Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation

Biochemical Pharmacology

Volumn 84, Issue 1, 2012, Pages 104-112

  Thirumaran, Ranjit K ^a   Lamba, Jatinder K ^b   Kim, Richard B ^c   Urquhart, Brad L ^d   Gregor, Jamie C ^c   Chande, Nilesh ^c   Fan, Yiping ^a   Qi, An ^a   Cheng, Cheng ^a   Thummel, Kenneth E ^e   Hall, Stephen D ^f   Schuetz, Erin G ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c LONDON HEALTH SCIENCES CENTRE   (Canada)

^d WESTERN UNIVERSITY   (Canada)

^e UNIVERSITY OF WASHINGTON   (United States)

^f ELI LILLY AND COMPANY   (United States)

Author keywords

CYP3A4; Polymorphism; Seasonal variation; VDR; Vitamin D

Indexed keywords

CYTOCHROME P450 3A4; INTESTINE ENZYME; MESSENGER RNA; MIDAZOLAM; VITAMIN D RECEPTOR;

AREA UNDER THE CURVE; ARTICLE; DNA POLYMORPHISM; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISPOSITION; DRUG PROTEIN BINDING; DUODENUM; GENE EXPRESSION REGULATION; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; JEJUNUM; PHARMACOGENETICS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEASONAL VARIATION; SINGLE NUCLEOTIDE POLYMORPHISM; SUN EXPOSURE; TRANSCRIPTION REGULATION; ULTRAVIOLET RADIATION;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; CYTOCHROME P-450 CYP3A; DUODENUM; EUROPEAN CONTINENTAL ANCESTRY GROUP; HUMANS; INJECTIONS, INTRAVENOUS; INTESTINAL MUCOSA; JEJUNUM; LIVER; METABOLIC CLEARANCE RATE; MIDAZOLAM; MIDDLE AGED; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTORS, CALCITRIOL; SEASONS; TISSUE DISTRIBUTION; YOUNG ADULT;

EID: 84860685116     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.03.017     Document Type: Article

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