-
2
-
-
11144315535
-
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
-
Issaeva N, Bozko P, Enge M, Protopopova M, Verhoef LG, Masucci M et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med 2004; 10: 1321-1328.
-
(2004)
Nat Med
, vol.10
, pp. 1321-1328
-
-
Issaeva, N.1
Bozko, P.2
Enge, M.3
Protopopova, M.4
Verhoef, L.G.5
Masucci, M.6
-
3
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004; 303: 844-848.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
-
4
-
-
33745154819
-
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction
-
Ding K, Lu Y, Nikolovska-Coleska Z, Wang G, Qiu S, Shangary S et al. Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction. J Med Chem 2006; 49: 3432-3435.
-
(2006)
J Med Chem
, vol.49
, pp. 3432-3435
-
-
Ding, K.1
Lu, Y.2
Nikolovska-Coleska, Z.3
Wang, G.4
Qiu, S.5
Shangary, S.6
-
5
-
-
60649103811
-
MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53
-
Enge M, Bao W, Hedstrom E, Jackson SP, Moumen A, Selivanova G. MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53. Cancer Cell 2009; 15: 171-183.
-
(2009)
Cancer Cell
, vol.15
, pp. 171-183
-
-
Enge, M.1
Bao, W.2
Hedstrom, E.3
Jackson, S.P.4
Moumen, A.5
Selivanova, G.6
-
6
-
-
30744449974
-
NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro
-
Krajewski M, Ozdowy P, D'Silva L, Rothweiler U, Holak TA. NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro. Nat Med 2005; 11: 1135-1136.
-
(2005)
Nat Med
, vol.11
, pp. 1135-1136
-
-
Krajewski, M.1
Ozdowy, P.2
D'Silva, L.3
Rothweiler, U.4
Holak, T.A.5
-
7
-
-
68049131458
-
HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating drugs nutlin-3 and RITA
-
Rinaldo C, Prodosmo A, Siepi F, Moncada A, Sacchi A, Selivanova G et al. HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating drugs nutlin-3 and RITA. Cancer Res 2009; 69: 6241-6428.
-
(2009)
Cancer Res
, vol.69
, pp. 6241-6428
-
-
Rinaldo, C.1
Prodosmo, A.2
Siepi, F.3
Moncada, A.4
Sacchi, A.5
Selivanova, G.6
-
8
-
-
70449730274
-
Selivanova P53-dependent inhibition of trxr1 contributes to the tumor-specific induction of apoptosis By Rita G
-
Hedstrom E, Eriksson S, Zawacka-Pankau J, Arner ES, Selivanova G. p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA. Cell Cycle 2009; 8: 3576-3583.
-
(2009)
Cell Cycle
, vol.8
, pp. 3576-3583
-
-
Hedstrom, E.1
Eriksson, S.2
Zawacka-Pankau, J.3
Arner, E.S.4
-
9
-
-
80053934582
-
Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX
-
Spinnler C, Hedstrom E, Li H, De Lange J, Nikulenkov F, Teunisse AF et al. Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX. Cell Death Differ 2011; 18: 1736-1745.
-
(2011)
Cell Death Differ
, vol.18
, pp. 1736-1745
-
-
Spinnler, C.1
Hedstrom, E.2
Li, H.3
De Lange, J.4
Nikulenkov, F.5
Teunisse, A.F.6
-
10
-
-
64649086259
-
Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia
-
Yang J, Ahmed A, Poon E, Perusinghe N, de Haven BA, Box G et al. Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia. Mol Cell Biol 2009; 29: 2243-2253.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2243-2253
-
-
Yang, J.1
Ahmed, A.2
Poon, E.3
Perusinghe, N.4
De Haven, B.A.5
Box, G.6
-
11
-
-
79959929894
-
Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1
-
Ahmed A, Yang J, Maya-Mendoza A, Jackson DA, Ashcroft M. Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1. Cell Death Dis 2011; 2: e160.
-
(2011)
Cell Death Dis
, vol.2
-
-
Ahmed, A.1
Yang, J.2
Maya-Mendoza, A.3
Jackson, D.A.4
Ashcroft, M.5
-
12
-
-
84857791061
-
Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma
-
e-pub ahead of print 18 July 2011; doi:10.1038/onc.2011.309
-
de Lange J, Ly LV, Lodder K, Verlaan-de Vries M, Teunisse AF, Jager MJ et al. Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma. Oncogene 2011; e-pub ahead of print 18 July 2011; doi:10.1038/onc.2011.309.
-
(2011)
Oncogene
-
-
De Lange, J.1
Ly, L.V.2
Lodder, K.3
Verlaan-De Vries, M.4
Teunisse, A.F.5
Jager, M.J.6
-
13
-
-
17644432403
-
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
-
Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000; 14: 1448-1459.
