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Volumn 13, Issue 2, 2008, Pages 221-230

Failure of lamivudine to reverse hepatitis B virus-associated changes in ERK, Akt and cell cycle regulatory proteins

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN B1; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; GLYCOGEN SYNTHASE KINASE 3BETA; LAMIVUDINE; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; PROTEIN KINASE B; PROTEIN P53; REGULATOR PROTEIN;

EID: 42149159013     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (8)

References (54)
  • 1
    • 0030707941 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Lee WM. Hepatitis B virus infection. N Engl J Med 1997; 337:1733-1745.
    • (1997) N Engl J Med , vol.337 , pp. 1733-1745
    • Lee, W.M.1
  • 2
    • 0042968962 scopus 로고    scopus 로고
    • Molecular viral oncology of hepatocellular carcinoma
    • Block TM, Mehta AS, Fimmel CJ, Jordan R. Molecular viral oncology of hepatocellular carcinoma. Oncogene 2003; 22:5093-5107.
    • (2003) Oncogene , vol.22 , pp. 5093-5107
    • Block, T.M.1    Mehta, A.S.2    Fimmel, C.J.3    Jordan, R.4
  • 3
    • 17244367083 scopus 로고    scopus 로고
    • Hepatitis B virus X antigen (HBxAg) and cell cycle control in chronic infection and hepatocarcinogenesis
    • Feitelson MA, Reis HM, Liu J, Lian Z, Pan J. Hepatitis B virus X antigen (HBxAg) and cell cycle control in chronic infection and hepatocarcinogenesis. Front Biosci 2005; 10:1558-1572.
    • (2005) Front Biosci , vol.10 , pp. 1558-1572
    • Feitelson, M.A.1    Reis, H.M.2    Liu, J.3    Lian, Z.4    Pan, J.5
  • 4
    • 3042822565 scopus 로고    scopus 로고
    • High viral load is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis B virus infection
    • Ohata K, Hamasaki K, Toriyama K, Ishikawa H, Nakao K, Eguchi K. High viral load is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis B virus infection. J Gastroenterol Hepatol 2004; 19:670-675.
    • (2004) J Gastroenterol Hepatol , vol.19 , pp. 670-675
    • Ohata, K.1    Hamasaki, K.2    Toriyama, K.3    Ishikawa, H.4    Nakao, K.5    Eguchi, K.6
  • 5
    • 29944436855 scopus 로고    scopus 로고
    • Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
    • Chen C-J, Yang H-I, Jun S, et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006; 295:65-73.
    • (2006) JAMA , vol.295 , pp. 65-73
    • Chen, C.-J.1    Yang, H.-I.2    Jun, S.3
  • 6
    • 28944442419 scopus 로고    scopus 로고
    • Therapeutic implications of hepatitis B virus genotypes
    • Liu C-J, Kao J-H, Chen D-S. Therapeutic implications of hepatitis B virus genotypes. Liver Int 2005; 25:1097-1107.
    • (2005) Liver Int , vol.25 , pp. 1097-1107
    • Liu, C.-J.1    Kao, J.-H.2    Chen, D.-S.3
  • 7
    • 33745597081 scopus 로고    scopus 로고
    • Impact of the hepatitis B virus genotype and genotype-mixtures on the course of liver disease in Vietnam
    • Song L, Toan N, Duy D, et al. Impact of the hepatitis B virus genotype and genotype-mixtures on the course of liver disease in Vietnam. Hepatology 2006; 43:1375-1384.
    • (2006) Hepatology , vol.43 , pp. 1375-1384
    • Song, L.1    Toan, N.2    Duy, D.3
  • 8
    • 26844444126 scopus 로고    scopus 로고
    • Natural history and treatment of hepatitis B virus and hepatitis C virus coinfection
    • Crockett S, Keeffe E. Natural history and treatment of hepatitis B virus and hepatitis C virus coinfection. Ann Clin Microbiol Antimicrob 2005; 4:1-12.
    • (2005) Ann Clin Microbiol Antimicrob , vol.4 , pp. 1-12
    • Crockett, S.1    Keeffe, E.2
  • 9
    • 33646250175 scopus 로고    scopus 로고
    • Hepatitis B virus (HBV) and hepatitis C virus (HCV) dual infection
    • Liu Z, Hou J. Hepatitis B virus (HBV) and hepatitis C virus (HCV) dual infection. Int J Med Sci 2006; 3:57-62.
