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Volumn 2012, Issue , 2012, Pages

Microvascular guidance: A challenge to support the development of vascularised tissue engineering construct

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; CD34 ANTIBODY; CELL ADHESION MOLECULE; COLLAGEN TYPE 1; FIBRINOGEN; FIBRONECTIN; GELATIN; MYOSIN HEAVY CHAIN ALPHA; NERVE CELL ADHESION MOLECULE; TISSUE SCAFFOLD;

EID: 84861086110     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/2012/201352     Document Type: Article
Times cited : (26)

References (111)
  • 1
    • 0027595948 scopus 로고
    • Tissue engineering
    • Langer R., Vacanti J. P., Tissue engineering Science 1993 260 5110 920 926 (Pubitemid 23209960)
    • (1993) Science , vol.260 , Issue.5110 , pp. 920-926
    • Langer, R.1    Vacanti, J.P.2
  • 2
    • 3843096162 scopus 로고    scopus 로고
    • Tissue engineering and regenerative medicine: Concepts for clinical application
    • Atala A., Tissue engineering and regenerative medicine: concepts for clinical application Rejuvenation Research 2004 7 1 15 31 (Pubitemid 39619805)
    • (2004) Rejuvenation Research , vol.7 , Issue.1 , pp. 15-31
    • Atala, A.1
  • 3
    • 0036299093 scopus 로고    scopus 로고
    • Tissue engineering and reparative medicine
    • Sipe J. D., Tissue engineering and reparative medicine Annals of the New York Academy of Sciences 2002 961 1 9 (Pubitemid 34721731)
    • (2002) Annals of the New York Academy of Sciences , vol.961 , pp. 1-9
    • Sipe, J.D.1
  • 4
    • 0031852915 scopus 로고    scopus 로고
    • Growth factors reverse the impaired sprouting of microvessels from aged mice
    • DOI 10.1006/mvre.1998.2078
    • Arthur W. T., Vernon R. B., Sage E. H., Reed M. J., Growth factors reverse the impaired sprouting of microvessels from aged mice Microvascular Research 1998 55 3 260 270 (Pubitemid 28368695)
    • (1998) Microvascular Research , vol.55 , Issue.3 , pp. 260-270
    • Arthur, W.T.1    Vernon, R.B.2    Sage, E.H.3    Reed, M.J.4
  • 8
    • 0036657516 scopus 로고    scopus 로고
    • Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation
    • Sakakibara Y., Nishimura K., Tambara K., Yamamoto M., Lu F., Tabata Y., Komeda M., Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation Journal of Thoracic and Cardiovascular Surgery 2002 124 1 50 56
    • (2002) Journal of Thoracic and Cardiovascular Surgery , vol.124 , Issue.1 , pp. 50-56
    • Sakakibara, Y.1    Nishimura, K.2    Tambara, K.3    Yamamoto, M.4    Lu, F.5    Tabata, Y.6    Komeda, M.7
  • 9
    • 16544386877 scopus 로고    scopus 로고
    • Advances in Tissue Engineering
    • DOI 10.1016/S0070-2153(04)61005-2, PII S0070215304610052
    • Levenberg S., Langer R., Advances in tissue engineering Current Topics in Developmental Biology 2004 61 113 134 (Pubitemid 39752368)
    • (2004) Current Topics in Developmental Biology , vol.61 , pp. 113-134
    • Levenberg, S.1    Langer, R.2
  • 10
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • DOI 10.1038/nature04478, PII NATURE04478
    • Carmeliet P., Angiogenesis in life, disease and medicine Nature 2005 438 7070 932 936 (Pubitemid 43093958)
    • (2005) Nature , vol.438 , Issue.7070 , pp. 932-936
    • Carmeliet, P.1
  • 11
  • 12
    • 0034136030 scopus 로고    scopus 로고
    • Systems for therapeutic angiogenesis in tissue engineering
    • Soker S., Machado M., Atala A., Systems for therapeutic angiogenesis in tissue engineering World Journal of Urology 2000 18 1 10 18
    • (2000) World Journal of Urology , vol.18 , Issue.1 , pp. 10-18
    • Soker, S.1    MacHado, M.2    Atala, A.3
  • 14
    • 0035054981 scopus 로고    scopus 로고
    • Scaffold design and fabrication technologies for engineering tissues - State of the art and future perspectives
    • DOI 10.1163/156856201744489
    • Hutmacher D. W., Scaffold design and fabrication technologies for engineering tissuesstate of the art and future perspectives Journal of Biomaterials Science, Polymer Edition 2001 12 1 107 124 (Pubitemid 32335467)
    • (2001) Journal of Biomaterials Science, Polymer Edition , vol.12 , Issue.1 , pp. 107-124
    • Hutmacher, D.W.1
  • 15
    • 3042588831 scopus 로고    scopus 로고
    • Molecular regulation of vascular smooth muscle cell differentiation in development and disease
    • DOI 10.1152/physrev.00041.2003
    • Owens G. K., Kumar M. S., Wamhoff B. R., Molecular regulation of vascular smooth muscle cell differentiation in development and disease Physiological Reviews 2004 84 3 767 801 (Pubitemid 38823766)
    • (2004) Physiological Reviews , vol.84 , Issue.3 , pp. 767-801
    • Owens, G.K.1    Kumar, M.S.2    Wamhoff, B.R.3
  • 16
    • 0027787707 scopus 로고
    • Calponin and SM 22 as differentiation markers of smooth muscle: Spatiotemporal distribution during avian embryonic development
    • Duband J. L., Gimona M., Scatena M., Sartore S., Small J. V., Calponin and SM 22 as differentiation markers of smooth muscle: spatiotemporal distribution during avian embryonic development Differentiation 1993 55 1 1 11
    • (1993) Differentiation , vol.55 , Issue.1 , pp. 1-11
