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Volumn 13, Issue 7, 2012, Pages 458-466

Sensitization of (colon) cancer cells to death receptor related therapies: A report from the FP6-ONCODEATH research consortium

Author keywords

Cancer; Death receptors; Kinase inhibitors; Mitochondria; Oncogenes; Rational combinations; Targeted therapies

Indexed keywords

AURORA KINASE INHIBITOR; B RAF KINASE; CHOLINE KINASE; DEATH RECEPTOR; DNA METHYLTRANSFERASE INHIBITOR; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

EID: 84861121305     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.19600     Document Type: Review
Times cited : (4)

References (60)
  • 1
    • 24044438464 scopus 로고    scopus 로고
    • Apoptotic pathways and therapy resistance in human malignancies
    • PMID:16096001
    • Viktorsson K, Lewensohn R, Zhivotovsky B. Apoptotic pathways and therapy resistance in human malignancies. Adv Cancer Res 2005; 94:143-96; PMID:16096001; http://dx.doi.org/10.1016/S0065-230X(05)94004-9.
    • (2005) Adv Cancer Res , vol.94 , pp. 143-196
    • Viktorsson, K.1    Lewensohn, R.2    Zhivotovsky, B.3
  • 3
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • PMID:12068308
    • Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, et al. Mutations of the BRAF gene in human cancer. Nature 2002; 417:949-54; PMID:12068308; http://dx.doi.org/10.1038/nature00766.
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3    Stephens, P.4    Edkins, S.5    Clegg, S.6
  • 4
    • 77954235111 scopus 로고    scopus 로고
    • Targeting the mitogen-activated protein kinase pathway: Physiological feedback and drug response
    • PMID:20472680
    • Pratilas CA, Solit DB. Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response. Clin Cancer Res 2010; 16:3329-34; PMID:20472680; http://dx.doi.org/10.1158/1078-0432.CCR-09-3064.
    • (2010) Clin Cancer Res , vol.16 , pp. 3329-3334
    • Pratilas, C.A.1    Solit, D.B.2
  • 5
    • 77950243447 scopus 로고    scopus 로고
    • Drugging the PI3 kinome: From chemical tools to drugs in the clinic
    • PMID:20179189
    • Workman P, Clarke PA, Raynaud FI, van Montfort RL. Drugging the PI3 kinome: from chemical tools to drugs in the clinic. Cancer Res 2010; 70:2146-57; PMID:20179189; http://dx.doi.org/10.1158/0008-5472.CAN-09-4355.
    • (2010) Cancer Res , vol.70 , pp. 2146-2157
    • Workman, P.1    Clarke, P.A.2    Raynaud, F.I.3    Van Montfort, R.L.4
  • 6
    • 84855457952 scopus 로고    scopus 로고
    • Hsp90 molecular chaperone inhibitors: Are we there yet?
    • PMID:22215907
    • Neckers L, Workman P. Hsp90 molecular chaperone inhibitors: are we there yet? Clin Cancer Res 2012; 18:64-76; PMID:22215907; http://dx.doi. org/10.1158/1078-0432.CCR-11-1000.
    • (2012) Clin Cancer Res , vol.18 , pp. 64-76
    • Neckers, L.1    Workman, P.2
  • 7
    • 67650064783 scopus 로고    scopus 로고
    • A critical role for choline kinasealpha in the aggressiveness of bladder carcinomas
    • PMID:19448670
    • Hernando E, Sarmentero-Estrada J, Koppie T, Belda- Iniesta C, Ramírez de Molina V, Cejas P, et al. A critical role for choline kinasealpha in the aggressiveness of bladder carcinomas. Oncogene 2009; 28:2425- 35; PMID:19448670; http://dx.doi.org/10.1038/ onc.2009.91.
    • (2009) Oncogene , vol.28 , pp. 2425-2435
    • Hernando, E.1    Sarmentero-Estrada, J.2    Koppie, T.3    Belda-Iniesta, C.4    Ramírez De Molina, V.5    Cejas, P.6
  • 9
    • 77953164298 scopus 로고    scopus 로고
    • Aurora-a is essential for the tumorigenic capacity and chemoresistance of colorectal cancer stem cells
    • PMID:20460511
    • Cammareri P, Scopelliti A, Todaro M, Eterno V, Francescangeli F, Moyer MP, et al. Aurora-a is essential for the tumorigenic capacity and chemoresistance of colorectal cancer stem cells. Cancer Res 2010; 70:4655-65; PMID:20460511; http://dx.doi. org/10.1158/0008-5472.CAN-09-3953.
