MicroRNAs and other mechanisms regulate interleukin-17 cytokines and receptors

Frontiers in Bioscience - Elite

Volumn 4 E, Issue 4, 2012, Pages 1478-1495

  Mai, Jietang ^a   Virtue, Anthony ^a   Maley, Erin ^a   Tran, Tran ^a   Yin, Ying ^a   Meng, Shu ^a   Pansuria, Meghana ^a   Jiang, Xiaohua ^a   Wang, Hong ^a   Yang, Xiao Feng ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gene Expression; Interleukin 17 Cytokines; Interleukin 17 Receptors; MRNA Stability; Review; Vascular Inflammation

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR; INTERLEUKIN 17F; INTERLEUKIN 27; MICRORNA; RNA BINDING PROTEIN;

3' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; ANIMAL TISSUE; ARTICLE; BINDING SITE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN STRUCTURE; DNA METHYLATION; GENE EXPRESSION PROFILING; GENETICS; PHYSIOLOGY;

3' UNTRANSLATED REGIONS; ALTERNATIVE SPLICING; DNA METHYLATION; GENE EXPRESSION PROFILING; HUMANS; INTERLEUKIN-17; MICRORNAS; RECEPTORS, INTERLEUKIN-17;

EID: 84860842285     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: None     Document Type: Article

References (102)

1. Packard, R. R., A. H. Lichtman & P. Libby: Innate and adaptive immunity in atherosclerosis. Semin Immunopathol, 31, 5-22 (2009)
2. Ait-Oufella, H., B. L. Salomon, S. Potteaux, A. K. Robertson, P. Gourdy, J. Zoll, R. Merval, B. Esposito, J. L. Cohen, S. Fisson, R. A. Flavell, G. K. Hansson, D. Klatzmann, A. Tedgui & Z. Mallat: Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med, 12, 178-80 (2006) (Pubitemid 43214743)
3. Xiong, Z., J. Song, Y. Yan, Y. Huang, A. Cowan, H. Wang & X. F. Yang: Higher expression of Bax in regulatory T cells increases vascular inflammation. Front Biosci, 13, 7143-55 (2008)
4. Xiong, Z., Y. Yan, J. Song, P. Fang, Y. Yin, Y. Yang, A. Cowan, H. Wang & X. F. Yang: Expression of TCTP antisense in CD25 (high) regulatory T cells aggravates cuff-injured vascular inflammation. Atherosclerosis, 203, 401-8 (2009)
5. Zhang, D., X. Jiang, P. Fang, Y. Yan, J. Song, S. Gupta, A. I. Schafer, W. Durante, W. D. Kruger, X. Yang & H. Wang: Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine beta-synthase-deficient mice. Circulation, 120, 1893-902 (2009)
6. Fouser, L. A., J. F. Wright, K. Dunussi-Joannopoulos & M. Collins: Th17 cytokines and their emerging roles in inflammation and autoimmunity. Immunol Rev, 226, 87-102 (2008)
7. Korn, T., E. Bettelli, M. Oukka & V. K. Kuchroo: IL-17 and Th17 Cells. Annu Rev Immunol, 27, 485-517 (2009)
8. van Es, T., G. H. van Puijvelde, O. H. Ramos, F. M. Segers, L. A. Joosten, W. B. van den Berg, I. M. Michon, P. de Vos, T. J. van Berkel & J. Kuiper: Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice. Biochem Biophys Res Commun, 388, 261-5 (2009)
9. Xie, J. J., J. Wang, T. T. Tang, J. Chen, X. L. Gao, J. Yuan, Z. H. Zhou, M. Y. Liao, R. Yao, X. Yu, D. Wang, Y. Cheng, Y. H. Liao & X. Cheng: The Th17/Treg functional imbalance during atherogenesis in ApoE (-/-) mice Th17/Treg imbalance in atherogenesis. Cytokine (2009)
10. Taleb, S., M. Romain, B. Ramkhelawon, C. Uyttenhove, G. Pasterkamp, O. Herbin, B. Esposito, N. Perez, H. Yasukawa, J. Van Snick, A. Yoshimura, A. Tedgui & Z. Mallat: Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis. J Exp Med, 206, 2067-77 (2009)
11. Erbel, C., Klingenberg, R, Celik, S, Wambsganss, N, Funke, B, Boeckler, D, Dengler, T.: Abstract 759: Inhibition of proinflammatory cytokine IL-17 reduces atherosclerotic lesion development in ApoE-/- mice. Circulation, 116, 145-146 (2007)
