Am J Clin Nutr 84, 5-17. (Pubitemid 44699166)
59. Chalupka S (2009) Omega-3 polyunsaturated fatty acid in primary and secondary cardiovascular disease prevention. AAOHN J 57, 480.
60. Knapp HR, Reilly IA, Alessandrini P, et al. (1986) In vivo indexes of platelet and vascular function during fish-oil administration in patients with atherosclerosis. N Engl J Med 314, 937-942. (Pubitemid 16129827)
61. Kristensen SD, Iversen AM & Schmidt EB (2001) n-3 polyunsaturated fatty acids and coronary thrombosis. Lipids 36, S79-S82. (Pubitemid 34106213)
62. Eritsland J, Arnesen H, Seljeflot I, et al. (1995) Long-term effects of n-3 polyunsaturated fatty acids on haemostatic variables and bleeding episodes in patients with coronary artery disease. Blood Coagul Fibrinolysis 6, 17-22.
63. - + clopidogrel in patients with cardiovascular disease. Am J Cardiol 104, 1052-1054.
64. Park K & Mozaffarian D (2010) Omega-3 fatty acids, mercury, and selenium in fish and the risk of cardiovascular diseases. Curr Atheroscler Rep 12, 414-422.
65. Fremont L, Gozzelino MT, Franchi MP, et al. (1998) Dietary flavonoids reduce lipid peroxidation in rats fed polyunsaturated or monounsaturated fat diets. J Nutr 128, 1495-1502. (Pubitemid 28399947)
66. Hau MF, Smelt AH, Bindels AJ, et al. (1996) Effects of fish oil on oxidation resistance of VLDL in hypertriglyceridemic patients. Arterioscler Thromb Vasc Biol 16, 1197-1202. (Pubitemid 26299294)
67. Sorensen NS, Marckmann P, Hoy CE, et al. (1998) Effect of fish-oil-enriched margarine on plasma lipids, low-densitylipoprotein particle composition, size, and susceptibility to oxidation. Am J Clin Nutr 68, 235-241. (Pubitemid 28355638)
68. Bonanome A, Biasia F, De Luca M, et al. (1996) n-3 fatty acids do not enhance LDL susceptibility to oxidation in hypertriacylglycerolemic hemodialyzed subjects. Am J Clin Nutr 63, 261-266.
69. Brude IR, Drevon CA, Hjermann I, et al. (1997) Peroxidation of LDL from combined-hyperlipidemic male smokers supplied with omega-3 fatty acids and antioxidants. Arterioscler Thromb Vasc Biol 17, 2576-2588. (Pubitemid 28015996)
70. Higdon JV, Du SH, Lee YS, et al. (2001) Supplementation of postmenopausal women with fish oil does not increase overall oxidation of LDL ex vivo compared to dietary oils rich in oleate and linoleate. J Lipid Res 42, 407-418. (Pubitemid 32270065)
71. Petersson H, Riserus U, McMonagle J, et al. (2010) Effects of dietary fat modification on oxidative stress and inflammatory markers in the LIPGENE study. Br J Nutr 104, 1357-1362.
72. Leaf A, Kang JX, Xiao YF, et al. (2003) Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils. Circulation 107, 2646-2652. (Pubitemid 36667234)
73. Leng GC, Taylor GS, Lee AJ, et al. (1999) Essential fatty acids and cardiovascular disease: the Edinburgh Artery Study. Vasc Med 4, 219-226. (Pubitemid 30010572)