Mapping the environmental fitness landscape of a synthetic gene circuit

PLoS Computational Biology

Volumn 8, Issue 4, 2012, Pages

  Nevozhay, Dmitry ^a   Adams, Rhys M ^a   van Itallie, Elizabeth ^b   Bennett, Matthew R ^b   Balázsi, Gábor ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b RICE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CELL CULTURE; CELL PROLIFERATION; FORECASTING; POPULATION STATISTICS; STOCHASTIC SYSTEMS; TIMING CIRCUITS; YEAST;

BIOLOGICAL MEASUREMENT; CELL POPULATIONS; DRUG-RESISTANCE; FITNESS LANDSCAPE; GENE NETWORKS; GENES EXPRESSION; MOLECULAR LEVELS; PHENOTYPE CELLS; POPULATION GROWTH RATES; SYNTHETIC GENE CIRCUITS;

GENE EXPRESSION;

PHLEOMYCIN; SACCHAROMYCES CEREVISIAE PROTEIN; SYNTHETIC DNA;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC RESISTANCE GENE; ANTIBIOTIC SENSITIVITY; ARTICLE; CELL DIVISION; CELL GROWTH; CELL MOTION; CELL SUBPOPULATION; CELLULAR MEMORY; CELLULAR PARAMETERS; ENVIRONMENTAL FITNESS LANDSCAPE; FUNGAL GENE; GENE EXPRESSION; GENE MAPPING; GENOTYPE ENVIRONMENT INTERACTION; GROWTH RATE; INSTANTANEOUS CELLULAR FITNESS; MOLECULAR GENETICS; NONHUMAN; OVERALL CELL POPULATION FITNESS; PHENOTYPE; POSITIVE FEEDBACK; REPRODUCTIVE FITNESS; SACCHAROMYCES CEREVISIAE; STOCHASTIC MODEL; SYNTHETIC GENE CIRCUIT; TRANSIENT CELLULAR FITNESS; BIOLOGICAL MODEL; CHROMOSOME MAP; COMPUTER SIMULATION; GENETICS; METHODOLOGY;

SACCHAROMYCES CEREVISIAE;

CHROMOSOME MAPPING; COMPUTER SIMULATION; DRUG RESISTANCE, MICROBIAL; GENE-ENVIRONMENT INTERACTION; GENES, SYNTHETIC; MODELS, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84861108510     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002480     Document Type: Article

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