    • Duband, J.L.1    Gimona, M.2    Scatena, M.3    Sartore, S.4    Small, J.V.5
  • 18
    • 0035015517 scopus 로고    scopus 로고
    • Pericytes: Cell biology and pathology
    • DOI 10.1159/000047855
    • Allt G., Lawrenson J. G., Pericytes: cell biology and pathology Cells Tissues Organs 2001 169 1 1 11 (Pubitemid 32437039)
    • (2001) Cells Tissues Organs , vol.169 , Issue.1 , pp. 1-11
    • Allt, G.1    Lawrenson, J.G.2
  • 19
    • 0023585264 scopus 로고
    • Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells
    • Orlidge A., D'Amore P. A., Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells Journal of Cell Biology 1987 105 3 1455 1462 (Pubitemid 18029870)
    • (1987) Journal of Cell Biology , vol.105 , Issue.3 , pp. 1455-1462
    • Orlidge, A.1    D'Amore, P.A.2
  • 20
    • 84861060335 scopus 로고    scopus 로고
    • Extracellular matrix
    • 7th chapter 11 San Francisco, Calif, USA Pearson/Benjamin Cummings
    • Becker, Extracellular matrix The World of the Cell 2009 7th chapter 11 San Francisco, Calif, USA Pearson/Benjamin Cummings 791
    • (2009) The World of the Cell , pp. 791
    • Becker1
  • 22
    • 61349201437 scopus 로고    scopus 로고
    • In vitro angiogenesis by human umbilical vein endothelial cells (HUVEC) induced by three-dimensional co-culture with glioblastoma cells
    • Chen Z., Htay A., Santos W. D., Gillies G. T., Fillmore H. L., Sholley M. M., Broaddus W. C., In vitro angiogenesis by human umbilical vein endothelial cells (HUVEC) induced by three-dimensional co-culture with glioblastoma cells Journal of Neuro-Oncology 2009 92 2 121 128
    • (2009) Journal of Neuro-Oncology , vol.92 , Issue.2 , pp. 121-128
    • Chen, Z.1    Htay, A.2    Santos, W.D.3    Gillies, G.T.4    Fillmore, H.L.5    Sholley, M.M.6    Broaddus, W.C.7
  • 23
    • 0042121208 scopus 로고    scopus 로고
    • Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: The role of fibroblasts and Angiopoietin-1
    • DOI 10.1016/S0026-2862(03)00045-1
    • Nakatsu M. N., Sainson R. C. A., Aoto J. N., Taylor K. L., Aitkenhead M., Pérez-del-Pulgar S., Carpenter P. M., Hughes C. C. W., Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1 Microvascular Research 2003 66 2 102 112 (Pubitemid 36962872)
    • (2003) Microvascular Research , vol.66 , Issue.2 , pp. 102-112
    • Nakatsu, M.N.1    Sainson, R.C.A.2    Aoto, J.N.3    Taylor, K.L.4    Aitkenhead, M.5    Perez-del-Pulgar, S.6    Carpenter, P.M.7    Hughes, C.C.W.8
  • 27
    • 0034904632 scopus 로고    scopus 로고
    • Tissue engineering: A 21st century solution to surgical reconstruction
    • DOI 10.1016/S0003-4975(01)02820-X, PII S000349750102820X
    • Fuchs J. R., Nasseri B. A., Vacanti J. P., Tissue engineering: a 21st century solution to surgical reconstruction Annals of Thoracic Surgery 2001 72 2 577 591 (Pubitemid 32727174)
    • (2001) Annals of Thoracic Surgery , vol.72 , Issue.2 , pp. 577-591
    • Fuchs, J.R.1    Nasseri, B.A.2    Vacanti, J.P.3
  • 28
    • 0038069208 scopus 로고    scopus 로고
    • Heterogeneity of microvascular endothelial cells isolated from human term placenta and macrovascular umbilical vein endothelial cells
    • DOI 10.1078/0171-9335-00306
    • Lang I., Pabst M. A., Hiden U., Blaschitz A., Dohr G., Hahn T., Desoye G., Heterogeneity of microvascular endothelial cells isolated from human term placenta and macrovascular umbilical vein endothelial cells European Journal of Cell Biology 2003 82 4 163 173 (Pubitemid 36546617)
    • (2003) European Journal of Cell Biology , vol.82 , Issue.4 , pp. 163-173
    • Lang, I.1    Pabst, M.A.2    Hiden, U.3    Blaschitz, A.4    Dohr, G.5    Hahn, T.6    Desoye, G.7
  • 29
    • 33846849237 scopus 로고    scopus 로고
    • Phenotypic heterogeneity of the endothelium: II. Representative vascular beds
    • DOI 10.1161/01.RES.0000255690.03436.ae, PII 0000301220070202000005
    • Aird W. C., Phenotypic heterogeneity of the endothelium: II. Representative vascular beds Circulation Research 2007 100 2 174 190 (Pubitemid 46208718)
    • (2007) Circulation Research , vol.100 , Issue.2 , pp. 174-190
    • Aird, W.C.1
  • 30
    • 79251472439 scopus 로고    scopus 로고
    • Scaffold vascularisation: A challenge for three-dimensional tissue engineering
    • Bramfeld H., Sabra G., Centis V., Vermette P., Scaffold vascularisation: a challenge for three-dimensional tissue engineering Current Medicinal Chemistry 2010 17 3944 3967
    • (2010) Current Medicinal Chemistry , vol.17 , pp. 3944-3967
    • Bramfeld, H.1    Sabra, G.2    Centis, V.3    Vermette, P.4
  • 32
    • 1842632667 scopus 로고    scopus 로고
    • Endothelial cell-cell junctions: Happy together
    • DOI 10.1038/nrm1357
    • Dejana E., Endothelial cell-cell junctions: happy together Nature Reviews Molecular Cell Biology 2004 5 4 261 270 (Pubitemid 38480607)
    • (2004) Nature Reviews Molecular Cell Biology , vol.5 , Issue.4 , pp. 261-270
    • Dejana, E.1
  • 33
    • 0036433637 scopus 로고    scopus 로고
    • Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression
    • DOI 10.1006/mvre.2002.2443