    • (2010) Cancer Res , vol.70 , pp. 4655-4665
    • Cammareri, P.1    Scopelliti, A.2    Todaro, M.3    Eterno, V.4    Francescangeli, F.5    Moyer, M.P.6
  • 10
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • PMID:9721089
    • Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998; 281:1305-8; PMID:9721089; http://dx.doi.org/10.1126/science. 281.5381.1305.
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 11
    • 38149122326 scopus 로고    scopus 로고
    • TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development
    • PMID:18079967
    • Grosse-Wilde A, Voloshanenko O, Bailey SL, Longton GM, Schaefer U, Csernok AI, et al. TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development. J Clin Invest 2008; 118:100-10; PMID:18079967; http://dx.doi. org/10.1172/JCI33061.
    • (2008) J Clin Invest , vol.118 , pp. 100-110
    • Grosse-Wilde, A.1    Voloshanenko, O.2    Bailey, S.L.3    Longton, G.M.4    Schaefer, U.5    Csernok, A.I.6
  • 12
    • 0032929520 scopus 로고    scopus 로고
    • Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
    • PMID:9930862
    • Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M, et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 1999; 5:157-63; PMID:9930862; http://dx.doi. org/10.1038/5517.
    • (1999) Nat Med , vol.5 , pp. 157-163
    • Walczak, H.1    Miller, R.E.2    Ariail, K.3    Gliniak, B.4    Griffith, T.S.5    Kubin, M.6
  • 13
    • 54249107246 scopus 로고    scopus 로고
    • The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway
    • PMID:18931688
    • Wang S. The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway. Oncogene 2008; 27:6207- 15; PMID:18931688; http://dx.doi.org/10.1038/ onc.2008.298.
    • (2008) Oncogene , vol.27 , pp. 6207-6215
    • Wang, S.1
  • 14
    • 63449085543 scopus 로고    scopus 로고
    • Enhancement of lexatumumabinduced apoptosis in human solid cancer cells by Cisplatin in caspase-dependent manner
    • PMID:19276256
    • Wu XX, Kakehi Y. Enhancement of lexatumumabinduced apoptosis in human solid cancer cells by Cisplatin in caspase-dependent manner. Clin Cancer Res 2009; 15:2039-47; PMID:19276256; http:// dx.doi.org/10.1158/1078-0432.CCR-08- 2667.
    • (2009) Clin Cancer Res , vol.15 , pp. 2039-2047
    • Wu, X.X.1    Kakehi, Y.2
  • 15
    • 34250645768 scopus 로고    scopus 로고
    • Bortezomib sensitizes primary human astrocytoma cells of WHO grades I to IV for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis
    • PMID:17545549
    • Koschny R, Holland H, Sykora J, Haas TL, Sprick MR, Ganten TM, et al. Bortezomib sensitizes primary human astrocytoma cells of WHO grades I to IV for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Clin Cancer Res 2007; 13:3403-12; PMID:17545549; http://dx.doi. org/10.1158/1078- 0432.CCR-07-0251.
    • (2007) Clin Cancer Res , vol.13 , pp. 3403-3412
    • Koschny, R.1    Holland, H.2    Sykora, J.3    Haas, T.L.4    Sprick, M.R.5    Ganten, T.M.6
  • 16
    • 34347347232 scopus 로고    scopus 로고
    • Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivo
    • PMID:17551494
    • Oikonomou E, Kothonidis K, Taoufik E, Probert E, Zografos G, Nasioulas G, et al. Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivo. Br J Cancer 2007; 97:73-84; PMID:17551494; http://dx.doi.org/10.1038/sj.bjc.6603835.
