메뉴 건너뛰기




Volumn 2, Issue 1, 2005, Pages 59-67

Oncopharmacological perspectives of a plant lectin (Viscum album agglutinin-I): Overview of recent results from in vitro experiments and in vivo animal models, and their possible relevance for clinical applications

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; VISCUM ALBUM EXTRACT; VISCUM ALBUM LECTIN;

EID: 25844444123     PISSN: 1741427X     EISSN: None     Source Type: Journal    
DOI: 10.1093/ecam/neh058     Document Type: Review
Times cited : (47)

References (81)
  • 1
    • 0024397491 scopus 로고
    • Modulatory potency of the β-galactoside-specific lectin from mistletoe extract (Iscador) on the host defense system in vivo in rabbits and patients
    • Hajto T, Hostanska K, Gabius H-J. Modulatory potency of the β-galactoside-specific lectin from mistletoe extract (Iscador) on the host defense system in vivo in rabbits and patients. Cancer Res 1989;49:4803-8.
    • (1989) Cancer Res , vol.49 , pp. 4803-4808
    • Hajto, T.1    Hostanska, K.2    Gabius, H.-J.3
  • 2
    • 0014916047 scopus 로고
    • Separation of viscotoxins from the European mistletoe Viscum album L (Loranthacea) by chromatography on sulfoethyl sephadex
    • Samuelsson G, Pettersson B. Separation of viscotoxins from the European mistletoe Viscum album L (Loranthacea) by chromatography on sulfoethyl sephadex. Acta Chem Scand 1970;24:2751-6.
    • (1970) Acta Chem Scand , vol.24 , pp. 2751-2756
    • Samuelsson, G.1    Pettersson, B.2
  • 3
    • 0028894133 scopus 로고
    • Comparative study on the cytotoxic effect of viscotoxin and mistletoe lectin on tumor cells in culture
    • Urech K, Schaller G, Ziska P, Giannattasio M. Comparative study on the cytotoxic effect of viscotoxin and mistletoe lectin on tumor cells in culture. Phytother Res 1995;9:49-55.
    • (1995) Phytother Res , vol.9 , pp. 49-55
    • Urech, K.1    Schaller, G.2    Ziska, P.3    Giannattasio, M.4
  • 4
    • 0025642937 scopus 로고
    • A Viscum album oligosaccharide activating human natural cytotoxicity is an interferon-gamma inducer
    • Müller EA, Anderer FA. A Viscum album oligosaccharide activating human natural cytotoxicity is an interferon-gamma inducer. Cancer Immunol Immunother 1990;32:221-7.
    • (1990) Cancer Immunol Immunother , vol.32 , pp. 221-227
    • Müller, E.A.1    Anderer, F.A.2
  • 5
    • 0343795174 scopus 로고
    • Chemical studies on the mistletoe. The structure of taxillusin, a new flavinoid glycoside isolated from Taxillus kaempferi
    • Sakurai A, Okumara Y. Chemical studies on the mistletoe. The structure of taxillusin, a new flavinoid glycoside isolated from Taxillus kaempferi. Bull Chem Soc Jpn 1983;56:542-4.
    • (1983) Bull Chem Soc Jpn , vol.56 , pp. 542-544
    • Sakurai, A.1    Okumara, Y.2
  • 6
    • 0006674665 scopus 로고
    • Vergleichende Untersuchungen von Misteln verschiedener Wirtsbäume an Hand der Flavonoide und Phenyl-carbonsäuren
    • Becker H, Exner J. Vergleichende Untersuchungen von Misteln verschiedener Wirtsbäume an Hand der Flavonoide und Phenyl-carbonsäuren. Z Pflanzenphysiol 1980;97:417-28.
    • (1980) Z Pflanzenphysiol , vol.97 , pp. 417-428
    • Becker, H.1    Exner, J.2
  • 7
    • 1942532012 scopus 로고    scopus 로고
    • Isolation and quantification of chitin-binding mistletoe lectin from mistletoe extracts and validation of these methods
    • Franz M, Vollmer S, Wacker R et al. Isolation and quantification of chitin-binding mistletoe lectin from mistletoe extracts and validation of these methods. Drug Res 2004;54:230-9.
    • (2004) Drug Res , vol.54 , pp. 230-239
    • Franz, M.1    Vollmer, S.2    Wacker, R.3
  • 8
    • 70449539226 scopus 로고
    • Zur Kenntnis der Inhaltsstoffe von Viscum album. Freie Aminosäuren
    • Vester F, Mai W. Zur Kenntnis der Inhaltsstoffe von Viscum album. Freie Aminosäuren. Hoppe-Seyler's Z Physiol Chem 1980;322:273-7.
    • (1980) Hoppe-Seyler's Z Physiol Chem , vol.322 , pp. 273-277
    • Vester, F.1    Mai, W.2
  • 9
    • 0021722661 scopus 로고
    • Carbohydrates as recognition determinants in phagocytosis and in lectin-mediated killing of target cells
    • Sharon N. Carbohydrates as recognition determinants in phagocytosis and in lectin-mediated killing of target cells. Biol Cell 1984;51:239-46.
    • (1984) Biol Cell , vol.51 , pp. 239-246
    • Sharon, N.1
  • 10
    • 0013174485 scopus 로고
    • Determination of lectin contents in commercial mistletoe preparations for cancer therapy using the ELISA technique
    • Bog Hansen TC, Breborowicz J (eds). Walter de Gruyter & Co., Berlin
    • Ziska P, Franz H. Determination of lectin contents in commercial mistletoe preparations for cancer therapy using the ELISA technique. In: Bog Hansen TC, Breborowicz J (eds). Lectins, Vol. IV. Walter de Gruyter & Co., Berlin, 1985, 473-80.
