메뉴 건너뛰기




Volumn 22, Issue 4, 2012, Pages 139-150

The prophylaxis and treatment with antiviral agents of respiratory syncytial virus infections

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; 1 CYCLOPROPYL 1,3 DIHYDRO 3 [[1 (4 HYDROXYBUTYL) 1H BENZIMIDAZOL 2 YL]METHYL] 2H IMIDAZO[4,5 C]PYRIDIN 2 ONE; 1 MORPHOLINO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; 2 [[2 [[1 (2 AMINOETHYL) 4 PIPERIDINYL]AMINO] 4 METHYL 1H BENZIMIDAZOL 1 YL]METHYL] 6 METHYL 3 PYRIDINOL; ACETAMIDE; ALN 01; ANTIVIRUS AGENT; ASPARTATE CARBAMOYLTRANSFERASE; BENZAZEPINE DERIVATIVE; BENZIMIDAZOLE; BENZODIAZEPINE DERIVATIVE; BTA 9881; CARBAMOYL PHOSPHATE SYNTHASE; CIGLITAZONE; GUANINE NUCLEOTIDE BINDING PROTEIN; MONOCLONAL ANTIBODY; MOTAVIZUMAB; PALIVIZUMAB; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROPYLENE GLYCOL; PYRIMIDINE DERIVATIVE; QUINAZOLINONE DERIVATIVE; RIBAVIRIN; ROSIGLITAZONE; RSV 604; SMALL INTERFERING RNA; TARIBAVIRIN; TMC 353121; UNCLASSIFIED DRUG; UNINDEXED DRUG; VP 14637; YM 53403; YM53403;

EID: 84860624662     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.3851/IMP1873     Document Type: Review
Times cited : (3)

References (77)
  • 1
    • 74049103602 scopus 로고    scopus 로고
    • Respiratory syncytial virus market
    • Storey S. Respiratory syncytial virus market. Nat Rev Drug Discov 2010; 9:15-16.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 15-16
    • Storey, S.1
  • 2
    • 77954656823 scopus 로고    scopus 로고
    • Pharmacotherapy of respiratory syncytial virus infection
    • Welliver RC. Pharmacotherapy of respiratory syncytial virus infection. Curr Opin Pharmacol 2010; 10:289-293.
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 289-293
    • Welliver, R.C.1
  • 4
    • 0037323608 scopus 로고    scopus 로고
    • Impact of severe disease caused by respiratory syncytial virus in children living in developed countries
    • Simoes EA, Carbonell-Estrany X. Impact of severe disease caused by respiratory syncytial virus in children living in developed countries. Pediatr Infect Dis J 2003; 22 Suppl 2: S13-S18.
    • (2003) Pediatr Infect Dis J , vol.22 , Issue.SUPPL. 2
    • Simoes, E.A.1    Carbonell-Estrany, X.2
  • 5
    • 84961060734 scopus 로고
    • Natural reinfection of adults by respiratory syncytial virus. Possible relation to mild upper respiratory disease
    • Johnson KM, Bloom HH, Mufson MA, Chanock RM. Natural reinfection of adults by respiratory syncytial virus. Possible relation to mild upper respiratory disease. N Engl J Med 1962; 267:68-72.
    • (1962) N Engl J Med , vol.267 , pp. 68-72
    • Johnson, K.M.1    Bloom, H.H.2    Mufson, M.A.3    Chanock, R.M.4
  • 6
    • 0030954397 scopus 로고    scopus 로고
    • Respiratory virus infections after marrow transplant: The Fred Hutchinson Cancer Research Center experience
    • Bowden RA. Respiratory virus infections after marrow transplant: the Fred Hutchinson Cancer Research Center experience. Am J Med 1997; 102 Suppl 1:27-30.
    • (1997) Am J Med , vol.102 , Issue.SUPPL. 1 , pp. 27-30
    • Bowden, R.A.1
  • 7
    • 0037323548 scopus 로고    scopus 로고
    • Respiratory syncytial virus epidemics: The ups and downs of a seasonal virus
    • Stensballe LG, Devasundaram JK, Simoes EA. Respiratory syncytial virus epidemics: the ups and downs of a seasonal virus. Pediatr Infect Dis J 2003; 22 Suppl 2:S21-S32.
