Nose-to-brain transport pathways of wheat germ agglutinin conjugated PEG-PLA nanoparticles

Pharmaceutical Research

Volumn 29, Issue 2, 2012, Pages 546-558

  Liu, Qingfeng ^a,b   Shen, Yehong ^a,b   Chen, Jie ^a,b   Gao, Xiaoling ^c   Feng, Chengcheng ^a,b   Wang, Lu ^a,b   Zhang, Qizhi ^a,b   Jiang, Xinguo ^a,b  

^a FUDAN UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

CNS; Nasal route; Olfactory pathway; Trigeminal nerve pathway; WGA NP

Indexed keywords

6 COUMARIN; COUMARIN DERIVATIVE; IODINE 125; MACROGOL 3000; NANOPARTICLE; POLYLACTIC ACID; POLYLACTIC ACID 50000; POLYLACTIC ACID 70000; UNCLASSIFIED DRUG; WHEAT GERM AGGLUTININ; COUMARIN 6; MACROGOL DERIVATIVE; MONOMETHOXYPOLYETHYLENEGLYCOL POLYLACTIDE BLOCK COPOLYMER; MONOMETHOXYPOLYETHYLENEGLYCOL-POLYLACTIDE BLOCK COPOLYMER; THIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CONNECTIVE TISSUE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG RELEASE; DRUG TRANSPORT; EX VIVO STUDY; IMAGE ANALYSIS; ISOTOPE LABELING; LAMINA PROPRIA; MALE; NANOENCAPSULATION; NONHUMAN; OLFACTORY BULB; OLFACTORY EPITHELIUM; OLFACTORY NERVE; OLFACTORY SYSTEM; PRIORITY JOURNAL; RAT; TRIGEMINAL NERVE; ANIMAL; BRAIN; CHEMISTRY; INTRANASAL DRUG ADMINISTRATION; METABOLISM; NOSE; SPRAGUE DAWLEY RAT; TRANSPORT AT THE CELLULAR LEVEL;

ADMINISTRATION, INTRANASAL; ANIMALS; BIOLOGICAL TRANSPORT; BRAIN; COUMARINS; NANOPARTICLES; NOSE; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; THIAZOLES; WHEAT GERM AGGLUTININS;

EID: 84860880165     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0641-0     Document Type: Article

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