    • (2007) Br J Cancer , vol.97 , pp. 73-84
    • Oikonomou, E.1    Kothonidis, K.2    Taoufik, E.3    Probert, E.4    Zografos, G.5    Nasioulas, G.6
  • 17
    • 34248371111 scopus 로고    scopus 로고
    • Multifaceted targeting in cancer: The recent cell death players meet the usual oncogene suspects
    • PMID:17465723
    • Drosopoulos K, Pintzas A. Multifaceted targeting in cancer: the recent cell death players meet the usual oncogene suspects. Expert Opin Ther Targets 2007; 11:641-59; PMID:17465723; http://dx.doi. org/10.1517/14728222.11.5.641.
    • (2007) Expert Opin Ther Targets , vol.11 , pp. 641-659
    • Drosopoulos, K.1    Pintzas, A.2
  • 18
    • 60249086345 scopus 로고    scopus 로고
    • Mitochondrial dynamics and cancer
    • PMID:19138741
    • Grandemange S, Herzig S, Martinou JC. Mitochondrial dynamics and cancer. Semin Cancer Biol 2009; 19:50- 6; PMID:19138741; http://dx.doi.org/10.1016/j. sem-cancer. 2008.12.001.
    • (2009) Semin Cancer Biol , vol.19 , pp. 50-56
    • Grandemange, S.1    Herzig, S.2    Martinou, J.C.3
  • 19
    • 79952336885 scopus 로고    scopus 로고
    • Combined modality therapy with TRAIL or agonistic death receptor antibodies
    • PMID:21263219
    • Amm HM, Oliver PG, Lee CH, Li Y, Buchsbaum DJ. Combined modality therapy with TRAIL or agonistic death receptor antibodies. Cancer Biol Ther 2011; 11:431-49; PMID:21263219; http://dx.doi. org/10.4161/cbt.11.5.14671.
    • (2011) Cancer Biol Ther , vol.11 , pp. 431-449
    • Amm, H.M.1    Oliver, P.G.2    Lee, C.H.3    Li, Y.4    Buchsbaum, D.J.5
  • 20
    • 2342495721 scopus 로고    scopus 로고
    • Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway
    • PMID:15144957
    • Wang Y, Engels IH, Knee DA, Nasoff M, Deveraux QL, Quon KC. Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway. Cancer Cell 2004; 5:501-12; PMID:15144957; http://dx.doi. org/10.1016/S1535-6108(04) 00113-8.
    • (2004) Cancer Cell , vol.5 , pp. 501-512
    • Wang, Y.1    Engels, I.H.2    Knee, D.A.3    Nasoff, M.4    Deveraux, Q.L.5    Quon, K.C.6
  • 21
    • 2542611366 scopus 로고    scopus 로고
    • Oncogenic Ras sensitizes normal human cells to tumor necrosis factoralpha-related apoptosis-inducing ligand-induced apoptosis
    • PMID:15173003
    • Nesterov A, Nikrad M, Johnson T, Kraft AS. Oncogenic Ras sensitizes normal human cells to tumor necrosis factoralpha-related apoptosis-inducing ligand-induced apoptosis. Cancer Res 2004; 64:3922-7; PMID:15173003; http://dx.doi.org/10.1158/0008-5472.CAN-03-2219.
    • (2004) Cancer Res , vol.64 , pp. 3922-3927
    • Nesterov, A.1    Nikrad, M.2    Johnson, T.3    Kraft, A.S.4
  • 22
    • 20744450585 scopus 로고    scopus 로고
    • Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by upregulating death receptor 4 and death receptor 5 through a MEK-dependent pathway
    • PMID:15757891
    • Drosopoulos KG, Roberts ML, Cermak L, Sasazuki T, Shirasawa S, Andera L, et al. Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by upregulating death receptor 4 and death receptor 5 through a MEK-dependent pathway. J Biol Chem 2005; 280:22856-67; PMID:15757891; http://dx.doi.org/10.1074/jbc.M412483200.
    • (2005) J Biol Chem , vol.280 , pp. 22856-22867
    • Drosopoulos, K.G.1    Roberts, M.L.2    Cermak, L.3    Sasazuki, T.4    Shirasawa, S.5    Andera, L.6
  • 23
    • 33749320834 scopus 로고    scopus 로고
    • APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression
    • PMID:17030180
    • Janssen KP, Alberici P, Fsihi H, Gaspar C, Breukel C, Franken P, et al. APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. Gastroenterology 2006; 131:1096-109; PMID:17030180; http://dx.doi. org/10.1053/j.gastro.2006.08.011.
