-
1
-
-
0013615899
-
RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease
-
Key paper on receptor for advanced glycation end products (RAGE)-Amyloid-b (Ab) in Alzheimer's disease
-
Yan SD, Chen X, Fu J et al. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature 382(6593), 685-691 (1996). Key paper on receptor for advanced glycation end products (RAGE)-Amyloid-b (Ab) in Alzheimer's disease.
-
(1996)
Nature
, vol.382
, Issue.6593
, pp. 685-691
-
-
Yan, S..D.1
Chen, X.2
Fu, J.3
-
2
-
-
77957775497
-
Structural basis for ligand recognition and activation of RAGE
-
Key paper on the molecular structure of RAGE and its interaction with ligands
-
Koch M, Chitayat S, Dattilo BM et al. Structural basis for ligand recognition and activation of RAGE. Structure 18(10), 1342-1352 (2010). Key paper on the molecular structure of RAGE and its interaction with ligands.
-
(2010)
Structure
, vol.18
, Issue.10
, pp. 1342-1352
-
-
Koch, M.1
Chitayat, S.2
Dattilo, B.M.3
-
3
-
-
82355190210
-
RAGE: A single receptor fits multiple ligands
-
Good review on RAGE-ligand interaction
-
Fritz G. RAGE: A single receptor fits multiple ligands. Trends Biochem. Sci. 36(12), 625-632 (2011). Good review on RAGE-ligand interaction.
-
(2011)
Trends Biochem. Sci.
, vol.36
, Issue.12
, pp. 625-632
-
-
Fritz, G.1
-
4
-
-
0026659883
-
Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins
-
Neeper M, Schmidt AM, Brett J et al. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J. Biol. Chem. 267(21), 14998-15004 (1992
-
(1992)
J. Biol. Chem.
, vol.267
, Issue.21
, pp. 14998-15004
-
-
Neeper, M.1
Schmidt, A.M.2
Brett, J.3
-
5
-
-
0037703255
-
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain
-
Key paper on RAGE/blood-brain barrier interaction
-
Deane R, Du Yan S, Submamaryan RK et al. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat. Med. 9(7), 907-913 (2003). Key paper on RAGE/blood-brain barrier interaction.
-
(2003)
Nat. Med.
, vol.9
, Issue.7
, pp. 907-913
-
-
Deane, R.1
Du Yan, S.2
Submamaryan, R.K.3
-
6
-
-
77649186801
-
Soluble RAGE: Therapy and biomarker in unraveling the RAGE axis in chronic disease and aging
-
Reviews RAGE as a therapeutic target
-
Yan SF, Ramasamy R, Schmidt AM. Soluble RAGE: Therapy and biomarker in unraveling the RAGE axis in chronic disease and aging. Biochem. Pharmacol. 79(10), 1379-1386 (2010). Reviews RAGE as a therapeutic target.
-
(2010)
Biochem. Pharmacol.
, vol.79
, Issue.10
, pp. 1379-1386
-
-
Yan, S.F.1
Ramasamy, R.2
Schmidt, A.M.3
-
7
-
-
0026650438
-
Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface
-
Schmidt AM, Vianna M, Gerlach M et al. Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. J. Biol. Chem. 267(21), 14987-14997 (1992
-
(1992)
J. Biol. Chem.
, vol.267
, Issue.21
, pp. 14987-14997
-
-
Schmidt, A.M.1
Vianna, M.2
Gerlach, M.3
-
8
-
-
84862682038
-
Advanced glycation endproducts: From precursors to RAGE: Round and round we go
-
Ramasamy R, Yan SF, Schmidt AM. Advanced glycation endproducts: From precursors to RAGE: Round and round we go. Amino Acids 42(4), 1151-1161 (2010
-
(2010)
Amino Acids
, vol.42
, Issue.4
, pp. 1151-1161
-
-
Ramasamy, R.1
Yan, S.F.2
Schmidt, A.M.3
-
9
-
-
67349265963
-
Binding of S100 proteins to RAGE: An update
-
Leclerc E, Fritz G, Vetter SW, Heizmann CW. Binding of S100 proteins to RAGE: An update. Biochim. Biophys. Acta 1793(6), 993-1007 (2009
-
(2009)
Biochim. Biophys. Acta
, vol.1793
, Issue.6
, pp. 993-1007
-
-
Leclerc, E.1
Fritz, G.2
Vetter, S.W.3
Heizmann, C.W.4
-
10
-
-
69249100372
-
RAGE: Therapeutic target and biomarker of the inflammatory response - The evidence mounts
-
Develops the possibility of RAGE as a therapeutic target
-
Ramasamy R, Yan SF, Schmidt AM. RAGE: Therapeutic target and biomarker of the inflammatory response - the evidence mounts. J. Leukoc. Biol. 86(3), 505-512 (2009). Develops the possibility of RAGE as a therapeutic target.
