β-Lactones inhibit N -acylethanolamine acid amidase by S-acylation of the catalytic N-terminal cysteine

ACS Medicinal Chemistry Letters

Volumn 3, Issue 5, 2012, Pages 422-426

  Armirotti, Andrea ^a   Romeo, Elisa ^a   Ponzano, Stefano ^a   Mengatto, Luisa ^a   Dionisi, Mauro ^a   Karacsonyi, Claudia ^a   Bertozzi, Fabio ^a   Garau, Gianpiero ^a   Tarozzo, Glauco ^a   Reggiani, Angelo ^a   Bandiera, Tiziano ^a   Tarzia, Giorgio ^d   Mor, Marco ^c   Piomelli, Daniele ^a,b  

^a ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF PARMA   (Italy)

^d UNIVERSITY OF URBINO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

5 PHENYLPENTYL N (2 METHYL 4 OXO OXETAN 3 YL)CARBAMATE; AMIDASE; ARN 077; CYSTEINE; LACTONE DERIVATIVE; N ACYLETHANOLAMINE ACID AMIDASE; UNCLASSIFIED DRUG;

ACYLATION; ALKYLATION; AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; DRUG MECHANISM; ENZYME INHIBITION; PRIORITY JOURNAL; SUBSTITUTION REACTION; TANDEM MASS SPECTROMETRY;

EID: 84861085138     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300056y     Document Type: Article

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