Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP

Journal of Neuroscience

Volumn 16, Issue 12, 1996, Pages 3934-3942

  Cadas, Hugues ^a   Gaillet, Sylvie ^b,c   Beltramo, Massimiliano ^a   Venance, Laurent ^b   Piomelli, Daniele ^a  

^a NEUROSCIENCES INSTITUTE   (United States)

^b INSERM   (France)

^c CNRS   (France)

Author keywords

anandamide; endogenous cannabinoids; N acylphosphatidylethanolamine; N acylethanolamines; N acyltransferase; phosphatidylethanolamine; vasoactive intestinal peptide

Indexed keywords

ACYLTRANSFERASE; ANANDAMIDE; CALCIUM; CANNABINOID; CYCLIC AMP; IONOMYCIN; PHOSPHATIDYLETHANOLAMINE; VASOACTIVE INTESTINAL POLYPEPTIDE;

ARTICLE; ASTROCYTE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL CULTURE; DATA ANALYSIS; ENZYME ACTIVITY; FATTY ACID SYNTHESIS; LIGHT SCATTERING; LIPID ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; SYNAPTIC TRANSMISSION;

EID: 0029889256     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-12-03934.1996     Document Type: Article

References (35)

1. Cadas H, Schinelli S, Piomelli D (1996) Membrane localization of N-acylphosphatidylethanolamine in central neurons: studies with exogenous phospholipases. J Lipid Med, in press.
2. Chapman K, Moore JT (1993) Catalytic properties of a newly discovered acyltransferase that synthesizes N-acylphosphatidylethanolamine in cottonseed (Gossipuim hirsutum L.) microsomes. Plant Physiol 102:761-769.
3. Colodzin M, Bachur N, Weissbach H, Udenfriend S (1963) Enzymatic formation of fatty acid amides of ethanolamine by rat liver microsomes. Biochem Biophys Res Commun 10:165-170.
4. Christie W (1987) HPLC and lipids: a practical guide, pp 23-25. Oxford: Pergamon.
5. Desarnaud F, Cadas H, Piomelli D (1995) Anandamide amidohydrolase activity in rat brain microsomes: identification and partial characterisation. J Biol Chem 270:6030-6035.
6. Deutsch D, Chin S (1993) Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist. Biochem Pharmacol 46:791-796.
7. Devane W, Axelrod J (1994) Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranes. Proc Natl Acad Sci USA 91:6698-6701.
8. Devane W, Hanuš L, Breuer A, Pertwee R, Stevenson L, Griffin G, Gibson D, Mandelbaum D, Etinger A, Mechoulam R (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258:1946-1949.
9. Di Marzo V, Fontana A, Cadas H, Schinelli S, Cimino G, Schwartz J-C, Piomelli D (1994) Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature 372:686-691.
10. +-induced depolarization and/or forskolin in rat striatal slices. J Neurochem 45:173-184.
11. Facci L, Dal Toso R, Romanello S, Buriani A, Skaper SD, Leon A (1995) Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamine. Proc Natl Acad Sci USA 92:3376-3380.
12. Gardner E (1992) Marijuana/cannabinoids: neurobiology and neurophysiology. In: CRC series in physiology of drug abuse (Bartke LMA, ed), pp 275-335. Boca Raton, FL: CRC.
13. Giachetti A, Said S, Reynolds R, Koniges S (1977) Vasoactive intestinal polypeptide in brain: localization in and release from isolated nerve terminals. Proc Natl Acad Sci USA 74:3424-3428.
14. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450.
15. Hansen H, Lauritzen L, Mette Strand A, Moesgaard B, Frandsen A (1995) Glutamate stimulates the formation of N-acylphosphatidylethanolamine and N-acylethanolamine in cortical neurons in culture. BBA 1258:303-308.
16. 2+/calmodulin-dependent protein kinases. Annu Rev Biochem 61:559-601.
17. Hanǔs L, Gopher A, Almog S, Mechoulam R (1993) Two new unsaturated fatty acid ethanolamines in brain that bind to the cannabinoid receptor. J Med Chem 36:3032-3034.
18. Hashimoto H, Ishihara T, Shigemoto R, Mori K, Nagata S (1993) Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide. Neuron 11:333-342.
19. Hazlewood G, Dawson M (1975) Intermolecular transacylation of phosphatidylethanolamine by a Butyrivibrio sp. Biochem J 150:521-525.
20. Hillard C, Wilkison D, Edgemond W, Campbell W (1995) Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain. Biochem Biophys Res Commun 1257:249-256.
21. Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S (1992) Functional expression and tissue distribution of a novel receptor for vasoactive intestinal peptide. Neuron 8:811-819.
22. Kishimoto Y (1983) Sphingolipid formation. In: The enzymes (Boyer PD, ed), pp 363-372. New York: Academic.
23. Kruszka K, Gross R (1994) The ATP-and CoA-independent synthesis of arachidonoylethanolamine. J Biol Chem 269:14345-14348.
24. Magistretti P, Morrison J (1988) Noradrenaline- and vasoactive intestinal peptide-containing neuronal systems in neocortex: functional convergence with contrasting morphology. Neuroscience 24:367-378.
25. Mechoulam R, Hanuš L, Martin B (1994) Search for endogenous ligands of the cannabinoid receptor. Biochem Pharmacol 48:1537-1544.
26. Natarajan V, Schmid P, Reddy P, Zuzarte-Augustin M, Schmid H (1983) Biosynthesis of N-acylethanolamine phospholipids by dog brain preparations. J Neurochem 41:1303-1312.
27. 2+ transients in dendritic spines of hippocampal pyramidal neurons in brain slice. Neuron 14:1223-1231.
28. Piomelli D (1994) Eicosanoids in synaptic transmission. Crit Rev Neurobiol 8:65-83.
29. Quick M, Iversen L, Bloom S (1978) Effect of vasoactive intestinal peptide (VIP) and other peptides on cAMP accumulation in rat brain. Biochem Pharmacol 27:2209-2213.
30. Schmid H, Schmid P, Natarajan V (1990) N-acylated glycerophospholipids and their derivatives. Prog Lipid Res 29:1-43.
31. 2+-dependent transacylase and phosphodiesterase activities. Biochem Biophys Res Commun 218:113-117.
32. Ueda N, Kurahashi Y, Yamamoto S, Tokunaga T (1995) Partial purification and characterization of the porcine brain enzyme hydrolysing and synthetizing anandamide. J Biol Chem 270:23823-23827.
33. Venance L, Piomelli D, Glowinski J, Giaume C (1995) Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes. Nature 376:590-593.
34. Walaas S, Greengard P (1987) Phosphorylation of brain proteins. In: The enzymes (Boyer PD, ed), pp 285-317. New York: Academic.
35. Zigmond R, Bowers C (1981) Influence of nerve activity on the macromolecular content of neurons and their effector organs. Annu Rev Physiol 43:673-673.