    • (2003) Pediatr Infect Dis J , vol.22 , Issue.SUPPL. 2
    • Stensballe, L.G.1    Devasundaram, J.K.2    Simoes, E.A.3
  • 8
    • 0344153462 scopus 로고    scopus 로고
    • Recent trends in severe respiratory syncytial virus (RSV) among US infants, 1997 to 2000
    • Leader S, Kohlhase K. Recent trends in severe respiratory syncytial virus (RSV) among US infants, 1997 to 2000.J Pediatr 2003; 143 Suppl 5:S127-S132.
    • (2003) J Pediatr , vol.143 , Issue.SUPPL. 5
    • Leader, S.1    Kohlhase, K.2
  • 9
    • 0022589125 scopus 로고
    • Risk of primary infection and reinfection with respiratory syncytial virus
    • Glezen WP, Taber LH, Frank AL, Kasel JA. Risk of primary infection and reinfection with respiratory syncytial virus. Am J Dis Child 1986; 140:543-546.
    • (1986) Am J Dis Child , vol.140 , pp. 543-546
    • Glezen, W.P.1    Taber, L.H.2    Frank, A.L.3    Kasel, J.A.4
  • 10
    • 0036675308 scopus 로고    scopus 로고
    • Respiratory syncytial virus infection in Navajo and White Mountain Apache children
    • Bockova J, O'Brien KL, Oski J, et al. Respiratory syncytial virus infection in Navajo and White Mountain Apache children. Pediatrics 2002; 110:e20.
    • (2002) Pediatrics , vol.110
    • Bockova, J.1    O'Brien, K.L.2    Oski, J.3
  • 11
    • 77951653074 scopus 로고    scopus 로고
    • Global burden of acute lower respiratory infections due to respiratory syncy-tial virus in young children: A systematic review and meta-analysis
    • Nair H, Nokes DJ, Gessner BD, et al. Global burden of acute lower respiratory infections due to respiratory syncy-tial virus in young children: a systematic review and meta-analysis. Lancet 2010; 375:1545-1555.
    • (2010) Lancet , vol.375 , pp. 1545-1555
    • Nair, H.1    Nokes, D.J.2    Gessner, B.D.3
  • 12
    • 74249116206 scopus 로고    scopus 로고
    • Respiratory viral infections in infants: Causes, clinical symptoms, virology, and immunology
    • Tregoning JS, Schwarze J. Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology. Clin Microbiol Rev 2010; 23:74-98.
    • (2010) Clin Microbiol Rev , vol.23 , pp. 74-98
    • Tregoning, J.S.1    Schwarze, J.2
  • 13
    • 0014493282 scopus 로고
    • An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine
    • Kapikian AZ, Mitchell RH, Chanock RM, Shvedoff RA, Stewart CE. An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine. Am J Epidemiol 1969; 89:405-421.
    • (1969) Am J Epidemiol , vol.89 , pp. 405-421
    • Kapikian, A.Z.1    Mitchell, R.H.2    Chanock, R.M.3    Shvedoff, R.A.4    Stewart, C.E.5
  • 14
    • 0027400931 scopus 로고
    • Immunoprophylaxis and immunotherapy: Role in the prevention and treatment of repiratory syncytial virus
    • Groothuis JR, Simoes EA. Immunoprophylaxis and immunotherapy: role in the prevention and treatment of repiratory syncytial virus. Int J Antimicrob Agents 1993; 2:97-103.
    • (1993) Int J Antimicrob Agents , vol.2 , pp. 97-103
    • Groothuis, J.R.1    Simoes, E.A.2
  • 15
    • 34748850172 scopus 로고    scopus 로고
    • The absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenuated, respiratory syncytial virus vaccines
    • Wright PF, Karron RA, Belshe RB, et al. The absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenuated, respiratory syncytial virus vaccines. Vaccine 2007; 25:7372-7378.
    • (2007) Vaccine , vol.25 , pp. 7372-7378
    • Wright, P.F.1    Karron, R.A.2    Belshe, R.B.3
  • 16
    • 79952539202 scopus 로고    scopus 로고
    • Prevention of serious respiratory syncytial virus-related illness. I: Disease patho-genesis and early attempts at prevention
    • Groothuis JR, Hoopes JM, Jessie VG. Prevention of serious respiratory syncytial virus-related illness. I: Disease patho-genesis and early attempts at prevention. Adv Ther 2011; 28:91-109.