    • (2006) Gastroenterology , vol.131 , pp. 1096-1109
    • Janssen, K.P.1    Alberici, P.2    Fsihi, H.3    Gaspar, C.4    Breukel, C.5    Franken, P.6
  • 24
    • 34247876271 scopus 로고    scopus 로고
    • Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites
    • PMID:17322390
    • Céspedes MV, Espina C, García-Cabezas MA, Trias M, Boluda A, Gómez del Pulgar MT, et al. Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites. Am J Pathol 2007; 170:1077-85; PMID:17322390; http://dx.doi.org/10.2353/ ajpath.2007.060773.
    • (2007) Am J Pathol , vol.170 , pp. 1077-1085
    • Céspedes, M.V.1    Espina, C.2    García-Cabezas, M.A.3    Trias, M.4    Boluda, A.5    Gómez Del Pulgar, M.T.6
  • 25
    • 77954358936 scopus 로고    scopus 로고
    • The phosphoinositide- 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy
    • PMID:20551061
    • Al-Saffar NM, Jackson LE, Raynaud FI, Clarke PA, Ramírez de Molina A, Lacal JC, et al. The phosphoinositide- 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy. Cancer Res 2010; 70:5507-17; PMID:20551061; http://dx.doi.org/10.1158/0008-5472.CAN-09-4476.
    • (2010) Cancer Res , vol.70 , pp. 5507-5517
    • Al-Saffar, N.M.1    Jackson, L.E.2    Raynaud, F.I.3    Clarke, P.A.4    Ramírez De Molina, A.5    Lacal, J.C.6
  • 26
    • 42349084306 scopus 로고    scopus 로고
    • NVP-AUY922: A novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis and metastasis
    • PMID:18413753
    • Eccles SA, Massey A, Raynaud FI, Sharp SY, Box G, Valenti M, et al. NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis and metastasis. Cancer Res 2008; 68:2850-60; PMID:18413753; http://dx.doi. org/10.1158/0008-5472.CAN-07-5256.
    • (2008) Cancer Res , vol.68 , pp. 2850-2860
    • Eccles, S.A.1    Massey, A.2    Raynaud, F.I.3    Sharp, S.Y.4    Box, G.5    Valenti, M.6
  • 27
    • 62449226171 scopus 로고    scopus 로고
    • Acquired resistance to 17-allylamino- 17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells
    • PMID:19244114
    • Gaspar N, Sharp SY, Pacey S, Jones C, Walton M, Vassal G, et al. Acquired resistance to 17-allylamino- 17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells. Cancer Res 2009; 69:1966-75; PMID:19244114; http://dx.doi.org/10.1158/0008-5472.CAN-08-3131.
    • (2009) Cancer Res , vol.69 , pp. 1966-1975
    • Gaspar, N.1    Sharp, S.Y.2    Pacey, S.3    Jones, C.4    Walton, M.5    Vassal, G.6
  • 28
    • 77952219448 scopus 로고    scopus 로고
    • Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma
    • PMID:20457619
    • Gaspar N, Sharp SY, Eccles SA, Gowan S, Popov S, Jones C, et al. Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma. Mol Cancer Ther 2010; 9:1219-33; PMID:20457619; http://dx.doi.org/10.1158/1535-7163.MCT-09-0683.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1219-1233
    • Gaspar, N.1    Sharp, S.Y.2    Eccles, S.A.3    Gowan, S.4    Popov, S.5    Jones, C.6
  • 29
    • 37549027270 scopus 로고    scopus 로고
    • Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity
    • PMID:18089709
    • Chan F, Sun C, Perumal M, Nguyen QD, Bavetsias V, McDonald E, et al. Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity. Mol Cancer Ther 2007; 6:3147-57; PMID:18089709; http://dx.doi. org/10.1158/1535-7163.MCT-07-2156.
