Valproic acid induces apoptosis in human leukemia cells by stimulating both caspase-dependent and -independent apoptotic signaling pathways

Leukemia Research

Volumn 26, Issue 5, 2002, Pages 495-502

  Kawagoe, Rika ^a   Kawagoe, Hiroyuki ^a   Sano, Kimihiko ^a  

^a KOBE UNIVERSITY   (Japan)

Author keywords

Apoptosis; Caspase dependent and independent pathways; Leukemia; Valproic acid

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; CYTOCHROME C; DNA FRAGMENT; PHOSPHATIDYLSERINE; VALPROIC ACID;

APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER SURVIVAL; CELL LINE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; CASPASES; CYTOCHROME C GROUP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; LEUKEMIA; TUMOR CELLS, CULTURED; VALPROIC ACID;

EID: 0036201888     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(01)00151-5     Document Type: Article

References (29)

1. Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-indeoendent pathway: Implications for the possible role of dietary fibre in the prevention of large-bowel cancer
2. Role of short-chain fatty acids in the prevention of colorectal cancer
3. Effects of sodium butyrate on growth, differentiation, and apoptosis in head and neck squamous carcinoma cell lines
4. Sodium butyrate induces apoptosis in human renal carcinoma cells and synergistic enhances their sensitivity to anti-Fas-mediated cytotoxicity
5. In vitro differentiation of human neuroblastoma cells induced by sodium phenylacetate
6. Apoptosis induced by the histone deacetylase inhibitor sodium butyrate in human leukemic lymphblasts
7. Phenylbutyrate-induced G1 arrest and apoptosis in myeloid leukemia cells: Structure-function analysis
8. Antitumor activity of sodium valproate in cultures of human neuroblastoma cells
9. Sodium valproate inhibits in vivo growth of human neuroblastoma cells
10. Bone marrow suppression induced by high dose valproic acid
11. Segregation of the growth slowing effects of valproic acid from phenytoin and carbamazepine on lymphoid tumor cells
12. HMBA induces activation of a caspase-independent pathway to overcome P-glycoprotein-mediated multidrug resistance
13. BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases
14. Caspase-independent commitment phase to apoptosis in activated blood T-lymphocytes: Reversibility at low apoptotic insult
15. Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T-lymphocytes
16. E4 or f4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk
17. Human acute leukemia cell line with t(4;11) chromosomal rearrangement exhibits B-lineage and monocytic characteristics
18. Growth factor requirements of childhood acute leukemia: Establishment of GM-CSF-dependent cell lines
19. Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL
20. Establishment and characterization of a human acute monocytic leukemia cell line (THP-1)
21. IgD on cell membranes of human lymphoid cell lines with multiple immunoglobulin classes
22. Acute myelogenous leukemia: A human cell line responsive to colony-stimulating activity
23. A novel assay for apoptosis: Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled annexin-V
24. Simple procedure or DNA isolation from human serum
25. Fluorometric and colormetric detection of caspase activity associated with apoptosis
26. A combinatorial approach defines specigicities of members of the caspase family and granzyme-B
27. Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3
28. +
29. A novel evidence of different mechanisms of lithium and valproate neuroprotective action on human SY5Y neuroblastoma cells: Caspase-3 dependency