    • (2011) Adv Ther , vol.28 , pp. 91-109
    • Groothuis, J.R.1    Hoopes, J.M.2    Jessie, V.G.3
  • 17
    • 79953242766 scopus 로고    scopus 로고
    • Hot topics in the prevention of respiratory syncytial virus disease
    • Habibi MS, Patel S, Openshaw P. Hot topics in the prevention of respiratory syncytial virus disease. Expert Rev Vaccines 2011; 10:291-293.
    • (2011) Expert Rev Vaccines , vol.10 , pp. 291-293
    • Habibi, M.S.1    Patel, S.2    Openshaw, P.3
  • 18
    • 79952533229 scopus 로고    scopus 로고
    • Prevention of serious respiratory syncytial virus-related illness. II: Immu-noprophylaxis
    • Groothuis JR, Hoopes JM, Hemming VG. Prevention of serious respiratory syncytial virus-related illness. II: Immu-noprophylaxis. Adv Ther 2011; 28:110-125.
    • (2011) Adv Ther , vol.28 , pp. 110-125
    • Groothuis, J.R.1    Hoopes, J.M.2    Hemming, V.G.3
  • 19
    • 0027384670 scopus 로고
    • Prophylactic administration of respiratory syncytial virus immune globulin to high-risk infants and young children. The Respiratory Syncytial Virus Immune Globulin Study Group
    • Groothuis JR, Simoes EA, Levin MJ, et al. Prophylactic administration of respiratory syncytial virus immune globulin to high-risk infants and young children. The Respiratory Syncytial Virus Immune Globulin Study Group. N Engl J Med 1993; 329:1524-1530.
    • (1993) N Engl J Med , vol.329 , pp. 1524-1530
    • Groothuis, J.R.1    Simoes, E.A.2    Levin, M.J.3
  • 20
    • 0037323511 scopus 로고    scopus 로고
    • Populations at risk for developing respiratory syncytial virus and risk factors for respiratory syncytial virus severity: Infants with predisposing conditions
    • Weisman LE. Populations at risk for developing respiratory syncytial virus and risk factors for respiratory syncytial virus severity: infants with predisposing conditions. Pediatr Infect Dis J 2003; 22 Suppl 2: S33-S37.
    • (2003) Pediatr Infect Dis J , vol.22 , Issue.SUPPL. 2
    • Weisman, L.E.1
  • 21
    • 0036744645 scopus 로고    scopus 로고
    • Development and use of palivi-zumab (Synagis): A passive immunoprophylactic agent for R S V
    • Pollack P, Groothuis JR, Development and use of palivi-zumab (Synagis): a passive immunoprophylactic agent for R S V. J infect Chemother 2002; 8: 201-206.
    • (2002) J Infect Chemother , vol.8 , pp. 201-206
    • Pollack, P.1    Groothuis, J.R.2
  • 22
    • 0032790024 scopus 로고    scopus 로고
    • Palivizumab
    • Scott LJ, Lamb HM. Palivizumab. Drugs 1999; 58:305-311.
    • (1999) Drugs , vol.58 , pp. 305-311
    • Scott, L.J.1    Lamb, H.M.2
  • 23
    • 0031683919 scopus 로고    scopus 로고
    • Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. The IMpact-RSV Study Group
    • The Impact-RSV Study Group
    • The Impact-RSV Study Group. Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. The IMpact-RSV Study Group. Pediatrics 1998; 102:531-537.
    • (1998) Pediatrics , vol.102 , pp. 531-537
  • 24
    • 0242298724 scopus 로고    scopus 로고
    • Palivizumab prophylaxis reduces hospitalization due to respiratory syn-cytial virus in young children with hemodynamically signif-cant congenital heart disease
    • Feltes TF, Cabalka AK, Meissner HC, et al. Palivizumab prophylaxis reduces hospitalization due to respiratory syn-cytial virus in young children with hemodynamically signif-cant congenital heart disease. J Pediatr 2003; 143:532-540.
    • (2003) J Pediatr , vol.143 , pp. 532-540
    • Feltes, T.F.1    Cabalka, A.K.2    Meissner, H.C.3
  • 25
    • 77958530071 scopus 로고    scopus 로고
    • Studies recommending palivizumab restriction have serious defciencies
    • Stewart DL. Studies recommending palivizumab restriction have serious defciencies. J Manag Care Pharm 2010; 16:509-511.