    • (2006) Int J Med Sci , vol.3 , pp. 57-62
    • Liu, Z.1    Hou, J.2
  • 10
    • 27444441182 scopus 로고    scopus 로고
    • Prognostic determinants for chronic nepatitis B in Asians: Therapeutic implications
    • Yuen MF, Yuan HJ, Wong DK, et al. Prognostic determinants for chronic nepatitis B in Asians: therapeutic implications. Gut 2005; 54:1610-1614.
    • (2005) Gut , vol.54 , pp. 1610-1614
    • Yuen, M.F.1    Yuan, H.J.2    Wong, D.K.3
  • 11
    • 33646193810 scopus 로고    scopus 로고
    • Activation of focal adhesion kinase by hepatitis B virus HBx protein: Multiple functions in viral replication
    • Bouchard MJ, Wang L, Schneider RJ. Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication. J Virol 2006; 80:4406-4414.
    • (2006) J Virol , vol.80 , pp. 4406-4414
    • Bouchard, M.J.1    Wang, L.2    Schneider, R.J.3
  • 12
    • 0029895723 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases
    • Benn J, Su F, Doria M, Schneider RJ. Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases. J Virol 1996; 70:4978-4985.
    • (1996) J Virol , vol.70 , pp. 4978-4985
    • Benn, J.1    Su, F.2    Doria, M.3    Schneider, R.J.4
  • 13
    • 0036776554 scopus 로고    scopus 로고
    • Hepatitis B virus X protein activates the p38 mitogen-activated protein kinase pathway in dedifferentiated hepatocytes
    • Tarn C, Zou L, Hullinger RL, Andrisani OM. Hepatitis B virus X protein activates the p38 mitogen-activated protein kinase pathway in dedifferentiated hepatocytes. J Virol 2002; 76:9763-9772.
    • (2002) J Virol , vol.76 , pp. 9763-9772
    • Tarn, C.1    Zou, L.2    Hullinger, R.L.3    Andrisani, O.M.4
  • 14
    • 0035860752 scopus 로고    scopus 로고
    • Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes
    • Tarn C, Lee S, Hu Y, Ashendel C, Andrisani OM. Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes. J Biol Chem 2001; 276:34671-34680.
    • (2001) J Biol Chem , vol.276 , pp. 34671-34680
    • Tarn, C.1    Lee, S.2    Hu, Y.3    Ashendel, C.4    Andrisani, O.M.5
  • 15
    • 0030696170 scopus 로고    scopus 로고
    • Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the nepatitis B virus X gene-transfected cells
    • Takada S, Kaneniwa N, Tsuchida N, Koike K. Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the nepatitis B virus X gene-transfected cells. Oncogene 1997; 15:1895-1901.
    • (1997) Oncogene , vol.15 , pp. 1895-1901
    • Takada, S.1    Kaneniwa, N.2    Tsuchida, N.3    Koike, K.4
  • 16
    • 33646562819 scopus 로고    scopus 로고
    • Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma
    • Branda M, Wands J. Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma. Hepatology 2006; 43:891-902.
    • (2006) Hepatology , vol.43 , pp. 891-902
    • Branda, M.1    Wands, J.2
  • 17
    • 0032772369 scopus 로고    scopus 로고
    • Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha
    • Weil R, Sirma H, Giannini C, et al. Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha. Mol Cell Biol 1999; 19:6345-6354.
    • (1999) Mol Cell Biol , vol.19 , pp. 6345-6354
    • Weil, R.1    Sirma, H.2    Giannini, C.3
  • 18
    • 34547593907 scopus 로고    scopus 로고
    • Modulation of MAPK pathways and cell cycle by replicating hepatitis B virus: Factors contributing to hepatocarcinogenesis
    • Chin R, Earnest-Silveira L, Koeberlein B, et al. Modulation of MAPK pathways and cell cycle by replicating hepatitis B virus: factors contributing to hepatocarcinogenesis. J Hepatology 2007; 47:325-337.
    • (2007) J Hepatology , vol.47 , pp. 325-337
    • Chin, R.1    Earnest-Silveira, L.2    Koeberlein, B.3
  • 19
    • 25844459154 scopus 로고    scopus 로고
    • NF-kappaB: Linking inflammation and immunity to cancer development and progression
    • Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005; 5:749-759.
