In vivo gene transfer to the mouse nasal cavity mucosa using a stable cationic lipid emulsion

Molecules and Cells

Volumn 10, Issue 2, 2000, Pages 142-147

  Kim, Tae Woo ^a,b   Chung, Hesson ^a   Kwon, Ick Chan ^a   Sung, Ha Chin ^b   Jeong, Seo Young ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Korea University   (South Korea)

Author keywords

DNA Delivery; Heparin; In Vivo Transfection; Liposome; Nasal Mucosa; Physicochemical property

Indexed keywords

GLYCINE MAX;

1,2 DIOLEOYLOXY 3 (TRIMETHYLAMMONIUM)PROPANE; 1,2-DIOLEOYLOXY-3-(TRIMETHYLAMMONIUM)PROPANE; CATION; HEPARIN; LIPID; LIPOSOME; MONOUNSATURATED FATTY ACID; QUATERNARY AMMONIUM DERIVATIVE; SOYBEAN OIL;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CHEMISTRY; EMULSION; EPITHELIUM CELL; GENE EXPRESSION; GENE TRANSFER; HUMAN; METABOLISM; MOUSE; NOSE MUCOSA; PLASMID; REPORTER GENE;

ANIMALS; CATIONS; EMULSIONS; EPITHELIAL CELLS; FATTY ACIDS, MONOUNSATURATED; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENES, REPORTER; HEPARIN; HUMANS; LIPIDS; LIPOSOMES; MICE; MICE, INBRED BALB C; NASAL MUCOSA; PLASMIDS; QUATERNARY AMMONIUM COMPOUNDS; SOYBEAN OIL;

EID: 0034732431     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10059-000-0142-1     Document Type: Article

References (17)

1. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
2. Davies, J. C., Geddes, D. M., and Alton, E. W. (1998) Prospects for gene therapy for cystic fibrosis. Mol. Med. Today 4, 292-299.
3. De Maio, A. and Buchman, T. G. (1990) Mammalian liver contains an activity which mimics bacterial chloramphenicol acetyltransferase. Biochim. Biophys. Acta 1087, 303-308.
4. Egilmez, N. K., Iwanuma, Y., and Bankert, R. B. (1996) Evaluation and optimization of different cationic liposome formulations for in vivo gene transfer. Biochem. Biophys. Res. Commun. 221, 169-173.
5. Gao, X. and Huang, L. (1991) A novel cationic liposome reagent for efficient transfection of mammalian cells. Biochem. Biophys. Res. Commun. 179, 280-285.
6. Kim, Y. S., Lim, H. K., and Kim, K. J. (1997) Production of high-titer retroviral vectors and detection of replication-competent retroviruses. Mol. Cells 8, 36-42.
7. Klavinskis, L. S., Barnfield, C., Gao, L., and Parker, S. (1999) Intranasal immunization with plasmid DNA-lipid complexes elicits mucosal immunity in the female genital and rectal tracts. J. Immunol. 162, 254-262.
8. Liu, F., Yang, J., Huang, L., and Liu, D. (1996a) Effect of nonionic surfactants on the formation of DNA/emulsion complexes and emulsion-mediated gene transfer. Pharm. Res. 13, 1642-1646.
9. Liu, F., Yang, J., Huang, L., and Liu, D. (1996b) New cationic lipid formulations for gene transfer. Pharm. Res. 13, 1856-1860.
10. McCluskie, M. J., Chu, Y., Xia, J. L., Jessee, J., Gebyehu, G., and Davis, H. L. (1998) Direct gene transfer to the respiratory tract of mice with pure plasmid and lipid-formulated DNA. Antisense Nucleic Acid Drug Dev. 8, 401-414.
11. Okada, E., Sasaki, S., Ishii, N., Aoki, I., Yasuda, T., Nishioka, K., Fukushima, J., Miyazaki, J., Wahren, B., and Okuda, K. (1997) Intranasal immunization of a DNA vaccine with IL-12-and granulocyte-macrophage colony-stimulating factor (GM-CSP)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens. J Immunol. 159, 3638-3647.
12. Orr, C. (1983) Emulsion droplet size data; in Encyclopedia of Emulsion Technology, Becher, P. (ed.), Vol. 1, pp. 369-404, Marcel Dekker, Inc., New York and Basel.
13. Wilson, J. (1993) Cystic fibrosis. Vehicles for gene therapy. Nature 365, 691-692.
14. Xu, Y. and Szoka, F. C. (1996) Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection. Biochemistry 35, 5616-5623.
15. Yi, S. W., Yun, T. Y, Kim, T. W., Chung, H., Choi, Y. W., Kwon, I. C., Lee, E. B., and Jeong, S. Y. (2000) A cationic lipid emulsion/DNA complex as a physically stable and serum-resistant gene delivery system. Pharm. Res. 3, 313-319.
16. Zelphati, O., Uyechi, L. S., Barron, L. G., and Szoka, F. C. (1998) Effect of serum components on the physico-chemical properties of cationic lipid/oligonucleotide complexes and on their interactions with cells. Biochim. Biophys. Acta 1390, 119-133.
17. Zhu, N., Liggitt, D., Liu, Y., and Debs, R. (1993) Systemic gene expression after intravenous DNA delivery into adult mice. Science 261, 209-211.