    • (2010) J Manag Care Pharm , vol.16 , pp. 509-511
    • Stewart, D.L.1
  • 26
    • 27644485407 scopus 로고    scopus 로고
    • Comparative effects of two neutralizing anti-respiratory syncytial virus (RSV) monoclonal antibodies in the RSV murine model: Time versus potency
    • Mejías A, Chavez-Bueno S, Rios AM, et al. Comparative effects of two neutralizing anti-respiratory syncytial virus (RSV) monoclonal antibodies in the RSV murine model: time versus potency. Antimicrob Agents Chemother 2005; 49:4700-4707.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4700-4707
    • Mejías, A.1    Chavez-Bueno, S.2    Rios, A.M.3
  • 27
    • 74049097923 scopus 로고    scopus 로고
    • Motavi-zumab for prophylaxis of respiratory syncytial virus in high-risk children: A noninferiority trial
    • Carbonell-Estrany X, Simoes EA, Dagan R, et al. Motavi-zumab for prophylaxis of respiratory syncytial virus in high-risk children: a noninferiority trial. Pediatrics 2010; 125:e35-e51.
    • (2010) Pediatrics , vol.125
    • Carbonell-Estrany, X.1    Simoes, E.A.2    Dagan, R.3
  • 28
    • 33750920325 scopus 로고    scopus 로고
    • Development of antivirals against respiratory syncytial virus
    • In P Cane (Editor), Amsterdam: Elsevier BV Publishers
    • Powell KL, Alber DG. Development of antivirals against respiratory syncytial virus. In P Cane (Editor). Respiratory syncytial virus. Perspectives in medical virology. Amsterdam: Elsevier BV Publishers 2006; pp. 279-298.
    • (2006) Respiratory Syncytial Virus. Perspectives In Medical Virology , pp. 279-298
    • Powell, K.L.1    Alber, D.G.2
  • 29
    • 33846821758 scopus 로고    scopus 로고
    • Respiratory syncytial virus fusion inhibitors. Part 4: Optimization for oral bioavailabil-ity
    • Yu KL, Sin N, Civiello RL, et al. Respiratory syncytial virus fusion inhibitors. Part 4: optimization for oral bioavailabil-ity. Bioorg Med Chem Lett 2007; 17:895-901.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 895-901
    • Yu, K.L.1    Sin, N.2    Civiello, R.L.3
  • 30
    • 34447310013 scopus 로고    scopus 로고
    • Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity
    • Wang XA, Cianci CW, Yu KL, et al. Respiratory syncytial virus fusion inhibitors. Part 5: optimization of benzimidazole substitution patterns towards derivatives with improved activity. Bioorg Med Chem Lett 2007; 17:4592-4598.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 4592-4598
    • Wang, X.A.1    Cianci, C.W.2    Yu, K.L.3
  • 31
    • 67651102834 scopus 로고    scopus 로고
    • Respiratory syncytial virus fusion inhibitors. Part 7: Structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo
    • Sin N, Venables BL, Combrink KD, et al. Respiratory syncytial virus fusion inhibitors. Part 7: structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo. Bioorg Med Chem Lett 2009; 19:4857-4862.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 4857-4862
    • Sin, N.1    Venables, B.L.2    Combrink, K.D.3
  • 32
    • 34547511172 scopus 로고    scopus 로고
    • Respiratory syncytial virus fusion inhibitors. Part 6: An examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety
    • Combrink KD, Gulgeze HB, Thuring JW, et al. Respiratory syncytial virus fusion inhibitors. Part 6: an examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety. Bioorg Med Chem Lett 2007; 17:4784-4790.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 4784-4790
    • Combrink, K.D.1    Gulgeze, H.B.2    Thuring, J.W.3
  • 34
    • 39749188747 scopus 로고    scopus 로고
    • Selection of a respiratory syncytial virus fusion inhibitor clinical candidate. 2. Discovery of a morpholino-propylaminobenzimidazole derivative (TMC353121)
    • Bonfanti JM, Meyer C, Doublet C, et al. Selection of a respiratory syncytial virus fusion inhibitor clinical candidate. 2. Discovery of a morpholino-propylaminobenzimidazole derivative (TMC353121). J Med Chem 2008; 51:875-896.