-
(2009)
J. Leukoc. Biol.
, vol.86
, Issue.3
, pp. 505-512
-
-
Ramasamy, R.1
Yan, S.F.2
Schmidt, A.M.3
-
11
-
-
33845681592
-
Soluble receptor for advanced glycation end products triggers a proinflammatory cytokine cascade via beta2 integrin Mac-1
-
Pullerits R, Brisslert M, Jonsson IM, Tarkowski A. Soluble receptor for advanced glycation end products triggers a proinflammatory cytokine cascade via beta2 integrin Mac-1. Arthritis Rheum. 54(12), 3898-3907 (2006
-
(2006)
Arthritis Rheum.
, vol.54
, Issue.12
, pp. 3898-3907
-
-
Pullerits, R.1
Brisslert, M.2
Jonsson, I.M.3
Tarkowski, A.4
-
12
-
-
79953316593
-
Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells
-
He M, Kubo H, Morimoto K et al. Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells. EMBO J. 12(4), 358-364 (2011
-
(2011)
EMBO J.
, vol.12
, Issue.4
, pp. 358-364
-
-
He, M.1
Kubo, H.2
Morimoto, K.3
-
13
-
-
79952751056
-
Septic shock is associated with receptor for advanced glycation end products ligation of LPS
-
Yamamoto Y, Harashima A, Saito H et al. Septic shock is associated with receptor for advanced glycation end products ligation of LPS. J. Immunol. 186(5), 3248-3257 (2011
-
(2011)
J. Immunol.
, vol.186
, Issue.5
, pp. 3248-3257
-
-
Yamamoto, Y.1
Harashima, A.2
Saito, H.3
-
14
-
-
0342646984
-
Interaction of the receptor for advanced glycation end products (RAGE) with transthyretin triggers nuclear transcription factor kB (NF-kB) activation
-
Sousa MM, Yan SD, Stern D, Saraiva MJ. Interaction of the receptor for advanced glycation end products (RAGE) with transthyretin triggers nuclear transcription factor kB (NF-kB) activation. Lab. Invest. J. Tech. Methods Pathol. 80(7), 1101-1110 (2000
-
(2000)
Lab. Invest. J. Tech. Methods Pathol.
, vol.80
, Issue.7
, pp. 1101-1110
-
-
Sousa, M.M.1
Yan, S..D.2
Stern, D.3
Saraiva, M.J.4
-
15
-
-
33646925693
-
In vitro inhibition of transthyretin aggregate-induced cytotoxicity by full and peptide derived forms of the soluble receptor for advanced glycation end products (RAGE
-
Monteiro FA, Cardoso I, Sousa MM, Saraiva MJ. In vitro inhibition of transthyretin aggregate-induced cytotoxicity by full and peptide derived forms of the soluble receptor for advanced glycation end products (RAGE). FEBS Lett. 580(14), 3451-3456 (2006
-
(2006)
FEBS Lett.
, vol.580
, Issue.14
, pp. 3451-3456
-
-
Monteiro, F.A.1
Cardoso, I.2
Sousa, M.M.3
Saraiva, M.J.4
-
16
-
-
45549097081
-
Site-specific blockade of RAGE-Vd prevents amyloid-beta oligomer neurotoxicity
-
Reports that V domain interacts with Ab
-
Sturchler E, Galichet A, Weibel M, Leclerc E, Heizmann CW. Site-specific blockade of RAGE-Vd prevents amyloid-beta oligomer neurotoxicity. J. Neurosci. 28(20), 5149-5158 (2008). Reports that V domain interacts with Ab.
-
(2008)
J. Neurosci.
, vol.28
, Issue.20
, pp. 5149-5158
-
-
Sturchler, E.1
Galichet, A.2
Weibel, M.3
Leclerc, E.4
Heizmann, C.W.5
-
17
-
-
54049108485
-
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10
-
Discusses soluble RAGE
-
Raucci A, Cugusi S, Antonelli A et al. A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10). FASEB J. 22(10), 3716-3727 (2008). Discusses soluble RAG.E.
-
(2008)
FASEB J.
, vol.22
, Issue.10
, pp. 3716-3727
-
-
Raucci, A.1
Cugusi, S.2
Antonelli, A.3
-
18
-
-
67649344400
-
Alternative splicing of the murine receptor for advanced glycation end-products (RAGE) gene
-
Kalea AZ, Reiniger N, Yang H, Arriero M, Schmidt AM, Hudson BI. Alternative splicing of the murine receptor for advanced glycation end-products (RAGE) gene. FASEB J. 23(6), 1766-1774 (2009
-
(2009)
FASEB J.
