Utilization of the herpes simplex virus type 1 latency-associated regulatory region to drive stable reporter gene expression in the nervous system

Journal of Virology

Volumn 71, Issue 4, 1997, Pages 3197-3207

  Lachmann, Robin H ^a   Efstathiou, Stacey ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Department of Pathology   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; VIRUS VECTOR;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FACIAL NERVE NUCLEUS; FEMALE; GENE EXPRESSION; GENE TARGETING; HERPES SIMPLEX VIRUS 1; HYPOGLOSSAL NUCLEUS; LATENT VIRUS INFECTION; MOUSE; NERVOUS SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; VERO CELL; VIRUS LATENCY; VIRUS RECOMBINANT;

EID: 0030997138     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.4.3197-3207.1997     Document Type: Article

References (45)

1. Arthur, J., S. Efstathiou, and A. Simmons. 1993. Intranuclear foci containing low abundance herpes simplex virus latency-associated transcripts visualized by non-isotopic in situ hybridization. J. Gen. Virol. 74:1363-1370.
2. Batchelor, A. H., and P. O'Hare. 1992. Localization of cis-acting sequence requirements in the promoter of the latency-associated transcript of herpes simplex virus type 1 required for cell-type-specific activity. J. Virol. 66:3573-3582.
3. Batchelor, A. H., and P. O'Hare. 1990. Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1. J. Virol. 64:3269-3279.
4. Bloom, D. C., N. T. Maidment, A. Tan, V. B. Dissette, L. T. Feldman, and J. G. Stevens. 1995. Long-term expression of a reporter gene from latent herpes simplex virus in the rat hippocampus. Brain Res. Mol. Brain Res. 31:48-60.
5. Chen, X., M. C. Schmidt, W. F. Goins, and J. C. Glorioso. 1995. Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infection. J. Virol. 69:7899-7908.
6. Cook, M. L., V. B. Bastone, and J. G. Stevens. 1974. Evidence that neurons harbor latent herpes simplex virus. Infect. Immun. 9:946-951.
7. Deatly, A. M., J. G. Spivack, E. Lavi, D. R. O'Boyle, and N. W. Fraser. 1988. Latent herpes simplex virus type 1 transcripts in peripheral and central nervous system tissues of mice map to similar regions of the viral genome. J. Virol. 62:749-756.
8. Deshmane, S. L., and N. W. Fraser. 1989. During latency, herpes simplex virus type 1 DNA is associated with nucleosomes in a chromatin structure. J. Virol. 63:943-947.
9. Deshmane, S. L., N. T. Valyi, T. Block, J. Maggioncalda, J. H. Wolfe, A. Dillner, and N. W. Fraser. 1995. An HSV-1 containing the rat beta-glucuronidase cDNA inserted within the LAT gene is less efficient than the parental strain at establishing a transcriptionally active state during latency in neurons. Gene Ther. 2:209-217.
10. Devi-Rao, G. B., S. A. Goodart, L. M. Hecht, R. Rochford, M. K. Rice, and E. K. Wagner. 1991. Relationship between polyadenylated and nonpolyadenylated herpes simplex virus type 1 latency-associated transcripts. J. Virol. 65:2179-2190.
11. Dobson, A. T., T. P. Margolis, W. A. Gomes, and L. T. Feldman. 1995. In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter. J. Virol. 69:2264-2270.
12. Dobson, A. T., T. P. Margolis, F. Sedarati, J. G. Stevens, and L. T. Feldman. 1990. A latent, nonpathogenic HSV-1-derived vector stably expresses beta-galactosidase in mouse neurons. Neuron 5:353-360.
13. Dobson, A. T., F. Sederati, R. G. Devi, W. M. Flanagan, M. J. Farrell, J. G. Stevens, E. K. Wagner, and L. T. Feldman. 1989. Identification of the latency-associated transcript promoter by expression of rabbit beta-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus. J. Virol. 63:3844-3851.
14. Ecob-Prince, M. S., K. Hassan, M. T. Denheen, and C. M. Preston. 1995. Expression of beta-galactosidase in neurons of dorsal root ganglia which are latently infected with herpes simplex virus type 1. J. Gen. Virol. 76:1527-1532.
15. Edwards, P. A. W., C. L. Abram, and J. M. Bradbury. 1996. Genetic manipulation of mammary epithelium by transplantation. J. Mammary Gland Biol. Neoplasia 1:75-89.
16. Efstathiou, S., A. C. Minson, H. J. Field, J. R. Anderson, and P. Wildy. 1986. Detection of herpes simplex virus-specific DNA sequences in latently infected mice and in humans. J. Virol. 57:446-455.
17. Forrester, A., H. Farrell, G. Wilkinson, J. Kaye, P. N. Davis, and T. Minson. 1992. Construction and properties of a mutant of herpes simplex virus type 1 with glycoprotein H coding sequences deleted. J. Virol. 66:341-348.
18. Fraser, N. W., T. M. Block, and J. G. Spivack. 1992. The latency-associated transcripts of herpes simplex virus: RNA in search of function. Virology 191:1-8.
19. Glorioso, J. C., N. A. DeLuca, and D. J. Fink. 1995. Development and application of herpes simplex virus vectors for human gene therapy. Annu. Rev. Microbiol. 49:675-710.
20. Goins, W. F., L. R. Sternberg, K. D. Croen, P. R. Krause, R. L. Hendricks, D. J. Fink, S. E. Straus, M. Levine, and J. C. Glorioso. 1994. A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats. J. Virol. 68:2239-2252.