    • (1985) Lectins , vol.4 , pp. 473-480
    • Ziska, P.1    Franz, H.2
  • 11
    • 0026615930 scopus 로고
    • Identity of the N-terminal sequences of the three A chains of mistletoe (Viscum album L.) lectins: Homology with ricin-like plant toxins and single-chain ribosome-inhibiting proteins
    • Dietrich JB, Ribereau-Gayon G, Jung ML, Franz H, Beck JP, Anton R. Identity of the N-terminal sequences of the three A chains of mistletoe (Viscum album L.) lectins: homology with ricin-like plant toxins and single-chain ribosome-inhibiting proteins. Anticancer Drug 1992;3:507-11.
    • (1992) Anticancer Drug , vol.3 , pp. 507-511
    • Dietrich, J.B.1    Ribereau-Gayon, G.2    Jung, M.L.3    Franz, H.4    Beck, J.P.5    Anton, R.6
  • 12
    • 0020433058 scopus 로고
    • Isolation and characterization of viscumin, a toxic lectin from Viscum album L. (mistletoe)
    • Olsnes S, Stirpe F, Sandvig K, Pihl A. Isolation and characterization of viscumin, a toxic lectin from Viscum album L. (mistletoe). J Biol Chem 1982;257:13263-70.
    • (1982) J Biol Chem , vol.257 , pp. 13263-13270
    • Olsnes, S.1    Stirpe, F.2    Sandvig, K.3    Pihl, A.4
  • 13
    • 0023951178 scopus 로고
    • Characterization of a toxic lectin in Iscador, a mistletoe preparation with alleged cancerostatic properties
    • Holtskog R, Sandvig K, Olsnes S. Characterization of a toxic lectin in Iscador, a mistletoe preparation with alleged cancerostatic properties. Oncology 1988;45:172-9.
    • (1988) Oncology , vol.45 , pp. 172-179
    • Holtskog, R.1    Sandvig, K.2    Olsnes, S.3
  • 14
    • 0022974277 scopus 로고
    • Mistletoe lectins and their A and B chains
    • Franz H. Mistletoe lectins and their A and B chains. Oncology 1986;43:23-34.
    • (1986) Oncology , vol.43 , pp. 23-34
    • Franz, H.1
  • 15
    • 0008613965 scopus 로고
    • Characterization of the different lectins from Viscum album (mistletoe) and their structural relationship with agglutinins from Abrus precatorius and Ricinus communis
    • Bog Hansen TC, Breborowicz J (eds). Walter de Gruyter & Co., Berlin
    • Samtleben R, Kiefer M, Luther P. Characterization of the different lectins from Viscum album (mistletoe) and their structural relationship with agglutinins from Abrus precatorius and Ricinus communis. In: Bog Hansen TC, Breborowicz J (eds). Lectins, Vol. IV. Walter de Gruyter & Co., Berlin, 1985, 617-26.
    • (1985) Lectins , vol.4 , pp. 617-626
    • Samtleben, R.1    Kiefer, M.2    Luther, P.3
  • 16
    • 0024299168 scopus 로고
    • Similarity of protein conformation at low pH and high temperature observed for B-chains of two plant toxins: Ricin and mistletoe lectin I
    • Bushueva TL, Tonevitsky AG. Similarity of protein conformation at low pH and high temperature observed for B-chains of two plant toxins: ricin and mistletoe lectin I. FEBS Lett 1988;229:119-122.
    • (1988) FEBS Lett , vol.229 , pp. 119-122
    • Bushueva, T.L.1    Tonevitsky, A.G.2
  • 18
    • 0028381203 scopus 로고
    • The sugar-combining area of the galactose-specific toxic lectin of mistletoe extends beyond the terminal sugar residue: Comparison with homologous toxic lectin, ricin
    • Lee RT, Gabius H-J, Lee YC. The sugar-combining area of the galactose-specific toxic lectin of mistletoe extends beyond the terminal sugar residue: comparison with homologous toxic lectin, ricin. Carbohydr Res 1994;254:269-76.
    • (1994) Carbohydr Res , vol.254 , pp. 269-276
    • Lee, R.T.1    Gabius, H.-J.2    Lee, Y.C.3
  • 19
    • 0024296613 scopus 로고
    • The site of action of the A-chain of mistletoe lectin I on eukaryotic ribosomes. The RNA N-glycosidase activity of the protein
    • Endo Y, Tsurugi K, Franz H. The site of action of the A-chain of mistletoe lectin I on eukaryotic ribosomes. The RNA N-glycosidase activity of the protein. FEBS Lett 1988;231:378-80.
    • (1988) FEBS Lett , vol.231 , pp. 378-380
    • Endo, Y.1    Tsurugi, K.2    Franz, H.3
  • 20
    • 0020265159 scopus 로고
    • Entry of the toxic proteins abrin, modeccin, ricin and diphtheria toxin into the cell. II. Effect of pH, metabolic inhibitors, and ionophores and evidence for toxin penetration from endocytotic vesicles
    • Sandvig K, Olsnes S. Entry of the toxic proteins abrin, modeccin, ricin and diphtheria toxin into the cell. II. Effect of pH, metabolic inhibitors, and ionophores and evidence for toxin penetration from endocytotic vesicles. J Biol Chem 1982;257:7504-13.
    • (1982) J Biol Chem , vol.257 , pp. 7504-7513
    • Sandvig, K.1    Olsnes, S.2
  • 21
    • 0026062413 scopus 로고
    • Internalization and action of an immunotoxin containing mistletoe lectin A-chain
    • Wiedlocha A, Sandvig K, Walzel H, Radzikowsky C, Olsnes S. Internalization and action of an immunotoxin containing mistletoe lectin A-chain. Cancer Res 1991;51:916-20.