, vol.23
, Issue.6
, pp. 1766-1774
-
-
Kalea, A.Z.1
Reiniger, N.2
Yang, H.3
Arriero, M.4
Schmidt, A.M.5
Hudson, B.I.6
-
19
-
-
0032529151
-
Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1-40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer
-
Mackic JB, Stins M, Mccomb JG et al. Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1-40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J. Clin. Invest. 102(4), 734-743 (1998
-
(1998)
J. Clin. Invest.
, vol.102
, Issue.4
, pp. 734-743
-
-
Mackic, J.B.1
Stins, M.2
Mccomb, J.G.3
-
20
-
-
8144223671
-
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice
-
Arancio O, Zhang HP, Chen X et al. RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice. EMBO J. 23(20), 4096-4105 (2004
-
(2004)
EMBO J.
, vol.23
, Issue.20
, pp. 4096-4105
-
-
Arancio, O.1
Zhang, H.P.2
Chen, X.3
-
21
-
-
0001358519
-
Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis
-
Yan SD, Zhu H, Zhu A et al. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis. Nat. Med. 6(6), 643-651 (2000
-
(2000)
Nat. Med.
, vol.6
, Issue.6
, pp. 643-651
-
-
Yan, S..D.1
Zhu, H.2
Zhu, A.3
-
22
-
-
67649739088
-
RAGE and Alzheimer's disease: A progression factor for amyloid-beta-induced cellular perturbation?
-
Yan SD, Bierhaus A, Nawroth PP, Stern DM. RAGE and Alzheimer's disease: A progression factor for amyloid-beta-induced cellular perturbation? J. Alzheimers Dis. 16(4), 833-843 (2009
-
(2009)
J. Alzheimers Dis.
, vol.16
, Issue.4
, pp. 833-843
-
-
Yan, S..D.1
Bierhaus, A.2
Nawroth, P.P.3
Stern, D.M.4
-
23
-
-
67649562150
-
Involvement of the receptor for advanced glycation-end products (RAGE) in beta-Amyloid-induced toxic effects in rat cerebromicrovascular endothelial cells cultured in vitro
-
Baiguera S, Fioravanzo L, Grandi C, Di Liddo R, Parnigotto PP, Folin M. Involvement of the receptor for advanced glycation-end products (RAGE) in beta-Amyloid-induced toxic effects in rat cerebromicrovascular endothelial cells cultured in vitro. Int. J. Mol. Med. 24(1), 9-15 (2009
-
(2009)
Int. J. Mol. Med.
, vol.24
, Issue.1
, pp. 9-15
-
-
Baiguera, S.1
Fioravanzo, L.2
Grandi, C.3
Di Liddo, R.4
Parnigotto, P.P.5
Folin, M.6
-
24
-
-
26444436438
-
The RAGE axis and endothelial dysfunction: Maladaptive roles in the diabetic vasculature and beyond
-
Ramasamy R, Yan SF, Schmidt AM. The RAGE axis and endothelial dysfunction: Maladaptive roles in the diabetic vasculature and beyond. Trends Cardiovasc. Med. 15(7), 237-243 (2005
-
(2005)
Trends Cardiovasc. Med.
, vol.15
, Issue.7
, pp. 237-243
-
-
Ramasamy, R.1
Yan, S.F.2
Schmidt, A.M.3
-
25
-
-
67650444350
-
Upregulation of RAGE at the blood-brain barrier in streptozotocin-induced diabetic mice
-
Liu LP, Hong H, Liao JM et al. Upregulation of RAGE at the blood-brain barrier in streptozotocin-induced diabetic mice. Synapse 63(8), 636-642 (2009
-
(2009)
Synapse
, vol.63
, Issue.8
, pp. 636-642
-
-
Liu, L.P.1
Hong, H.2
Liao, J.M.3
-
26
-
-
43049127240
-
V domain of RAGE interacts with AGEs on prostate carcinoma cells
-
Allmen EU, Koch M, Fritz G, Legler DF. V domain of RAGE interacts with AGEs on prostate carcinoma cells. Prostate 68(7), 748-758 (2008
-
(2008)
Prostate
, vol.68
, Issue.7
, pp. 748-758
-
-
Allmen, E.U.1
Koch, M.2
Fritz, G.3
Legler, D.F.4
-
27
-
-
67651099181
-
Regulation of advanced glycation end product (AGE)-receptor (RAGE) system by PPAR-gamma agonists and its implication in cardiovascular disease
-
Yamagishi S, Nakamura K, Matsui T. Regulation of advanced glycation end product (AGE)-receptor (RAGE) system by PPAR-gamma agonists and its implication in cardiovascular disease. Pharm. Res. 60(3), 174-178 (2009
-
(2009)
Pharm. Res.
, vol.60
, Issue.3
, pp. 174-178
-
-
Yamagishi, S.1
Nakamura, K.2
Matsui, T.3
-
28
-
-
77950898257
-
The RAGE axis: A fundamental mechanism signaling danger to the vulnerable vasculature
-
Reviews the RAGE-ligand axis
-
Yan SF, Ramasamy R, Schmidt AM. The RAGE axis: A fundamental mechanism signaling danger to the vulnerable vasculature. Circ. Res. 106(5), 842-853 (2010). Reviews the RAGE-ligand axis.