12. Mai, J., H Wang, X-F Yang T Helper 17 Cells Interplay with CD4+CD25highFoxp3+ Tregs in Regulation of Inflammations and Autoimmune Diseases Frontiers in Bioscience, in press, (2010)
13. Syrjala, S. O., M. A. Keranen, R. Tuuminen, A. I. Nykanen, M. Tammi, R. Krebs & K. B. Lemstrom: Increased Th17 rather than Th1 alloimmune response is associated with cardiac allograft vasculopathy after hypothermic preservation in the rat. J Heart Lung Transplant (2010)
14. Kolls, J. K. & A. Linden: Interleukin-17 family members and inflammation. Immunity, 21, 467-76 (2004) (Pubitemid 39370503)
15. Rouvier, E., M. F. Luciani, M. G. Mattei, F. Denizot & P. Golstein: CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol, 150, 5445-56 (1993) (Pubitemid 23180658)
16. Yao, Z., S. L. Painter, W. C. Fanslow, D. Ulrich, B. M. Macduff, M. K. Spriggs & R. J. Armitage: Human IL-17: a novel cytokine derived from T cells. J Immunol, 155, 5483-6 (1995)
17. Li, H., J. Chen, A. Huang, J. Stinson, S. Heldens, J. Foster, P. Dowd, A. L. Gurney & W. I. Wood: Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. Proc Natl Acad Sci U S A, 97, 773-8 (2000) (Pubitemid 30070385)
18. Lee, J., W. H. Ho, M. Maruoka, R. T. Corpuz, D. T. Baldwin, J. S. Foster, A. D. Goddard, D. G. Yansura, R. L. Vandlen, W. I. Wood & A. L. Gurney: IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL- 17Rh1. J Biol Chem, 276, 1660-4 (2001)
19. Hymowitz, S. G., E. H. Filvaroff, J. P. Yin, J. Lee, L. Cai, P. Risser, M. Maruoka, W. Mao, J. Foster, R. F. Kelley, G. Pan, A. L. Gurney, A. M. de Vos & M. A. Starovasnik: IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. Embo J, 20, 5332-41 (2001) (Pubitemid 32959452)
20. Starnes, T., M. J. Robertson, G. Sledge, S. Kelich, H. Nakshatri, H. E. Broxmeyer & R. Hromas: Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J Immunol, 167, 4137-40 (2001) (Pubitemid 32954284)
21. Park, H., Z. Li, X. O. Yang, S. H. Chang, R. Nurieva, Y. H. Wang, Y. Wang, L. Hood, Z. Zhu, Q. Tian & C. Dong: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol, 6, 1133-41 (2005) (Pubitemid 41541791)
22. Kawaguchi, M., F. Kokubu, M. Odaka, S. Watanabe, S. Suzuki, K. Ieki, S. Matsukura, M. Kurokawa, M. Adachi & S. K. Huang: Induction of granulocyte-macrophage colonystimulating factor by a new cytokine, ML-1 (IL-17F), via Raf I-MEK-ERK pathway. J Allergy Clin Immunol, 114, 444-50 (2004) (Pubitemid 39119050)
23. Awane, M., P. G. Andres, D. J. Li & H. C. Reinecker: NF-kappa B-inducing kinase is a common mediator of IL- 17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells. J Immunol, 162, 5337-44 (1999) (Pubitemid 29307140)
24. Shalom-Barak, T., J. Quach & M. Lotz: Interleukin-17- induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB. J Biol Chem, 273, 27467-73 (1998)
25. Chang, S. H. & C. Dong: A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell Res, 17, 435-40 (2007) (Pubitemid 46763094)
26. Moseley, T. A., D. R. Haudenschild, L. Rose & A. H. Reddi: Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev, 14, 155-74 (2003) (Pubitemid 36389528)
27. Yao, Z., W. C. Fanslow, M. F. Seldin, A. M. Rousseau, S. L. Painter, M. R. Comeau, J. I. Cohen & M. K. Spriggs: Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity, 3, 811-21 (1995) (Pubitemid 26091152)