    • (1991) Cancer Res , vol.51 , pp. 916-920
    • Wiedlocha, A.1    Sandvig, K.2    Walzel, H.3    Radzikowsky, C.4    Olsnes, S.5
  • 22
    • 14744291476 scopus 로고
    • Ribosome-inactivating proteins from plants: Present status and future prospects
    • Stirpe F, Barbieri L, Batelli MG, Soria M, Lappi DA. Ribosome- inactivating proteins from plants: present status and future prospects. BioTechnology 1992;10:405-12.
    • (1992) BioTechnology , vol.10 , pp. 405-412
    • Stirpe, F.1    Barbieri, L.2    Batelli, M.G.3    Soria, M.4    Lappi, D.A.5
  • 24
    • 0032577201 scopus 로고    scopus 로고
    • Complete fluid acid sequence of the B chain of mistletoe lectin I
    • Soler MH, Stoeva S, Voelter W. Complete fluid acid sequence of the B chain of mistletoe lectin I. Biochem Biophys Res Commun 1998;246:596-601.
    • (1998) Biochem Biophys Res Commun , vol.246 , pp. 596-601
    • Soler, M.H.1    Stoeva, S.2    Voelter, W.3
  • 25
    • 25844529670 scopus 로고    scopus 로고
    • Molecular cloning of the Viscum album L (mistletoe) gene for ML-1 and characterization of the recombinant protein
    • Zinke H, Eck J, Langer M, Möckel B, Baur A, Lentzen H. Molecular cloning of the Viscum album L (mistletoe) gene for ML-1 and characterization of the recombinant protein. Phytomedicine 1996;3 Suppl 1: 25.
    • (1996) Phytomedicine , vol.3 , Issue.1 SUPPL. , pp. 25
    • Zinke, H.1    Eck, J.2    Langer, M.3    Möckel, B.4    Baur, A.5    Lentzen, H.6
  • 26
    • 0032699795 scopus 로고    scopus 로고
    • Selective modulation of phosphatitylserine expression on various subpopulations of human peripheral blood lymphocytes by a plant lectin, Viscum album agglutinin VAA-I and its recombinant form (rVAA) in vitro
    • Hostanska K, Hajto T, Fischer J et al. Selective modulation of phosphatitylserine expression on various subpopulations of human peripheral blood lymphocytes by a plant lectin, Viscum album agglutinin VAA-I and its recombinant form (rVAA) in vitro. Cancer Detect Prevent 1999;23:511-23.
    • (1999) Cancer Detect Prevent , vol.23 , pp. 511-523
    • Hostanska, K.1    Hajto, T.2    Fischer, J.3
  • 27
    • 0031794944 scopus 로고    scopus 로고
    • Effect of a recombinant lectin, Viscum album agglutinin (rVAA) on secretion of interleukin-12 in cultured human peripheral blood mononuclear cells and on NK cell-mediated cytotoxicity of rat splenocytes in vitro and in in vivo
    • Hajto T, Hostanska K, Weber K et al. Effect of a recombinant lectin, Viscum album agglutinin (rVAA) on secretion of interleukin-12 in cultured human peripheral blood mononuclear cells and on NK cell-mediated cytotoxicity of rat splenocytes in vitro and in in vivo. Nat Immunol 1998;16:34-46.
    • (1998) Nat Immunol , vol.16 , pp. 34-46
    • Hajto, T.1    Hostanska, K.2    Weber, K.3
  • 28
    • 0027374994 scopus 로고
    • In vitro effects of mistletoe extracts and mistletoe lectins. Cytotoxicity towards tumor cells due to the induction of programmed cell death (apoptosis)
    • Janssen O, Scheffler A, Kabelitz D. In vitro effects of mistletoe extracts and mistletoe lectins. Cytotoxicity towards tumor cells due to the induction of programmed cell death (apoptosis). Drug Res 1993;43:1221-7
    • (1993) Drug Res , vol.43 , pp. 1221-1227
    • Janssen, O.1    Scheffler, A.2    Kabelitz, D.3
  • 29
    • 0042608534 scopus 로고    scopus 로고
    • Induction of apoptosis in human lymphocytes treated with Viscum album L is mediated by mistletoe lectins
    • Büssing A, Suzart K, Bergmann J, Pfüller U, Schietzel M, Schweizer K. Induction of apoptosis in human lymphocytes treated with Viscum album L is mediated by mistletoe lectins. Cancer Lett 1996;99:59-72.
    • (1996) Cancer Lett , vol.99 , pp. 59-72
    • Büssing, A.1    Suzart, K.2    Bergmann, J.3    Pfüller, U.4    Schietzel, M.5    Schweizer, K.6
  • 30
    • 0025313821 scopus 로고
    • Increased secretion of tumor necrosis factor α, interleukin 1, and interleukin 6 by human mononuclear cells exposed to β-galactoside-specific lectin from clinically applied misletoe extract
    • Hajto T, Hostanska K, Frei K, Rordorf C, Gabius H-J. Increased secretion of tumor necrosis factor α, interleukin 1, and interleukin 6 by human mononuclear cells exposed to β-galactoside-specific lectin from clinically applied misletoe extract. Cancer Res 1990;50:3322-6.
    • (1990) Cancer Res , vol.50 , pp. 3322-3326
    • Hajto, T.1    Hostanska, K.2    Frei, K.3    Rordorf, C.4    Gabius, H.-J.5
  • 31
    • 0029548382 scopus 로고
    • A plant lectin derived from Viscum album induces cytokine gene expression and protein production in cultures of human peripheral blood mononuclear cells
    • Hostanska K, Hajto T, Spagnoli G, Fischer J, Lentzen H, Herrmann R. A plant lectin derived from Viscum album induces cytokine gene expression and protein production in cultures of human peripheral blood mononuclear cells. Nat Immunol 1995;14:295-304.