-
(2010)
Circ. Res.
, vol.106
, Issue.5
, pp. 842-853
-
-
Yan, S.F.1
Ramasamy, R.2
Schmidt, A.M.3
-
29
-
-
33646435289
-
The ligand/RAGE axis: Lighting the fuse and igniting vascular stress
-
Discusses RAGE and vascular stress
-
Yan SF, Naka Y, Hudson BI et al. The ligand/RAGE axis: Lighting the fuse and igniting vascular stress. Curr. Atheroscler. Rep. 8(3), 232-239 (2006). Discusses RAGE and vascular stress.
-
(2006)
Curr. Atheroscler. Rep.
, vol.8
, Issue.3
, pp. 232-239
-
-
Yan, S.F.1
Naka, Y.2
Hudson, B.I.3
-
30
-
-
68149132859
-
The role of RAGE in amyloid-beta peptide-mediated pathology in Alzheimer's disease
-
Schmidt AM, Sahagan B, Nelson RB, Selmer J, Rothlein R, Bell JM. The role of RAGE in amyloid-beta peptide-mediated pathology in Alzheimer's disease. Curr. Opin. Investig. Drugs 10(7), 672-680 (2009
-
(2009)
Curr. Opin. Investig. Drugs
, vol.10
, Issue.7
, pp. 672-680
-
-
Schmidt, A.M.1
Sahagan, B.2
Nelson, R.B.3
Selmer, J.4
Rothlein, R.5
Bell, J.M.6
-
31
-
-
0042697530
-
Glycation and diabetes: The RAGE connection
-
Hudson BI, Hofmann MA, Bucciarelli L et al. Glycation and diabetes: The RAGE connection. Curr. Sci. 83(12), 1515-1521 (2002
-
(2002)
Curr. Sci.
, vol.83
, Issue.12
, pp. 1515-1521
-
-
Hudson, B.I.1
Hofmann, M.A.2
Bucciarelli, L.3
-
32
-
-
43249092154
-
Identification, classification, and expression of RAGE gene splice variants
-
Hudson BI, Carter AM, Harja E et al. Identification, classification, and expression of RAGE gene splice variants. FASEB J. 22(5), 1572-1580 (2008
-
(2008)
FASEB J.
, vol.22
, Issue.5
, pp. 1572-1580
-
-
Hudson, B.I.1
Carter, A.M.2
Harja, E.3
-
33
-
-
78650341420
-
The 1.5 A° crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding
-
Describes RAGE structure and its ligand binding
-
Park H, Adsit FG, Boyington JC. The 1.5 A° crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding. J. Biol. Chem. 285(52), 40762-40770 (2010).Describes RAGE structure and its ligand binding.
-
(2010)
J. Biol. Chem.
, vol.285
, Issue.52
, pp. 40762-40770
-
-
Park, H.1
Adsit, F.G.2
Boyington, J.C.3
-
34
-
-
34250171731
-
The extracellular region of the receptor for advanced glycation end products is composed of two independent structural units
-
Dattilo BM, Fritz G, Leclerc E, Kooi CW, Heizmann CW, Chazin WJ. The extracellular region of the receptor for advanced glycation end products is composed of two independent structural units. Biochemistry 46(23), 6957-6970 (2007
-
(2007)
Biochemistry
, vol.46
, Issue.23
, pp. 6957-6970
-
-
Dattilo, B.M.1
Fritz, G.2
Leclerc, E.3
Kooi, C.W.4
Heizmann, C.W.5
Chazin, W.J.6
-
35
-
-
79953891845
-
Pattern recognition with a fibril-specific antibody fragment reveals the surface variability of natural amyloid fibrils
-
Haupt C, Bereza M, Kumar ST et al. Pattern recognition with a fibril-specific antibody fragment reveals the surface variability of natural amyloid fibrils. J. Mol. Biol. 408(3), 529-540 (2011
-
(2011)
J. Mol. Biol.
, vol.408
, Issue.3
, pp. 529-540
-
-
Haupt, C.1
Bereza, M.2
Kumar, S.T.3
-
36
-
-
10744229528
-
The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: A novel pathway for inflammatory cell recruitment
-
Chavakis T, Bierhaus A, Al-Fakhri N et al. The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: A novel pathway for inflammatory cell recruitment. J. Exp. Med. 198(10), 1507-1515 (2003
-
(2003)
J. Exp. Med.
, vol.198
, Issue.10
, pp. 1507-1515
-
-
Chavakis, T.1
Bierhaus, A.2
Al-Fakhri, N.3
-
37
-
-
55249118389
-
Structural basis for pattern recognition by the receptor for advanced glycation end products (RAGE
-
Paper on RAGE as a pattern receptor
-
Xie J, Reverdatto S, Frolov A, Hoffmann R, Burz DS, Shekhtman A. Structural basis for pattern recognition by the receptor for advanced glycation end products (RAGE). J. Biol. Chem. 283(40), 27255-27269 (2008). Paper on RAGE as a pattern receptor.