    • (2005) Nat Rev Immunol , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 20
    • 19544391413 scopus 로고    scopus 로고
    • Lamivudine for patients with chronic hepatitis B and advanced liver disease
    • Liaw YF, Sung JJ, Chow WC, et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease. N Engl J Med 2004; 351:1521-1531.
    • (2004) N Engl J Med , vol.351 , pp. 1521-1531
    • Liaw, Y.F.1    Sung, J.J.2    Chow, W.C.3
  • 21
    • 20444504309 scopus 로고    scopus 로고
    • HBV-DNA suppression and disease course in HBV cirrhosis patients on long-term lamivudine therapy
    • Di Marco V, Di Stefano R, Ferraro D, et al. HBV-DNA suppression and disease course in HBV cirrhosis patients on long-term lamivudine therapy. Antivir Ther 2005; 10:431-439.
    • (2005) Antivir Ther , vol.10 , pp. 431-439
    • Di Marco, V.1    Di Stefano, R.2    Ferraro, D.3
  • 22
    • 33644818518 scopus 로고    scopus 로고
    • A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B
    • Chang TT, Gish RG, de Man R, et al. A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. N Engl J Med 2006; 354:1001-1010.
    • (2006) N Engl J Med , vol.354 , pp. 1001-1010
    • Chang, T.T.1    Gish, R.G.2    de Man, R.3
  • 23
    • 21244455293 scopus 로고    scopus 로고
    • Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B
    • Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, et al. Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B. N Engl J Med 2005; 352:2673-2681.
    • (2005) N Engl J Med , vol.352 , pp. 2673-2681
    • Hadziyannis, S.J.1    Tassopoulos, N.C.2    Heathcote, E.J.3
  • 24
    • 33644822860 scopus 로고    scopus 로고
    • Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B
    • Lai CL, Shouval D, Lok AS, et al. Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B. N Engl J Med 2006; 354:1011-1020.
    • (2006) N Engl J Med , vol.354 , pp. 1011-1020
    • Lai, C.L.1    Shouval, D.2    Lok, A.S.3
  • 25
    • 4644295202 scopus 로고    scopus 로고
    • Clinical outcome of HBeAg-negative chronic hepatitis B in relation to virological response to lamivudine
    • Di Marco V, Marzano A, Lampertico P, et al. Clinical outcome of HBeAg-negative chronic hepatitis B in relation to virological response to lamivudine. Hepatology 2004; 40:883-891.
    • (2004) Hepatology , vol.40 , pp. 883-891
    • Di Marco, V.1    Marzano, A.2    Lampertico, P.3
  • 26
    • 33644858331 scopus 로고    scopus 로고
    • Prediciting cirrhosis risk based on the level of circulating hepatitis B viral load
    • Iloeje HU, Yang H-I, Su J, Jen C-L, You S-L, Chen C-J. Prediciting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006; 130:678-686.
    • (2006) Gastroenterology , vol.130 , pp. 678-686
    • Iloeje, H.U.1    Yang, H.-I.2    Su, J.3    Jen, C.-L.4    You, S.-L.5    Chen, C.-J.6
  • 28
    • 2642572726 scopus 로고    scopus 로고
    • Quantification of HBV covalently closed circular DNA from liver tissue by real-time PCR
    • Bowden S, Jackson K, Littlejohn M, Locarnini S. Quantification of HBV covalently closed circular DNA from liver tissue by real-time PCR. Methods Mol Med 2004; 95:41-50.
    • (2004) Methods Mol Med , vol.95 , pp. 41-50
    • Bowden, S.1    Jackson, K.2    Littlejohn, M.3    Locarnini, S.4
  • 29
    • 33846785187 scopus 로고    scopus 로고
    • Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod
    • Choudhari SR, Khan MA, Harris G, et al. Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod. Mol Cancer Ther 2007; 6:112-121.
    • (2007) Mol Cancer Ther , vol.6 , pp. 112-121
    • Choudhari, S.R.1    Khan, M.A.2    Harris, G.3
  • 30
    • 14544281476 scopus 로고    scopus 로고
    • Hepatocellular carcinoma - survival andclinical characteristics in relation to various histologic molecular markers in Western patients
    • Schoniger-Hekele M, Hanel S, Wrba F, Muller C. Hepatocellular carcinoma - survival andclinical characteristics in relation to various histologic molecular markers in Western patients. Liv Int 2005; 25:62-69.