    • (2008) J Med Chem , vol.51 , pp. 875-896
    • Bonfanti, J.M.1    Meyer, C.2    Doublet, C.3
  • 35
    • 76249116900 scopus 로고    scopus 로고
    • Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein
    • Roymans D, De Bondt HL, Arnoult E, et al. Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein. Proc Natl Acad Sci U S A 2010; 107:308-313.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 308-313
    • Roymans, D.1    de Bondt, H.L.2    Arnoult, E.3
  • 36
    • 78049277866 scopus 로고    scopus 로고
    • Pharmacokinetics-pharmacodynamics of a respiratory syncytial virus fusion inhibitor in the cotton rat model
    • Rouan MC, Gevers T, Roymans D, et al. Pharmacokinetics-pharmacodynamics of a respiratory syncytial virus fusion inhibitor in the cotton rat model. Antimicrob Agents Chem-other 2010; 54:4534-4539.
    • (2010) Antimicrob Agents Chem-other , vol.54 , pp. 4534-4539
    • Rouan, M.C.1    Gevers, T.2    Roymans, D.3
  • 38
    • 0037405114 scopus 로고    scopus 로고
    • Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specifc interactions with F protein
    • Douglas JL, Panis ML, Ho E, et al. Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specifc interactions with F protein. J Virol 2003; 77:5054-5064.
    • (2003) J Virol , vol.77 , pp. 5054-5064
    • Douglas, J.L.1    Panis, M.L.2    Ho, E.3
  • 39
    • 84863097170 scopus 로고    scopus 로고
    • 7th International Respiratory Syncytial Virus (RSV) Symposium. 2-5 December, Rotterdam, the Netherlands. Abstract 0.04
    • Cook R. MDT-637, a novel antiviral treatment for respiratory syncytial virus infection. 7th International Respiratory Syncytial Virus (RSV) Symposium. 2-5 December 2010, Rotterdam, the Netherlands. Abstract 0.04
    • (2010) MDT-637, a Novel Antiviral Treatment For Respiratory Syncytial Virus Infection
    • Cook, R.1
  • 42
    • 78650510640 scopus 로고    scopus 로고
    • A fuorescence polarization assay using an engineered human respiratory syncytial virus F protein as a direct screening platform
    • Park M, Matsuura H, Lamb RA, et al. A fuorescence polarization assay using an engineered human respiratory syncytial virus F protein as a direct screening platform. Anal Biochem 2001; 409:195-201.
    • (2001) Anal Biochem , vol.409 , pp. 195-201
    • Park, M.1    Matsuura, H.2    Lamb, R.A.3
  • 45
    • 77955369875 scopus 로고    scopus 로고
    • Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency
    • Harrison RS, Shepherd NE, Hoang HN, et al. Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency. Proc Natl Acad Sci U S A 2010; 107:11686-11691.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 11686-11691
    • Harrison, R.S.1    Shepherd, N.E.2    Hoang, H.N.3
  • 46
    • 0033892730 scopus 로고    scopus 로고
    • Antiviral activity of NMSO3 against respiratory syncytial virus infection in vitro and in vivo
    • Kimura K, Mori S, Tomita K, et al. Antiviral activity of NMSO3 against respiratory syncytial virus infection in vitro and in vivo. Antiviral Res 2000; 47:41-51.
    • (2000) Antiviral Res , vol.47 , pp. 41-51
    • Kimura, K.1    Mori, S.2    Tomita, K.3
  • 47
    • 0842311254 scopus 로고    scopus 로고
    • Isolation and characterization of NMSO3-resistant mutants of respiratory syncytial virus
    • Kimura K, Ishioka K, Hashimoto K, et al. Isolation and characterization of NMSO3-resistant mutants of respiratory syncytial virus. Antiviral Res 2004; 61:165-171.
    • (2004) Antiviral Res , vol.61 , pp. 165-171
    • Kimura, K.1    Ishioka, K.2    Hashimoto, K.3
  • 48
    • 79955458991 scopus 로고    scopus 로고
    • A respiratory syncytial virus replicon that is noncyto-toxic and capable of long-term foreign gene expression
    • Malykhina O, Yednak MA, Collins PL, Olivo PD, Peeples ME. A respiratory syncytial virus replicon that is noncyto-toxic and capable of long-term foreign gene expression. J Virol 2011; 85:4792-4801.