    • (2007) Mol Cancer Ther , vol.6 , pp. 3147-3157
    • Chan, F.1    Sun, C.2    Perumal, M.3    Nguyen, Q.D.4    Bavetsias, V.5    McDonald, E.6
  • 30
    • 34447092454 scopus 로고    scopus 로고
    • Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells
    • PMID:17148506
    • Psahoulia FH, Moumtzi S, Roberts ML, Sasazuki T, Shirasawa S, Pintzas A. Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells. Carcinogenesis 2007; 28:1021-31; PMID:17148506; http://dx.doi.org/10.1093/carcin/bgl232.
    • (2007) Carcinogenesis , vol.28 , pp. 1021-1031
    • Psahoulia, F.H.1    Moumtzi, S.2    Roberts, M.L.3    Sasazuki, T.4    Shirasawa, S.5    Pintzas, A.6
  • 31
    • 34748906001 scopus 로고    scopus 로고
    • Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts
    • PMID:17876056
    • Psahoulia FH, Drosopoulos KG, Doubravska L, Andera L, Pintzas A. Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts. Mol Cancer Ther 2007; 6:2591-9; PMID:17876056; http://dx.doi.org/10.1158/1535-7163.MCT-07-0001.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2591-2599
    • Psahoulia, F.H.1    Drosopoulos, K.G.2    Doubravska, L.3    Andera, L.4    Pintzas, A.5
  • 32
    • 79959594837 scopus 로고    scopus 로고
    • V600E inhibitor PLX4720, requires TRAIL assistance to overcome oncogenic PIK3CA resistance
    • PMID:21738740
    • V600E inhibitor PLX4720, requires TRAIL assistance to overcome oncogenic PIK3CA resistance. PLoS One 2011; 6:21632; PMID:21738740; http://dx.doi.org/10.1371/journal.pone.0021632.
    • (2011) PLoS One , vol.6 , pp. 21632
    • Oikonomou, E.1    Koc, M.2    Sourkova, V.3    Andera, L.4    Pintzas, A.5
  • 33
  • 34
    • 4644270297 scopus 로고    scopus 로고
    • Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action
    • PMID:15378008
    • Rodríguez-González A, Ramírez de Molina A, Fernández F, Lacal JC. Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action. Oncogene 2004; 23:8247-59; PMID:15378008; http://dx.doi. org/10.1038/sj.onc.1208045.
    • (2004) Oncogene , vol.23 , pp. 8247-8259
    • Rodríguez-González, A.1    Ramírez De Molina, A.2    Fernández, F.3    Lacal, J.C.4
  • 36
    • 42649143835 scopus 로고    scopus 로고
    • Homoharringtonine for the treatment of chronic myelogenous leukemia
    • PMID:18377344
    • Quintás-Cardama A, Cortes J. Homoharringtonine for the treatment of chronic myelogenous leukemia. Expert Opin Pharmacother 2008; 9:1029-37; PMID:18377344; http://dx.doi. org/10.1517/14656566.9.6.1029.
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 1029-1037
    • Quintás-Cardama, A.1    Cortes, J.2
  • 37
    • 77951119197 scopus 로고    scopus 로고
    • Doxorubicin and etoposide sensitize small cell lung carcinoma cells expressing caspase-8 to TRAIL
    • PMID:20416058
    • Vaculova A, Kaminskyy V, Jalalvand E, Surova O, Zhivotovsky B. Doxorubicin and etoposide sensitize small cell lung carcinoma cells expressing caspase-8 to TRAIL. Mol Cancer 2010; 9:87; PMID:20416058; http://dx.doi.org/10. 1186/1476-4598-9-87.
    • (2010) Mol Cancer , vol.9 , pp. 87
    • Vaculova, A.1    Kaminskyy, V.2    Jalalvand, E.3    Surova, O.4    Zhivotovsky, B.5
  • 38
    • 80053161379 scopus 로고    scopus 로고
    • Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL
    • PMID:21771726
    • Kaminskyy VO, Surova OV, Vaculova A, Zhivotovsky B. Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL. Carcinogenesis 2011; 32:1450-8; PMID:21771726; http://dx.doi. org/10.1093/carcin/bgr135.
