Midlife gene expressions identify modulators of aging through dietary interventions

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 19, 2012, Pages

  Zhou, Bing ^a,b,c   Yang, Liu ^a   Li, Shoufeng ^a   Huang, Jialiang ^a,b,c   Chen, Haiyang ^b   Hou, Lei ^a,b,c   Wang, Jinbo ^b,c   Green, Christopher D ^a   Yan, Zhen ^d   Huang, Xun ^b   Kaeberlein, Matt ^e   Zhu, Li ^f   Xiao, Huasheng ^f   Liu, Yong ^a   Han, Jing Dong J ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d UNIVERSITY OF VIRGINIA   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

^f Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

Diet induced obesity; Systems biology

Indexed keywords

PEROXIDE; REACTIVE OXYGEN METABOLITE;

AGING; ANIMAL EXPERIMENT; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET; DIETARY INTAKE; DROSOPHILA MELANOGASTER; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HUMAN; LIFESPAN; LONGEVITY; MALE; MIDDLE AGED; MITOCHONDRIAL GENE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PEROXISOME; PHENOTYPE; PRIORITY JOURNAL;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; CLUSTER ANALYSIS; DIET; DROSOPHILA MELANOGASTER; ENERGY METABOLISM; FEMALE; GENE EXPRESSION PROFILING; HYDROGEN PEROXIDE; LONGEVITY; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA, LIVER; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEROXISOMES; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE;

CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; MUS;

EID: 84860803581     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1119304109     Document Type: Article

References (46)

1. Khaitovich P, et al. (2004) Regional patterns of gene expression in human and chimpanzee brains. Genome Res 14:1462-1473. (Pubitemid 39198896)
2. Lu T, et al. (2004) Gene regulation and DNA damage in the ageing human brain. Nature 429:883-891. (Pubitemid 38843301)
3. Somel M, et al. (2009) Transcriptional neoteny in the human brain. Proc Natl Acad Sci USA 106:5743-5748.
4. Zahn JM, et al. (2007) AGEMAP: A gene expression database for aging in mice. PLoS Genet 3:e201.
5. Zahn JM, et al. (2006) Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet 2:e115.
6. Pletcher SD, et al. (2002) Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr Biol 12:712-723. (Pubitemid 34455424)
7. Lund J, et al. (2002) Transcriptional profile of aging in C. elegans. Curr Biol 12:1566-1573.
8. McCarroll SA, et al. (2004) Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat Genet 36:197-204. (Pubitemid 38174381)
9. Kim SK (2007) Common aging pathways in worms, flies, mice and humans. J Exp Biol 210:1607-1612.
10. Xue H, et al. (2007) A modular network model of aging. Mol Syst Biol 3:147.
11. Fontana L, Partridge L, Longo VD (2010) Extending healthy life span-from yeast to humans. Science 328:321-326.
12. Kenyon C (2005) The plasticity of aging: Insights from long-lived mutants. Cell 120: 449-460.
13. Baur JA, et al. (2006) Resveratrol improves health and survival of mice on a highcalorie diet. Nature 444:337-342. (Pubitemid 44764104)
14. Milne JC, et al. (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450:712-716.
15. Pearson KJ, et al. (2008) Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab 8:157-168.
16. Goodrick CL, Ingram DK, Reynolds MA, Freeman JR, Cider NL (1983) Differential effects of intermittent feeding and voluntary exercise on body weight and lifespan in adult rats. J Gerontol 38:36-45. (Pubitemid 13217828)
17. Hietakangas V, Cohen SM (2009) Regulation of tissue growth through nutrient sensing. Annu Rev Genet 43:389-410.
18. Kleiber M (1947) Body size and metabolic rate. Physiol Rev 27:511-541.
19. de Magalhães JP, Costa J, Toussaint O (2005) HAGR: The Human Ageing Genomic Resources. Nucleic Acids Res 33:D537-D543.
20. Breitling R, Armengaud P, Amtmann A, Herzyk P (2004) Rank products: A simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments. FEBS Lett 573:83-92. (Pubitemid 39141040)
21. Ernst J, Bar-Joseph Z (2006) STEM: A tool for the analysis of short time series gene expression data. BMC Bioinformatics 7:191.
22. Subramanian A, et al. (2005) Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102:15545-15550. (Pubitemid 41528093)
23. Russell SJ, Kahn CR (2007) Endocrine regulation of ageing. Nat Rev Mol Cell Biol 8: 681-691. (Pubitemid 47312823)
24. Schibler U (2005) The daily rhythms of genes, cells and organs. Biological clocks and circadian timing in cells. EMBO Rep 6:S9-S13.
25. Lee SS, et al. (2003) A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33:40-48. (Pubitemid 36068680)
26. Steffen KK, et al. (2008) Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell 133:292-302. (Pubitemid 351508304)
27. Schrader M, Fahimi HD (2004) Mammalian peroxisomes and reactive oxygen species. Histochem Cell Biol 122:383-393. (Pubitemid 39506595)
28. Jin C, et al. (2011) Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. Cell Metab 14:161-172.
29. Curran SP, Ruvkun G (2007) Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet 3:e56.
30. Cantó C, Auwerx J (2009) Caloric restriction, SIRT1 and longevity. Trends Endocrinol Metab 20:325-331.
31. Gurd BJ (2011) Deacetylation of PGC-1α by SIRT1: Importance for skeletal muscle function and exercise-induced mitochondrial biogenesis. Appl Physiol Nutr Metab 36: 589-597.
32. Guarente LP, Partridge L, Wallace DC (2007) Molecular Biology of Aging (Cold Spring Harbor Laboratory Press, Plainview, NY), pp 409-425.
33. Cha DR, et al. (2007) Peroxisome proliferator-activated receptor-alpha deficiency protects aged mice from insulin resistance induced by high-fat diet. Am J Nephrol 27: 479-482. (Pubitemid 47482004)
34. Delille HK, Alves R, Schrader M (2009) Biogenesis of peroxisomes and mitochondria: Linked by division. Histochem Cell Biol 131:441-446.
35. D'Antona G, et al. (2010) Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice. Cell Metab 12:362-372.
36. Nisoli E, et al. (2005) Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 310:314-317. (Pubitemid 41457197)
37. López-Lluch G, et al. (2006) Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc Natl Acad Sci USA 103:1768-1773. (Pubitemid 43228768)
38. Hagopian K, et al. (2011) Caloric restriction influences hydrogen peroxide generation in mitochondrial sub-populations from mouse liver. J Bioenerg Biomembr 43:227-236.
39. Hagopian K, et al. (2005) Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria. Am J Physiol Endocrinol Metab 288:E674-E684. (Pubitemid 40397201)
40. Civitarese AE, et al. (2007) Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med 4:e76.
41. Hong F, et al. (2006) RankProd: A bioconductor package for detecting differentially expressed genes in meta-analysis. Bioinformatics 22:2825-2827. (Pubitemid 44742407)
42. Chen H, Liu Z, Huang X (2010) Drosophila models of peroxisomal biogenesis disorder: Peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism. Hum Mol Genet 19:494-505.
43. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71-94.
44. Kamath RS, Martinez-Campos M, Zipperlen P, Fraser AG, Ahringer J (2001) Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol 2:RESEARCH0002.
45. Kamath RS, et al. (2003) Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421:231-237. (Pubitemid 36139121)
46. Lee SJ, Hwang AB, Kenyon C (2010) Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr Biol 20:2131-2136.