28. Kuestner, R. E., D. W. Taft, A. Haran, C. S. Brandt, T. Brender, K. Lum, B. Harder, S. Okada, C. D. Ostrander, J. L. Kreindler, S. J. Aujla, B. Reardon, M. Moore, P. Shea, R. Schreckhise, T. R. Bukowski, S. Presnell, P. Guerra-Lewis, J. Parrish-Novak, J. L. Ellsworth, S. Jaspers, K. E. Lewis, M. Appleby, J. K. Kolls, M. Rixon, J. W. West, Z. Gao & S. D. Levin: Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. J Immunol, 179, 5462-73 (2007)
29. Toy, D., D. Kugler, M. Wolfson, T. Vanden Bos, J. Gurgel, J. Derry, J. Tocker & J. Peschon: Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J Immunol, 177, 36-9 (2006) (Pubitemid 43939112)
30. Gratchev, A., J. Kzhyshkowska, K. Duperrier, J. Utikal, F. W. Velten & S. Goerdt: The receptor for interleukin-17E is induced by Th2 cytokines in antigen-presenting cells. Scand J Immunol, 60, 233-7 (2004) (Pubitemid 39141253)
31. Novatchkova, M., A. Leibbrandt, J. Werzowa, A. Neubuser & F. Eisenhaber: The STIR-domain superfamily in signal transduction, development and immunity. Trends Biochem Sci, 28, 226-9 (2003) (Pubitemid 36588662)
32. Dong, C.: Regulation and pro-inflammatory function of interleukin-17 family cytokines. Immunol Rev, 226, 80-6 (2008)
33. Linden, A.: A role for the cytoplasmic adaptor protein Act1 in mediating IL-17 signaling. Sci STKE, 2007, re4 (2007)
34. Qian, Y., C. Liu, J. Hartupee, C. Z. Altuntas, M. F. Gulen, D. Jane-Wit, J. Xiao, Y. Lu, N. Giltiay, J. Liu, T. Kordula, Q. W. Zhang, B. Vallance, S. Swaidani, M. Aronica, V. K. Tuohy, T. Hamilton & X. Li: The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat Immunol, 8, 247-56 (2007) (Pubitemid 46745374)
35. Sandler, H. & G. Stoecklin: Control of mRNA decay by phosphorylation of tristetraprolin. Biochem Soc Trans, 36, 491-6 (2008) (Pubitemid 351839361)
36. Anderson, P.: Post-transcriptional control of cytokine production. Nat Immunol, 9, 353-9 (2008) (Pubitemid 351405104)
37. Zhang, C.: MicroRNAs: role in cardiovascular biology and disease. Clin Sci (Lond), 114, 699-706 (2008) (Pubitemid 351799329)
38. Ng, B., F. Yang, D. P. Huston, Y. Yan, Y. Yang, Z. Xiong, L. E. Peterson, H. Wang & X. F. Yang: Increased noncanonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes. J Allergy Clin Immunol, 114, 1463-70 (2004) (Pubitemid 39575906)
39. Chen, N. C., F. Yang, L. M. Capecci, Z. Gu, A. I. Schafer, W. Durante, X. F. Yang & H. Wang: Regulation of homocysteine metabolism and methylation in human and mouse tissues. Faseb J, 24, 2804-17 (2010)
40. Yin, Y., Y. Yan, X. Jiang, J. Mai, N. C. Chen, H. Wang & X. F. Yang: Inflammasomes are differentially expressed in cardiovascular and other tissues. Int J Immunopathol Pharmacol, 22, 311-22 (2009)
41. Pires Martins, R., R. E. Leach & S. A. Krawetz: Wholebody gene expression by data mining. Genomics, 72, 34-42 (2001) (Pubitemid 32225177)
42. Chen, C. Y. & A. B. Shyu: AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem Sci, 20, 465-70 (1995)
43. Ueland, P. M., S. Helland, O. J. Broch & J. S. Schanche: Homocysteine in tissues of the mouse and rat. J Biol Chem, 259, 2360-4 (1984)
44. Helland, S. & P. M. Ueland: S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase in various tissues of mice given injections of 9-beta-D-arabinofuranosyladenine. Cancer Res, 43, 1847-50 (1983) (Pubitemid 13122593)
45. Helland, S. & P. M. Ueland: Effect of 2'-deoxycoformycin infusion on S-adenosylhomocysteine hydrolase and the amount of S-adenosylhomocysteine and related compounds in tissues of mice. Cancer Res, 43, 4142-7 (1983) (Pubitemid 13041044)
46. Sethupathy, P., B. Corda & A. G. Hatzigeorgiou: TarBase: A comprehensive database of experimentally supported animal microRNA targets. Rna, 12, 192-7 (2006) (Pubitemid 43121923)