    • (2011) J Virol , vol.85 , pp. 4792-4801
    • Malykhina, O.1    Yednak, M.A.2    Collins, P.L.3    Olivo, P.D.4    Peeples, M.E.5
  • 49
    • 33645681649 scopus 로고    scopus 로고
    • 1,4-Benzodiaz-epines as inhibitors of respiratory syncytial virus
    • Carter MC, Alber DG, Baxter RC, et al. 1,4-Benzodiaz-epines as inhibitors of respiratory syncytial virus. J Med Chem 2006; 49:2311-2319.
    • (2006) J Med Chem , vol.49 , pp. 2311-2319
    • Carter, M.C.1    Alber, D.G.2    Baxter, R.C.3
  • 50
    • 35948949782 scopus 로고    scopus 로고
    • RSV604, a novel inhibitor of respiratory syncytial virus replication
    • Chapman J, Abbott E, Alber DG, et al. RSV604, a novel inhibitor of respiratory syncytial virus replication. Antimi-crob Agents Chemother 2007; 51:3346-3353.
    • (2007) Antimi-crob Agents Chemother , vol.51 , pp. 3346-3353
    • Chapman, J.1    Abbott, E.2    Alber, D.G.3
  • 51
    • 0036094947 scopus 로고    scopus 로고
    • Respiratory syncytial virus infection of human airway epithelial cells is polarized, specifc to ciliated cells, and without obvious cytopathology
    • Zhang L, Peeples ME, Boucher RC, Collins PL, Pickles RJ. Respiratory syncytial virus infection of human airway epithelial cells is polarized, specifc to ciliated cells, and without obvious cytopathology. J Virol 2002; 76:5654-5666.
    • (2002) J Virol , vol.76 , pp. 5654-5666
    • Zhang, L.1    Peeples, M.E.2    Boucher, R.C.3    Collins, P.L.4    Pickles, R.J.5
  • 52
    • 85020645226 scopus 로고    scopus 로고
    • Randomised, placebo-controlled study to evaluate the safety and effcacy of RSV604 in adults with Respiratory Syncytial Virus (RSV) infection following stem sell transplantation
    • 3-6 March, Hong Kong SAR, China
    • Marty FM, Chemaly RF, Liakopoulou E, Dent JC, Powell KL. Randomised, placebo-controlled study to evaluate the safety and effcacy of RSV604 in adults with Respiratory Syncytial Virus (RSV) infection following stem sell transplantation. IX International symposium on Respiratory Virus Infection. 3-6 March 2007, Hong Kong SAR, China.
    • (2007) IX International Symposium On Respiratory Virus Infection
    • Marty, F.M.1    Chemaly, R.F.2    Liakopoulou, E.3    Dent, J.C.4    Powell, K.L.5
  • 53
    • 70849108252 scopus 로고    scopus 로고
    • Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus
    • Tawar RG, Duquerroy S, Vonrhein C, et al. Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus. Science 2009; 326:1279-1283.
    • (2009) Science , vol.326 , pp. 1279-1283
    • Tawar, R.G.1    Duquerroy, S.2    Vonrhein, C.3
  • 54
    • 0015523596 scopus 로고
    • Broad-spectrum antiviral activity of vira-zole: 1-beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide
    • Sidwell RW, Huffman JH, Khare GP, Allen LB, Witkowski JT, Robins RK. Broad-spectrum antiviral activity of vira-zole: 1-beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide. Science 1972; 177:705-706.
    • (1972) Science , vol.177 , pp. 705-706
    • Sidwell, R.W.1    Huffman, J.H.2    Khare, G.P.3    Allen, L.B.4    Witkowski, J.T.5    Robins, R.K.6
  • 55
    • 0035715149 scopus 로고    scopus 로고
    • Mechanisms of action of ribavi-rin in antiviral therapies
    • Tam RC, Lau JY, Hong Z. Mechanisms of action of ribavi-rin in antiviral therapies. Antivir Chem Chemother 2001; 12:261-272.
    • (2001) Antivir Chem Chemother , vol.12 , pp. 261-272
    • Tam, R.C.1    Lau, J.Y.2    Hong, Z.3
  • 56
    • 77952688315 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus
    • DeVincenzo J, Lambkin-Williams R, Wilkinson T, et al. A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus. Proc Natl Acad Sci U S A 2010; 107:8800-8805.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 8800-8805
    • Devincenzo, J.1    Lambkin-Williams, R.2    Wilkinson, T.3
  • 57
    • 1242277744 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of viramidine, a prodrug of ribavirin, in healthy volunteers
    • Lin CC, Philips L, Xu C, Yeh LT. Pharmacokinetics and safety of viramidine, a prodrug of ribavirin, in healthy volunteers. J Clin Pharmacol 2004; 44:265-275.