    • (1995) Nat Immunol , vol.14 , pp. 295-304
    • Hostanska, K.1    Hajto, T.2    Spagnoli, G.3    Fischer, J.4    Lentzen, H.5    Herrmann, R.6
  • 32
    • 0030319568 scopus 로고    scopus 로고
    • A natural immunity activating plant lectin, Viscum album agglutinin-I (VAA-I) induces apoptosis in human lymphocytes, monocytes, monocytic THP-1 cells and murine thymocytes
    • Hostanska K, Hajto T, Weber K et al. A natural immunity activating plant lectin, Viscum album agglutinin-I (VAA-I) induces apoptosis in human lymphocytes, monocytes, monocytic THP-1 cells and murine thymocytes. Nat Immunol 1996-97;15:295-311.
    • (1996) Nat Immunol , vol.15 , pp. 295-311
    • Hostanska, K.1    Hajto, T.2    Weber, K.3
  • 33
    • 0031021999 scopus 로고    scopus 로고
    • In U-937 peomonocytes, mistletoe lectin I increases basal (Ca2+)i, enhances histamin H1- and complement C5a-receptor-mediated rises in (Ca2+)i, and induces cell death
    • Wenzel-Seifert K, Lentzen H, Seifert R. In U-937 peomonocytes, mistletoe lectin I increases basal (Ca2+)i, enhances histamin H1- and complement C5a-receptor-mediated rises in (Ca2+)i, and induces cell death. Naunyn-Schmiedeberg's Arch Pharmacol 1997;355:190-7.
    • (1997) Naunyn-Schmiedeberg's Arch Pharmacol , vol.355 , pp. 190-197
    • Wenzel-Seifert, K.1    Lentzen, H.2    Seifert, R.3
  • 34
    • 0033135490 scopus 로고    scopus 로고
    • Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis
    • Bantel H, Engels I, Voelter W, Schulze-Osthoff K, Wesselborg S. Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis. Cancer Res 1999;59:2083-90.
    • (1999) Cancer Res , vol.59 , pp. 2083-2090
    • Bantel, H.1    Engels, I.2    Voelter, W.3    Schulze-Osthoff, K.4    Wesselborg, S.5
  • 35
    • 0037928493 scopus 로고    scopus 로고
    • Recombinant mistletoe lectin induces p53-independent apoptosis in tumour cells and cooperates with ionizing radiation
    • Hostanska K, Vuong V, Rocha S et al. Recombinant mistletoe lectin induces p53-independent apoptosis in tumour cells and cooperates with ionizing radiation. Br J Cancer 2003;88:1785-92.
    • (2003) Br J Cancer , vol.88 , pp. 1785-1792
    • Hostanska, K.1    Vuong, V.2    Rocha, S.3
  • 36
    • 0033674183 scopus 로고    scopus 로고
    • Activation of human neutrophils by the plant lectin Viscum album agglutinin-I: Modulation of de novo protein synthesis and evidence that caspases are involved in induction of apoptosis
    • Savoie A, Lavastre V, Pelletier M, Hajto T, Hostanska K, Girard D. Activation of human neutrophils by the plant lectin Viscum album agglutinin-I: modulation of de novo protein synthesis and evidence that caspases are involved in induction of apoptosis. J Leukoc Biol 2000;68:845-53.
    • (2000) J Leukoc Biol , vol.68 , pp. 845-853
    • Savoie, A.1    Lavastre, V.2    Pelletier, M.3    Hajto, T.4    Hostanska, K.5    Girard, D.6
  • 37
    • 0036467549 scopus 로고    scopus 로고
    • Mechanisms involved in spontaneous and Viscum album agglutinin-I-induced human neutrophil apoptosis: Viscum album agglutinin-I accelerates the loss of antiapoptotic Mcl-1 expression and the degradation of cytoskeletal paxillin and vimentin proteins via caspases
    • Lavastre V, Pelletier M, Saller R, Hostanska K, Girard D. Mechanisms involved in spontaneous and Viscum album agglutinin-I-induced human neutrophil apoptosis: Viscum album agglutinin-I accelerates the loss of antiapoptotic Mcl-1 expression and the degradation of cytoskeletal paxillin and vimentin proteins via caspases. J Immunol 2002;168:1419-27.
    • (2002) J Immunol , vol.168 , pp. 1419-1427
    • Lavastre, V.1    Pelletier, M.2    Saller, R.3    Hostanska, K.4    Girard, D.5
  • 38
    • 3542996933 scopus 로고    scopus 로고
    • Anti-inflammatory effect of Viscum album agglutinin-I (VAA-I): Induction of apoptosis in activated neutrophils and inhibition of lipopolysaccharide- induced neutrophil inflammation in vivo
    • Lavastre V, Cavalli H, Ratthe C, Girard G. Anti-inflammatory effect of Viscum album agglutinin-I (VAA-I): induction of apoptosis in activated neutrophils and inhibition of lipopolysaccharide-induced neutrophil inflammation in vivo. Clin Exp Immunol 2004;137:272-8.
    • (2004) Clin Exp Immunol , vol.137 , pp. 272-278
    • Lavastre, V.1    Cavalli, H.2    Ratthe, C.3    Girard, G.4
  • 41
    • 0030568057 scopus 로고    scopus 로고
    • Mistletoe lectins I, II and III induce the production of cytokines by cultured human monocytes
    • Ribereau-Gayon G, Dumont S, Müller C, Jung ML, Poindron P, Anton R. Mistletoe lectins I, II and III induce the production of cytokines by cultured human monocytes. Cancer Lett 1996;109:33-8.
