The thymus and central tolerance

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 356, Issue 1409, 2001, Pages 609-616

  Sprent, J ^a   Kishimoto, H ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Central tolerance; Negative selection; Positive selection; Thymus

Indexed keywords

EID: 0035967465     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2001.0846     Document Type: Review

References (73)

1. Positive selection of the T cell repertoire: Where and when does it occur?
2. T-lymphocyte differentiation and biology
3. The MHC molecule I-E is necessary but not sufficient for the clonal deletion of Vβ11-bearing T cells
4. 'Actively acquired tolerance' of foreign cells
5. Survival of naive CD4 T cells: Roles of restricting versus selecting MHC class II and cytokine milieu
6. - T cells by trangenic I-E restricted to medullary epithelium
7. Assembly, transport, and function of MHC class II molecules
8. Timing and casting for actors of thymic negative selection
9. + thymocytes
10. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
11. Positive selection of thymocytes
12. T-cell tolerance
13. Positive selection of T cells
14. Peripheral T cell survival
15. Antigen processing and presentation
16. + T cells in lymphopenic hosts
17. Activation-induced apoptosis in lymphoid systems
18. Peripheral-antigen-expressing cells in thymic medulla: Factors in self-tolerance and autoimmunity
19. Current trends in transplant immunology
20. Intrathymic expression of genes involved in organ specific autoimmune disease
21. Superantigens: Mechanism of T-cell stimulation and role in immune responses
22. T cell recognition of Mls-like superantigens: Analysis of TCR requirements, superantigenic ligands, and signal transduction
23. + thymocytes in vivo by anti-CD3 or 5′(N-ethyl)-carboxamide-adenosine is blocked by glucocorticoid receptor antagonist RU-486
24. T cell tolerance by clonal elimination in the thymus
25. + T cells in mice tolerant to Staphylococcus aureus enterotoxin B
26. Negative selection in the thymus includes semi-mature T cells
27. Several different cell-surface molecules control negative selection of medullary thymocytes
28. Differing roles for B7 and ICAM-1 in negative selection of thymocytes
29. A role for Fas in negative selection of thymocytes in vivo
30. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells
31. Mechanism of tolerance induction
32. Using thymus anatomy to dissect T cell repertoire selection
33. Mature T lymphocyte apoptosis-immune regulation in a dynamic and unpredictable antigenic environment
34. Antigen-specific major histocompatibility complex-restricted T cell receptors
35. The staphylococcal enterotoxins and their relatives
36. Antigen-specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection
37. Does T-cell tolerance require a dedicated antigen-presenting cell?
38. Immunological function of the thymus
39. Effect of neonatal thymectomy on the immunological responsiveness of the mouse
40. Persistence of memory CD8 T cells in MHC class I-deficient mice
41. lo thymocytes in vivo
42. The Fas death factor
43. Tolerance and ways to break it
44. Immunogenetic consequence of vascular anastomoses between bovine twins
45. Thymic selection and autoreactivity are regulated by multiple coreceptors involved in T cell activation
46. + thymocytes
47. Mechanisms of MHC class I-restricted antigen processing
48. Pathways of antigen processing and presentation
49. Fas ligand, death gene
50. + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28
51. + thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: Implications for negative selection in the thymus
52. Social controls on cell survival and cell death
53. Selective events in T cell development
54. Degradation of cell proteins and the generation of MHC class I-presented peptides
55. Selection of the T cell repertoire
56. Structural requirements for the interaction between class II MHC molecules and peptide antigens
57. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen
58. Specific tolerance induction across a xenogeneic barrier: Production of mixed rat/mouse lymphohematopoietic chimeras using a nonlethal preparative regimen
59. Self recognition in allogeneic radiation chimeras. A radiation-resistant host element dictates the self specificity and immune response gene phenotype of T-helper cells
60. T lymphocytes and the thymus
61. Central tolerance of T cells
62. Lymphocyte life-span and memory
63. Function and specificity of T cell subsets in the mouse
64. Intrathymic and extrathymic clonal deletion of T cells
65. T cell tolerance after bone marrow transplantation in mice
66. Intrathymic and extrathymic tolerance in bone marrow chimeras
67. Dendritic cells
68. T-cell apoptosis detected in situ during positive and negative selection in the thymus
69. What's new in transplant immunology: Problems and prospects
70. Designing and maintaining the mature TCR repertoire: The continuum of self-peptide:Self-MHC complex recognition
71. Developmental biology of T cells in T cell receptor transgenic mice
72. CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance
73. Tolerogenicity of thymic epithelium