    • (2005) Liv Int , vol.25 , pp. 62-69
    • Schoniger-Hekele, M.1    Hanel, S.2    Wrba, F.3    Muller, C.4
  • 31
    • 0036017536 scopus 로고    scopus 로고
    • High expression of p21waf1/cip1 is correlated with human hepatocellular carcinoma in patients with hepatitis C virus-associated chronic liver diseases
    • Wagayama H, Shiraki K, Sugimoto K, et al. High expression of p21waf1/cip1 is correlated with human hepatocellular carcinoma in patients with hepatitis C virus-associated chronic liver diseases. Hum Pathol 2002; 33:429-434.
    • (2002) Hum Pathol , vol.33 , pp. 429-434
    • Wagayama, H.1    Shiraki, K.2    Sugimoto, K.3
  • 32
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999; 13:1501-1512.
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 33
    • 0037192852 scopus 로고    scopus 로고
    • Li Y, Dowbenko D, Lasky LA. AKT/PKB phosphorylation of p21cip/waf1 enhances protein stability of p21cip/waf1 and promotes cell survival. J Biol Chem 2002; 277:11352-11361.
    • Li Y, Dowbenko D, Lasky LA. AKT/PKB phosphorylation of p21cip/waf1 enhances protein stability of p21cip/waf1 and promotes cell survival. J Biol Chem 2002; 277:11352-11361.
  • 34
    • 0034941567 scopus 로고    scopus 로고
    • Akt-Dependent Phosphorylation of p21Cip1 Regulates PCNA Binding and Proliferation of Endothelial Cells
    • Rossig L, Jadidi AS, Urbich C, Badorff C, Zeiher AM, Dimmeler S. Akt-Dependent Phosphorylation of p21Cip1 Regulates PCNA Binding and Proliferation of Endothelial Cells. Mol Cell Biol 2001; 21:5644-5657.
    • (2001) Mol Cell Biol , vol.21 , pp. 5644-5657
    • Rossig, L.1    Jadidi, A.S.2    Urbich, C.3    Badorff, C.4    Zeiher, A.M.5    Dimmeler, S.6
  • 35
    • 34547101027 scopus 로고    scopus 로고
    • AKT-mediated liver growth promotes induction of cyclin E through a novel mechanism and a p21-mediated cell cycle arrest
    • Mullany LK, Nelsen CJ, Hanse EA, et al. AKT-mediated liver growth promotes induction of cyclin E through a novel mechanism and a p21-mediated cell cycle arrest. J Biol Chem 2007; 282:21244-21252.
    • (2007) J Biol Chem , vol.282 , pp. 21244-21252
    • Mullany, L.K.1    Nelsen, C.J.2    Hanse, E.A.3
  • 36
    • 26444584958 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and liver carcinogenesis
    • Arsura M, Cavin LG. Nuclear factor-kappaB and liver carcinogenesis. Cancer Lett 2005; 229:157-169.
    • (2005) Cancer Lett , vol.229 , pp. 157-169
    • Arsura, M.1    Cavin, L.G.2
  • 37
    • 21244472975 scopus 로고    scopus 로고
    • IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005; 121:977-990.
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 38
    • 0030691794 scopus 로고    scopus 로고
    • Early bioenergetic changes in hepatocarcinogenesis: Preneoplastic phenotypes mimic responses to insulin and thyroid hormone
    • Bannasch P, Klimek F, Mayer D. Early bioenergetic changes in hepatocarcinogenesis: preneoplastic phenotypes mimic responses to insulin and thyroid hormone. J Bioenerg Biomembr 1997; 29:303-313.
    • (1997) J Bioenerg Biomembr , vol.29 , pp. 303-313
    • Bannasch, P.1    Klimek, F.2    Mayer, D.3
  • 39
    • 0030660181 scopus 로고    scopus 로고
    • Human hepatic preneoplasia: Phenotypes and proliferation kinetics of foci and nodules of altered hepatocytes and their relationship to liver cell dysplasia
    • Su Q, Benner A, Hofmann WJ, Otto G, Pichlmayr R, Bannasch P. Human hepatic preneoplasia: phenotypes and proliferation kinetics of foci and nodules of altered hepatocytes and their relationship to liver cell dysplasia. Virchows Arch 1997; 431:391-406.