    • (1996) Cancer Lett , vol.109 , pp. 33-38
    • Ribereau-Gayon, G.1    Dumont, S.2    Müller, C.3    Jung, M.L.4    Poindron, P.5    Anton, R.6
  • 42
    • 25844522928 scopus 로고
    • Lectin-induced alterations in the level of phospholipids, inositol phosphates, and phosphoproteins
    • Gabius H-J, Gabius S (eds). Springer Verlag, Berlin
    • Walzel H, Bremer H, Gabius H-J. Lectin-induced alterations in the level of phospholipids, inositol phosphates, and phosphoproteins. In: Gabius H-J, Gabius S (eds). Lectins and Glycobiology. Springer Verlag, Berlin, 1993, 357-61.
    • (1993) Lectins and Glycobiology , pp. 357-361
    • Walzel, H.1    Bremer, H.2    Gabius, H.-J.3
  • 43
    • 12144288364 scopus 로고    scopus 로고
    • Mistletoe lectin I is a sialic acid-specific lectin with strict preference to gangliosides and glycoproteins with terminal Neu5Ac alpha 2-6Gal beta 1-4GlcNAc residues
    • Muthing J, Meisen I, Bullau P et al. Mistletoe lectin I is a sialic acid-specific lectin with strict preference to gangliosides and glycoproteins with terminal Neu5Ac alpha 2-6Gal beta 1-4GlcNAc residues. Biochemistry 2004;43:2996-3007.
    • (2004) Biochemistry , vol.43 , pp. 2996-3007
    • Muthing, J.1    Meisen, I.2    Bullau, P.3
  • 44
    • 0029999199 scopus 로고    scopus 로고
    • Stimulation of cytokine production via a special standardized mistletoe preparation in an in vitro human skin bioassay
    • Joller PW, Menrad JM, Schwarz T et al. Stimulation of cytokine production via a special standardized mistletoe preparation in an in vitro human skin bioassay. Drug Res 1996;46:649-53.
    • (1996) Drug Res , vol.46 , pp. 649-653
    • Joller, P.W.1    Menrad, J.M.2    Schwarz, T.3
  • 45
    • 0037256196 scopus 로고    scopus 로고
    • Cytokine release of a keratinocyte model after incubation with two different Viscum album L extracts
    • Gorter RW, Joller P, Stoss M. Cytokine release of a keratinocyte model after incubation with two different Viscum album L extracts. Am J Ther 2003;10:40-7.
    • (2003) Am J Ther , vol.10 , pp. 40-47
    • Gorter, R.W.1    Joller, P.2    Stoss, M.3
  • 46
    • 0032521401 scopus 로고    scopus 로고
    • Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: Up-regulation of interleukin 10 and down-regulation of interleukin 12 production
    • Huang M, Stolina M, Sharma S et al. Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: up-regulation of interleukin 10 and down-regulation of interleukin 12 production. Cancer Res 1998;58:1208-16.
    • (1998) Cancer Res , vol.58 , pp. 1208-1216
    • Huang, M.1    Stolina, M.2    Sharma, S.3
  • 47
    • 0027409793 scopus 로고
    • Natural killer cell stimulating factor (IL-12) induces T helper type (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
    • Manetti R, Parronchi P, Guidizi MG et al. Natural killer cell stimulating factor (IL-12) induces T helper type (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med 1993;177:1199-204.
    • (1993) J Exp Med , vol.177 , pp. 1199-1204
    • Manetti, R.1    Parronchi, P.2    Guidizi, M.G.3
  • 48
    • 0035191478 scopus 로고    scopus 로고
    • Modulation of interleukin-15-induced human neutrophil responses by the plant lectin Viscum album agglutinin-I
    • Pelletier M, Lavastre V, Savoie A et al. Modulation of interleukin-15-induced human neutrophil responses by the plant lectin Viscum album agglutinin-I. Clin Immunol 2001;101:229-236.
    • (2001) Clin Immunol , vol.101 , pp. 229-236
    • Pelletier, M.1    Lavastre, V.2    Savoie, A.3
  • 49
    • 0021879176 scopus 로고
    • The in vitro activity of lectin from mistletoe (ML-I) and its isolated A and B chains on functions of macrophages and poly-morphonuclear cells
    • Metzner G, Franz H, Kindt A, Fahlbusch B, Süss J. The in vitro activity of lectin from mistletoe (ML-I) and its isolated A and B chains on functions of macrophages and poly-morphonuclear cells. Immunobiology 1985;169:461-71.
    • (1985) Immunobiology , vol.169 , pp. 461-471
    • Metzner, G.1    Franz, H.2    Kindt, A.3    Fahlbusch, B.4    Süss, J.5
  • 50
    • 0027585153 scopus 로고
    • Efficient induction of superoxide release from human neutrophils by the galactoside-specific lectin from Viscum album
    • Timoshenko AV, Gabius HJ. Efficient induction of superoxide release from human neutrophils by the galactoside-specific lectin from Viscum album. Biol Chem Hoppe-Seyler 1993;374:237-43.
    • (1993) Biol Chem Hoppe-Seyler , vol.374 , pp. 237-243
    • Timoshenko, A.V.1    Gabius, H.J.2
  • 51
    • 0029791975 scopus 로고    scopus 로고
    • Concavalin A and mistletoe lectin I differentially activate cation entry and exocytosis in human neutrophils: Lectins may activate multiple subtypes of cation channels
    • Wenzel-Seifert K, Krautwurst D, Lentzen H, Seifert R. Concavalin A and mistletoe lectin I differentially activate cation entry and exocytosis in human neutrophils: lectins may activate multiple subtypes of cation channels. J Leukoc Biol 1996;60:345-55.