-
(2000)
Genes Dev
, vol.14
, pp. 1448-1459
-
-
Liu, Q.1
Guntuku, S.2
Cui, X.S.3
Matsuoka, S.4
Cortez, D.5
Tamai, K.6
-
14
-
-
0034967556
-
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
-
Zhao H, Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 2001; 21: 4129-4139.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 4129-4139
-
-
Zhao, H.1
Piwnica-Worms, H.2
-
15
-
-
0034326802
-
Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation
-
Ahn JY, Schwarz JK, Piwnica-Worms H, Canman CE. Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Res 2000; 60: 5934-5936.
-
(2000)
Cancer Res
, vol.60
, pp. 5934-5936
-
-
Ahn, J.Y.1
Schwarz, J.K.2
Piwnica-Worms, H.3
Canman, C.E.4
-
16
-
-
33750340969
-
DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues
-
Buscemi G, Carlessi L, Zannini L, Lisanti S, Fontanella E, Canevari S et al. DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues. Mol Cell Biol 2006; 26: 7832-7845.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 7832-7845
-
-
Buscemi, G.1
Carlessi, L.2
Zannini, L.3
Lisanti, S.4
Fontanella, E.5
Canevari, S.6
-
17
-
-
70349438994
-
Tumour suppression by p53: A role for the DNA damage response?
-
Meek DW. Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer 2009; 9: 714-723.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 714-723
-
-
Meek, D.W.1
-
18
-
-
33646550549
-
MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells
-
Coll-Mulet L, Iglesias-Serret D, Santidrian AF, Cosialls AM, de FM, Castano E et al. MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells. Blood 2006; 107: 4109-4114.
-
(2006)
Blood
, vol.107
, pp. 4109-4114
-
-
Coll-Mulet, L.1
Iglesias-Serret, D.2
Santidrian, A.F.3
Cosialls, A.M.4
De Fm Castano, E.5
-
19
-
-
77951622712
-
Role of Mdm4 in drug sensitivity of breast cancer cells
-
Lam S, Lodder K, Teunisse AF, Rabelink MJ, Schutte M, Jochemsen AG. Role of Mdm4 in drug sensitivity of breast cancer cells. Oncogene 2010; 29: 2415-2426.
-
(2010)
Oncogene
, vol.29
, pp. 2415-2426
-
-
Lam, S.1
Lodder, K.2
Teunisse, A.F.3
Rabelink, M.J.4
Schutte, M.5
Jochemsen, A.G.6
-
20
-
-
33750590095
-
Inactivation of the p53 pathway in retinoblastoma
-
Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C et al. Inactivation of the p53 pathway in retinoblastoma. Nature 2006; 444: 61-66.
-
(2006)
Nature
, vol.444
, pp. 61-66
-
-
Laurie, N.A.1
Donovan, S.L.2
Shih, C.S.3
Zhang, J.4
Mills, N.5
Fuller, C.6
-
21
-
-
78649645749
-
RITA inhibits multiple myeloma cell growth through induction of p53-mediated caspase-dependent apoptosis and synergistically enhances nutlin-induced cytotoxic responses
-
Saha MN, Jiang H, Mukai A, Chang H. RITA inhibits multiple myeloma cell growth through induction of p53-mediated caspase-dependent apoptosis and synergistically enhances nutlin-induced cytotoxic responses. Mol Cancer Ther 2010; 9: 3041-3051.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 3041-3051
-
-
Saha, M.N.1
Jiang, H.2
Mukai, A.3
Chang, H.4
-
22
-
-
33748794547
-
Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
-
Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 2006; 58: 621-681.
-
(2006)
Pharmacol Rev
, vol.58
, pp. 621-681
-
-
Chou, T.C.1
-
23
-
-
2442527878
-
DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage
-
Jack MT, Woo RA, Motoyama N, Takai H, Lee PW. DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage. J Biol Chem 2004; 279: 15269-15273.
-
(2004)
J Biol Chem
, vol.279
, pp. 15269-15273
-
-
Jack, M.T.1
Woo, R.A.2
Motoyama, N.3
Takai, H.4
Lee, P.W.5
-
24
-
-
0033485261
-
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
-
Bulavin DV, Saito S, Hollander MC, Sakaguchi K, Anderson CW, Appella E et al. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J 1999; 18: 6845-6854.
-
(1999)
EMBO J
, vol.18
, pp. 6845-6854
-
-
Bulavin, D.V.1
Saito, S.2
Hollander, M.C.3
Sakaguchi, K.4
Anderson, C.W.5
Appella, E.6
-
25
-
-
0037066695
-
ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation
-
Saito S, Goodarzi AA, Higashimoto Y, Noda Y, Lees-Miller SP, Appella E et al. ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. J Biol Chem 2002; 277: 12491-12494.