    • (2011) Carcinogenesis , vol.32 , pp. 1450-1458
    • Kaminskyy, V.O.1    Surova, O.V.2    Vaculova, A.3    Zhivotovsky, B.4
  • 39
    • 40049092624 scopus 로고    scopus 로고
    • Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane
    • PMID:18165900
    • Símová S, Klíma M, Cermak L, Sourková V, Andera L. Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. Apoptosis 2008; 13:423-36; PMID:18165900; http://dx.doi.org/10.1007/s10495- 007-0171-8.
    • (2008) Apoptosis , vol.13 , pp. 423-436
    • Símová, S.1    Klíma, M.2    Cermak, L.3    Sourková, V.4    Andera, L.5
  • 40
    • 70249144378 scopus 로고    scopus 로고
    • TRAIL Receptor Upregulation Correlates to KRAS/BRAF Mutations in Human Colon Cancer Tumors and Respective Normal Tissue
    • PMID:19637313
    • Oikonomou E, Kosmidou V, Katseli A, Kothonidis K, Mourtzoukou D, Kontogeorgos G, et al. TRAIL Receptor Upregulation Correlates to KRAS/BRAF Mutations in Human Colon Cancer Tumors and Respective Normal Tissue. Int J Cancer 2009; 125:2127-35; PMID:19637313; http://dx.doi. org/10.1002/ijc.24613.
    • (2009) Int J Cancer , vol.125 , pp. 2127-2135
    • Oikonomou, E.1    Kosmidou, V.2    Katseli, A.3    Kothonidis, K.4    Mourtzoukou, D.5    Kontogeorgos, G.6
  • 41
    • 34748827371 scopus 로고    scopus 로고
    • Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: A retrospective study
    • PMID:17851129
    • Ramírez de Molina A, Sarmentero-Estrada J, Belda- Iniesta C, Tarón M, Ramírez de Molina V, Cejas P, et al. Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study. Lancet Oncol 2007; 8:889-97; PMID:17851129; http://dx.doi.org/10.1016/S1470- 2045(07)70279-6.
    • (2007) Lancet Oncol , vol.8 , pp. 889-897
    • Ramírez De Molina, A.1    Sarmentero-Estrada, J.2    Belda-Iniesta, C.3    Tarón, M.4    Ramírez De Molina, V.5    Cejas, P.6
  • 42
    • 47549091727 scopus 로고    scopus 로고
    • p73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis
    • PMID:18362891
    • Sayan AE, Sayan BS, Gogvadze V, Dinsdale D, Nyman U, Hansen TM, et al. p73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis. Oncogene 2008; 27:4363- 72; PMID:18362891; http://dx.doi.org/10.1038/ onc.2008.64.
    • (2008) Oncogene , vol.27 , pp. 4363-4372
    • Sayan, A.E.1    Sayan, B.S.2    Gogvadze, V.3    Dinsdale, D.4    Nyman, U.5    Hansen, T.M.6
  • 43
    • 33847724638 scopus 로고    scopus 로고
    • Aurora-A regulation of nuclear factorkappaB signaling by phosphorylation of IkappaBalpha
    • PMID:17308110
    • Briassouli P, Chan F, Savage K, Reis-Filho JS, Linardopoulos S. Aurora-A regulation of nuclear factorkappaB signaling by phosphorylation of IkappaBalpha. Cancer Res 2007; 67:1689-95; PMID:17308110; http://dx.doi.org/10.1158/0008- 5472.CAN-06-2272.
    • (2007) Cancer Res , vol.67 , pp. 1689-1695
    • Briassouli, P.1    Chan, F.2    Savage, K.3    Reis-Filho, J.S.4    Linardopoulos, S.5
  • 44
    • 42149094346 scopus 로고    scopus 로고
    • Contributions to Bax insertion and oligomerization of lipids of the mitochondrial outer membrane
    • PMID:18259190
    • Lucken-Ardjomande S, Montessuit S, Martinou JC. Contributions to Bax insertion and oligomerization of lipids of the mitochondrial outer membrane. Cell Death Differ 2008; 15:929-37; PMID:18259190; http://dx.doi.org/10.1038/cdd. 2008.9.
    • (2008) Cell Death Differ , vol.15 , pp. 929-937
    • Lucken-Ardjomande, S.1    Montessuit, S.2    Martinou, J.C.3
  • 45
    • 39449130146 scopus 로고    scopus 로고
    • Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes
    • PMID:18084240
    • Lucken-Ardjomande S, Montessuit S, Martinou JC. Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes. Cell Death Differ 2008; 15:484- 93; PMID:18084240; http://dx.doi.org/10.1038/ sj.cdd.4402280.