    • (1996) J Leukoc Biol , vol.60 , pp. 345-355
    • Wenzel-Seifert, K.1    Krautwurst, D.2    Lentzen, H.3    Seifert, R.4
  • 52
    • 0031661236 scopus 로고    scopus 로고
    • Mistletoe lectin I-induced effects on human cytotoxic lymphocytes. Synergism with IL-2 in the induction of enhanced LAK cytotoxicity
    • Baxevanis CN, Voutsas LF, Soler MH et al. Mistletoe lectin I-induced effects on human cytotoxic lymphocytes. Synergism with IL-2 in the induction of enhanced LAK cytotoxicity. Immunopharmacol Immunotoxicol 1998;20:355-72.
    • (1998) Immunopharmacol Immunotoxicol , vol.20 , pp. 355-372
    • Baxevanis, C.N.1    Voutsas, L.F.2    Soler, M.H.3
  • 53
    • 0031973960 scopus 로고    scopus 로고
    • Lectin-induced increase in clonogenic growth of hematopoietic progenitor cells
    • Vehmeyer K, Hajto T, Hostanska K et al. Lectin-induced increase in clonogenic growth of hematopoietic progenitor cells. Eur J Hematol 1998;60:16-20.
    • (1998) Eur J Hematol , vol.60 , pp. 16-20
    • Vehmeyer, K.1    Hajto, T.2    Hostanska, K.3
  • 54
    • 0028674783 scopus 로고
    • Immunaktive Wirkung von Mistellektin 1 in Abhängigkeit von der Dosierung
    • Beuth J, Ko HL, Tunggal L et al. Immunaktive Wirkung von Mistellektin 1 in Abhängigkeit von der Dosierung. Arzneim Forsch 1994;44:1255-8.
    • (1994) Arzneim Forsch , vol.44 , pp. 1255-1258
    • Beuth, J.1    Ko, H.L.2    Tunggal, L.3
  • 55
    • 0028934789 scopus 로고
    • Immunaktive Wirkung verschiedener Mistellektin-1 Dosierungen in Mammakarzinompatientinennen
    • Beuth J, Stoffel B, Ko HL, Buss G, Tunggal L, Pulverer G. Immunaktive Wirkung verschiedener Mistellektin-1 Dosierungen in Mammakarzinompatientinennen. Arzneim Forsch 1995;45:505-7.
    • (1995) Arzneim Forsch , vol.45 , pp. 505-507
    • Beuth, J.1    Stoffel, B.2    Ko, H.L.3    Buss, G.4    Tunggal, L.5    Pulverer, G.6
  • 56
    • 25844472528 scopus 로고
    • Immunomodulatory potency of mistletoe lectins in cancer patients. Results of a dose finding study
    • Hajto T, Hostanska K, Herrmann R. Immunomodulatory potency of mistletoe lectins in cancer patients. Results of a dose finding study. Allergy (Suppl) 1993;48:548.
    • (1993) Allergy (Suppl) , vol.48 , pp. 548
    • Hajto, T.1    Hostanska, K.2    Herrmann, R.3
  • 57
    • 0001350310 scopus 로고
    • Zytokine als Lektin-induzierte Mediatoren in der Misteltherapie
    • Hajto T, Hostanska K, Gabius H-J. Zytokine als Lektin-induzierte Mediatoren in der Misteltherapie. Therapeutikon 1990;4:136-45.
    • (1990) Therapeutikon , vol.4 , pp. 136-145
    • Hajto, T.1    Hostanska, K.2    Gabius, H.-J.3
  • 58
    • 0001999662 scopus 로고
    • Interaction of mistletoe lectins ML-I, ML-II, and ML-III with carbohydrates
    • Van Driessche E, Franz H, Beeckmans R, Pfüller U, Kallikorm A, Bog-Hansen TC (eds). Walter de Gruyter & Co., Berlin
    • Ziska P, Gelbin M, Franz H. Interaction of mistletoe lectins ML-I, ML-II, and ML-III with carbohydrates. In: Van Driessche E, Franz H, Beeckmans R, Pfüller U, Kallikorm A, Bog-Hansen TC (eds). Lectins: Biology Biochemistry, Clinical Biochemistry, Vol. 8. Walter de Gruyter & Co., Berlin, 1993, 10-3.
    • (1993) Lectins: Biology Biochemistry, Clinical Biochemistry , vol.8 , pp. 10-13
    • Ziska, P.1    Gelbin, M.2    Franz, H.3
  • 59
    • 0037361256 scopus 로고    scopus 로고
    • Immunobiological features of the galactoside lectin L-Lc isolated from the Argentine mistletoe Ligaria cuneifolia
    • Fernandez T, Cerdà Zolezzi P, Caldas Lopes E et al. Immunobiological features of the galactoside lectin L-Lc isolated from the Argentine mistletoe Ligaria cuneifolia. J Ethnopharmacol 2003;85:81-92.
    • (2003) J Ethnopharmacol , vol.85 , pp. 81-92
    • Fernandez, T.1    Cerdà Zolezzi, P.2    Caldas Lopes, E.3
  • 60
    • 0026779122 scopus 로고
    • Behaviour of lymphocyte subsets and expression of activation markers in response to immunotherapy with galactoside-specific lectin from mistletoe in breast cancer patients
    • Beuth J, Ko HL, Gabius HJ, Burrichter H, Oette K, Pulverer G. Behaviour of lymphocyte subsets and expression of activation markers in response to immunotherapy with galactoside-specific lectin from mistletoe in breast cancer patients. Clin Invest 1992;70:658-61.
    • (1992) Clin Invest , vol.70 , pp. 658-661
    • Beuth, J.1    Ko, H.L.2    Gabius, H.J.3    Burrichter, H.4    Oette, K.5    Pulverer, G.6
  • 61
    • 0027153254 scopus 로고
    • Effect of mistletoe lectin therapy on serum level of defined serum proteins (acute phase proteins) in tumor patients
    • Beuth J, Gabius HJ, Steuer MK et al Effect of mistletoe lectin therapy on serum level of defined serum proteins (acute phase proteins) in tumor patients. Med Klin 1993;88:287-90.