47. Papadopoulos, G. L., M. Reczko, V. A. Simossis, P. Sethupathy & A. G. Hatzigeorgiou: The database of experimentally supported targets: a functional update of TarBase. Nucleic Acids Res, 37, D155-8 (2009)
48. Starnes, T., H. E. Broxmeyer, M. J. Robertson & R. Hromas: Cutting edge: IL-17D, a novel member of the IL- 17 family, stimulates cytokine production and inhibits hemopoiesis. J Immunol, 169, 642-6 (2002) (Pubitemid 34753417)
49. Silva, W. A., Jr., D. T. Covas, R. A. Panepucci, R. Proto-Siqueira, J. L. Siufi, D. L. Zanette, A. R. Santos & M. A. Zago: The profile of gene expression of human marrow mesenchymal stem cells. Stem Cells, 21, 661-9 (2003) (Pubitemid 37329159)
50. Harrington, L. E., R. D. Hatton, P. R. Mangan, H. Turner, T. L. Murphy, K. M. Murphy & C. T. Weaver: Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol, 6, 1123-32 (2005) (Pubitemid 41541790)
51. Weaver, C. T., L. E. Harrington, P. R. Mangan, M. Gavrieli & K. M. Murphy: Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity, 24, 677-88 (2006) (Pubitemid 43867371)
52. Claudio, E., S. U. Sonder, S. Saret, G. Carvalho, T. R. Ramalingam, T. A. Wynn, A. Chariot, A. Garcia-Perganeda, A. Leonardi, A. Paun, A. Chen, N. Y. Ren, H. Wang & U. Siebenlist: The adaptor protein CIKS/Act1 is essential for IL- 25-mediated allergic airway inflammation. J Immunol, 182, 1617-30 (2009)
53. Chang, S. H., H. Park & C. Dong: Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor. J Biol Chem, 281, 35603-7 (2006)
54. Gaffen, S. L.: Structure and signalling in the IL-17 receptor family. Nat Rev Immunol, 9, 556-67 (2009)
55. Letuve, S., S. Lajoie-Kadoch, S. Audusseau, M. E. Rothenberg, P. O. Fiset, M. S. Ludwig & Q. Hamid: IL- 17E upregulates the expression of proinflammatory cytokines in lung fibroblasts. J Allergy Clin Immunol, 117, 590-6 (2006) (Pubitemid 43340223)
56. Kornblihtt, A. R.: Promoter usage and alternative splicing. Curr Opin Cell Biol, 17, 262-8 (2005) (Pubitemid 40719915)
57. Kornblihtt, A. R.: Coupling transcription and alternative splicing. Adv Exp Med Biol, 623, 175-89 (2007)
58. Thierry-Mieg, D. & J. Thierry-Mieg: AceView: a comprehensive cDNA-supported gene and transcripts annotation. Genome Biol, 7 Suppl 1, S12 1-14 (2006)
59. Akimzhanov, A. M., X. O. Yang & C. Dong: Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J Biol Chem, 282, 5969-72 (2007) (Pubitemid 47100812)
60. Ordovas, J. M. & C. E. Smith: Epigenetics and cardiovascular disease. Nat Rev Cardiol (2010)
61. Jamaluddin, M. S., X. Yang & H. Wang: Hyperhomocysteinemia, DNA methylation and vascular disease. Clin Chem Lab Med, 45, 1660-6 (2007)
62. James, S. J., S. Melnyk, M. Pogribna, I. P. Pogribny & M. A. Caudill: Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr, 132, 2361S-2366S (2002) (Pubitemid 34848108)
63. Caudill, M. A., J. C. Wang, S. Melnyk, I. P. Pogribny, S. Jernigan, M. D. Collins, J. Santos-Guzman, M. E. Swendseid, E. A. Cogger & S. J. James: Intracellular Sadenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice. J Nutr, 131, 2811-8 (2001)
64. Taylor, G. A., E. Carballo, D. M. Lee, W. S. Lai, M. J. Thompson, D. D. Patel, D. I. Schenkman, G. S. Gilkeson, H. E. Broxmeyer, B. F. Haynes & P. J. Blackshear: A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity, 4, 445-54 (1996) (Pubitemid 26354654)
65. Bakheet, T., B. R. Williams & K. S. Khabar: ARED 2.0: an update of AU-rich element mRNA database. Nucleic Acids Res, 31, 421-3 (2003) (Pubitemid 36150418)