    • Taylor K. L., Henderson A. M., Hughes C. C. W., Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression Microvascular Research 2002 64 3 372 383 (Pubitemid 35370739)
    • (2002) Microvascular Research , vol.64 , Issue.3 , pp. 372-383
    • Taylor, K.L.1    Henderson, A.M.2    Hughes, C.C.W.3
  • 34
    • 44949204637 scopus 로고    scopus 로고
    • Endothelial cell-matrix interactions in neovascularization
    • Francis M. E., Uriel S., Brey E. M., Endothelial cell-matrix interactions in neovascularization Tissue EngineeringPart B 2008 14 1 19 32
    • (2008) Tissue EngineeringPart B , vol.14 , Issue.1 , pp. 19-32
    • Francis, M.E.1    Uriel, S.2    Brey, E.M.3
  • 35
    • 64549159842 scopus 로고    scopus 로고
    • Micropatterning of poly(ethylene glycol) diacrylate hydrogels with biomolecules to regulate and guide endothelial morphogenesis
    • Moon J. J., Hahn M. S., Kim I., Nsiah B. A., West J. L., Micropatterning of poly(ethylene glycol) diacrylate hydrogels with biomolecules to regulate and guide endothelial morphogenesis Tissue EngineeringPart A 2009 15 3 579 585
    • (2009) Tissue EngineeringPart A , vol.15 , Issue.3 , pp. 579-585
    • Moon, J.J.1    Hahn, M.S.2    Kim, I.3    Nsiah, B.A.4    West, J.L.5
  • 37
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W., Mechanisms of angiogenesis Nature 1997 386 6626 671 674 (Pubitemid 27193480)
    • (1997) Nature , vol.386 , Issue.6626 , pp. 671-674
    • Risau, W.1
  • 38
    • 0019133502 scopus 로고
    • Angiogenesis in vitro
    • DOI 10.1038/288551a0
    • Folkman J., Haudenschild C., Angiogenesis in vitro Nature 1980 288 5791 551 556 (Pubitemid 11223680)
    • (1980) Nature , vol.288 , Issue.5791 , pp. 551-556
    • Folkman, J.1    Haudenschild, C.2
  • 39
    • 40949088119 scopus 로고    scopus 로고
    • Vascular lumen formation from a cell biological perspective
    • Chadwick D. J. Goode J. West Sussex, UK John Willey Sons
    • Kucera T., Eglinger J., Strilic B., Lammert E., Chadwick D. J., Goode J., Vascular lumen formation from a cell biological perspective Vascular Development 2007 West Sussex, UK John Willey Sons 46 56
    • (2007) Vascular Development , pp. 46-56
    • Kucera, T.1    Eglinger, J.2    Strilic, B.3    Lammert, E.4
  • 40
    • 0344942651 scopus 로고    scopus 로고
    • Endothelial cell apoptosis during glomerular capillary lumen formation in vivo
    • DOI 10.1097/01.ASN.0000061779.70530.06
    • Fierlbeck W., Liu A., Coyle R., Ballermann B. J., Endothelial cell apoptosis during glomerular capillary lumen formation in vivo Journal of the American Society of Nephrology 2003 14 5 1349 1354 (Pubitemid 36514675)
    • (2003) Journal of the American Society of Nephrology , vol.14 , Issue.5 , pp. 1349-1354
    • Fierlbeck, W.1    Liu, A.2    Coyle, R.3    Ballermann, B.J.4
  • 41
    • 0030782001 scopus 로고    scopus 로고
    • Lumen formation during angiogenesis in vitro involves phagocytic activity, formation and secretion of vacuoles, cell death, and capillary tube remodelling by different populations of endothelial cells
    • DOI 10.1002/(SICI)1097-0185(199711)249:3<327::AID-AR3>3.0.CO;2-R
    • Meyer G. T., Matthias L. J., Noack L., Vadas M. A., Gamble J. R., Lumen formation during angiogenesis in vitro involves phagocytic activity, formation and secretion of vacuoles, cell death, and capillary tube remodelling by different populations of endothelial cells Anatomical Record 1997 249 3 327 340 (Pubitemid 27469284)
    • (1997) Anatomical Record , vol.249 , Issue.3 , pp. 327-340
    • Meyer, G.T.1    Matthias, L.J.2    Noack, L.3    Vadas, M.A.4    Gamble, J.R.5
  • 42
    • 0020636931 scopus 로고
    • TEM-studies on development and canalization of the dorsal aorta in the chick embryo
    • Hirakow R., Hiruma T., TEM-studies on development and canalization of the dorsal aorta in the chick embryo Anatomy and Embryology 1983 166 3 307 315 (Pubitemid 13118750)
    • (1983) Anatomy and Embryology , vol.166 , Issue.3 , pp. 307-315
    • Hirakow, R.1    Hiruma, T.2
  • 44
    • 0033652114 scopus 로고    scopus 로고
    • Capillary morphogenesis during human endothelial cell invasion of three-dimensional collagen matrices
    • Davis G. E., Black S. M., Bayless K. J., Capillary morphogenesis during human endothelial cell invasion of three-dimensional collagen matrices In Vitro Cellular and Developmental Biology 2000 36 8 513 519
    • (2000) Vitro Cellular and Developmental Biology , vol.36 , Issue.8 , pp. 513-519
    • Davis, G.E.1    Black, S.M.2    Bayless, K.J.3
  • 45
    • 0037087648 scopus 로고    scopus 로고
    • The Cdc42 and Rac1 GTPases are required for capillary lumen formation in three-dimensional extracellular matrices
    • Bayless K. J., Davis G. E., The Cdc42 and Rac1 GTPases are required for capillary lumen formation in three-dimensional extracellular matrices Journal of Cell Science 2002 115 6 1123 1136 (Pubitemid 34272478)
    • (2002) Journal of Cell Science , vol.115 , Issue.6 , pp. 1123-1136
    • Bayless, K.J.1    Davis, G.E.2
  • 48
    • 0035236215 scopus 로고    scopus 로고
    • Cell cell interactions in vascular development
    • PII S0070215301520104