    • (1993) Med Klin , vol.88 , pp. 287-290
    • Beuth, J.1    Gabius, H.J.2    Steuer, M.K.3
  • 62
    • 0027465312 scopus 로고
    • Comparative studies on the immunoactive action of galactoside-specific mistletoe lectin. Pure substance compared to the standardized extract
    • Beuth J, Ko HL, Tunggal L, Geisel J, Pulverer G. Comparative studies on the immunoactive action of galactoside-specific mistletoe lectin. Pure substance compared to the standardized extract. Arznem Forsch 1993;43:166-9.
    • (1993) Arznem Forsch , vol.43 , pp. 166-169
    • Beuth, J.1    Ko, H.L.2    Tunggal, L.3    Geisel, J.4    Pulverer, G.5
  • 63
  • 64
    • 0001492829 scopus 로고    scopus 로고
    • Investigations of cellular parameters to establish the response of a biomodulator: Galactoside-specific lectin from Viscum album plant extract
    • Hajto T, Hostanska K, Fischer J, Lentzen H. Investigations of cellular parameters to establish the response of a biomodulator: galactoside-specific lectin from Viscum album plant extract. Phytomedicine 1996;3:129-37.
    • (1996) Phytomedicine , vol.3 , pp. 129-137
    • Hajto, T.1    Hostanska, K.2    Fischer, J.3    Lentzen, H.4
  • 65
    • 3042955271 scopus 로고
    • Galactoside-specific lectin from clinically applied mistletoe extract reduces tumor growth by augmentation of host defense system
    • Hajto T, Hostanska K, Steinberg F, Gabius H-J. Galactoside-specific lectin from clinically applied mistletoe extract reduces tumor growth by augmentation of host defense system. Blut 1990;61:164.
    • (1990) Blut , vol.61 , pp. 164
    • Hajto, T.1    Hostanska, K.2    Steinberg, F.3    Gabius, H.-J.4
  • 66
    • 0025772039 scopus 로고
    • Antitumorale Aktivität des immunmodu-latorisch wirkenden Beta-galaktosidspezifischen Mistellektins bei der klinischen Anwendung von Mistelextrakten (Iscador)
    • Hajto T, Hostanska K, Fornalski M, Kirsch A. Antitumorale Aktivität des immunmodu-latorisch wirkenden Beta-galaktosidspezifischen Mistellektins bei der klinischen Anwendung von Mistelextrakten (Iscador). Dtsch Zschr Onkol 1991;23:1-6.
    • (1991) Dtsch Zschr Onkol , vol.23 , pp. 1-6
    • Hajto, T.1    Hostanska, K.2    Fornalski, M.3    Kirsch, A.4
  • 67
    • 0028040372 scopus 로고
    • Mistletoe extract standardized for the galactoside-specific lectin (ML-1) induces beta-endorphin release and immunopotentiation in breast cancer patients
    • Heiny BM, Beuth J. Mistletoe extract standardized for the galactoside-specific lectin (ML-1) induces beta-endorphin release and immunopotentiation in breast cancer patients. Anticancer Res 1994;14:1339-1342.
    • (1994) Anticancer Res , vol.14 , pp. 1339-1342
    • Heiny, B.M.1    Beuth, J.2
  • 68
    • 0031922838 scopus 로고    scopus 로고
    • Correlation of immune cell activities and beta-endorphin release in breast carcinoma patients treated with galactose-specific lectin standardized mistletoe extract
    • Heiny BM, Albrecht V, Beuth J. Correlation of immune cell activities and beta-endorphin release in breast carcinoma patients treated with galactose-specific lectin standardized mistletoe extract. Anticancer Res 1998;18:583-6.
    • (1998) Anticancer Res , vol.18 , pp. 583-586
    • Heiny, B.M.1    Albrecht, V.2    Beuth, J.3
  • 69
    • 0037416801 scopus 로고    scopus 로고
    • Galactoside-specific plant lectin, Viscum album agglutinin-I induces enhanced proliferation and apoptosis of murine thymocytes in vivo
    • Hajtó T, Berki T, Boldizsár F, Németh P. Galactoside-specific plant lectin, Viscum album agglutinin-I induces enhanced proliferation and apoptosis of murine thymocytes in vivo. Immunol Lett 2003;86:23-7.
    • (2003) Immunol Lett , vol.86 , pp. 23-27
    • Hajtó, T.1    Berki, T.2    Boldizsár, F.3    Németh, P.4
  • 70
    • 0038180328 scopus 로고    scopus 로고
    • Galactoside-specific misletoe lectin modulate the dexamethasone-induced apoptosis and glucocorticoid receptor level in Balb/c thymocytes
    • Hajtó T, Berki T, Pálinkás L, Boldizsár F, Nagy G, Németh P. Galactoside-specific misletoe lectin modulate the dexamethasone-induced apoptosis and glucocorticoid receptor level in Balb/c thymocytes. In vivo 2003;17:163-8.
    • (2003) In Vivo , vol.17 , pp. 163-168
    • Hajtó, T.1    Berki, T.2    Pálinkás, L.3    Boldizsár, F.4    Nagy, G.5    Németh, P.6
  • 71
    • 0031807897 scopus 로고    scopus 로고
    • Effects of a standardized mistletoe preparation on metastatic B16 melanoma colonization in murine lungs
    • Weber K, Mengs U, Schwarz T et al. Effects of a standardized mistletoe preparation on metastatic B16 melanoma colonization in murine lungs. Arznem Forsch 1998;48:497-502.
