Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 19, 2012, Pages 7415-7420

  Stephen, Tom Li ^a   Wilson, Bridget S ^b   Laufer, Terri M ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Autoreactivity; T cell receptor signaling; Thymic selection

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN KINASE LCK; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL MATURATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME LOCALIZATION; IMMUNOGOLD ELECTRON MICROSCOPY; IMMUNOREGULATION; MEMBRANE STRUCTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THYMOCYTE; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; ANTIGENS, CD3; BLOTTING, WESTERN; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL MEMBRANE; CELLS, CULTURED; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTRACELLULAR SPACE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, IMMUNOELECTRON; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; THIAZOLES; THYMOCYTES; THYMUS GLAND;

MUS;

EID: 84860812557     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1119272109     Document Type: Article

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