    • Darland D. C., D'Amore P. A., Cell cell interactions in vascular development Current Topics in Developmental Biology 2001 52 107 149 (Pubitemid 33804626)
    • (2001) Current Topics in Developmental Biology , vol.52 , pp. 107-149
    • Darland, D.C.1    D'Amore, P.A.2
  • 49
    • 9644255525 scopus 로고    scopus 로고
    • The roles of tissue engineering and vascularisation in the development of micro-vascular networks: A review
    • DOI 10.1016/j.biomaterials.2004.07.006, PII S0142961204005824
    • Kannan R. Y., Salacinski H. J., Sales K., Butler P., Seifalian A. M., The roles of tissue engineering and vascularisation in the development of micro-vascular networks: a review Biomaterials 2005 26 14 1857 1875 (Pubitemid 39575328)
    • (2005) Biomaterials , vol.26 , Issue.14 , pp. 1857-1875
    • Kannan, R.Y.1    Salacinski, H.J.2    Sales, K.3    Butler, P.4    Seifalian, A.M.5
  • 50
    • 30944441438 scopus 로고    scopus 로고
    • Photolithographic patterning of polyethylene glycol hydrogels
    • DOI 10.1016/j.biomaterials.2005.11.045, PII S0142961205010872
    • Hahn M. S., Taite L. J., Moon J. J., Rowland M. C., Ruffino K. A., West J. L., Photolithographic patterning of polyethylene glycol hydrogels Biomaterials 2006 27 12 2519 2524 (Pubitemid 43113276)
    • (2006) Biomaterials , vol.27 , Issue.12 , pp. 2519-2524
    • Hahn, M.S.1    Taite, L.J.2    Moon, J.J.3    Rowland, M.C.4    Ruffino, K.A.5    West, J.L.6
  • 51
    • 44249089298 scopus 로고    scopus 로고
    • Vascularization of engineered tissues: Approaches to promote angiogenesis in biomaterials
    • DOI 10.2174/156802608783790983
    • Moon J. J., West J. L., Vascularization of engineered tissues: approaches to promote angiogenesis in biomaterials Current Topics in Medicinal Chemistry 2008 8 4 300 310 (Pubitemid 351791025)
    • (2008) Current Topics in Medicinal Chemistry , vol.8 , Issue.4 , pp. 300-310
    • Moon, J.J.1    West, J.L.2
  • 52
    • 0036192028 scopus 로고    scopus 로고
    • Prospects for microtechnology and nanotechnology in bioengineering of replacement microvessels
    • Moldovan N. I., Ferrari M., Prospects for microtechnology and nanotechnology in bioengineering of replacement microvessels Archives of Pathology and Laboratory Medicine 2002 126 3 320 324 (Pubitemid 34208123)
    • (2002) Archives of Pathology and Laboratory Medicine , vol.126 , Issue.3 , pp. 320-324
    • Moldovan, N.I.1    Ferrari, M.2
  • 53
    • 0030250442 scopus 로고    scopus 로고
    • Evaluation of acellular human dermis as a dermal analog in a composite skin graft
    • Medalie D. A., Tompkins R. G., Morgan J. R., Evaluation of acellular human dermis as a dermal analog in a composite skin graft ASAIO Journal 1996 42 5 M455 M462
    • (1996) ASAIO Journal , vol.42 , Issue.5
    • Medalie, D.A.1    Tompkins, R.G.2    Morgan, J.R.3
  • 54
    • 0034326877 scopus 로고    scopus 로고
    • Scaffold precoating with human autologous extracellular matrix for improved cell attachment in cardiovascular tissue engineering
    • Ye Q., Zund G., Jockenhoevel S., Schoeberlein A., Hoerstrup S. P., Grunenfelder J., Benedikt P., Turina M., Scaffold precoating with human autologous extracellular matrix for improved cell attachment in cardiovascular tissue engineering ASAIO Journal 2000 46 6 730 733
    • (2000) ASAIO Journal , vol.46 , Issue.6 , pp. 730-733
    • Ye, Q.1    Zund, G.2    Jockenhoevel, S.3    Schoeberlein, A.4    Hoerstrup, S.P.5    Grunenfelder, J.6    Benedikt, P.7    Turina, M.8
  • 55
    • 33750315715 scopus 로고    scopus 로고
    • Electrospun poly (ε-caprolactone) microfiber and multilayer nanofiber/microfiber scaffolds: Characterization of scaffolds and measurement of cellular infiltration
    • DOI 10.1021/bm060680j
    • Pham Q. P., Sharma U., Mikos A. G., Electrospun poly ( -caprolactone) microfiber and multilayer nanofiber/microfiber scaffolds: characterization of scaffolds and measurement of cellular infiltration Biomacromolecules 2006 7 10 2796 2805 (Pubitemid 44615263)
    • (2006) Biomacromolecules , vol.7 , Issue.10 , pp. 2796-2805
    • Pham, Q.P.1    Sharma, U.2    Mikos, A.G.3
  • 56
    • 33644683263 scopus 로고    scopus 로고
    • Endothelial extracellular matrix: Biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization
    • Davis G. E., Senger D. R., Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization Circulation Research 2005 97 11 1093 1107
    • (2005) Circulation Research , vol.97 , Issue.11 , pp. 1093-1107
    • Davis, G.E.1    Senger, D.R.2
  • 57
    • 0035802109 scopus 로고    scopus 로고
    • Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo
    • DOI 10.1083/jcb.200103111
    • Xu J., Rodriguez D., Petitclerc E., Kim J. J., Hangai M., Moon Yuen S., Davis G. E., Brooks P. C., Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo Journal of Cell Biology 2001 154 5 1069 1079 (Pubitemid 34286185)
    • (2001) Journal of Cell Biology , vol.154 , Issue.5 , pp. 1069-1079
    • Xu, J.1    Rodriguez, D.2    Petitclerc, E.3    Kim, J.J.4    Hangai, M.5    Moon Yuen, S.6    Davis, G.E.7    Brooks, P.C.8
  • 58
    • 0032482156 scopus 로고    scopus 로고
    • Protein release from gelatin matrices