    • (1997) Virchows Arch , vol.431 , pp. 391-406
    • Su, Q.1    Benner, A.2    Hofmann, W.J.3    Otto, G.4    Pichlmayr, R.5    Bannasch, P.6
  • 40
    • 0031052692 scopus 로고    scopus 로고
    • Focal hepatic glycogenosis: A putative preneoplastic lesion associated with neoplasia and cirrhosis in explanted human livers
    • Bannasch P, Jahn U-R, Hacker HJ, et al. Focal hepatic glycogenosis: a putative preneoplastic lesion associated with neoplasia and cirrhosis in explanted human livers. Int J Oncol 1997; 10:261-268.
    • (1997) Int J Oncol , vol.10 , pp. 261-268
    • Bannasch, P.1    Jahn, U.-R.2    Hacker, H.J.3
  • 41
    • 0037255302 scopus 로고    scopus 로고
    • Significance of hepatic preneoplasia in risk identification and early detection of neoplasia
    • Bannasch P, Haertel T, Su Q. Significance of hepatic preneoplasia in risk identification and early detection of neoplasia. Toxicol Pathol 2003; 31:134-139.
    • (2003) Toxicol Pathol , vol.31 , pp. 134-139
    • Bannasch, P.1    Haertel, T.2    Su, Q.3
  • 42
    • 7444249697 scopus 로고    scopus 로고
    • Insulin receptor, insulin receptor substrate-1, Raf-1, and Mek-1 during hormonal hepatocarcinogenesis by intrahepatic pancreatic islet transplantation in diabetic rats
    • Evert M, Sun J, Pichler S, Slavova N, Schneider-Stock R, Dombrowski F. Insulin receptor, insulin receptor substrate-1, Raf-1, and Mek-1 during hormonal hepatocarcinogenesis by intrahepatic pancreatic islet transplantation in diabetic rats. Cancer Res 2004; 64:8093-8100.
    • (2004) Cancer Res , vol.64 , pp. 8093-8100
    • Evert, M.1    Sun, J.2    Pichler, S.3    Slavova, N.4    Schneider-Stock, R.5    Dombrowski, F.6
  • 43
    • 0030769166 scopus 로고    scopus 로고
    • Biological effects of human insulin receptor substrate-1 overexpression in hepatocytes
    • Tanaka S, Mohr L, Schmidt EV, Sugimachi K, Wands JR. Biological effects of human insulin receptor substrate-1 overexpression in hepatocytes. Hepatology 1997; 26:598-604.
    • (1997) Hepatology , vol.26 , pp. 598-604
    • Tanaka, S.1    Mohr, L.2    Schmidt, E.V.3    Sugimachi, K.4    Wands, J.R.5
  • 44
    • 0023941830 scopus 로고
    • Hit and run' transformation of mouse C127 cells by bovine papillomavirus type 4: The viral DNA is required for the initiation but not for maintenance of the transformed phenotype
    • Smith KT, Campq MS. 'Hit and run' transformation of mouse C127 cells by bovine papillomavirus type 4: the viral DNA is required for the initiation but not for maintenance of the transformed phenotype. Virology 1988; 164:39-47.
    • (1988) Virology , vol.164 , pp. 39-47
    • Smith, K.T.1    Campq, M.S.2
  • 45
    • 0026708088 scopus 로고
    • Transformation of rodent fibroblasts by herpes simplex virus: Presence of morphological transforming region 1 (MTR 1) is not required for the maintenance of the transformed state
    • Bauer G, Kahl S, Sawhney IS, Hofler P, Gerspach R, Matz B. Transformation of rodent fibroblasts by herpes simplex virus: presence of morphological transforming region 1 (MTR 1) is not required for the maintenance of the transformed state. Int J Cancer 1992; 51:754-760.
