Butyl pocket formation in the vitamin D receptor strongly affects the agonistic or antagonistic behavior of ligands

Journal of Medicinal Chemistry

Volumn 55, Issue 9, 2012, Pages 4373-4381

  Yoshimoto, Nobuko ^a,b   Sakamaki, Yuta ^a,c   Haeta, Minoru ^a   Kato, Akira ^a   Inaba, Yuka ^a   Itoh, Toshimasa ^a   Nakabayashi, Makoto ^c   Ito, Nobutoshi ^c   Yamamoto, Keiko ^a,b  

^a Laboratory of Drug Design and Medicinal Chemistry   (Japan)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLIDENE 26,27 DIMETHYL 19,24 DINOR 1ALPHA, 25 DIHYDROXYVITAMIN D3; 4 [1 [(17BETA) 1,3 BIS [[TERT BUTYL (DIMETHYL) SILYL] OXY] 2 METHYLIDENE 9,10 SECOESTRA 5,7 DIEN 17 YL] ETHYL] 3 ETHYLNONAN 3 OL; 6 [(17BETA) 1,3BIS [[TERT BUTYL (DIMETHYL) SILYL]OXY] 2 METHYLIDENE 9,10 SECOESTRA 5,7 DIEN 17 YL] 3 ETHYLHEPTAN 3 OL; 6 [1 [(17BETA) 1,3 BIS [[TERT BUTYL (DIMETHYL) SILYL] OXY] 2 METHYLIDENE 9,10 SECOESTRA 5,7 DIEN 17 YL] ETHYL] 3,5 DIETHYLHEPTAN 3 OL; BUTYL 2 METHYLIDENE 26,27 DIMETHYL 19,24 DINOR 1ALPHA, 25 DIHYROXYVITAMIN D3; ETHYL 2 METHYLIDENE 26,27 DIMETHYL 19,24 DINOR 1ALPHA, 25 DIHYDOXYVITAMIN D3; LIGAND; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE; VITAMIN D RECEPTOR;

ARTICLE; BUTYL POCKET; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; TRANSACTIVATION;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CERCOPITHECUS AETHIOPS; CHOLECALCIFEROL; COS CELLS; CRYSTALLOGRAPHY, X-RAY; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; PROTEIN BINDING; RECEPTORS, CALCITRIOL; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861063420     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300230a     Document Type: Article

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