    • DOI 10.1016/S0169-409X(97)00125-7, PII S0169409X97001257
    • Ikada Y., Tabata Y., Protein release from gelatin matrices Advanced Drug Delivery Reviews 1998 31 3 287 301 (Pubitemid 28191870)
    • (1998) Advanced Drug Delivery Reviews , vol.31 , Issue.3 , pp. 287-301
    • Tabata, Y.1    Ikada, Y.2
  • 59
    • 84861069766 scopus 로고    scopus 로고
    • Biosynthetic Scaffold
    • Ma X. P. Elisseeff J. H. Boca Raton, Fla, USA Taylor Francis
    • Tabata Y., Ma X. P., Elisseeff J. H., Biosynthetic Scaffold Scaffolding in Tissue Engineering 2006 Boca Raton, Fla, USA Taylor Francis 46 59
    • (2006) Scaffolding in Tissue Engineering , pp. 46-59
    • Tabata, Y.1
  • 60
    • 84861017510 scopus 로고    scopus 로고
    • Biomaterial technology for tissue engineering applications
    • Tabata Y., Biomaterial technology for tissue engineering applications Journal of Controlled Release 2009 31 189 199
    • (2009) Journal of Controlled Release , vol.31 , pp. 189-199
    • Tabata, Y.1
  • 61
    • 77955057133 scopus 로고    scopus 로고
    • Effects of surface properties and bioactivation of biomaterials on endothelial cells
    • Monchaux E., Vermette P., Effects of surface properties and bioactivation of biomaterials on endothelial cells Frontiers in Bioscience 2010 2 239 255
    • (2010) Frontiers in Bioscience , vol.2 , pp. 239-255
    • Monchaux, E.1    Vermette, P.2
  • 62
    • 0023365422 scopus 로고
    • The influence of protein adsorption on interactions of cultured human endothelial cells with polymers
    • DOI 10.1002/jbm.820210603
    • van Wachem P. B., Vreriks C. M., Beugeling T., The influence of protein adsorption on interactions of cultured human endothelial cells with polymers Journal of Biomedical Materials Research 1987 21 6 701 718 (Pubitemid 17097118)
    • (1987) Journal of Biomedical Materials Research , vol.21 , Issue.6 , pp. 701-718
    • Van Wachem, P.B.1    Vreriks, C.M.2    Beugeling, T.3
  • 63
    • 0030818072 scopus 로고    scopus 로고
    • Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells
    • George E. L., Baldwin H. S., Hynes R. O., Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells Blood 1997 90 8 3073 3081 (Pubitemid 27444201)
    • (1997) Blood , vol.90 , Issue.8 , pp. 3073-3081
    • George, E.L.1    Baldwin, H.S.2    Hynes, R.O.3
  • 64
    • 10044290786 scopus 로고    scopus 로고
    • Biosynthetic hydrogel scaffolds made from fibrinogen and polyethylene glycol for 3D cell cultures
    • DOI 10.1016/j.biomaterials.2004.06.047, PII S014296120400609X
    • Almany L., Seliktar D., Biosynthetic hydrogel scaffolds made from fibrinogen and polyethylene glycol for 3D cell cultures Biomaterials 2005 26 15 2467 2477 (Pubitemid 39600699)
    • (2005) Biomaterials , vol.26 , Issue.15 , pp. 2467-2477
    • Almany, L.1    Seliktar, D.2
  • 65
    • 33644897831 scopus 로고    scopus 로고
    • A PEGylated fibrin patch for mesenchymal stem cell delivery
    • Zhang G., Wang X., Wang Z., Zhang J., Suggs L., A PEGylated fibrin patch for mesenchymal stem cell delivery Tissue Engineering 2006 12 1 9 19
    • (2006) Tissue Engineering , vol.12 , Issue.1 , pp. 9-19
    • Zhang, G.1    Wang, X.2    Wang, Z.3    Zhang, J.4    Suggs, L.5
  • 66
    • 17444392120 scopus 로고    scopus 로고
    • Fibrinogen and fibrin
    • DOI 10.1016/S0065-3233(05)70008-5, Fibrous Proteins Coiled-Coils, Collagen and Elastomers
    • Weisel J. W., Fibrinogen and fibrin Advances in Protein Chemistry 2005 70 247 299 (Pubitemid 40544785)
    • (2005) Advances in Protein Chemistry , vol.70 , pp. 247-299
    • Weisel, J.W.1
  • 67
    • 0037086722 scopus 로고    scopus 로고
    • A comparative evaluation of the tissue responses associated with polymeric implants in the rat and mouse
    • DOI 10.1002/jbm.10032
    • Kidd K. R., Dal Ponte D. B., Kellar R. S., Williams S. K., A comparative evaluation of the tissue responses associated with polymeric implants in the rat and mouse Journal of Biomedical Materials Research 2002 59 4 682 689 (Pubitemid 34044471)
    • (2002) Journal of Biomedical Materials Research , vol.59 , Issue.4 , pp. 682-689
    • Kidd, K.R.1    Dal Ponte, D.B.2    Kellar, R.S.3    Williams, S.K.4
  • 68
    • 0036829020 scopus 로고    scopus 로고
    • Molecular basis of endothelial cell morphogenesis in three-dimensional extracellular matrices
    • DOI 10.1002/ar.10159
    • Davis G. E., Bayless K. J., Mavila A., Molecular basis of endothelial cell morphogenesis in three-dimensional extracellular matrices Anatomical Record 2002 268 3 252 275 (Pubitemid 35246845)
    • (2002) Anatomical Record , vol.268 , Issue.3 , pp. 252-275
    • Davis, G.E.1    Bayless, K.J.2    Mavila, A.3
  • 69
    • 77349086418 scopus 로고    scopus 로고
    • Polymer fibers as contact guidance to orient microvascularization in a 3D environment
    • Sukmana I., Vermette P., Polymer fibers as contact guidance to orient microvascularization in a 3D environment Journal of Biomedical Materials ResearchPart A 2010 92 4 1587 1597
    • (2010) Journal of Biomedical Materials ResearchPart A , vol.92 , Issue.4 , pp. 1587-1597
    • Sukmana, I.1    Vermette, P.2
  • 70