-
(2008)
J. Biol. Chem.
, vol.283
, Issue.40
, pp. 27255-27269
-
-
Xie, J.1
Reverdatto, S.2
Frolov, A.3
Hoffmann, R.4
Burz, D.S.5
Shekhtman, A.6
-
38
-
-
80054814015
-
Solution structure of the soluble receptor for advanced glycation end products (sRAGE
-
Describes RAGE-ligand interactions
-
Sarkany Z, Ikonen TP, Ferreira-Da-Silva F, Saraiva MJ, Svergun D, Damas AM. Solution structure of the soluble receptor for advanced glycation end products (sRAGE). J. Biol. Chem. 286(43), 37525-37534 (2011). Describes RAGE-ligand interactions.
-
(2011)
J. Biol. Chem.
, vol.286
, Issue.43
, pp. 37525-37534
-
-
Sarkany, Z.1
Ikonen, T.P.2
Ferreira-Da-Silva, F.3
Saraiva, M.J.4
Svergun, D.5
Damas, A.M.6
-
39
-
-
79955825348
-
Advanced glycation end product recognition by the receptor for AGEs
-
Xue J, Rai V, Singer D et al. Advanced glycation end product recognition by the receptor for AGEs. Structure 19(5), 722-732 (2011
-
(2011)
Structure
, vol.19
, Issue.5
, pp. 722-732
-
-
Xue, J.1
Rai, V.2
Singer, D.3
-
40
-
-
79955115531
-
Binding studies of truncated variants of the Ab peptide to the V-domain of the RAGE receptor reveal Ab residues responsible for binding
-
Discusses RAGE-Ab interaction
-
Gospodarska E, Kupniewska-Kozak A, Goch G, Dadlez M. Binding studies of truncated variants of the Ab peptide to the V-domain of the RAGE receptor reveal Ab residues responsible for binding. Biochim. Biophys. Acta 1814(5), 592-609 (2011). Discusses RAGE-Ab interaction.
-
(2011)
Biochim. Biophys. Acta
, vol.1814
, Issue.5
, pp. 592-609
-
-
Gospodarska, E.1
Kupniewska-Kozak, A.2
Goch, G.3
Dadlez, M.4
-
42
-
-
17144430517
-
Roles of the receptor for advanced glycation endproducts in diabetes-induced vascular injury
-
Yonekura H, Yamamoto Y, Sakurai S, Watanabe T, Yamamoto H. Roles of the receptor for advanced glycation endproducts in diabetes-induced vascular injury. J. Pharmacol. Sci. 97(3), 305-311 (2005
-
(2005)
J. Pharmacol. Sci.
, vol.97
, Issue.3
, pp. 305-311
-
-
Yonekura, H.1
Yamamoto, Y.2
Sakurai, S.3
Watanabe, T.4
Yamamoto, H.5
-
44
-
-
67651180986
-
The amyloid hypothesis for Alzheimer's disease: A critical reappraisal
-
Hardy J. The amyloid hypothesis for Alzheimer's disease: A critical reappraisal. J. Neurochem. 110(4), 1129-1134 (2009
-
(2009)
J. Neurochem.
, vol.110
, Issue.4
, pp. 1129-1134
-
-
Hardy, J.1
-
45
-
-
7644225312
-
RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier
-
Deane R, Wu Z, Zlokovic BV. RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke 35(11 Suppl. 1), 2628-2631 (2004
-
(2004)
Stroke
, vol.35
, Issue.11 SUPPL. 1
, pp. 2628-2631
-
-
Deane, R.1
Wu, Z.2
Zlokovic, B.V.3
-
46
-
-
0033943469
-
Clearance of amyloid beta-peptide from brain: Transport or metabolism?
-
Zlokovic BV, Yamada S, Holtzman D, Ghiso J, Frangione B. Clearance of amyloid beta-peptide from brain: Transport or metabolism? Nat. Med. 6(7), 718-719 (2000
-
(2000)
Nat. Med.