    • (1992) Int J Cancer , vol.51 , pp. 754-760
    • Bauer, G.1    Kahl, S.2    Sawhney, I.S.3    Hofler, P.4    Gerspach, R.5    Matz, B.6
  • 46
    • 0033802836 scopus 로고    scopus 로고
    • Hepadnaviral hepatocarcinogenesis: In situ visualization of viral antigens, cytoplasmic compartmentation, enzymic patterns, and cellular proliferation in preneoplastic hepatocellular lineages in woodchucks
    • Radaeva S, Li Y, Hacker HJ, Burger V, Kopp-Schneider A, Bannasch P. Hepadnaviral hepatocarcinogenesis: in situ visualization of viral antigens, cytoplasmic compartmentation, enzymic patterns, and cellular proliferation in preneoplastic hepatocellular lineages in woodchucks. J Hepatol 2000; 33:580-600.
    • (2000) J Hepatol , vol.33 , pp. 580-600
    • Radaeva, S.1    Li, Y.2    Hacker, H.J.3    Burger, V.4    Kopp-Schneider, A.5    Bannasch, P.6
  • 47
    • 0342313805 scopus 로고    scopus 로고
    • Overexpression of p53 protein is not directly related to hepatitis B x protein expression and is associated with neoplastic progression in hepatocellular carcinomas rather than hepatic preneoplasia
    • Su Q, Schroder CH, Otto G, Bannasch P. Overexpression of p53 protein is not directly related to hepatitis B x protein expression and is associated with neoplastic progression in hepatocellular carcinomas rather than hepatic preneoplasia. Mutat Res 2000; 462:365-380.
    • (2000) Mutat Res , vol.462 , pp. 365-380
    • Su, Q.1    Schroder, C.H.2    Otto, G.3    Bannasch, P.4
  • 48
    • 32444435472 scopus 로고    scopus 로고
    • Five years of sequential LAM to LAM+ADV therapy supresses HBV replication in most HBEAG-negative cirrhotics, preventing decompensation but not hepatocellular carcinoma
    • Lampertico P, Vigano M, Manenti E, Iavarone M, Lunghi G, Colombo M. Five years of sequential LAM to LAM+ADV therapy supresses HBV replication in most HBEAG-negative cirrhotics, preventing decompensation but not hepatocellular carcinoma. Hepatology 2005; 42:983A.
    • (2005) Hepatology , vol.42
    • Lampertico, P.1    Vigano, M.2    Manenti, E.3    Iavarone, M.4    Lunghi, G.5    Colombo, M.6
  • 49
    • 33751514752 scopus 로고    scopus 로고
    • Interferon therapy in HBeAg positive chronic hepatitis reduces progression to cirrhosis and hepatocellular carcinoma
    • Lin SM, Yu ML, Lee CM, et al. Interferon therapy in HBeAg positive chronic hepatitis reduces progression to cirrhosis and hepatocellular carcinoma. J Hepatol 2007; 46:45-52.
    • (2007) J Hepatol , vol.46 , pp. 45-52
    • Lin, S.M.1    Yu, M.L.2    Lee, C.M.3
  • 50
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001; 414:799-806.
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 52
    • 0032560475 scopus 로고    scopus 로고
    • Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice
    • Kaplan DH, Shankaran V, Dighe AS, et al. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci U S A 1998; 95:7556-7561.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 7556-7561
    • Kaplan, D.H.1    Shankaran, V.2    Dighe, A.S.3
  • 53
    • 0036161381 scopus 로고    scopus 로고
    • Selection of hepatitis B virus polymerase mutants with enhanced replication by lamivuaine treatment after liver transplantation
    • Bock TC, Tillmann HL, Torresi J, et al. Selection of hepatitis B virus polymerase mutants with enhanced replication by lamivuaine treatment after liver transplantation. Gastroenterology 2002; 122:264-273.
    • (2002) Gastroenterology , vol.122 , pp. 264-273
    • Bock, T.C.1    Tillmann, H.L.2    Torresi, J.3
  • 54
    • 15844387385 scopus 로고    scopus 로고
    • Neoplastic transformation induced by insulin receptor substrate 1 (IRS-1) overexpression requires an interaction with both Grb2 and Syp signaling molecules
    • Tanaka S, Ito T, Wands J. Neoplastic transformation induced by insulin receptor substrate 1 (IRS-1) overexpression requires an interaction with both Grb2 and Syp signaling molecules. J Biol Chem 1996; 271:14610- 14616.
    • (1996) J Biol Chem , vol.271 , pp. 14610-14616
    • Tanaka, S.1    Ito, T.2    Wands, J.3


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