8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 48, 2008, Pages 18877-18882

  Saxowsky, Tina T ^a   Meadows, Kellen L ^a,c   Klungland, Arne ^b   Doetsch, Paul W ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OSLO   (Norway)

^c DUKE CLINICAL RESEARCH INSTITUTE   (United States)

Author keywords

Csb; DNA repair; MAP kinase; Transcription coupled repair; Tumorigenesis

Indexed keywords

8 HYDROXYGUANINE; COCKAYNE SYNDROME B PROTEIN; DNA GLYCOSYLTRANSFERASE; DNA GLYCOSYLTRANSFERASE OGG1; GUANINE; MUTANT PROTEIN; PHOSPHOTRANSFERASE; RAS PROTEIN; RNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL; COCKAYNE SYNDROME; CODON; CONGENIC STRAIN; DNA DAMAGE; EMBRYO; FIBROBLAST; GENE REPLICATION; GENETIC TRANSFECTION; MAMMAL CELL; MOUSE; MOUSE EMBRYO; MUTAGENESIS; MUTANT; NONHUMAN; ONCOGENE RAS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WILD TYPE;

ANIMALS; CELLS, CULTURED; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; DNA REPAIR ENZYMES; ENZYME ACTIVATION; FIBROBLASTS; GUANINE; HUMANS; MICE; MICE, KNOCKOUT; MUTAGENESIS; RAS PROTEINS; TRANSCRIPTION, GENETIC;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 57749121608     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0806464105     Document Type: Article

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