    • (2008) Cell Death Differ , vol.15 , pp. 484-493
    • Lucken-Ardjomande, S.1    Montessuit, S.2    Martinou, J.C.3
  • 46
    • 77956634444 scopus 로고    scopus 로고
    • Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization
    • PMID:20850011
    • Montessuit S, Somasekharan SP, Terrones O, Lucken- Ardjomande S, Herzig S, Schwarzenbacher R, et al. Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization. Cell 2010; 142:889-901; PMID:20850011; http://dx.doi. org/10.1016/j.cell.2010.08.017.
    • (2010) Cell , vol.142 , pp. 889-901
    • Montessuit, S.1    Somasekharan, S.P.2    Terrones, O.3    Lucken-Ardjomande, S.4    Herzig, S.5    Schwarzenbacher, R.6
  • 47
    • 66149103719 scopus 로고    scopus 로고
    • DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis
    • PMID:19347032
    • Olsson M, Vakifahmetoglu H, Abruzzo PM, Högstrand K, Grandien A, Zhivotovsky B. DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis. Oncogene 2009; 28:1949-59; PMID:19347032; http://dx.doi.org/10.1038/ onc.2009.36.
    • (2009) Oncogene , vol.28 , pp. 1949-1959
    • Olsson, M.1    Vakifahmetoglu, H.2    Abruzzo, P.M.3    Högstrand, K.4    Grandien, A.5    Zhivotovsky, B.6
  • 48
    • 50349096803 scopus 로고    scopus 로고
    • Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis
    • PMID:18772114
    • Powers MV, Clarke PA, Workman P. Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis. Cancer Cell 2008; 14:250-62; PMID:18772114; http://dx.doi. org/10.1016/j.ccr.2008.08.002.
    • (2008) Cancer Cell , vol.14 , pp. 250-262
    • Powers, M.V.1    Clarke, P.A.2    Workman, P.3
  • 49
    • 52249108496 scopus 로고    scopus 로고
    • Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37
    • PMID:18922470
    • Vaughan CK, Mollapour M, Smith JR, Truman A, Hu B, Good VM, et al. Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Mol Cell 2008; 31:886- 95; PMID:18922470; http://dx.doi.org/10.1016/j. molcel.2008.07.021.
    • (2008) Mol Cell , vol.31 , pp. 886-895
    • Vaughan, C.K.1    Mollapour, M.2    Smith, J.R.3    Truman, A.4    Hu, B.5    Good, V.M.6
  • 50
    • 0032929520 scopus 로고    scopus 로고
    • Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
    • PMID:9930862
    • Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M, et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 1999; 5:157-63; PMID:9930862; http://dx.doi. org/10.1038/5517.
    • (1999) Nat Med , vol.5 , pp. 157-163
    • Walczak, H.1    Miller, R.E.2    Ariail, K.3    Gliniak, B.4    Griffith, T.S.5    Kubin, M.6
  • 51
    • 13344285339 scopus 로고
    • Identification and characterization of a new member of the TNF family that induces apoptosis
    • PMID:8777713
    • Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995; 3:673-82; PMID:8777713; http://dx.doi.org/10. 1016/1074-7613(95)90057-8.
    • (1995) Immunity , vol.3 , pp. 673-682
    • Wiley, S.R.1    Schooley, K.2    Smolak, P.J.3    Din, W.S.4    Huang, C.P.5    Nicholl, J.K.6
  • 52
    • 0035692171 scopus 로고    scopus 로고
    • Death receptor ligands, in particular TRAIL, to overcome drug resistance
    • PMID:11831647
    • de Jong S, Timmer T, Heijenbrok FJ, de Vries EG. Death receptor ligands, in particular TRAIL, to overcome drug resistance. Cancer Metastasis Rev 2001; 20:51-6; PMID:11831647; http://dx.doi. org/10.1023/A:1013112624971.