, vol.6
, Issue.7
, pp. 718-719
-
-
Zlokovic, B.V.1
Yamada, S.2
Holtzman, D.3
Ghiso, J.4
Frangione, B.5
-
47
-
-
0034521392
-
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
-
Shibata M, Yamada S, Kumar SR et al. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J. Clin. Invest. 106(12), 1489-1499 (2000
-
(2000)
J. Clin. Invest.
, vol.106
, Issue.12
, pp. 1489-1499
-
-
Shibata, M.1
Yamada, S.2
Kumar, S.R.3
-
48
-
-
4444276735
-
Clearance of Alzheimer's Abeta peptide: The many roads to perdition
-
Tanzi RE, Moir RD, Wagner SL. Clearance of Alzheimer's Abeta peptide: The many roads to perdition. Neuron 43(5), 605-608 (2004
-
(2004)
Neuron
, vol.43
, Issue.5
, pp. 605-608
-
-
Tanzi, R.E.1
Moir, R..D.2
Wagner, S.L.3
-
49
-
-
38149090292
-
The blood-brain barrier in health and chronic neurodegenerative disorders
-
Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57(2), 178-201 (2008
-
(2008)
Neuron
, vol.57
, Issue.2
, pp. 178-201
-
-
Zlokovic, B.V.1
-
50
-
-
4043061467
-
LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms
-
Deane R, Wu Z, Sagare A et al. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron 43(3), 333-344 (2004
-
(2004)
Neuron
, vol.43
, Issue.3
, pp. 333-344
-
-
Deane, R.1
Wu, Z.2
Sagare, A.3
-
51
-
-
33749157416
-
RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease
-
Donahue JE, Flaherty SL, Johanson CE et al. RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease. Acta Neuropathol. 112(4), 405-415 (2006
-
(2006)
Acta Neuropathol.
, vol.112
, Issue.4
, pp. 405-415
-
-
Donahue, J.E.1
Flaherty, S.L.2
Johanson, C.E.3
-
52
-
-
54049094343
-
Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease
-
Miller MC, Tavares R, Johanson CE et al. Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease. Brain Res. 1230, 273-280 (2008
-
(2008)
Brain Res.
, vol.1230
, pp. 273-280
-
-
Miller, M.C.1
Tavares, R.2
Johanson, C.E.3
-
53
-
-
74049111316
-
Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging
-
Silverberg GD, Miller MC, Messier AA et al. Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging. J. Neuropathol. Exp. Neurol. 69(1), 98-108 (2010
-
(2010)
J. Neuropathol. Exp. Neurol.
, vol.69
, Issue.1
, pp. 98-108
-
-
Silverberg, G..D.1
Miller, M.C.2
Messier, A.A.3
-
54
-
-
33847627937
-
Inhibition of Abeta production by NF-kappaB inhibitors
-
Paris D, Patel N, Quadros A et al. Inhibition of Abeta production by NF-kappaB inhibitors. Neurosci. Lett. 415(1), 11-16 (2007
-
(2007)
Neurosci. Lett.
, vol.415
, Issue.1
, pp. 11-16
-
-
Paris, D.1
Patel, N.2
Quadros, A.3
-
55
-
-
34248178463
-
Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-Amyloid peptides
-
Bourne KZ, Ferrari DC, Lange-Dohna C, Rossner S, Wood TG, Perez-Polo JR. Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-Amyloid peptides. J. Neurosci. Res. 85(6), 1194-1204 (2007
-
(2007)
J. Neurosci. Res.
, vol.85
, Issue.6
, pp. 1194-1204
-
-
Bourne, K.Z.1
Ferrari, D.C.2
Lange-Dohna, C.3
Rossner, S.4
Wood, T.G.5
Perez-Polo, J.R.6
-
56
-
-
0033370498
-
Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice
-
Benzing WC, Wujek JR, Ward EK et al. Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice. Neurobiol. Aging 20(6), 581-589 (1999
-
(1999)
Neurobiol. Aging
, vol.20
, Issue.6
, pp. 581-589
-
-
Benzing, W.C.1
Wujek, J.R.2
Ward, E.K.3
-
57
-
-
0035704245
-
Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease
-
Sly LM, Krzesicki RF, Brashler JR et al. Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease. Brain Res. Bull. 56(6), 581-588 (2001
-
(2001)
Brain Res. Bull.
, vol.56
, Issue.6
, pp. 581-588
-
-
Sly, L.M.1
Krzesicki, R.F.2
Brashler, J.R.3
-
58
-
-
0034130707
-
Cell mediators of inflammation in the Alzheimer disease brain
-
Akiyama H, Arai T, Kondo H, Tanno E, Haga C, Ikeda K. Cell mediators of inflammation in the Alzheimer disease brain. Alzheimer Dis. Assoc. Disord. 14(Suppl. 1), S47-S53 (2000
-
(2000)
Alzheimer Dis. Assoc. Disord.
, vol.14
, Issue.SUPPL. 1
-
-
Akiyama, H.1
Arai, T.2
Kondo, H.3
Tanno, E.4
Haga, C.5
Ikeda, K.6
-
59
-
-
33748471099
-
Inflammation in Alzheimer disease: Driving force, bystander or beneficial response?
-
Wyss-Coray T. Inflammation in Alzheimer disease: Driving force, bystander or beneficial response? Nat. Med. 12(9), 1005-1015 (2006
-
(2006)
Nat. Med.