    • (1998) Arznem Forsch , vol.48 , pp. 497-502
    • Weber, K.1    Mengs, U.2    Schwarz, T.3
  • 72
    • 0033877281 scopus 로고    scopus 로고
    • Survival of glioma patients after complementary treatment with galactoside-specific lectin from mistletoe
    • Lenartz D; Dott U, Menzel J, Schierholz JM, Beuth J. Survival of glioma patients after complementary treatment with galactoside-specific lectin from mistletoe. Anticancer Res 2000;20:2073-6.
    • (2000) Anticancer Res , vol.20 , pp. 2073-2076
    • Lenartz, D.1    Dott, U.2    Menzel, J.3    Schierholz, J.M.4    Beuth, J.5
  • 73
    • 0031922838 scopus 로고    scopus 로고
    • Correlation of immune cell activities and beta-endorphin release in breast carcinoma patients treated with galactose-specific lectin standardized mistletoe extract
    • Heiny BM, Albrecht V, Beuth J. Correlation of immune cell activities and beta-endorphin release in breast carcinoma patients treated with galactose-specific lectin standardized mistletoe extract. Anticancer Res 1998;18:583-6.
    • (1998) Anticancer Res , vol.18 , pp. 583-586
    • Heiny, B.M.1    Albrecht, V.2    Beuth, J.3
  • 74
    • 0030518747 scopus 로고    scopus 로고
    • Immunoprotective activity of the galactoside-specific lectin from mistletoe after tumor destructive therapy in glioma patients
    • Lenartz D, Stoffel B, Menzel J, Beuth J. Immunoprotective activity of the galactoside-specific lectin from mistletoe after tumor destructive therapy in glioma patients. Anticancer Res 1996;16:799-802.
    • (1996) Anticancer Res , vol.16 , pp. 799-802
    • Lenartz, D.1    Stoffel, B.2    Menzel, J.3    Beuth, J.4
  • 75
    • 0028641635 scopus 로고
    • Immuno-protective activity of the galactoside-specific mistletoe lectin in cortisone-treated BALB/c-mice
    • Beuth J, Ko HL, Tunggal L et al. Immuno-protective activity of the galactoside-specific mistletoe lectin in cortisone-treated BALB/c-mice. In vivo 1994;8:989-92.
    • (1994) In Vivo , vol.8 , pp. 989-992
    • Beuth, J.1    Ko, H.L.2    Tunggal, L.3
  • 76
    • 0030479526 scopus 로고    scopus 로고
    • Stimulation of neutropoiesis by a special standardized mistletoe preparation after cyclophosphamide chemotherapy in mice
    • Weber K, Mengs U, Schwarz T, Becker H, Lentzen H. Stimulation of neutropoiesis by a special standardized mistletoe preparation after cyclophosphamide chemotherapy in mice. Arzneim Forsch 1996;46:1174-8.
    • (1996) Arzneim Forsch , vol.46 , pp. 1174-1178
    • Weber, K.1    Mengs, U.2    Schwarz, T.3    Becker, H.4    Lentzen, H.5
  • 77
    • 0030199010 scopus 로고    scopus 로고
    • Effect of immunomodulation with galactoside-specific mistletoe lectin on experimental listerosis
    • Stoffel B, Beuth J, Pulverer G. Effect of immunomodulation with galactoside-specific mistletoe lectin on experimental listerosis. Zentralbl Bakteriol 1996;284:439-42.
    • (1996) Zentralbl Bakteriol , vol.284 , pp. 439-442
    • Stoffel, B.1    Beuth, J.2    Pulverer, G.3
  • 78
    • 0026337647 scopus 로고
    • Improvement of DNA repair in lymphocytes of breast cancer patients treated with Viscum album extract (Iscador)
    • Kovacs E, Hajto T, Hostanska K. Improvement of DNA repair in lymphocytes of breast cancer patients treated with Viscum album extract (Iscador). Eur J Cancer 1991;27:1672-6.
    • (1991) Eur J Cancer , vol.27 , pp. 1672-1676
    • Kovacs, E.1    Hajto, T.2    Hostanska, K.3
  • 79
    • 0036322607 scopus 로고    scopus 로고
    • Mistletoe extracts standardized to mistletoe lectins in oncology: Review on current status of preclinical research
    • Mengs U, Göthel D, Leng-Peschlow E. Mistletoe extracts standardized to mistletoe lectins in oncology: review on current status of preclinical research. Anticancer Res 2002;22:1399-408.
    • (2002) Anticancer Res , vol.22 , pp. 1399-1408
    • Mengs, U.1    Göthel, D.2    Leng-Peschlow, E.3
  • 80
    • 4944253616 scopus 로고    scopus 로고
    • Antitumor activity of the Korean mistletoe lectin is attributed to activation of macrophages and NK cells
    • Yoon TJ, Yoo YC, Kang TB et al. Antitumor activity of the Korean mistletoe lectin is attributed to activation of macrophages and NK cells. Arch Pharm Res 2003;26:861-7.
    • (2003) Arch Pharm Res , vol.26 , pp. 861-867
    • Yoon, T.J.1    Yoo, Y.C.2    Kang, T.B.3
  • 81
    • 0035281928 scopus 로고    scopus 로고
    • Antitumoral effect of recombinant mistletoe lectin on chemically induced urinary bladder carcinogenesis in a rat model
    • Elsasser-Beile U, Ruhnau T, Freudenberg N, Wetterauer U, Mengs U. Antitumoral effect of recombinant mistletoe lectin on chemically induced urinary bladder carcinogenesis in a rat model. Cancer 2001;91:998-1004.
    • (2001) Cancer , vol.91 , pp. 998-1004
    • Elsasser-Beile, U.1    Ruhnau, T.2    Freudenberg, N.3    Wetterauer, U.4    Mengs, U.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.