HDL-like discs for assaying membrane proteins in drug discovery

Biophysical Chemistry

Volumn 165-166, Issue , 2012, Pages 56-61

  Fiez Vandal, Cédric ^a   Leder, Lukas ^a   Freuler, Felix ^a   Sykes, David ^b   Charlton, Steven J ^b   Siehler, Sandra ^a   Schopfer, Ulrich ^a   Duckely, Myriam ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b NOVARTIS HORSHAM RESEARCH CENTRE   (United Kingdom)

Author keywords

Beta 2 adrenoceptor; G protein coupled receptor; Kinetics; Membrane protein; Recombinant high density lipoprotein; Scintillation proximity assay

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CHELATE; COPPER; CYANOPINDOLOL; DIHYDROALPRENOLOL; HIGH DENSITY LIPOPROTEIN; MEMBRANE PROTEIN; RECOMBINANT HIGH DENSITY LIPOPROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING KINETICS; CELL MEMBRANE; DRUG DEVELOPMENT; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN PURIFICATION; SCINTILLATION; SCINTILLATION PROXIMITY BINDING ASSAY;

ADRENERGIC BETA-2 RECEPTOR ANTAGONISTS; ANIMALS; APOLIPOPROTEIN A-I; DRUG DISCOVERY; HEK293 CELLS; HUMANS; KINETICS; LIPID BILAYERS; LIPOPROTEINS, HDL; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, ADRENERGIC, BETA-2; RECOMBINANT PROTEINS;

EID: 84860772289     PISSN: 03014622     EISSN: 18734200     Source Type: Journal    
DOI: 10.1016/j.bpc.2012.03.005     Document Type: Article

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