, vol.12
, Issue.9
, pp. 1005-1015
-
-
Wyss-Coray, T.1
-
60
-
-
0031974406
-
Microglial response to amyloid plaques in APPsw transgenic mice
-
Frautschy SA, Yang F, Irrizarry M et al. Microglial response to amyloid plaques in APPsw transgenic mice. Am. J. Pahol. 152(1), 307-317 (1998
-
(1998)
Am. J. Pahol.
, vol.152
, Issue.1
, pp. 307-317
-
-
Frautschy, S.A.1
Yang, F.2
Irrizarry, M.3
-
61
-
-
51149120624
-
Microglial dysfunction and defective beta-Amyloid clearance pathways in aging Alzheimer's disease mice
-
Hickman SE, Allison EK, El Khoury J. Microglial dysfunction and defective beta-Amyloid clearance pathways in aging Alzheimer's disease mice. J. Neurosci. 28(33), 8354-8360 (2008
-
(2008)
J. Neurosci.
, vol.28
, Issue.33
, pp. 8354-8360
-
-
Hickman, S.E.1
Allison, E.K.2
El Khoury, J.3
-
62
-
-
74949127437
-
Formation and maintenance of Alzheimer's disease beta-Amyloid plaques in the absence of microglia
-
Grathwohl SA, Kalin RE, Bolmont T et al. Formation and maintenance of Alzheimer's disease beta-Amyloid plaques in the absence of microglia. Nat. Neurosci. 12(11), 1361-1363 (2009
-
(2009)
Nat. Neurosci.
, vol.12
, Issue.11
, pp. 1361-1363
-
-
Grathwohl, S.A.1
Kalin, R.E.2
Bolmont, T.3
-
63
-
-
70349323417
-
CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation
-
Reed-Geaghan EG, Savage JC, Hise AG, Landreth GE. CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. J. Neurosci. 29(38), 11982-11992 (2009
-
(2009)
J. Neurosci.
, vol.29
, Issue.38
, pp. 11982-11992
-
-
Reed-Geaghan, E.G.1
Savage, J.C.2
Hise, A.G.3
Landreth, G.E.4
-
64
-
-
24744467358
-
Microglial phagocytosis induced by fibrillar beta-Amyloid and IgGs are differentially regulated by proinflammatory cytokines
-
Koenigsknecht-Talboo J, Landreth GE. Microglial phagocytosis induced by fibrillar beta-Amyloid and IgGs are differentially regulated by proinflammatory cytokines. J. Neurosci. 25(36), 8240-8249 (2005
-
(2005)
J. Neurosci.
, vol.25
, Issue.36
, pp. 8240-8249
-
-
Koenigsknecht-Talboo, J.1
Landreth, G.E.2
-
65
-
-
34147115541
-
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
-
El Khoury J, Toft M, Hickman SE et al. Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat. Med. 13(4), 432-438 (2007
-
(2007)
Nat. Med.
, vol.13
, Issue.4
, pp. 432-438
-
-
El Khoury, J.1
Toft, M.2
Hickman, S.E.3
-
66
-
-
0033639245
-
Beta-Amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1
-
Giri R, Shen Y, Stins M et al. Beta-Amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. Am. J. Physiol. Cell Physiol. 279(6), C1772-C1781 (2000
-
(2000)
Am. J. Physiol. Cell Physiol.
, vol.279
, Issue.6
-
-
Giri, R.1
Shen, Y.2
Stins, M.3
-
67
-
-
57149101898
-
Chronic neuron-specific tumor necrosis factor-Alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice
-
Janelsins MC, Mastrangelo MA, Park KM et al. Chronic neuron-specific tumor necrosis factor-Alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. Am. J. Pathol. 173(6), 1768-1782 (2008
-
(2008)
Am. J. Pathol.
, vol.173
, Issue.6
, pp. 1768-1782
-
-
Janelsins, M.C.1
Mastrangelo, M.A.2
Park, K.M.3
-
68
-
-
70350482470
-
Tumor necrosis factor-Alpha-mediated regulation of the inositol 1,4,5-Trisphosphate receptor promoter
-
Park KM, Yule DI, Bowers WJ. Tumor necrosis factor-Alpha-mediated regulation of the inositol 1,4,5-Trisphosphate receptor promoter. J. Biol. Chem. 284(40), 27557-27566 (2009
-
(2009)
J. Biol. Chem.
, vol.284
, Issue.40
, pp. 27557-27566
-
-
Park, K.M.1
Yule, D.I.2
Bowers, W.J.3
-
69
-
-
33947545098
-
Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid
-
Fan R, Xu F, Previti ML et al. Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid. J. Neurosci. 27(12), 3057-3063 (2007
-
(2007)