    • (2004) J Clin Pharmacol , vol.44 , pp. 265-275
    • Lin, C.C.1    Philips, L.2    Xu, C.3    Yeh, L.T.4
  • 58
    • 33745244104 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells
    • Arnold R, König K. Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells. Virology 2006; 350:335-346.
    • (2006) Virology , vol.350 , pp. 335-346
    • Arnold, R.1    König, K.2
  • 59
    • 1342289537 scopus 로고    scopus 로고
    • HIV-1 Nef protein in the nucleus infuences adipogenesis as well as viral transcription through the peroxisome proliferator-activated receptors
    • Otake K, Omoto S, Yamamoto T, et al. HIV-1 Nef protein in the nucleus infuences adipogenesis as well as viral transcription through the peroxisome proliferator-activated receptors. AIDS 2004; 18:189-198.
    • (2004) AIDS , vol.18 , pp. 189-198
    • Otake, K.1    Omoto, S.2    Yamamoto, T.3
  • 60
    • 13544274227 scopus 로고    scopus 로고
    • YM-53403, a unique anti-respiratory syncytial virus agent with a novel mechanism of action
    • Sudo K, Miyazaki Y, Kojima N, et al. YM-53403, a unique anti-respiratory syncytial virus agent with a novel mechanism of action. Antiviral Res 2005; 65:125-131.
    • (2005) Antiviral Res , vol.65 , pp. 125-131
    • Sudo, K.1    Miyazaki, Y.2    Kojima, N.3
  • 62
    • 4444345610 scopus 로고    scopus 로고
    • Polyadenylation-dependent screening assay for respiratory syncytial virus RNA transcriptase activity and identifcation of an inhibitor
    • Mason SW, Lawetz C, Gaudette Y, et al. Polyadenylation-dependent screening assay for respiratory syncytial virus RNA transcriptase activity and identifcation of an inhibitor. Nucleic Acids Res 2004; 32:4758-4767.
    • (2004) Nucleic Acids Res , vol.32 , pp. 4758-4767
    • Mason, S.W.1    Lawetz, C.2    Gaudette, Y.3
  • 63
    • 26444479397 scopus 로고    scopus 로고
    • Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA poly-merase
    • Liuzzi M, Mason SW, Cartier M, et al. Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA poly-merase. J Virol 2005; 79:13105-13115.
    • (2005) J Virol , vol.79 , pp. 13105-13115
    • Liuzzi, M.1    Mason, S.W.2    Cartier, M.3
  • 65
    • 44349115145 scopus 로고    scopus 로고
    • Inhibition of respiratory syncytial virus infections with morpholino oligomers in cell cultures and in mice
    • Lai SH, Stein DA, Guerreo-Plata A et al. Inhibition of respiratory syncytial virus infections with morpholino oligomers in cell cultures and in mice. Mol Ther 2008; 16:1120-1128.
    • (2008) Mol Ther , vol.16 , pp. 1120-1128
    • Lai, S.H.1    Stein, D.A.2    Guerreo-Plata, A.3
  • 66
    • 79955559702 scopus 로고    scopus 로고
    • Organic synthesis toward small-molecule probes and drugs special feature: Identifcation of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)
    • Bonavia A, Franti M, Pusateri Keaney E, et al. Organic synthesis toward small-molecule probes and drugs special feature: identifcation of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV). Proc Natl Acad Sci U S A 2011; 108:6739-6744.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 6739-6744
    • Bonavia, A.1    Franti, M.2    Pusateri Keaney, E.3
  • 67
    • 78449309070 scopus 로고    scopus 로고
    • Effcient and targeted delivery of siRNA in vivo
    • Shim MS, Kwon YJ. Effcient and targeted delivery of siRNA in vivo. FEBS J 2010; 277:4814-4827.
    • (2010) FEBS J , vol.277 , pp. 4814-4827
    • Shim, M.S.1    Kwon, Y.J.2
  • 68
    • 13444262170 scopus 로고    scopus 로고
    • Inhibition of respiratory viruses by nasally administered siRNA
    • Bitko V, Musiyenko A, Shulyayeva O, Barik S. Inhibition of respiratory viruses by nasally administered siRNA. Nat Med 2005; 11:50-55.