66. Charlesworth, A., A. Wilczynska, P. Thampi, L. L. Cox & A. M. MacNicol: Musashi regulates the temporal order of mRNA translation during Xenopus oocyte maturation. Embo J, 25, 2792-801 (2006) (Pubitemid 43980386)
67. Lai, E. C. & J. W. Posakony: The Bearded box, a novel 3' UTR sequence motif, mediates negative posttranscriptional regulation of Bearded and Enhancer of split Complex gene expression. Development, 124, 4847-56 (1997) (Pubitemid 28014387)
68. Dinur, M., R. Kilav, A. Sela-Brown, H. Jacquemin-Sablon & T. Naveh-Many: In vitro evidence that upstream of N-ras participates in the regulation of parathyroid hormone messenger ribonucleic acid stability. Mol Endocrinol, 20, 1652-60 (2006) (Pubitemid 43967572)
69. Lai, E. C., C. Burks & J. W. Posakony: The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts. Development, 125, 4077-88 (1998) (Pubitemid 28515445)
70. Bartel, D. P.: MicroRNAs: target recognition and regulatory functions. Cell, 136, 215-33 (2009)
71. Rasmussen, K. D., S. Simmini, C. Abreu-Goodger, N. Bartonicek, M. Di Giacomo, D. Bilbao-Cortes, R. Horos, M. Von Lindern, A. J. Enright & D. O'Carroll: The miR- 144/451 locus is required for erythroid homeostasis. J Exp Med, 207, 1351-8 (2010)
72. Cordes, K. R., N. T. Sheehy, M. P. White, E. C. Berry, S. U. Morton, A. N. Muth, T. H. Lee, J. M. Miano, K. N. Ivey & D. Srivastava: miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature, 460, 705-10 (2009)
73. Naeem, H., R. Kuffner, G. Csaba & R. Zimmer: miRSel: automated extraction of associations between microRNAs and genes from the biomedical literature. BMC Bioinformatics, 11, 135 (2010)
74. Jing, Q., S. Huang, S. Guth, T. Zarubin, A. Motoyama, J. Chen, F. Di Padova, S. C. Lin, H. Gram & J. Han: Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell, 120, 623-34 (2005) (Pubitemid 40343075)
75. Asirvatham, A. J., C. J. Gregorie, Z. Hu, W. J. Magner & T. B. Tomasi: MicroRNA targets in immune genes and the Dicer/Argonaute and ARE machinery components. Mol Immunol, 45, 1995-2006 (2008) (Pubitemid 351226272)
76. Asirvatham, A. J., W. J. Magner & T. B. Tomasi: miRNA regulation of cytokine genes. Cytokine, 45, 58-69 (2009)
77. Yin, Y., Y. Yan, X. Jiang, J. Mai, N. C. Chen, H. Wang & X. F. Yang: Inflammasomes are differentially expressed in cardiovascular and other tissues. Int J Immunopathol Pharmacol, 22, 311-322 (2009)
78. Chiu, I. M., K. Touhalisky & C. Baran: Multiple controlling mechanisms of FGF1 gene expression through multiple tissue-specific promoters. Prog Nucleic Acid Res Mol Biol, 70, 155-74 (2001) (Pubitemid 33804685)
79. Ademokun, A. & M. Turner: Regulation of B-cell differentiation by microRNAs and RNA-binding proteins. Biochem Soc Trans, 36, 1191-3 (2008)
80. Kedde, M. & R. Agami: Interplay between microRNAs and RNA-binding proteins determines developmental processes. Cell Cycle, 7, 899-903 (2008) (Pubitemid 351573784)
81. Du, C., C. Liu, J. Kang, G. Zhao, Z. Ye, S. Huang, Z. Li, Z. Wu & G. Pei: MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol, 10, 1252-9 (2009)
82. Vickers, K. C. & A. T. Remaley: MicroRNAs in atherosclerosis and lipoprotein metabolism. Curr Opin Endocrinol Diabetes Obes, 17, 150-5 (2010)
83. Rosero, S., V. Bravo-Egana, Z. Jiang, S. Khuri, N. Tsinoremas, D. Klein, E. Sabates, M. Correa-Medina, C. Ricordi, J. Dominguez-Bendala, J. Diez & R. L. Pastori: MicroRNA signature of the human developing pancreas. BMC Genomics, 11, 509 (2010)
84. Dong, H., M. Paquette, A. Williams, R. T. Zoeller, M. Wade & C. Yauk: Thyroid hormone may regulate mRNA abundance in liver by acting on microRNAs. PLoS One, 5, (2010)