J. Neurosci.
, vol.27
, Issue.12
, pp. 3057-3063
-
-
Fan, R.1
Xu, F.2
Previti, M.L.3
-
70
-
-
75849133906
-
Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease
-
Mori T, Koyama N, Arendash GW, Horikoshi-Sakuraba Y, Tan J, Town T. Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease. Glia 58(3), 300-314 (2010
-
(2010)
Glia
, vol.58
, Issue.3
, pp. 300-314
-
-
Mori, T.1
Koyama, N.2
Arendash, G.W.3
Horikoshi-Sakuraba, Y.4
Tan, J.5
Town, T.6
-
71
-
-
79953693557
-
S100B alters neuronal survival and dendrite extension via RAGE-mediated NF-kappaB signaling
-
Villarreal A, Aviles Reyes RX, Angelo MF, Reines AG, Ramos AJ. S100B alters neuronal survival and dendrite extension via RAGE-mediated NF-kappaB signaling. J. Neurochem. 117(2), 321-332 (2011
-
(2011)
J. Neurochem.
, vol.117
, Issue.2
, pp. 321-332
-
-
Villarreal, A.1
Aviles Reyes, R.X.2
Angelo, M.F.3
Reines, A.G.4
Ramos, A.J.5
-
72
-
-
84861047683
-
Tertiary amide preferentially blocks Ab/RAGE interaction without causing toxicity
-
Presented at: Washington, DC, USA, 12-16 November
-
Deane R, Singh I, Sagare AP et al. Tertiary amide preferentially blocks Ab/RAGE interaction without causing toxicity. Presented at: Society for Neuroscience. Washington, DC, USA, 12-16 November 2011.
-
(2011)
Society for Neuroscience
-
-
Deane, R.1
Singh, I.2
Sagare, A.P.3
-
73
-
-
84861074104
-
Tertiary amide reduced BACE1 activity and Ab production in a mouse model of AD
-
Presented at: San Diego, CA, USA, 13-17 November
-
Deane R, Singh I, Sagare A et al. Tertiary amide reduced BACE1 activity and Ab production in a mouse model of AD. Presented at: Society for Neuroscience. San Diego, CA, USA, 13-17 November 2010.
-
(2010)
Society for Neuroscience
-
-
Deane, R.1
Singh, I.2
Sagare, A.3
-
74
-
-
84861047687
-
Differential action of lipophilic and hydrophilic tertiary amide-based RAGE/Ab blockers in a mouse model of AD
-
Presented at: Chicago, IL, USA, 17-21 November
-
Deane R, Singh I, Love R et al. Differential action of lipophilic and hydrophilic tertiary amide-based RAGE/Ab blockers in a mouse model of AD. Presented at: Society for Neuroscience. Chicago, IL, USA, 17-21 November 2009.
-
(2009)
Society for Neuroscience
-
-
Deane, R.1
Singh, I.2
Love, R.3
-
75
-
-
84861047684
-
Tertiary amide improves cerebral blood flow and behavioral performance in a mouse model of AD by blocking RAGE/Ab interaction
-
Presented at: Washington, DC, USA, 15-19 November
-
Deane R, Sagare A, Paquette N et al. Tertiary amide improves cerebral blood flow and behavioral performance in a mouse model of AD by blocking RAGE/Ab interaction. Presented at: Society for Neuroscience. Washington, DC, USA, 15-19 November 2008.
-
(2008)
Society for Neuroscience
-
-
Deane, R.1
Sagare, A.2
Paquette, N.3
-
76
-
-
84861074103
-
Tertiary amides block RAGE-mediated Ab transport into brain in a mouse model of AD
-
Presented at: Atlanta, GA, USA, 14-18 October
-
Deane R, Perry S, Sagare A et al. Tertiary amides block RAGE-mediated Ab transport into brain in a mouse model of AD. Presented at: Society for Neuroscience. Atlanta, GA, USA, 14-18 October 2006.
-
(2006)
Society for Neuroscience
-
-
Deane, R.1
Perry, S.2
Sagare, A.3
-
77
-
-
84859723641
-
A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease
-
Key paper on a type of tertiary amide as a RAGE blocker
-
Deane R, Singh I, Sagare AP et al. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J. Clin. Invest. 122(4), 1377-1392 (2012). n Key paper on a type of tertiary amide as a RAGE blocker.
-
(2012)
J. Clin. Invest.
, vol.122
, Issue.4
, pp. 1377-1392
-
-
Deane, R.1
Singh, I.2
Sagare, A.P.3
-
78
-
-
77954057601
-
Deletion of RAGE causes hyperactivity and increased sensitivity to auditory stimuli in mice
-
Sakatani S, Yamada K, Homma C et al. Deletion of RAGE causes hyperactivity and increased sensitivity to auditory stimuli in mice. PLoS ONE 4(12), e8309 (2009).
-
(2009)
PLoS ONE
, vol.4
, Issue.12
-
-
Sakatani, S.1
Yamada, K.2
Homma, C.3
|