    • (2001) Cancer Metastasis Rev , vol.20 , pp. 51-56
    • De Jong, S.1    Timmer, T.2    Heijenbrok, F.J.3    De Vries, E.G.4
  • 53
    • 0030763774 scopus 로고    scopus 로고
    • How TRAIL kills cancer cells, but not normal cells
    • PMID:9273698
    • Gura T. How TRAIL kills cancer cells, but not normal cells. Science 1997; 277:768; PMID:9273698; http:// dx.doi.org/10.1126/science.277.5327.768.
    • (1997) Science , vol.277 , pp. 768
    • Gura, T.1
  • 54
    • 33644669224 scopus 로고    scopus 로고
    • Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring downregulation of cellular FLICE inhibitory protein
    • PMID:16170023
    • Voelkel-Johnson C, Hannun YA, El-Zawahry A. Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring downregulation of cellular FLICE inhibitory protein. Mol Cancer Ther 2005; 4:1320-7; PMID:16170023; http://dx.doi. org/10.1158/1535-7163.MCT-05-0086.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1320-1327
    • Voelkel-Johnson, C.1    Hannun, Y.A.2    El-Zawahry, A.3
  • 55
    • 61349193762 scopus 로고    scopus 로고
    • Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells
    • PMID:19137010
    • White-Gilbertson S, Mullen T, Senkal C, Lu P, Ogretmen B, Obeid L, et al. Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells. Oncogene 2009; 28:1132-41; PMID:19137010; http://dx.doi. org/10.1038/onc.2008.468.
    • (2009) Oncogene , vol.28 , pp. 1132-1141
    • White-Gilbertson, S.1    Mullen, T.2    Senkal, C.3    Lu, P.4    Ogretmen, B.5    Obeid, L.6
  • 56
    • 4644270297 scopus 로고    scopus 로고
    • Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action
    • PMID:15378008
    • Rodríguez-González A, Ramirez de Molina A, Fernández F, Lacal JC. Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action. Oncogene 2004; 23:8247-59; PMID:15378008; http://dx.doi. org/10.1038/sj.onc.1208045.
    • (2004) Oncogene , vol.23 , pp. 8247-8259
    • Rodríguez-González, A.1    Ramirez De Molina, A.2    Fernández, F.3    Lacal, J.C.4
  • 57
    • 62449263569 scopus 로고    scopus 로고
    • Clinical perspectives of cell death: Where we are and where to go
    • PMID:19238546
    • Zhivotovsky B, Orrenius S. Clinical perspectives of cell death: where we are and where to go... Apoptosis 2009; 14:333-5; PMID:19238546; http://dx.doi. org/10.1007/s10495-009-0326-x.
    • (2009) Apoptosis , vol.14 , pp. 333-335
    • Zhivotovsky, B.1    Orrenius, S.2
  • 58
    • 77953722717 scopus 로고    scopus 로고
    • Probing the probes: Fitness factors for small molecule tools
    • PMID:20609406
    • Workman P, Collins I. Probing the probes: fitness factors for small molecule tools. Chem Biol 2010; 17:561- 77; PMID:20609406; http://dx.doi.org/10. 1016/j. chembiol.2010.05.013.
    • (2010) Chem Biol , vol.17 , pp. 561-577
    • Workman, P.1    Collins, I.2
  • 59
    • 51449103841 scopus 로고    scopus 로고
    • Targeted therapeutics for cancer treatment: Major progress towards personalised molecular medicine
    • PMID:18678282
    • Workman P, de Bono J. Targeted therapeutics for cancer treatment: major progress towards personalised molecular medicine. Curr Opin Pharmacol 2008; 8:359-62; PMID:18678282; http://dx.doi. org/10.1016/j.coph.2008.07.007.
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 359-362
    • Workman, P.1    De Bono, J.2
  • 60
    • 77954028523 scopus 로고    scopus 로고
    • Envisioning the future of early anticancer drug development
    • PMID:20535131
    • Yap TA, Sandhu SK, Workman P, de Bono JS. Envisioning the future of early anticancer drug development. Nat Rev Cancer 2010; 10:514-23; PMID:20535131; http://dx.doi.org/10.1038/nrc2870.
    • (2010) Nat Rev Cancer , vol.10 , pp. 514-523
    • Yap, T.A.1    Sandhu, S.K.2    Workman, P.3    De Bono, J.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.