85. Sonkoly, E. & A. Pivarcsi: microRNAs in inflammation. Int Rev Immunol, 28, 535-61 (2009)
86. Haver, V. G., R. H. Slart, C. J. Zeebregts, M. P. Peppelenbosch & R. A. Tio: Rupture of vulnerable atherosclerotic plaques: microRNAs conducting the orchestra? Trends Cardiovasc Med, 20, 65-71 (2010)
87. Nakasa, T., S. Miyaki, A. Okubo, M. Hashimoto, K. Nishida, M. Ochi & H. Asahara: Expression of microRNA- 146 in rheumatoid arthritis synovial tissue. Arthritis Rheum, 58, 1284-92(2008)
88. Tang, Y., X. Luo, H. Cui, X. Ni, M. Yuan, Y. Guo, X. Huang, H. Zhou, N. de Vries, P. P. Tak, S. Chen & N. Shen: MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum, 60, 1065-75(2009)
89. Doebele, C., A. Bonauer, A. Fischer, A. Scholz, Y. Reiss, C. Urbich, W. K. Hofmann, A. M. Zeiher & S. Dimmeler: Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells. Blood, 115, 4944-50(2010)
90. Fontana, L., E. Pelosi, P. Greco, S. Racanicchi, U. Testa, F. Liuzzi, C. M. Croce, E. Brunetti, F. Grignani & C. Peschle: MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation. Nat Cell Biol, 9, 775-87(2007) (Pubitemid 47019464)
91. Volinia, S., G. A. Calin, C. G. Liu, S. Ambs, A. Cimmino, F. Petrocca, R. Visone, M. Iorio, C. Roldo, M. Ferracin, R. L. Prueitt, N. Yanaihara, G. Lanza, A. Scarpa, A. Vecchione, M. Negrini, C. C. Harris & C. M. Croce: A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A, 103, 2257-61(2006) (Pubitemid 43271657)
92. Hua, Z., Q. Lv, W. Ye, C. K. Wong, G. Cai, D. Gu, Y. Ji, C. Zhao, J. Wang, B. B. Yang & Y. Zhang: MiRNAdirected regulation of VEGF and other angiogenic factors under hypoxia. PLoS One, 1, e116(2006)
93. Pauley, K.M., M. Satoh, A. L. Chan, M. R. Bubb, W. H. Reeves & E. K. Chan: Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther, 10, R101(2008)
94. Martinez-Nunez, R.T., F. Louafi, P. S. Friedmann & T. Sanchez-Elsner: MicroRNA-155 modulates the pathogen binding ability of dendritic cells (DCs) by down-regulation of DC-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN). J Biol Chem, 284, 16334-42(2009)
95. Ceppi, M., P. M. Pereira, I. Dunand-Sauthier, E. Barras, W. Reith, M. A. Santos & P. Pierre: MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proc Natl Acad Sci U S A, 106, 2735-40(2009)
96. Martin, M. M., E. J. Lee, J. A. Buckenberger, T. D. Schmittgen & T. S. Elton: MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts. J Biol Chem, 281, 18277-84(2006)
97. Poliseno, L., A. Tuccoli, L. Mariani, M. Evangelista, L. Citti, K. Woods, A. Mercatanti, S. Hammond & G. Rainaldi: MicroRNAs modulate the angiogenic properties of HUVECs. Blood, 108, 3068-71(2006)
98. Suarez, Y., C. Fernandez-Hernando, J. S. Pober & W. C. Sessa: Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells. Circ Res, 100, 1164-73(2007) (Pubitemid 46684129)
99. Gabriely, G., T. Wurdinger, S. Kesari, C. C. Esau, J. Burchard, P. S. Linsley & A. M. Krichevsky: MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol, 28, 5369-80(2008)
100. Zhu, S., M. L. Si, H. Wu & Y. Y. Mo: MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem, 282, 14328-36(2007)
101. Meng, F., R. Henson, M. Lang, H. Wehbe, S. Maheshwari, J. T. Mendell, J. Jiang, T. D. Schmittgen & T. Patel: Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology, 130, 2113-29(2006)
102. Asangani, I. A., S. A. Rasheed, D. A. Nikolova, J. H. Leupold, N. H. Colburn, S. Post & H. Allgayer: MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene, 27, 2128-36(2008)