Twin screw granulation as a simple and efficient tool for continuous wet granulation

International Journal of Pharmaceutics

Volumn 273, Issue 1-2, 2004, Pages 183-194

  Keleb, E I ^a   Vermeire, A ^a   Vervaet, C ^a   Remon, J P ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Continuous granulation; Formulation variables; Granule quality; Lactose monohydrate; Process continuity; Processing parameters; Twin screw granulator

Indexed keywords

ALPHA LACTOSE; EXCIPIENT; HYDROCHLOROTHIAZIDE;

ARTICLE; DRUG DESIGN; DRUG FORMULATION; DRUG GRANULATION; EVALUATION; PRIORITY JOURNAL; REPRODUCIBILITY; TABLET FORMULATION; TENSILE STRENGTH; WATER CONTENT; WETTABILITY;

EXCIPIENTS; HYDROCHLOROTHIAZIDE; LACTOSE; PARTICLE SIZE; SOLUBILITY; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TENSILE STRENGTH; WETTABILITY;

EID: 1542268927     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.01.001     Document Type: Article

References (11)

1. Keleb E.I., Vermeire A., Vervaet C., Remon J.P. Continuous twin screw extrusion for the wet granulation of lactose. Int. J. Pharm. 239:2002;69-80.
2. Fell J.T., Newton J.M. Determination of tablet strength by the diametral compression test. J. Pharm. Sci. 59:1970;688-691.
3. Kleinebudde P., Lindner H. Experiments with an instrumented twin-screw extruder using a single-step granulation/extrusion process. Int. J. Pharm. 94:1993;49-58.
4. Leuenberger H. New trends in the production of pharmaceutical granules: batch versus continuous processing. Eur. J. Pharm. Biopharm. 52:2001;289-296.
5. Lindberg N.O., Tufvesson C., Olbjer L. Extrusion of an effervescent granulation with twin screw extruder Baker Perkins MPF 50 D. Drug Dev. Ind. Pharm. 13:1987;1891-1913.
6. Lindberg N.O. Some experiences of continuous wet granulation. Acta Pharm. Suec. 25:1988;239-246.
7. Lindberg N.O., Tufvesson C., Holm P., Olbjer L. Extrusion of an effervescent granulation with twin screw extruder, Baker Perkins MPF 50 D. Influence on intragranular porosity and liquid saturation. Drug Dev. Ind. Pharm. 14:1988;1791-1798.
8. Schroeder R., Steffens K.J. A new system for continuous wet granulation (Ger). Pharm. Ind. 3:2002;283-288.
9. Schroeder, R., Steffens, K.J., 2002. A new system for improved and continuous wet granulation. In: Proceedings of the 4th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. Florence, 8-10 April, pp. 27-28.
10. Wan L.S.C., Heng P.W.S., Ling B.L. Effect of polyvinylpyrrolidone solution containing dissolved drug on characteristics of lactose fluid bed granules. Int. J. Pharm. 141:1996;161-170.
11. Wikberg M., Alderborn G. Compression characteristics of granulated materials. 6. Pore size distribution assessed by mercury penetration of compacts of two lactose granulation with different fragmentation propensity. Int. J. Pharm. 84:1992;191-195.