    • 0028757965 scopus 로고
    • In vitro effects of extracellular matrix and growth factors on endothelial cell migration and vessel formation
    • Fournier N., Doillon C. J., In vitro effects of extracellular matrix and growth factors on endothelial cell migration and vessel formation Cells and Materials 1994 4 4 399 408
    • (1994) Cells and Materials , vol.4 , Issue.4 , pp. 399-408
    • Fournier, N.1    Doillon, C.J.2
  • 71
    • 0029967619 scopus 로고    scopus 로고
    • An α2β1 integrin-dependent pinocytic mechanism involving intracellular vacuole formation and coalescence regulates capillary lumen and tube formation in three-dimensional collagen matrix
    • DOI 10.1006/excr.1996.0109
    • Davis G. E., Camarillo C. W., An 2 1 integrin-dependent pinocytic mechanism involving intracellular vacuole formation and coalescence regulates capillary lumen and tube formation in three-dimensional collagen matrix Experimental Cell Research 1996 224 1 39 51 (Pubitemid 26116886)
    • (1996) Experimental Cell Research , vol.224 , Issue.1 , pp. 39-51
    • Davis, G.E.1    Camarillo, C.W.2
  • 73
    • 0242551681 scopus 로고    scopus 로고
    • Biopolymeric delivery matrices for angiogenic growth factors
    • DOI 10.1016/S1054-8807(03)00089-9
    • Zisch A. H., Lutolf M. P., Hubbell J. A., Biopolymeric delivery matrices for angiogenic growth factors Cardiovascular Pathology 2003 12 6 295 310 (Pubitemid 37433840)
    • (2003) Cardiovascular Pathology , vol.12 , Issue.6 , pp. 295-310
    • Zisch, A.H.1    Lutolf, M.P.2    Hubbell, J.A.3
  • 74
    • 0142122300 scopus 로고    scopus 로고
    • Tissue and cell engineering
    • DOI 10.1016/j.copbio.2003.09.006
    • Hubbell J. A., Tissue and cell engineering Current Opinion in Biotechnology 2003 14 517 519 (Pubitemid 37298037)
    • (2003) Current Opinion in Biotechnology , vol.14 , Issue.5 , pp. 517-519
    • Hubbell, J.A.1
  • 75
    • 19644367664 scopus 로고    scopus 로고
    • Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
    • DOI 10.1038/nbt1055
    • Lutolf M. P., Hubbell J. A., Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering Nature Biotechnology 2005 23 1 47 55 (Pubitemid 41724624)
    • (2005) Nature Biotechnology , vol.23 , Issue.1 , pp. 47-55
    • Lutolf, M.P.1    Hubbell, J.A.2
  • 77
    • 10644257537 scopus 로고    scopus 로고
    • Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration
    • DOI 10.1016/j.biomaterials.2004.09.021, PII S014296120400818X
    • DeLong S. A., Moon J. J., West J. L., Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration Biomaterials 2005 26 16 3227 3234 (Pubitemid 39647256)
    • (2005) Biomaterials , vol.26 , Issue.16 , pp. 3227-3234
    • DeLong, S.A.1    Moon, J.J.2    West, J.L.3
  • 79
    • 0034760458 scopus 로고    scopus 로고
    • Polymeric system for dual growth factor delivery
    • DOI 10.1038/nbt1101-1029
    • Richardson T. P., Peters M. C., Ennett A. B., Mooney D. J., Polymeric system for dual growth factor delivery Nature Biotechnology 2001 19 11 1029 1034 (Pubitemid 33041886)
    • (2001) Nature Biotechnology , vol.19 , Issue.11 , pp. 1029-1034
    • Richardson, T.P.1    Peters, M.C.2    Ennett, A.B.3    Mooney, D.J.4
  • 80
    • 0035967892 scopus 로고    scopus 로고
    • The evolving concept of a stem cell: Entity or function?
    • DOI 10.1016/S0092-8674(01)00409-3
    • Blau H. M., Brazelton T. R., Weimann J. M., The evolving concept of a stem cell: entity or function? Cell 2001 105 7 829 841 (Pubitemid 32635085)
    • (2001) Cell , vol.105 , Issue.7 , pp. 829-841
    • Blau, H.M.1    Brazelton, T.R.2    Weimann, J.M.3
  • 81
    • 0036918642 scopus 로고    scopus 로고
    • Tissue engineering strategies for in vivo neovascularisation
    • DOI 10.1517/14712598.2.8.805
    • Ennett A. B., Mooney D. J., Tissue engineering strategies for in vivo neovascularisation Expert Opinion on Biological Therapy 2002 2 8 805 818 (Pubitemid 36033247)
    • (2002) Expert Opinion on Biological Therapy , vol.2 , Issue.8 , pp. 805-818
    • Ennett, A.B.1    Mooney, D.J.2
  • 82
    • 0038376002 scopus 로고    scopus 로고
    • Molecular regulation of vessel maturation
    • DOI 10.1038/nm0603-685
    • Jain R. K., Molecular regulation of vessel maturation Nature Medicine 2003 9 6 685 693 (Pubitemid 36749217)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 685-693
    • Jain, R.K.1
  • 83
    • 74849104257 scopus 로고    scopus 로고
    • Modeling of flow-induced shear stress applied on 3D cellular scaffolds: Implications for vascular tissue engineering
    • Lesman A., Blinder Y., Levenberg S., Modeling of flow-induced shear stress applied on 3D cellular scaffolds: implications for vascular tissue engineering Biotechnology and Bioengineering 2010 105 3 645 654
    • (2010) Biotechnology and Bioengineering , vol.105 , Issue.3 , pp. 645-654
    • Lesman, A.1    Blinder, Y.2    Levenberg, S.3
  • 85
    • 77952288453 scopus 로고    scopus 로고
    • The effects of co-culture with fibroblasts and angiogenic growth factors on microvascular maturation and multi-cellular lumen formation in HUVEC-oriented polymer fibre constructs