    • (2005) Nat Med , vol.11 , pp. 50-55
    • Bitko, V.1    Musiyenko, A.2    Shulyayeva, O.3    Barik, S.4
  • 69
    • 70349147840 scopus 로고    scopus 로고
    • RNA interference-mediated silencing of the respiratory syncytial virus nucle-ocapsid defnes a potent antiviral strategy
    • Alvarez R, Elbashir S, Borland T, et al. RNA interference-mediated silencing of the respiratory syncytial virus nucle-ocapsid defnes a potent antiviral strategy. Antimicrob Agents Chemother 2009; 53:3952-3962.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 3952-3962
    • Alvarez, R.1    Elbashir, S.2    Borland, T.3
  • 70
    • 77957951081 scopus 로고    scopus 로고
    • Use of a highly sensitive strand-specifc quantitative PCR to identify abortive replication in the mouse model of respiratory syncytial virus disease
    • Bannister R, Rodrigues D, Murray EJ, Laxton C, Westby M, Bright H. Use of a highly sensitive strand-specifc quantitative PCR to identify abortive replication in the mouse model of respiratory syncytial virus disease. Virol J 2010; 7:250-261.
    • (2010) Virol J , vol.7 , pp. 250-261
    • Bannister, R.1    Rodrigues, D.2    Murray, E.J.3    Laxton, C.4    Westby, M.5    Bright, H.6
  • 71
    • 79951849229 scopus 로고    scopus 로고
    • RNA interference therapy in lung transplant patients infected with respiratory syncytial virus
    • Zamora MR, Budev M, Rolfe M, et al. RNA interference therapy in lung transplant patients infected with respiratory syncytial virus. Am J Respir Crit Care Med 2011; 183:531-538.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 531-538
    • Zamora, M.R.1    Budev, M.2    Rolfe, M.3
  • 72
    • 78149363346 scopus 로고    scopus 로고
    • Exploiting the therapeutic potential of microRNAs in viral diseases: Expectations and limitations
    • Hemida MG, Ye X, Thair S, Yang D. Exploiting the therapeutic potential of microRNAs in viral diseases: expectations and limitations. Mol Diagn Ther 2010; 14:271-282.
    • (2010) Mol Diagn Ther , vol.14 , pp. 271-282
    • Hemida, M.G.1    Ye, X.2    Thair, S.3    Yang, D.4
  • 74
    • 78349243640 scopus 로고    scopus 로고
    • Viral load drives disease in humans experimentally infected with respiratory syncytial virus
    • DeVincenzo J P, Wilkinson T, Vaishnaw A, et al. Viral load drives disease in humans experimentally infected with respiratory syncytial virus. Am J Respir Crit Care Med 2010; 182:1305-1314.
    • (2010) Am J Respir Crit Care Med , vol.182 , pp. 1305-1314
    • Devincenzo, J.P.1    Wilkinson, T.2    Vaishnaw, A.3
  • 75
    • 34547783897 scopus 로고    scopus 로고
    • VII International Symposium on Respiratory Viral Infections
    • Bermingham A, Henrickson K, Hayden F, Zambon M. VII International Symposium on Respiratory Viral Infections. Antivir Ther 2007; 12:671-693.
    • (2007) Antivir Ther , vol.12 , pp. 671-693
    • Bermingham, A.1    Henrickson, K.2    Hayden, F.3    Zambon, M.4
  • 76
    • 79953082205 scopus 로고    scopus 로고
    • Management of RSV infections in adult recipients of hematopoietic stem cell transplantation
    • Shah JN, Chemaly RF. Management of RSV infections in adult recipients of hematopoietic stem cell transplantation. Blood 2011; 117:2755-2763.
    • (2011) Blood , vol.117 , pp. 2755-2763
    • Shah, J.N.1    Chemaly, R.F.2
  • 77
    • 18944399906 scopus 로고    scopus 로고
    • Respiratory syncy-tial virus load predicts disease severity in previously healthy infants
    • DeVincenzo J P, El Saleeby CM, Bush AJ. Respiratory syncy-tial virus load predicts disease severity in previously healthy infants. J Infect Dis 2005; 191:1861-1868.
    • (2005) J Infect Dis , vol.191 , pp. 1861-1868
    • Devincenzo, J.P.1    El Saleeby, C.M.2    Bush, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.