Identification, characterization, and epitope mapping of human monoclonal antibody J19 that specifically recognizes activated integrin α4β7

Journal of Biological Chemistry

Volumn 287, Issue 19, 2012, Pages 15749-15759

  Qi, JunPeng ^a   Zhang, Kun ^a   Zhang, Qiao ^a   Sun, Yi ^a   Fu, Ting ^b   Li, GuoHui ^b   Chen, JianFeng ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; ACTIVE STATE; CRITICAL STEPS; DYNAMIC SHIFT; EPITOPE MAPPING; HIGH AFFINITY; INTEGRINS; PHAGE LIBRARIES; VARIABLE FRAGMENT; VASCULAR ENDOTHELIUM;

ADHESION; CONFORMATIONS; INDUSTRY; MANGANESE; MANGANESE COMPOUNDS; MONOCLONAL ANTIBODIES; TISSUE;

ANTIGENS;

ADENOSINE DIPHOSPHATE; ALANINE; ALPHA4BETA7 INTEGRIN; DITHIOTHREITOL; IMMUNOGLOBULIN G; INTEGRIN; MANGANESE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY J19; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; SERINE; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

ANTIBODY AFFINITY; ANTIBODY DETECTION; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; EPITOPE MAPPING; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; MOLECULAR LIBRARY; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SUBUNIT; RAT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; EPITOPE MAPPING; EPITOPES; FLOW CYTOMETRY; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN G; INTEGRINS; K562 CELLS; MICE; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; MUTATION; PEPTIDE LIBRARY; POLYSACCHARIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RATS; SINGLE-CHAIN ANTIBODIES;

EID: 84860873942     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.341263     Document Type: Article

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