    • Sukmana I., Vermette P., The effects of co-culture with fibroblasts and angiogenic growth factors on microvascular maturation and multi-cellular lumen formation in HUVEC-oriented polymer fibre constructs Biomaterials 2010 31 19 5091 5099
    • (2010) Biomaterials , vol.31 , Issue.19 , pp. 5091-5099
    • Sukmana, I.1    Vermette, P.2
  • 86
    • 80051825164 scopus 로고    scopus 로고
    • Engineering vessel-like networks within multicellular fibrin-based constructs
    • Lesman A., Koffler J., Atlas R., Blinder Y. J., Kam Z., Levenberg S., Engineering vessel-like networks within multicellular fibrin-based constructs Biomaterials 2011 32 31 7856 7869
    • (2011) Biomaterials , vol.32 , Issue.31 , pp. 7856-7869
    • Lesman, A.1    Koffler, J.2    Atlas, R.3    Blinder, Y.J.4    Kam, Z.5    Levenberg, S.6
  • 87
    • 1642563967 scopus 로고    scopus 로고
    • The role of bioreactors in tissue engineering
    • DOI 10.1016/j.tibtech.2003.12.001
    • Martin I., Wendt D., Heberer M., The role of bioreactors in tissue engineering Trends in Biotechnology 2004 22 2 80 86 (Pubitemid 38130175)
    • (2004) Trends in Biotechnology , vol.22 , Issue.2 , pp. 80-86
    • Martin, I.1    Wendt, D.2    Heberer, M.3
  • 88
    • 23644448920 scopus 로고    scopus 로고
    • Bioreactors for tissue mass culture: Design, characterization, and recent advances
    • DOI 10.1016/j.biomaterials.2005.05.057, PII S0142961205004734, Canadian Biomaterials Research
    • Martin Y., Vermette P., Bioreactors for tissue mass culture: design, characterization, and recent advances Biomaterials 2005 26 35 7481 7503 (Pubitemid 41133599)
    • (2005) Biomaterials , vol.26 , Issue.35 , pp. 7481-7503
    • Martin, Y.1    Vermette, P.2
  • 90
    • 0033586733 scopus 로고    scopus 로고
    • Gas exchange is essential for bioreactor cultivation of tissue engineered cartilage
    • DOI 10.1002/(SICI)1097-0290(19990420)63:2<197::AID-BIT8>3.0.CO;2-2
    • Obradovic B., Carrier R. L., Vunjak-Novakovic G., Freed L. E., Gas exchange is essential for bioreactor cultivation of tissue engineered cartilage Biotechnology and Bioengineering 1999 63 2 197 205 (Pubitemid 29095629)
    • (1999) Biotechnology and Bioengineering , vol.63 , Issue.2 , pp. 197-205
    • Obradovic, B.1    Carrier, R.L.2    Vunjak-Novakovic, G.3    Freed, L.E.4
  • 92
    • 4444346035 scopus 로고    scopus 로고
    • Long-term culture of tissue engineered cartilage in a perfused chamber with mechanical stimulation
    • Selected Papers of the 3rd International Symposium on Mechanobiology of Cartilage and Chondrocyte
    • Seidel J. O., Pei M., Gray M. L., Langer R., Freed L. E., Vunjak-Novakovic G., Long-term culture of tissue engineered cartilage in a perfused chamber with mechanical stimulation Biorheology 2004 41 3-4 445 458 (Pubitemid 39277101)
    • (2004) Biorheology , vol.41 , Issue.3-4 , pp. 445-458
    • Seidel, J.O.1    Pei, M.2    Gray, M.L.3    Langer, R.4    Freed, L.E.5    Vunjak-Novakovic, G.6
  • 93
    • 10044252178 scopus 로고    scopus 로고
    • Osseointegration of alumina with a bioactive coating under load-bearing and unloaded conditions
    • DOI 10.1016/j.biomaterials.2004.07.029, PII S014296120400660X
    • Ignatius A., Peraus M., Schorlemmer S., Augat P., Burger W., Leyen S., Claes L., Osseointegration of alumina with a bioactive coating under load-bearing and unloaded conditions Biomaterials 2005 26 15 2325 2332 (Pubitemid 39600686)
    • (2005) Biomaterials , vol.26 , Issue.15 , pp. 2325-2332
    • Ignatius, A.1    Peraus, M.2    Schorlemmer, S.3    Augat, P.4    Burger, W.5    Leyen, S.6    Claes, L.7
  • 97
    • 19044376270 scopus 로고    scopus 로고
    • Differential pretensions of a flexor tendon graft for anterior cruciate ligament reconstruction: A biomechanical comparison in a porcine knee model
    • DOI 10.1016/j.arthro.2005.01.013, PII S0749806305000630
    • Lee C. H., Huang G. S., Chao K. H., Wu S. S., Chen Q., Differential pretensions of a flexor tendon graft for anterior cruciate ligament reconstruction: a biomechanical comparison in a porcine knee model Arthroscopy 2005 21 5 540 546 (Pubitemid 40712213)
    • (2005) Arthroscopy - Journal of Arthroscopic and Related Surgery , vol.21 , Issue.5 , pp. 540-546
    • Lee, C.-H.1    Huang, G.-S.2    Chao, K.-H.3    Wu, S.-S.4    Chen, Q.5
  • 98
    • 0034002891 scopus 로고    scopus 로고
    • New pulsatile bioreactor for in vitro formation of tissue engineered heart valves
    • DOI 10.1089/107632700320919
    • Hoerstrup S. P., Sodian R., Sperling J. S., Vacanti J. P., Mayer J. E., New pulsatile bioreactor for in vitro formation of tissue engineered heart valves Tissue Engineering 2000 6 1 75 79 (Pubitemid 30123985)
    • (2000) Tissue Engineering , vol.6 , Issue.1 , pp. 75-79
    • Hoerstrup, S.P.1    Sodian, R.2    Sperling, J.S.3    Vacanti, J.P.4    Mayer Jr., J.E.5
  • 99
    • 0024621726 scopus 로고
    • Membranes and bioreactors: A technical challenge in biotechnology
    • Belfort G., Membranes and bioreactors: a technical challenge in biotechnology Biotechnology and Bioengineering 1989 33 8 1047 1066
    • (1989) Biotechnology and Bioengineering , vol.33 , Issue.8 , pp. 1047-1066