-
(2002)
J Biol Chem
, vol.277
, pp. 12491-12494
-
-
Saito, S.1
Goodarzi, A.A.2
Higashimoto, Y.3
Noda, Y.4
Lees-Miller, S.P.5
Appella, E.6
-
26
-
-
0033552873
-
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
-
Blasina A, de IV W, Laus MC, Luyten WH, Parker AE, McGowan CH. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Curr Biol 1999; 9: 1-10.
-
(1999)
Curr Biol
, vol.9
, pp. 1-10
-
-
Blasina, A.1
De Iv, W.2
Laus, M.C.3
Luyten, W.H.4
Parker, A.E.5
McGowan, C.H.6
-
27
-
-
0035848819
-
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
-
Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 2001; 410: 842-847.
-
(2001)
Nature
, vol.410
, pp. 842-847
-
-
Falck, J.1
Mailand, N.2
Syljuasen, R.G.3
Bartek, J.4
Lukas, J.5
-
28
-
-
0034624718
-
HCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
-
Lee JS, Collins KM, Brown AL, Lee CH, Chung JH. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 2000; 404: 201-204.
-
(2000)
Nature
, vol.404
, pp. 201-204
-
-
Lee, J.S.1
Collins, K.M.2
Brown, A.L.3
Lee, C.H.4
Chung, J.H.5
-
30
-
-
0036847998
-
PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2
-
Yang S, Kuo C, Bisi JE, Kim MK. PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. Nat Cell Biol 2002; 4: 865-870.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 865-870
-
-
Yang, S.1
Kuo, C.2
Bisi, J.E.3
Kim, M.K.4
-
31
-
-
36448973875
-
CHK2 kinase: Cancer susceptibility and cancer therapy-two sides of the same coin?
-
Antoni L, Sodha N, Collins I, Garrett MD. CHK2 kinase: cancer susceptibility and cancer therapy-two sides of the same coin? Nat Rev Cancer 2007; 7: 925-936.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 925-936
-
-
Antoni, L.1
Sodha, N.2
Collins, I.3
Garrett, M.D.4
-
32
-
-
79651470785
-
Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics
-
Ma CX, Janetka JW, Piwnica-Worms H. Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics. Trends Mol Med 2011; 17: 88-96.
-
(2011)
Trends Mol Med
, vol.17
, pp. 88-96
-
-
Ma, C.X.1
Janetka, J.W.2
Piwnica-Worms, H.3
-
33
-
-
22244486020
-
Dual induction of apoptosis and senescence in cancer cells by Chk2 activation: Checkpoint activation as a strategy against cancer
-
Chen CR, Wang W, Rogoff HA, Li X, Mang W, Li CJ. Dual induction of apoptosis and senescence in cancer cells by Chk2 activation: checkpoint activation as a strategy against cancer. Cancer Res 2005; 65: 6017-6021.
-
(2005)
Cancer Res
, vol.65
, pp. 6017-6021
-
-
Chen, C.R.1
Wang, W.2
Rogoff, H.A.3
Li, X.4
Mang, W.5
Li, C.J.6
-
34
-
-
34147177714
-
Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2
-
Carlessi L, Buscemi G, Larson G, Hong Z, Wu JZ, Delia D. Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2. Mol Cancer Ther 2007; 6: 935-944.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 935-944
-
-
Carlessi, L.1
Buscemi, G.2
Larson, G.3
Hong, Z.4
Wu, J.Z.5
Delia, D.6
-
35
-
-
18644375649
-
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
-
Takai H, Naka K, Okada Y, Watanabe M, Harada N, Saito S et al. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J 2002; 21: 5195-5205.
-
(2002)
EMBO J
, vol.21
, pp. 5195-5205
-
-
Takai, H.1
Naka, K.2
Okada, Y.3
Watanabe, M.4
Harada, N.5
Saito, S.6
-
36
-
-
17144377827
-
The role of checkpoint kinase 1 in sensitivity to topoisomerase i poisons
-
Flatten K, Dai NT, Vroman BT, Loegering D, Erlichman C, Karnitz LM et al. The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons. J Biol Chem 2005; 280: 14349-14355.
-
(2005)
J Biol Chem
, vol.280
, pp. 14349-14355
-
-
Flatten, K.1
Dai, N.T.2
Vroman, B.T.3
Loegering, D.4
Erlichman, C.5
Karnitz, L.M.6
-
37
-
-
77951064789
-
Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition
-
Macurek L, Lindqvist A, Voets O, Kool J, Vos HR, Medema RH. Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition. Oncogene 2010; 29: 2281-2291.
-
(2010)
Oncogene
, vol.29
, pp. 2281-2291
-
-
MacUrek, L.1
Lindqvist, A.2
Voets, O.3
Kool, J.4
Vos, H.R.5
Medema, R.H.6
|