21. Hill, J. M., F. Sedarati, R. T. Javier, E. K. Wagner, and J. G. Stevens. 1990. Herpes simplex virus latent phase transcription facilitates in vivo reactivation. Virology 174:117-125.
22. Hill, T. J., W. A. Blyth, D. A. Harbour, E. L. Berrie, and A. B. Tullo. 1983. Latency and other consequences of infection of the nervous system with herpes simplex virus. Prog. Brain Res. 59:173-184.
23. Hill, T. J., H. J. Field, and W. A. Blyth. 1975. Acute and recurrent infection with herpes simplex virus in the mouse: a model for studying latency and recurrent disease. J. Gen. Virol. 28:341-353.
24. Ho, D. Y., and E. S. Mocarski. 1989. Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse. Proc. Natl. Acad. Sci. USA 86:7596-7600.
25. Lachmann, R. H., C. Brown, and S. Efstathiou. 1996. A murine RNA polymerase I promoter inserted into the herpes simplex virus type 1 genome is functional during lytic, but not latent, infection. J. Gen. Virol. 77:2575-2582.
26. Leib, D. A., K. C. Nadeau, S. A. Rundle, and P. A. Schaffer. 1991. The promoter of the latency-associated transcripts of herpes simplex virus type 1 contains a functional cAMP-response element: role of the latency-associated transcripts and cAMP in reactivation of viral latency. Proc. Natl. Acad. Sci. USA 88:48-52.
27. Lokensgard, J. R., D. C. Bloom, A. T. Dobson, and L. T. Feldman. 1994. Long-term promoter activity during herpes simplex virus latency. J. Virol. 68:7148-7158.
28. Macpherson, I., and M. Stoker. 1962. Polyoma transformation of hamster cell clones - an investigation of genetic factors affecting cell competence. Virology 16:147-151.
29. Margolis, T. P., D. C. Bloom, A. T. Dobson, L. T. Feldman, and J. G. Stevens. 1993. Decreased reporter gene expression during latent infection with HSV LAT promoter constructs. Virology 197:585-592.
30. McGeoch, D. J., C. Cunningham, G. McIntyre, and A. Dolan. 1991. Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2. J. Gen. Virol. 72:3057-3075.
31. McLennan, J. L., and G. Darby. 1980. Herpes simplex virus latency: the cellular location of virus in dorsal root ganglia and the fate of the infected cell following virus activation. J. Gen. Virol. 51:233-243.
32. Mellerick, D. M., and N. W. Fraser. 1987. Physical state of the latent herpes simplex virus genome in a mouse model system: evidence suggesting an episomal state. Virology 158:265-275.
33. Morgenstern, J. P., and H. Land. 1990. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18:3587-3596.
34. Nicosia, M., S. L. Deshmane, J. M. Zabolotny, N. T. Valyi, and N. W. Fraser. 1993. Herpes simplex virus type 1 latency-associated transcript (LAT) promoter deletion mutants can express a 2-kilobase transcript mapping to the LAT region. J. Virol. 67:7276-7283.
35. Perng, G.-C., H. Ghiasi, S. M. Slanina, A. B. Nesburn, and S. L. Wechsler. 1996. The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kb of the 8.3-kb primary transcript. J. Virol. 70:976-984.
36. Perry, L. J., and D. J. McGeoch. 1988. The DNA sequences of the long repeat region and adjoining parts of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. 69:2831-2846.
37. Rock, D. L., and N. W. Fraser. 1983. Detection of HSV-1 genome in central nervous system of latently infected mice. Nature 302:523-525.
38. Soares, K., D.-Y. Hwang, R. Ramakrishnan, M. C. Schmidt, D. J. Fink, and J. C. Glorioso. 1996. cis-acting elements involved in transcriptional regulation of the herpes simplex virus type 1 latency-associated promoter 1 (LAP1) in vitro and in vivo. J. Virol. 70:5384-5394.
39. Spivack, J. G., and N. W. Fraser. 1988. Expression of herpes simplex virus type 1 (HSV-1) latency-associated transcripts and transcripts affected by the deletion in avirulent mutant HFEM: evidence for a new class of HSV-1 genes. J. Virol. 62:3281-3287.
40. Stevens, J. G., E. K. Wagner, R. G. Devi, M. L. Cook, and L. T. Feldman. 1987. RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons. Science 235:1056-1059.
41. Stow, N. D., and N. M. Wilkie. 1976. An improved technique for obtaining enhanced infectivity with herpes simplex virus type 1 DNA. J. Gen. Virol. 33:447-458.
42. Wilkinson, G. W., and A. Akrigg. 1992. Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector. Nucleic Acids Res. 20:2233-2239.
43. Wolfe, J. H., S. L. Deshmane, and N. W. Fraser. 1992. Herpesvirus vector gene transfer and expression of beta-glucuronidase in the central nervous system of MPS VII mice. Nat. Genet. 1:379-384.
44. Zwaagstra, J. C., H. Ghiasi, A. B. Nesburn, and S. L. Wechsler. 1991. Identification of a major regulatory sequence in the latency associated transcript (LAT) promoter of herpes simplex virus type 1 (HSV-1). Virology 182:287-297.
45. Zwaagstra, J. C., H. Ghiasi, S. M. Slanina, A. B. Nesburn, S. C. Wheatley, K. Lillycrop, J. Wood, D. S. Latchman, K. Patel, and S. L. Wechsler. 1990. Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript. J. Virol. 64:5019-5028.