    • Belfort, G.1
  • 100
    • 0029940157 scopus 로고    scopus 로고
    • Use of mammalian liver cells for artificial liver support
    • DOI 10.1016/0963-6897(95)02020-9
    • Jauregui H. O., Chowdhury N. R., Chowdhury J. R., Use of mammalian liver cells for artificial liver support Cell Transplantation 1996 5 3 353 367 (Pubitemid 26153036)
    • (1996) Cell Transplantation , vol.5 , Issue.3 , pp. 353-367
    • Jauregui, H.O.1    Chowdhury, N.R.2    Chowdhury, J.R.3
  • 101
    • 0027105562 scopus 로고
    • Cell culture for three-dimensional modeling in rotating-wall vessels: An application of simulated microgravity
    • Schwarz R. P., Goodwin T. J., Wolf D. A., Cell culture for three-dimensional modeling in rotating-wall vessels: an application of simulated microgravity Journal of Tissue Culture Methods 1992 14 2 51 57
    • (1992) Journal of Tissue Culture Methods , vol.14 , Issue.2 , pp. 51-57
    • Schwarz, R.P.1    Goodwin, T.J.2    Wolf, D.A.3
  • 102
    • 33750937779 scopus 로고    scopus 로고
    • Bioreactors for tissue engineering: Focus on mechanical constraints. A comparative review
    • DOI 10.1089/ten.2006.12.2367
    • Bilodeau K., Mantovani D., Bioreactors for tissue engineering: focus on mechanical constraints. A comparative review Tissue Engineering 2006 12 8 2367 2383 (Pubitemid 44734994)
    • (2006) Tissue Engineering , vol.12 , Issue.8 , pp. 2367-2383
    • Bilodeau, K.1    Mantovani, D.2
  • 104
    • 57549113794 scopus 로고    scopus 로고
    • Cell colonization in degradable 3D porous matrices
    • Lawrence B. J., Madihally S. V., Cell colonization in degradable 3D porous matrices Cell Adhesion Migration 2008 2 1 9 16
    • (2008) Cell Adhesion Migration , vol.2 , Issue.1 , pp. 9-16
    • Lawrence, B.J.1    Madihally, S.V.2
  • 105
    • 0036772517 scopus 로고    scopus 로고
    • Tissue-engineering bioreactors: A new combined cell-seeding and perfusion system for vascular tissue engineering
    • DOI 10.1089/10763270260424222
    • Sodian R., Lemke T., Fritsche C., Hoerstrup S. P., Fu P., Potapov E. V., Hausmann H., Hetzer R., Tissue-engineering bioreactors: a new combined cell-seeding and perfusion system for vascular tissue engineering Tissue Engineering 2002 8 5 863 870 (Pubitemid 35239764)
    • (2002) Tissue Engineering , vol.8 , Issue.5 , pp. 863-870
    • Sodian, R.1    Lemke, T.2    Fritsche, C.3    Hoerstrup, S.P.4    Fu, P.5    Potapov, E.V.6    Hausmann, H.7    Hetzer, R.8
  • 106
    • 24944455046 scopus 로고    scopus 로고
    • Fibrin-based tissue-engineered blood vessels: Differential effects of biomaterial and culture parameters on mechanical strength and vascular reactivity
    • DOI 10.1089/ten.2005.11.991
    • Yao L., Swartz D. D., Gugino S. F., Russell J. A., Andreadis S. T., Fibrin-based tissue-engineered blood vessels: differential effects of biomaterial and culture parameters on mechanical strength and vascular reactivity Tissue Engineering 2005 11 7-8 991 1003 (Pubitemid 41321402)
    • (2005) Tissue Engineering , vol.11 , Issue.7-8 , pp. 991-1003
    • Yao, L.1    Swartz, D.D.2    Gugino, S.F.3    Russell, J.A.4    Andreadis, S.T.5
  • 107
    • 27944431593 scopus 로고    scopus 로고
    • Mechanotransduction in endothelial cell migration
    • DOI 10.1002/jcb.20614
    • Li S., Huang N. F., Hsu S., Mechanotransduction in endothelial cell migration Journal of Cellular Biochemistry 2005 96 6 1110 1126 (Pubitemid 41681854)
    • (2005) Journal of Cellular Biochemistry , vol.96 , Issue.6 , pp. 1110-1126
    • Li, S.1    Huang, N.F.2    Hsu, S.3
  • 108
    • 0038532474 scopus 로고    scopus 로고
    • Phenotype modulation in vascular tissue engineering using biochemical and mechanical stimulation
    • Stegemann J. P., Nerem R. M., Phenotype modulation in vascular tissue engineering using biochemical and mechanical stimulation Annals of Biomedical Engineering 2003 31 4 391 402
    • (2003) Annals of Biomedical Engineering , vol.31 , Issue.4 , pp. 391-402
    • Stegemann, J.P.1    Nerem, R.M.2
  • 109
    • 0036354085 scopus 로고    scopus 로고
    • Shear stress regulates occludin and VEGF expression in porcine arterial endothelial cells
    • Conklin B. S., Zhong D. S., Zhao W., Lin P. H., Chen C., Shear stress regulates occludin and VEGF expression in porcine arterial endothelial cells Journal of Surgical Research 2002 102 1 13 21
    • (2002) Journal of Surgical Research , vol.102 , Issue.1 , pp. 13-21
    • Conklin, B.S.1    Zhong, D.S.2    Zhao, W.3    Lin, P.H.4    Chen, C.5
  • 110
    • 0037167701 scopus 로고    scopus 로고
    • Mechanical stretch regimen enhances the formation of bioengineered autologous cardiac muscle grafts
    • Akhyari P., Fedak P. W. M., Weisel R. D., Lee T. Y. J., Verma S., Mickle D. A. G., Li R. K., Mechanical stretch regimen enhances the formation of bioengineered autologous cardiac muscle grafts Circulation 2002 106 13 I137 I142
    • (2002) Circulation , vol.106 , Issue.13
    • Akhyari, P.1    Fedak, P.W.M.2    Weisel, R.D.3    Lee, T.Y.J.4    Verma, S.5    Mickle, D.A.G.6    Li, R.K.7


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