Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 5, 2003, Pages 2403-2408

  Luo, Bing Hao ^a   Springer, Timothy A ^a   Takagi, Junichi ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCAN; INTEGRIN; PROTEIN SUBUNIT;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASM; GLYCOSYLATION; HUMAN; HUMAN CELL; LIGAND BINDING; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CHO CELLS; CRICETINAE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GLYCOSYLATION; HUMANS; INTEGRIN ALPHAVBETA3; INTEGRINS; LIGANDS; LINKAGE (GENETICS); MODELS, MOLECULAR; MUTATION; PHENOTYPE; PLASMIDS; POLYSACCHARIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; TRANSFECTION;

ANIMALIA;

EID: 0037418254     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0438060100     Document Type: Article

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